N6-methyladenosine-modified CircRNA-SORE sustains sorafenib resistance in hepatocellular carcinoma by regulating β-catenin signaling

m6A-dependent biogenesis of circular RNAs in male germ cells

(2020) Chong Tang et al.   CELL RESEARCH

Molecular Mechanisms Driving mRNA Degradation by m6A Modification

(2020) Yujin Lee et al.   TRENDS IN GENETICS

The microenvironmental and metabolic aspects of sorafenib resistance in hepatocellular carcinoma

(2020) Shunjie Xia et al.   EBioMedicine

SIRT1 regulates N 6 ‐methyladenosine RNA modification in hepatocarcinogenesis by inducing RANBP2‐dependent FTO SUMOylation

(2020) Xiaoming Liu et al.   HEPATOLOGY

miR-486-3p mediates hepatocellular carcinoma sorafenib resistance by targeting FGFR4 and EGFR

(2020) Lin Ji et al.   Cell Death & Disease

Endoribonucleolytic Cleavage of m6A-Containing RNAs by RNase P/MRP Complex

(2019) Ok Hyun Park et al.   MOLECULAR CELL

Circular RNA circRHOT1 promotes hepatocellular carcinoma progression by initiation of NR2F6 expression

(2019) Liyan Wang et al.   Molecular Cancer

Circular RNAs in hepatocellular carcinoma: Biomarkers, functions and mechanisms

(2019) Lipeng Qiu et al.   LIFE SCIENCES

Programmable RNA N6-methyladenosine editing by CRISPR-Cas9 conjugates

(2019) Xiao-Min Liu et al.   Nature Chemical Biology

Tumor‐suppressive circular RNAs: Mechanisms underlying their suppression of tumor occurrence and use as therapeutic targets

(2019) Zhe Li et al.   CANCER SCIENCE

CircPLEKHM3 acts as a tumor suppressor through regulation of the miR-9/BRCA1/DNAJB6/KLF4/AKT1 axis in ovarian cancer

(2019) Lei Zhang et al.   Molecular Cancer

circ_0003418 Inhibits Tumorigenesis And Cisplatin Chemoresistance Through Wnt/β-Catenin Pathway In Hepatocellular Carcinoma

(2019) Hang Chen et al.   OncoTargets and Therapy

N6-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis

(2019) Ri-Xin Chen et al.   Nature Communications

HBXIP-elevated methyltransferase METTL3 promotes the progression of breast cancer via inhibiting tumor suppressor let-7g

(2018) Xiaoli Cai et al.   CANCER LETTERS

Dynamic transcriptomic m6A decoration: writers, erasers, readers and functions in RNA metabolism

(2018) Ying Yang et al.   CELL RESEARCH

Hepatocellular carcinoma

(2018) Alejandro Forner et al.   LANCET

circFBLIM1 act as a ceRNA to promote hepatocellular cancer progression by sponging miR-346

(2018) Ning Bai et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

mRNA circularization by METTL3–eIF3h enhances translation and promotes oncogenesis

(2018) Junho Choe et al.   NATURE

YTHDF2 suppresses cell proliferation and growth via destabilizing the EGFR mRNA in hepatocellular carcinoma

(2018) Li Zhong et al.   CANCER LETTERS

Circular RNA circMTO1 acts as the sponge of microRNA-9 to suppress hepatocellular carcinoma progression

(2017) Dan Han et al.   HEPATOLOGY

MicroRNA-145 ModulatesN6-Methyladenosine Levels by Targeting the 3′-Untranslated mRNA Region of theN6-Methyladenosine Binding YTH Domain Family 2 Protein

(2017) Zhe Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells

(2017) Ly P Vu et al.   NATURE MEDICINE

GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses

(2017) Zefang Tang et al.   NUCLEIC ACIDS RESEARCH

Increasing AR by HIF-2α inhibitor (PT-2385) overcomes the side-effects of sorafenib by suppressing hepatocellular carcinoma invasion via alteration of pSTAT3, pAKT and pERK signals

(2017) Junjie Xu et al.   Cell Death & Disease

Genome-Wide Maps of m6A circRNAs Identify Widespread and Cell-Type-Specific Methylation Patterns that Are Distinct from mRNAs

(2017) Chan Zhou et al.   Cell Reports

Advanced Hepatocellular Cancer: the Current State of Future Research

(2016) Louise C. Connell et al.   CURRENT TREATMENT OPTIONS IN ONCOLOGY

Sorafenib with ASC-J9®synergistically suppresses the HCC progressionviaaltering the pSTAT3-CCL2/Bcl2 signals

(2016) Junjie Xu et al.   INTERNATIONAL JOURNAL OF CANCER

The emerging role and clinical implication of human exonic circular RNA

(2016) Dongbin Lyu et al.   RNA Biology

Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs

(2016) Qiupeng Zheng et al.   Nature Communications

The miR-367-3p Increases Sorafenib Chemotherapy Efficacy to Suppress Hepatocellular Carcinoma Metastasis through Altering the Androgen Receptor Signals

(2016) Junjie Xu et al.   EBioMedicine

Potential molecular, cellular and microenvironmental mechanism of sorafenib resistance in hepatocellular carcinoma

(2015) Jiang Chen et al.   CANCER LETTERS

HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events

(2015) Claudio R. Alarcón et al.   CELL

Adjuvant sorafenib for hepatocellular carcinoma after resection or ablation (STORM): a phase 3, randomised, double-blind, placebo-controlled trial

(2015) Jordi Bruix et al.   LANCET ONCOLOGY

N6-methyladenosine-dependent RNA structural switches regulate RNA–protein interactions

(2015) Nian Liu et al.   NATURE

Gene expression regulation mediated through reversible m6A RNA methylation

(2014) Ye Fu et al.   NATURE REVIEWS GENETICS

The dynamic epitranscriptome: N6-methyladenosine and gene expression control

(2014) Kate D. Meyer et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Circular RNAs: diversity of form and function

(2014) Erika Lasda et al.   RNA

Circular RNAs: splicing’s enigma variations

(2013) Matthias W Hentze et al.   EMBO JOURNAL

MicroRNA-216a/217-induced epithelial-mesenchymal transition targets PTEN and SMAD7 to promote drug resistance and recurrence of liver cancer

(2013) Hongping Xia et al.   HEPATOLOGY

Natural RNA circles function as efficient microRNA sponges

(2013) Thomas B. Hansen et al.   NATURE

Circular RNAs are a large class of animal RNAs with regulatory potency

(2013) Sebastian Memczak et al.   NATURE

MicroRNAs and their targets: recognition, regulation and an emerging reciprocal relationship

(2012) Amy E. Pasquinelli   NATURE REVIEWS GENETICS

Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial

(2008) Ann-Lii Cheng et al.   LANCET ONCOLOGY

Sorafenib in Advanced Hepatocellular Carcinoma

(2008) Josep M. Llovet et al.   NEW ENGLAND JOURNAL OF MEDICINE