The First-in-Human Synthetic Glycan-Based Conjugate Vaccine Candidate against Shigella

The role of vaccines in combatting antimicrobial resistance

(2021) Francesca Micoli et al.   NATURE REVIEWS MICROBIOLOGY

Recent advances on smart glycoconjugate vaccines in infections and cancer

(2021) Marko Anderluh et al.   FEBS Journal

Human challenge study with a Shigella bioconjugate vaccine: Analyses of clinical efficacy and correlate of protection

(2021) Kawsar R. Talaat et al.   EBioMedicine

Immunogenicity of PCV24, an expanded pneumococcal conjugate vaccine, in adult monkeys and protection in mice

(2021) Debra McGuinness et al.   VACCINE

Impact of O-Acetylation on S. flexneri 1b and 2a O-Antigen Immunogenicity in Mice

(2021) Vanessa Arato et al.   Microorganisms

Carbohydrate Conjugates in Vaccine Developments

(2020) Shuyao Lang et al.   Frontiers in Chemistry

Improving efficacy of glycoconjugate vaccines: from chemical conjugates to next generation constructs

(2020) Francesco Berti et al.   CURRENT OPINION IN IMMUNOLOGY

Expanding the role of bacterial vaccines into life-course vaccination strategies and prevention of antimicrobial-resistant infections

(2020) Jan T. Poolman   npj Vaccines

Exploratory N‐protecting group manipulation for the total synthesis of zwitterionic Shigella sonnei oligosaccharides

(2020) Debashis DHARA et al.   CHEMISTRY-A EUROPEAN JOURNAL

Safety and immunogenicity of a synthetic carbohydrate conjugate vaccine against Shigella flexneri 2a in healthy adult volunteers: a phase 1, dose-escalating, single-blind, randomised, placebo-controlled study

(2020) Dani Cohen et al.   LANCET INFECTIOUS DISEASES

Serum IgG antibodies to Shigella lipopolysaccharide antigens – a correlate of protection against shigellosis

(2019) Dani Cohen et al.   Human Vaccines & Immunotherapeutics

Classical and novel strategies to develop a Shigella glycoconjugate vaccine: from concept to efficacy in human

(2019) Louis-Antoine Barel et al.   Human Vaccines & Immunotherapeutics

Glycoconjugates: What It Would Take To Master These Well-Known yet Little-Understood Immunogens for Vaccine Development

(2019) Fikri Avci et al.   mSphere

Consensus Report on Shigella Controlled Human Infection Model: Clinical Endpoints

(2019) Calman A MacLennan et al.   CLINICAL INFECTIOUS DISEASES

Shigellosis

(2018) Karen L Kotloff et al.   LANCET

Role of O-Acetylation in the Immunogenicity of Bacterial Polysaccharide Vaccines

(2018) Francesco Berti et al.   MOLECULES

The role of vaccines in preventing bacterial antimicrobial resistance

(2018) Kathrin U Jansen et al.   NATURE MEDICINE

WHO consultation on ETEC and Shigella burden of disease, Geneva, 6–7th April 2017: Meeting report

(2018) Divya Hosangadi et al.   VACCINE

Global disability-adjusted life-year estimates of long-term health burden and undernutrition attributable to diarrhoeal diseases in children younger than 5 years

(2018) Christopher Troeger et al.   Lancet Global Health

Development, Interlaboratory Evaluations, and Application of a Simple, High-Throughput Shigella Serum Bactericidal Assay

(2018) Moon H. Nahm et al.   mSphere

Bioconjugation with Maleimides: A useful Tool for Chemical Biology

(2018) Pedro Miguel pimenta Gois et al.   CHEMISTRY-A EUROPEAN JOURNAL

Recent insights into Shigella

(2018) Stephen Baker et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Morbidity and mortality due to shigella and enterotoxigenic Escherichia coli diarrhoea: the Global Burden of Disease Study 1990–2016

(2018) Ibrahim A Khalil et al.   LANCET INFECTIOUS DISEASES

Glycoconjugate vaccines: Principles and mechanisms

(2018) Rino Rappuoli   Science Translational Medicine

Polysaccharide structure dictates mechanism of adaptive immune response to glycoconjugate vaccines

(2018) Ximei Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

On the mechanisms of conjugate vaccines

(2018) Rino Rappuoli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Travelers' Diarrhea: An Update on the Incidence, Etiology, and Risk in Military Deployments and Similar Travel Populations

(2017) Chad K. Porter et al.   MILITARY MEDICINE

A Phase 2a Randomized Study to Evaluate the Safety and Immunogenicity of the 1790GAHB Generalized Modules for Membrane Antigen Vaccine against Shigella sonnei Administered Intramuscularly to Adults from a Shigellosis-Endemic Country

(2017) Christina W. Obiero et al.   Frontiers in Immunology

A Synthetic Carbohydrate Conjugate Vaccine Candidate against Shigellosis: Improved Bioconjugation and Impact of Alum on Immunogenicity

(2016) Robert M. F. van der Put et al.   BIOCONJUGATE CHEMISTRY

Detailed Investigation of the Immunodominant Role of O-Antigen Stoichiometric O-Acetylation as Revealed by Chemical Synthesis, Immunochemistry, Solution Conformation and STD-NMR Spectroscopy for Shigella flexneri  3a

(2016) Julien Boutet et al.   CHEMISTRY-A EUROPEAN JOURNAL

Use of quantitative molecular diagnostic methods to identify causes of diarrhoea in children: a reanalysis of the GEMS case-control study

(2016) Jie Liu et al.   LANCET

Programmed chemo-enzymatic synthesis of the oligosaccharide component of a carbohydrate-based antibacterial vaccine candidate

(2015) Stéphane Salamone et al.   CHEMICAL COMMUNICATIONS

Pathogen-specific burdens of community diarrhoea in developing countries: a multisite birth cohort study (MAL-ED)

(2015) James A Platts-Mills et al.   Lancet Global Health

Chemical Biology Approaches to Designing Defined Carbohydrate Vaccines

(2014) Chakkumkal Anish et al.   CHEMISTRY & BIOLOGY

Shigella Isolates From the Global Enteric Multicenter Study Inform Vaccine Development

(2014) S. Livio et al.   CLINICAL INFECTIOUS DISEASES

Recent trends in the epidemiology of shigellosis in Israel

(2014) D. COHEN et al.   EPIDEMIOLOGY AND INFECTION

Linear synthesis of the branched pentasaccharide repeats of O-antigens from Shigella flexneri 1a and 1b demonstrating the major steric hindrance associated with type-specific glucosylation

(2014) Jason M. Hargreaves et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Non-stoichiometric O-acetylation of Shigella flexneri 2a O-specific polysaccharide: synthesis and antigenicity

(2014) Charles Gauthier et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Structural Studies of theO-Acetyl-Containing O-Antigen from aShigella flexneriSerotype 6 Strain and Synthesis of Oligo­saccharide Fragments Thereof

(2013) Pierre Chassagne et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

The history of pneumococcal conjugate vaccine development: dose selection

(2013) Jan T Poolman et al.   Expert Review of Vaccines

Shigella flexneriO-antigens revisited: final elucidation of the O-acetylation profiles and a survey of the O-antigen structure diversity

(2012) Andrei V. Perepelov et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Conjugation site modulates the in vivo stability and therapeutic activity of antibody-drug conjugates

(2012) Ben-Quan Shen et al.   NATURE BIOTECHNOLOGY

Dynamic aspects of antibody:oligosaccharide complexes characterized by molecular dynamics simulations and saturation transfer difference nuclear magnetic resonance

(2011) François-Xavier Theillet et al.   GLYCOBIOLOGY

Effects of backbone substitutions on the conformational behavior of Shigella flexneri O-antigens: implications for vaccine strategy

(2010) François-Xavier Theillet et al.   GLYCOBIOLOGY

Age-related efficacy of Shigella O-specific polysaccharide conjugates in 1–4-year-old Israeli children

(2010) Justen H. Passwell et al.   VACCINE

A similarity in the O-acetylation pattern of the O-antigens of Shigellaflexneri types 1a, 1b, and 2a

(2009) Andrei V. Perepelov et al.   CARBOHYDRATE RESEARCH

A Synthetic Carbohydrate-Protein Conjugate Vaccine Candidate against Shigella flexneri 2a Infection

(2009) A. Phalipon et al.   JOURNAL OF IMMUNOLOGY

Rational design and immunogenicity of liposome-based diepitope constructs: Application to synthetic oligosaccharides mimicking the Shigella flexneri 2a O-antigen

(2009) Fatouma Said Hassane et al.   VACCINE

Preparation of bacterial polysaccharide–protein conjugates: Analytical and manufacturing challenges

(2009) Carl E. Frasch   VACCINE

Structures of synthetic O-antigen fragments from serotype 2a Shigella flexneri in complex with a protective monoclonal antibody

(2008) B. Vulliez-Le Normand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA