Thioredoxin reductase inhibitors: a patent review

Why Nature Chose Selenium

(2016) Hans J. Reich et al.   ACS Chemical Biology

Inhibition of thioredoxin reductase by alantolactone prompts oxidative stress-mediated apoptosis of HeLa cells

(2016) Junmin Zhang et al.   BIOCHEMICAL PHARMACOLOGY

Piperlongumine as a direct TrxR1 inhibitor with suppressive activity against gastric cancer

(2016) Peng Zou et al.   CANCER LETTERS

A small molecule probe reveals declined mitochondrial thioredoxin reductase activity in a Parkinson's disease model

(2016) Yaping Liu et al.   CHEMICAL COMMUNICATIONS

A fast response and red emission probe for mammalian thioredoxin reductase

(2016) Huilong Ma et al.   CHEMICAL COMMUNICATIONS

Inhibitory nitrosylation of mammalian thioredoxin reductase 1: Molecular characterization and evidence for its functional role in cellular nitroso-redox imbalance

(2016) Rotem Engelman et al.   FREE RADICAL BIOLOGY AND MEDICINE

Targeting Thioredoxin Reductase by Parthenolide Contributes to Inducing Apoptosis of HeLa Cells

(2016) Dongzhu Duan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dual targeting of the thioredoxin and glutathione systems in cancer and HIV

(2016) Moran Benhar et al.   JOURNAL OF CLINICAL INVESTIGATION

Knockout of Mitochondrial Thioredoxin Reductase Stabilizes Prolyl Hydroxylase 2 and Inhibits Tumor Growth and Tumor-Derived Angiogenesis

(2015) Juliane Hellfritsch et al.   ANTIOXIDANTS & REDOX SIGNALING

Insights into the importance for designing curcumin-inspired anticancer agents by a prooxidant strategy: The case of diarylpentanoids

(2015) Fang Dai et al.   FREE RADICAL BIOLOGY AND MEDICINE

Gold(I) NHC-based homo- and heterobimetallic complexes: synthesis, characterization and evaluation as potential anticancer agents

(2015) Benoît Bertrand et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

Synthesis of Piperlongumine Analogues and Discovery of Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Activators as Potential Neuroprotective Agents

(2015) Shoujiao Peng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of Xanthohumol Analogues and Discovery of Potent Thioredoxin Reductase Inhibitor as Potential Anticancer Agent

(2015) Baoxin Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Metal- and Semimetal-Containing Inhibitors of Thioredoxin Reductase as Anticancer Agents

(2015) Valentina Gandin et al.   MOLECULES

Dual protection of hydroxytyrosol, an olive oil polyphenol, against oxidative damage in PC12 cells

(2015) Shoujiao Peng et al.   Food & Function

Hot spot-based design of small-molecule inhibitors for protein–protein interactions

(2014) Wenxing Guo et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Phospho-aspirin (MDC-22) inhibits breast cancer in preclinical animal models: an effect mediated by EGFR inhibition, p53 acetylation and oxidative stress

(2014) Liqun Huang et al.   BMC CANCER

Shikonin targets cytosolic thioredoxin reductase to induce ROS-mediated apoptosis in human promyelocytic leukemia HL-60 cells

(2014) Dongzhu Duan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Gambogic acid induces apoptosis in hepatocellular carcinoma SMMC-7721 cells by targeting cytosolic thioredoxin reductase

(2014) Dongzhu Duan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Evidence for Targeting Thioredoxin Reductases with Ferrocenyl Quinone Methides. A Possible Molecular Basis for the Antiproliferative Effect of Hydroxyferrocifens on Cancer Cells

(2014) Anna Citta et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Molecular Recognition Studies on Small-Molecule Inhibitors for Thioredoxin Reductase

(2014) Di Zhang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Thioredoxins, Glutaredoxins, and Peroxiredoxins—Molecular Mechanisms and Health Significance: from Cofactors to Antioxidants to Redox Signaling

(2013) Eva-Maria Hanschmann et al.   ANTIOXIDANTS & REDOX SIGNALING

Identification of Michael Acceptor-Centric Pharmacophores with Substituents That Yield Strong Thioredoxin Reductase Inhibitory Character Correlated to Antiproliferative Activity

(2013) Fei-Fei Gan et al.   ANTIOXIDANTS & REDOX SIGNALING

Crystal Structure of the Plasmodium falciparum Thioredoxin Reductase–Thioredoxin Complex

(2013) Karin Fritz-Wolf et al.   JOURNAL OF MOLECULAR BIOLOGY

Highly Selective Off–On Fluorescent Probe for Imaging Thioredoxin Reductase in Living Cells

(2013) Liangwei Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fluorescent silver(i) and gold(i)–N-heterocyclic carbene complexes with cytotoxic properties: mechanistic insights

(2013) Anna Citta et al.   Metallomics

Curcumin targeting the thioredoxin system elevates oxidative stress in HeLa cells

(2012) Wenqing Cai et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Is Serum Thioredoxin-1 a Useful Clinical Marker for Malignant Pleural Mesothelioma?

(2011) Risa Maeda et al.   ANTIOXIDANTS & REDOX SIGNALING

Small molecule inhibitors of mammalian thioredoxin reductase

(2011) Wenqing Cai et al.   FREE RADICAL BIOLOGY AND MEDICINE

Crystal structure of the human thioredoxin reductase–thioredoxin complex

(2011) Karin Fritz-Wolf et al.   Nature Communications

A randomized phase II study of PX-12, an inhibitor of thioredoxin in patients with advanced cancer of the pancreas following progression after a gemcitabine-containing combination

(2010) Ramesh K. Ramanathan et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Thioredoxin Reductase-1 Mediates Curcumin-Induced Radiosensitization of Squamous Carcinoma Cells

(2010) P. Javvadi et al.   CANCER RESEARCH

Focus on mammalian thioredoxin reductases — Important selenoproteins with versatile functions

(2009) Elias S.J. Arnér   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The human selenoproteome: recent insights into functions and regulation

(2009) M. A. Reeves et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Thioredoxin reductase: A target for gold compounds acting as potential anticancer drugs

(2009) Alberto Bindoli et al.   COORDINATION CHEMISTRY REVIEWS

Cinnamaldehydes inhibit thioredoxin reductase and induce Nrf2: potential candidates for cancer therapy and chemoprevention

(2009) Eng-Hui Chew et al.   FREE RADICAL BIOLOGY AND MEDICINE

Thioredoxin system inhibitors as mediators of apoptosis for cancer therapy

(2008) Kathryn F. Tonissen et al.   MOLECULAR NUTRITION & FOOD RESEARCH