Mecheliolide elicits ROS-mediated ERS driven immunogenic cell death in hepatocellular carcinoma

Drug delivery strategies in maximizing anti-angiogenesis and anti-tumor immunity

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Chitosan-based nanoparticle co-delivery of docetaxel and curcumin ameliorates anti-tumor chemoimmunotherapy in lung cancer

(2021) Xiongjie Zhu et al.   CARBOHYDRATE POLYMERS

IRF2 regulates cellular survival and Lenvatinib-sensitivity of hepatocellular carcinoma (HCC) through regulating β-catenin

(2021) Yarong Guo et al.   Translational Oncology

Auranofin reveals therapeutic anticancer potential by triggering distinct molecular cell death mechanisms and innate immunity in mutant p53 non-small cell lung cancer

(2021) Laurie Freire Boullosa et al.   Redox Biology

Ultrasensitive Genetically Encoded Indicator for Hydrogen Peroxide Identifies Roles for the Oxidant in Cell Migration and Mitochondrial Function

(2020) Valeriy V. Pak et al.   Cell Metabolism

Sanguinarine as a new chemical entity of thioredoxin reductase inhibitor to elicit oxidative stress and promote tumor cell apoptosis

(2020) Juan Yao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Icaritin Exacerbates Mitophagy and Synergizes with Doxorubicin to Induce Immunogenic Cell Death in Hepatocellular Carcinoma

(2020) Zhuo Yu et al.   ACS Nano

OTULIN protects the liver against cell death, inflammation, fibrosis, and cancer

(2020) Rune Busk Damgaard et al.   CELL DEATH AND DIFFERENTIATION

Micheliolide Enhances Radiosensitivities of p53-Deficient Non-Small-Cell Lung Cancer via Promoting HIF-1α Degradation

(2020) Peizhong Kong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Discovery of Potent Inhibitors against P-Glycoprotein-Mediated Multidrug Resistance Aided by Late-Stage Functionalization of a 2-(4-(Pyridin-2-yl)phenoxy)pyridine Analogue

(2020) Yao Ma et al.   JOURNAL OF MEDICINAL CHEMISTRY

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

(2020) Helmut Sies et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Paclitaxel induces immunogenic cell death in ovarian cancer via TLR4/IKK2/SNARE-dependent exocytosis

(2020) Tat San Lau et al.   Cancer Immunology Research

Chemical strategies to overcome resistance against targeted anticancer therapeutics

(2020) Rudolf Pisa et al.   Nature Chemical Biology

A Hepatocellular Carcinoma Targeting Nanostrategy with Hypoxia-Ameliorating and Photothermal Abilities that, Combined with Immunotherapy, Inhibits Metastasis and Recurrence

(2020) Tianjun Zhou et al.   ACS Nano

Oxaliplatin induces immunogenic cell death in hepatocellular carcinoma cells and synergizes with immune checkpoint blockade therapy

(2020) Hanzhang Zhu et al.   CELLULAR ONCOLOGY

Sophoridine suppresses lenvatinib‐resistant hepatocellular carcinoma growth by inhibiting RAS/MEK/ERK axis via decreasing VEGFR2 expression

(2020) Zhongwei Zhao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Rationally Designed Redox-Active Au(I) N-Heterocyclic Carbene: An Immunogenic Cell Death Inducer

(2020) Sajal Sen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

N6-methyladenosine-modified CircRNA-SORE sustains sorafenib resistance in hepatocellular carcinoma by regulating β-catenin signaling

(2020) Junjie Xu et al.   Molecular Cancer

Lenvatinib-zinc phthalocyanine conjugates as potential agents for enhancing synergistic therapy of multidrug-resistant cancer by glutathione depletion

(2019) Gaofei Wei et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Targeting the Thioredoxin System as a Strategy for Cancer Therapy

(2019) Mianli Bian et al.   JOURNAL OF MEDICINAL CHEMISTRY

Virtual screening-guided discovery of thioredoxin reductase inhibitors

(2019) Ruijuan Liu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Liver organoids: from basic research to therapeutic applications

(2019) Nicole Prior et al.   GUT

Overview of thioredoxin system and targeted therapies for acute leukemia

(2019) Weiling Xie et al.   MITOCHONDRION

ROS-mediated inactivation of the PI3K/AKT pathway is involved in the antigastric cancer effects of thioredoxin reductase-1 inhibitor chaetocin

(2019) Chuangyu Wen et al.   Cell Death & Disease

Lineage tracing of acute myeloid leukemia reveals the impact of hypomethylating agents on chemoresistance selection

(2019) Francisco Caiado et al.   Nature Communications

Micheliolide Inhibits Liver Cancer Cell Growth Via Inducing Apoptosis And Perturbing Actin Cytoskeleton

(2019) Lili Yu et al.   Cancer Management and Research

Human aquaporin-11 guarantees efficient transport of H2O2 across the endoplasmic reticulum membrane

(2019) Stefano Bestetti et al.   Redox Biology

The plant sesquiterpene lactone parthenolide inhibits Wnt/β-catenin signaling by blocking synthesis of the transcriptional regulators TCF4/LEF1

(2018) Xiaoliang Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small molecule inhibitors of mammalian thioredoxin reductase as potential anticancer agents: An update

(2018) Junmin Zhang et al.   MEDICINAL RESEARCH REVIEWS

The long non-coding RNA PTTG3P promotes cell growth and metastasis via up-regulating PTTG1 and activating PI3K/AKT signaling in hepatocellular carcinoma

(2018) Jin-lan Huang et al.   Molecular Cancer

Endoplasmic Reticulum–Mitochondrial Contactology: Structure and Signaling Functions

(2018) György Csordás et al.   TRENDS IN CELL BIOLOGY

Recent progresses in small-molecule enzymatic fluorescent probes for cancer imaging

(2018) Hong-Wen Liu et al.   CHEMICAL SOCIETY REVIEWS

Next Steps for Immune Checkpoints in Hepatocellular Carcinoma

(2018) Patricia M. Santos et al.   GASTROENTEROLOGY

Induction of Oxidative Stress via Inhibition of Thioredoxin Reductase 1 is an Effective Therapeutic Approach for Hepatocellular Carcinoma

(2018) Derek Lee et al.   HEPATOLOGY

Curcuminoid B63 induces ROS-mediated paraptosis-like cell death by targeting TrxR1 in gastric cells

(2018) Xi Chen et al.   Redox Biology

Targeting the Thioredoxin System for Cancer Therapy

(2017) Junmin Zhang et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Thioredoxin reductase inhibitors: a patent review

(2016) Baoxin Zhang et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Innate Immune Recognition of Cancer

(2015) Seng-Ryong Woo et al.   Annual Review of Immunology

TrxR1 as a Potent Regulator of the Nrf2-Keap1 Response System

(2015) Marcus Cebula et al.   ANTIOXIDANTS & REDOX SIGNALING

Immunogenic cell death

(2015) Abhishek D. Garg et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Caspase-1–mediated pathway promotes generation of thromboinflammatory microparticles

(2015) Andrea S. Rothmeier et al.   JOURNAL OF CLINICAL INVESTIGATION

A furanyl acryl conjugated coumarin as an efficient inhibitor and a highly selective off–on fluorescent probe for covalent labelling of thioredoxin reductase

(2014) Lei Huang et al.   CHEMICAL COMMUNICATIONS

Antioxidants Accelerate Lung Cancer Progression in Mice

(2014) V. I. Sayin et al.   Science Translational Medicine

Danger signalling during cancer cell death: origins, plasticity and regulation

(2013) A D Garg et al.   CELL DEATH AND DIFFERENTIATION

Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

(2013) D. M. Molina et al.   SCIENCE

Role of Reactive Oxygen Species-Mediated Signaling in Aging

(2012) Vyacheslav M. Labunskyy et al.   ANTIOXIDANTS & REDOX SIGNALING

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

(2011) Ira Tabas et al.   NATURE CELL BIOLOGY

Improved Clinical Outcome in Indolent B-Cell Lymphoma Patients Vaccinated with Autologous Tumor Cells Experiencing Immunogenic Death

(2010) R. Zappasodi et al.   CANCER RESEARCH