Classical and novel strategies to develop a Shigella glycoconjugate vaccine: from concept to efficacy in human

Overexpression of O-polysaccharide chain length regulators in Gram-negative bacteria using the Wzx-/Wzy-dependent pathway enhances production of defined modal length O-polysaccharide polymers for use as haptens in glycoconjugate vaccines

(2018) N. Hegerle et al.   JOURNAL OF APPLIED MICROBIOLOGY

Shigellosis

(2018) Karen L Kotloff et al.   LANCET

Role of O-Acetylation in the Immunogenicity of Bacterial Polysaccharide Vaccines

(2018) Francesco Berti et al.   MOLECULES

Clinical endpoints in the controlled human challenge model for Shigella: A call for standardization and the development of a disease severity score

(2018) Chad K. Porter et al.   PLoS One

Assembly, Biochemical Characterization, Immunogenicity, Adjuvanticity, and Efficacy of Shigella Artificial Invaplex

(2018) K. Ross Turbyfill et al.   mSphere

Recent insights into Shigella

(2018) Stephen Baker et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Characterization of a serologically atypical Shigella flexneri Z isolated from diarrheal patients in Bangladesh and a proposed serological scheme for Shigella flexneri

(2018) Mohammad Shahnaij et al.   PLoS One

Glycoconjugate vaccines: Principles and mechanisms

(2018) Rino Rappuoli   Science Translational Medicine

Evaluation of a conjugate vaccine platform against enterotoxigenic Escherichia coli (ETEC), Campylobacter jejuni and Shigella

(2018) Renee M. Laird et al.   VACCINE

Polysaccharide structure dictates mechanism of adaptive immune response to glycoconjugate vaccines

(2018) Ximei Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Vaccination with Shigella flexneri 2a conjugate induces type 2a and cross-reactive type 6 antibodies in humans but not in mice

(2017) Nahid Farzam et al.   VACCINE

A Phase 2a Randomized Study to Evaluate the Safety and Immunogenicity of the 1790GAHB Generalized Modules for Membrane Antigen Vaccine against Shigella sonnei Administered Intramuscularly to Adults from a Shigellosis-Endemic Country

(2017) Christina W. Obiero et al.   Frontiers in Immunology

A Synthetic Carbohydrate Conjugate Vaccine Candidate against Shigellosis: Improved Bioconjugation and Impact of Alum on Immunogenicity

(2016) Robert M. F. van der Put et al.   BIOCONJUGATE CHEMISTRY

Safety and Immunogenicity of a Candidate Bioconjugate Vaccine against Shigella flexneri 2a Administered to Healthy Adults: a Single-Blind, Randomized Phase I Study

(2016) Mark S. Riddle et al.   Clinical and Vaccine Immunology

A two-step method for extraction of lipopolysaccharide from Shigella dysenteriae serotype 1 and Salmonella typhimurium : An improved method for enhanced yield and purity

(2016) Nadim Ahamad et al.   JOURNAL OF MICROBIOLOGICAL METHODS

Use of quantitative molecular diagnostic methods to identify causes of diarrhoea in children: a reanalysis of the GEMS case-control study

(2016) Jie Liu et al.   LANCET

Status of vaccine research and development for Shigella

(2016) Sachin Mani et al.   VACCINE

O-Antigen modifications providing antigenic diversity of Shigella flexneri and underlying genetic mechanisms

(2015) Y. A. Knirel et al.   BIOCHEMISTRY-MOSCOW

Programmed chemo-enzymatic synthesis of the oligosaccharide component of a carbohydrate-based antibacterial vaccine candidate

(2015) Stéphane Salamone et al.   CHEMICAL COMMUNICATIONS

Purification and characterization of aShigellaconjugate vaccine, produced by glycoengineeringEscherichia coli

(2015) Neil Ravenscroft et al.   GLYCOBIOLOGY

Safety and immunogenicity of a candidate bioconjugate vaccine against Shigella dysenteriae type 1 administered to healthy adults: A single blind, partially randomized Phase I study

(2015) Christoph F.R Hatz et al.   VACCINE

Pathogen-specific burdens of community diarrhoea in developing countries: a multisite birth cohort study (MAL-ED)

(2015) James A Platts-Mills et al.   Lancet Global Health

Shigella Isolates From the Global Enteric Multicenter Study Inform Vaccine Development

(2014) S. Livio et al.   CLINICAL INFECTIOUS DISEASES

Glycoconjugate vaccines: an update

(2014) Mairi Vella et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Non-stoichiometric O-acetylation of Shigella flexneri 2a O-specific polysaccharide: synthesis and antigenicity

(2014) Charles Gauthier et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis of the Zwitterionic Repeating Unit of the O-Antigen from Shigella sonnei and Chain Elongation at Both Ends

(2014) Hélène B. Pfister et al.   ORGANIC LETTERS

HR-MAS NMR reveals a pH-dependent LPS alteration by de-O-acetylation at abequose in the O-antigen of Salmonella enterica serovar Typhimurium

(2013) Karin Ilg et al.   CARBOHYDRATE RESEARCH

Structural Studies of theO-Acetyl-Containing O-Antigen from aShigella flexneriSerotype 6 Strain and Synthesis of Oligo­saccharide Fragments Thereof

(2013) Pierre Chassagne et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Progress and pitfalls in Shigella vaccine research

(2013) Eileen M. Barry et al.   Nature Reviews Gastroenterology & Hepatology

Synthetically defined glycoprotein vaccines: current status and future directions

(2013) Roberto Adamo et al.   Chemical Science

Shigella flexneriO-antigens revisited: final elucidation of the O-acetylation profiles and a survey of the O-antigen structure diversity

(2012) Andrei V. Perepelov et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Dynamic aspects of antibody:oligosaccharide complexes characterized by molecular dynamics simulations and saturation transfer difference nuclear magnetic resonance

(2011) François-Xavier Theillet et al.   GLYCOBIOLOGY

Immunochemical studies of Shigella flexneri 2a and 6, and Shigella dysenteriae type 1 O-specific polysaccharide-core fragments and their protein conjugates as vaccine candidates

(2010) Joanna Kubler-Kielb et al.   CARBOHYDRATE RESEARCH

Effects of backbone substitutions on the conformational behavior of Shigella flexneri O-antigens: implications for vaccine strategy

(2010) François-Xavier Theillet et al.   GLYCOBIOLOGY

Production of glycoprotein vaccines in Escherichia coli

(2010) Julian Ihssen et al.   Microbial Cell Factories

Age-related efficacy of Shigella O-specific polysaccharide conjugates in 1–4-year-old Israeli children

(2010) Justen H. Passwell et al.   VACCINE

Safety, dose, immunogenicity, and transmissibility of an oral live attenuated Shigella flexneri 2a vaccine candidate (SC602) among healthy adults and school children in Matlab, Bangladesh

(2010) Kazi Mizanur Rahman et al.   VACCINE

A similarity in the O-acetylation pattern of the O-antigens of Shigellaflexneri types 1a, 1b, and 2a

(2009) Andrei V. Perepelov et al.   CARBOHYDRATE RESEARCH

A Synthetic Carbohydrate-Protein Conjugate Vaccine Candidate against Shigella flexneri 2a Infection

(2009) A. Phalipon et al.   JOURNAL OF IMMUNOLOGY

Synthesis, characterization, and immunogenicity in mice of Shigella sonnei O-specific oligosaccharide-core-protein conjugates

(2009) J. B. Robbins et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rational design and immunogenicity of liposome-based diepitope constructs: Application to synthetic oligosaccharides mimicking the Shigella flexneri 2a O-antigen

(2009) Fatouma Said Hassane et al.   VACCINE

Characteristics of carbohydrate antigen binding to the presentation protein HLA-DR

(2008) Brian A Cobb et al.   GLYCOBIOLOGY

Structures of synthetic O-antigen fragments from serotype 2a Shigella flexneri in complex with a protective monoclonal antibody

(2008) B. Vulliez-Le Normand et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA