Sophoridine suppresses lenvatinib‐resistant hepatocellular carcinoma growth by inhibiting RAS/MEK/ERK axis via decreasing VEGFR2 expression

Activation of the HGF/c-MET axis promotes lenvatinib resistance in hepatocellular carcinoma cells with high c-MET expression

(2020) Rongdang Fu et al.   MEDICAL ONCOLOGY

miR-486-3p mediates hepatocellular carcinoma sorafenib resistance by targeting FGFR4 and EGFR

(2020) Lin Ji et al.   Cell Death & Disease

Compound kushen injection relieves tumor-associated macrophage-mediated immunosuppression through TNFR1 and sensitizes hepatocellular carcinoma to sorafenib

(2020) Yang Yang et al.   Journal for ImmunoTherapy of Cancer

Anti-cancer potential of sophoridine and its derivatives: Recent progress and future perspectives

(2020) Haroon ur Rashid et al.   BIOORGANIC CHEMISTRY

Sophoridine inhibits lung cancer cell growth and enhances cisplatin sensitivity through activation of the p53 and Hippo signaling pathways

(2020) Lingling Zhu et al.   GENE

Antiviral activity of sophoridine against enterovirus 71 in vitro

(2019) Gang Ren et al.   JOURNAL OF ETHNOPHARMACOLOGY

Hepatocellular Carcinoma

(2019) Augusto Villanueva   NEW ENGLAND JOURNAL OF MEDICINE

Sophoridine inhibits human colorectal cancer progression via targeting MAPKAPK2

(2019) Rui Wang et al.   MOLECULAR CANCER RESEARCH

Sophoridine suppresses macrophage-mediated immunosuppression through TLR4/IRF3 pathway and subsequently upregulates CD8+ T cytotoxic function against gastric cancer

(2019) Haiwen Zhuang et al.   BIOMEDICINE & PHARMACOTHERAPY

Diagnosis and staging of hepatocellular carcinoma (HCC): current guidelines

(2018) Carmen Ayuso et al.   EUROPEAN JOURNAL OF RADIOLOGY

Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial

(2018) Masatoshi Kudo et al.   LANCET

Hepatocellular carcinoma

(2018) Alejandro Forner et al.   LANCET

Lenvatinib inhibits angiogenesis and tumor fibroblast growth factor signaling pathways in human hepatocellular carcinoma models

(2018) Masahiro Matsuki et al.   Cancer Medicine

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Molecular therapies and precision medicine for hepatocellular carcinoma

(2018) Josep M. Llovet et al.   Nature Reviews Clinical Oncology

Sophoridine from Sophora Flower Attenuates Ovariectomy Induced Osteoporosis through the RANKL-ERK-NFAT Pathway

(2017) Xiaoying Zhao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Sophoridine induces apoptosis and S phase arrest via ROS-dependent JNK and ERK activation in human pancreatic cancer cells

(2017) Zihang Xu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Targeting the Ras/Raf/MEK/ERK pathway in hepatocellular carcinoma

(2017) Sufang Yang et al.   Oncology Letters

Cancer statistics in China, 2015

(2016) Wanqing Chen et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Mechanisms and regulation of endothelial VEGF receptor signalling

(2016) Michael Simons et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Hepatocellular carcinoma

(2016) Josep M. Llovet et al.   Nature Reviews Disease Primers

The Ras/MAPK pathway and hepatocarcinoma: pathogenesis and therapeutic implications

(2015) Bénédicte Delire et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Autocrine vascular endothelial growth factor signaling promotes cell proliferation and modulates sorafenib treatment efficacy in hepatocellular carcinoma

(2014) Sui Peng et al.   HEPATOLOGY

Expression and prognostic value of VEGFR-2, PDGFR-β, and c-Met in advanced hepatocellular carcinoma

(2013) Jie Sheng Chu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Hepatocellular Carcinoma

(2011) Hashem B. El-Serag   NEW ENGLAND JOURNAL OF MEDICINE

Effect of sophoridine on dextran sulfate sodium-induced colitis in C57BL/6 mice

(2010) Wen-Chang Zhao et al.   JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH