ROS-mediated inactivation of the PI3K/AKT pathway is involved in the antigastric cancer effects of thioredoxin reductase-1 inhibitor chaetocin
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
ROS-mediated inactivation of the PI3K/AKT pathway is involved in the antigastric cancer effects of thioredoxin reductase-1 inhibitor chaetocin
Authors
Keywords
-
Journal
Cell Death & Disease
Volume 10, Issue 11, Pages -
Publisher
Springer Science and Business Media LLC
Online
2019-10-25
DOI
10.1038/s41419-019-2035-x
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- The interplay of reactive oxygen species and the epidermal growth factor receptor in tumor progression and drug resistance
- (2018) Meng-Shih Weng et al. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
- Physiological role of reactive oxygen species as promoters of natural defenses
- (2017) Jérôme Roy et al. FASEB JOURNAL
- Reactive oxygen species and cancer paradox: To promote or to suppress?
- (2017) Sehamuddin Galadari et al. FREE RADICAL BIOLOGY AND MEDICINE
- Cardamonin induces ROS-mediated G2/M phase arrest and apoptosis through inhibition of NF-κB pathway in nasopharyngeal carcinoma
- (2017) Yuting Li et al. Cell Death & Disease
- Furanodienone induces G0/G1 arrest and causes apoptosis via the ROS/MAPKs-mediated caspase-dependent pathway in human colorectal cancer cells: a study in vitro and in vivo
- (2017) Ying Jiang et al. Cell Death & Disease
- Piperlongumine as a direct TrxR1 inhibitor with suppressive activity against gastric cancer
- (2016) Peng Zou et al. CANCER LETTERS
- Chaetocin inhibits IBMX-induced melanogenesis in B16F10 mouse melanoma cells through activation of ERK
- (2016) Jung-Soo Bae et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Thioredoxin reductase inhibitors: a patent review
- (2016) Baoxin Zhang et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Gastric cancer
- (2016) Eric Van Cutsem et al. LANCET
- The Interplay of Reactive Oxygen Species, Hypoxia, Inflammation, and Sirtuins in Cancer Initiation and Progression
- (2016) Marco Tafani et al. Oxidative Medicine and Cellular Longevity
- Knockout of Mitochondrial Thioredoxin Reductase Stabilizes Prolyl Hydroxylase 2 and Inhibits Tumor Growth and Tumor-Derived Angiogenesis
- (2015) Juliane Hellfritsch et al. ANTIOXIDANTS & REDOX SIGNALING
- Chaetocin induces endoplasmic reticulum stress response and leads to death receptor 5-dependent apoptosis in human non-small cell lung cancer cells
- (2015) Xianfang Liu et al. APOPTOSIS
- Synergistic antitumor activity of withaferin A combined with oxaliplatin triggers reactive oxygen species-mediated inactivation of the PI3K/AKT pathway in human pancreatic cancer cells
- (2015) Xu Li et al. CANCER LETTERS
- The SUV39H1 inhibitor chaetocin induces differentiation and shows synergistic cytotoxicity with other epigenetic drugs in acute myeloid leukemia cells
- (2015) Y-S Lai et al. Blood Cancer Journal
- Cellular mechanisms and physiological consequences of redox-dependent signalling
- (2014) Kira M. Holmström et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Chaetocin-induced ROS-mediated apoptosis involves ATM–YAP1 axis and JNK-dependent inhibition of glucose metabolism
- (2014) D Dixit et al. Cell Death & Disease
- Chaetocin antileukemia activity against chronic myelogenous leukemia cells is potentiated by bone marrow stromal factors and overcomes innate imatinib resistance
- (2014) L Truitt et al. Oncogenesis
- Chaetocin is a nonspecific inhibitor of histone lysine methyltransferases
- (2013) Fanny L Cherblanc et al. Nature Chemical Biology
- Targeted therapies in gastric cancer—the dawn of a new era
- (2013) Manish A. Shah Nature Reviews Clinical Oncology
- Principles in Redox Signaling: From Chemistry to Functional Significance
- (2012) Alberto Bindoli et al. ANTIOXIDANTS & REDOX SIGNALING
- Thioredoxin and thioredoxin-interacting protein as prognostic markers for gastric cancer recurrence
- (2012) Jae Yun Lim WORLD JOURNAL OF GASTROENTEROLOGY
- The anticancer effects of chaetocin are independent of programmed cell death and hypoxia and are associated with inhibition of endothelial cell proliferation
- (2011) C R Isham et al. BRITISH JOURNAL OF CANCER
- Akt signalling in health and disease
- (2011) Ingeborg Hers et al. CELLULAR SIGNALLING
- Small molecule inhibitors of mammalian thioredoxin reductase
- (2011) Wenqing Cai et al. FREE RADICAL BIOLOGY AND MEDICINE
- Anti-leukemia activity of chaetocin via death receptor-dependent apoptosis and dual modulation of the histone methyl-transferase SUV39H1
- (2011) H Chaib et al. LEUKEMIA
- Oxidative stress, inflammation, and cancer: How are they linked?
- (2010) Simone Reuter et al. FREE RADICAL BIOLOGY AND MEDICINE
- Antihepatoma activity of chaetocin due to deregulated splicing of hypoxia-inducible factor 1α pre-mRNA in mice and in vitro
- (2010) Yoon-Mi Lee et al. HEPATOLOGY
- Cancer cell death induced by phosphine gold(I) compounds targeting thioredoxin reductase
- (2009) Valentina Gandin et al. BIOCHEMICAL PHARMACOLOGY
- ROS-driven Akt dephosphorylation at Ser-473 is involved in 4-HPR-mediated apoptosis in NB4 cells
- (2009) Ji Cao et al. FREE RADICAL BIOLOGY AND MEDICINE
- Terpyridine–platinum(II) complexes are effective inhibitors of mammalian topoisomerases and human thioredoxin reductase 1
- (2009) Yan-Chung Lo et al. JOURNAL OF INORGANIC BIOCHEMISTRY
- Targeting the phosphoinositide 3-kinase pathway in cancer
- (2009) Pixu Liu et al. NATURE REVIEWS DRUG DISCOVERY
- The Anticancer Agent Chaetocin Is a Competitive Substrate and Inhibitor of Thioredoxin Reductase
- (2008) Jennifer D. Tibodeau et al. ANTIOXIDANTS & REDOX SIGNALING
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started