Regulation of developmental hierarchy in Drosophila neural stem cell tumors by COMPASS and Polycomb complexes

Integrated analysis of multimodal single-cell data

(2021) Yuhan Hao et al.   CELL

Polycomb repressive complex 2 in the driver’s seat of childhood and young adult brain tumours

(2021) Brian Krug et al.   TRENDS IN CELL BIOLOGY

A shared transcriptional code orchestrates temporal patterning of the central nervous system

(2021) Andreas Sagner et al.   PLOS BIOLOGY

Imp/IGF2BP levels modulate individual neural stem cell growth and division through myc mRNA stability

(2020) Tamsin J Samuels et al.   eLife

Uncoupling histone H3K4 trimethylation from developmental gene expression via an equilibrium of COMPASS, Polycomb and DNA methylation

(2020) Delphine Douillet et al.   NATURE GENETICS

Single-Cell RNA-Seq Reveals Cellular Hierarchies and Impaired Developmental Trajectories in Pediatric Ependymoma

(2020) Johannes Gojo et al.   CANCER CELL

Temporal patterning in neural progenitors: from Drosophila development to childhood cancers

(2020) Cédric Maurange   Disease Models & Mechanisms

EZH2: a novel target for cancer treatment

(2020) Ran Duan et al.   Journal of Hematology & Oncology

Single-cell RNA-seq reveals that glioblastoma recapitulates a normal neurodevelopmental hierarchy

(2020) Charles P. Couturier et al.   Nature Communications

Oxidative Metabolism Drives Immortalization of Neural Stem Cells during Tumorigenesis

(2020) François Bonnay et al.   CELL

COMPASS and SWI/SNF complexes in development and disease

(2020) Bercin K. Cenik et al.   NATURE REVIEWS GENETICS

Cellpose: a generalist algorithm for cellular segmentation

(2020) Carsen Stringer et al.   NATURE METHODS

The single-cell transcriptional landscape of mammalian organogenesis

(2019) Junyue Cao et al.   NATURE

Polycomb/Trithorax Antagonism: Cellular Memory in Stem Cell Fate and Function

(2019) Marjorie Brand et al.   Cell Stem Cell

Stem Cell Proliferation Is Kept in Check by the Chromatin Regulators Kismet/CHD7/CHD8 and Trr/MLL3/4

(2019) Louis Gervais et al.   DEVELOPMENTAL CELL

Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex

(2019) L. Telley et al.   SCIENCE

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Glioblastoma stem cells: lessons from the tumor hierarchy in a lethal cancer

(2019) Ryan C. Gimple et al.   GENES & DEVELOPMENT

Neural stem cell temporal patterning and brain tumour growth rely on oxidative phosphorylation

(2019) Jelle van den Ameele et al.   eLife

Coopted temporal patterning governs cellular hierarchy, heterogeneity and metabolism in Drosophila neuroblast tumors

(2019) Sara Genovese et al.   eLife

Neural stem cell dynamics: the development of brain tumours

(2019) Anna E Hakes et al.   CURRENT OPINION IN CELL BIOLOGY

Dynamics of activating and repressive histone modifications in Drosophila neural stem cell lineages and brain tumors

(2019) Merve Deniz Abdusselamoglu et al.   DEVELOPMENT

Resetting the epigenetic balance of Polycomb and COMPASS function at enhancers for cancer therapy

(2018) Lu Wang et al.   NATURE MEDICINE

Neuronal specification in space and time

(2018) Isabel Holguera et al.   SCIENCE

Polycomb and Trithorax Group Genes inDrosophila

(2017) Judith A. Kassis et al.   GENETICS

Epigenetic plasticity and the hallmarks of cancer

(2017) William A. Flavahan et al.   SCIENCE

Inactivation of Ezh2 Upregulates Gfi1 and Drives Aggressive Myc-Driven Group 3 Medulloblastoma

(2017) BaoHan T. Vo et al.   Cell Reports

Steroid hormone induction of temporal gene expression in Drosophila brain neuroblasts generates neuronal and glial diversity

(2017) Mubarak Hussain Syed et al.   eLife

Polycomb and Trithorax Group Genes inDrosophila

(2017) Judith A. Kassis et al.   GENETICS

The LIN28/let-7 Pathway in Cancer

(2017) Julien Balzeau et al.   Frontiers in Genetics

Cancer Stem Cells: Basic Concepts and Therapeutic Implications

(2016) Dany Nassar et al.   Annual Review of Pathology-Mechanisms of Disease

Ezh2 regulates the Lin28/let-7 pathway to restrict activation of fetal gene signature in adult hematopoietic stem cells

(2016) Motohiko Oshima et al.   EXPERIMENTAL HEMATOLOGY

IMPs: an RNA-binding protein family that provides a link between stem cell maintenance in normal development and cancer

(2016) Nils Degrauwe et al.   GENES & DEVELOPMENT

Stable Binding of the Conserved Transcription Factor Grainy Head to its Target Genes Throughout Drosophila melanogaster Development

(2016) Markus Nevil et al.   GENETICS

Cancer stem cells

(2016) Jeremy N. Rich   MEDICINE

Single-cell RNA-seq supports a developmental hierarchy in human oligodendroglioma

(2016) Itay Tirosh et al.   NATURE

Targeting EZH2 in cancer

(2016) Kimberly H Kim et al.   NATURE MEDICINE

Neural stem cell-encoded temporal patterning delineates an early window of malignant susceptibility in Drosophila

(2016) Karine Narbonne-Reveau et al.   eLife

Stable Binding of the Conserved Transcription Factor Grainy Head to its Target Genes Throughout Drosophila melanogaster Development

(2016) Markus Nevil et al.   GENETICS

Trithorax and Polycomb group-dependent regulation: a tale of opposing activities

(2015) S. J. Geisler et al.   DEVELOPMENT

Opposing intrinsic temporal gradients guide neural stem cell production of varied neuronal fates

(2015) Z. Liu et al.   SCIENCE

Prolonged Ezh2 Depletion in Glioblastoma Causes a Robust Switch in Cell Fate Resulting in Tumor Progression

(2015) Nienke A. de Vries et al.   Cell Reports

Histone H3 lysine-to-methionine mutants as a paradigm to study chromatin signaling

(2014) H.-M. Herz et al.   SCIENCE

Transcriptional Regulation by Trithorax-Group Proteins

(2014) R. E. Kingston et al.   Cold Spring Harbor Perspectives in Biology

Trithorax maintains the functional heterogeneity of neural stem cells through the transcription factor Buttonhead

(2014) Hideyuki Komori et al.   eLife

Combinatorial temporal patterning in progenitors expands neural diversity

(2013) Omer Ali Bayraktar et al.   NATURE

Tumour heterogeneity and cancer cell plasticity

(2013) Corbin E. Meacham et al.   NATURE

Mutational landscape and significance across 12 major cancer types

(2013) Cyriac Kandoth et al.   NATURE

A network of heterochronic genes including Imp1 regulates temporal changes in stem cell properties

(2013) Jinsuke Nishino et al.   eLife

GADD45 Proteins: Central Players in Tumorigenesis

(2012) R. E. Tamura et al.   CURRENT MOLECULAR MEDICINE

Drosophila neuroblasts: a model for stem cell biology

(2012) C. C. F. Homem et al.   DEVELOPMENT

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Genome-Wide Analysis of Self-Renewal in Drosophila Neural Stem Cells by Transgenic RNAi

(2011) Ralph A. Neumüller et al.   Cell Stem Cell

The COMPASS Family of H3K4 Methylases in Drosophila

(2011) M. Mohan et al.   MOLECULAR AND CELLULAR BIOLOGY

Epigenetic Antagonism between Polycomb and SWI/SNF Complexes during Oncogenic Transformation

(2010) Boris G. Wilson et al.   CANCER CELL

A tumor suppressor activity of Drosophila Polycomb genes mediated by JAK-STAT signaling

(2009) Anne-Kathrin Classen et al.   NATURE GENETICS

Polyhomeotic has a tumor suppressor activity mediated by repression of Notch signaling

(2009) Anne-Marie Martinez et al.   NATURE GENETICS

Temporal Transcription Factors and Their Targets Schedule the End of Neural Proliferation in Drosophila

(2008) Cédric Maurange et al.   CELL