The Influence of Genetic and Environmental Factors and Their Interactions on Immune Response to Helminth Infections

Microbial regulation of intestinal motility provides resistance against helminth infection

(2022) Mati Moyat et al.   Mucosal Immunology

Naturalizing mouse models for immunology

(2021) Andrea L. Graham   NATURE IMMUNOLOGY

Natural resistance to worms exacerbates bovine tuberculosis severity independently of worm coinfection

(2021) Vanessa O. Ezenwa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune System Investigation Using Parasitic Helminths

(2021) Bonnie Douglas et al.   Annual Review of Immunology

Enteric helminth coinfection enhances host susceptibility to neurotropic flaviviruses via a tuft cell-IL-4 receptor signaling axis

(2021) Pritesh Desai et al.   CELL

The Genetics of Human Schistosomiasis Infection Intensity and Liver Disease: A Review

(2021) Estelle M. Mewamba et al.   Frontiers in Immunology

WSB1 and IL21R Genetic Variants Are Involved in Th2 Immune Responses to Ascaris lumbricoides

(2021) Valdirene Leão Carneiro et al.   Frontiers in Immunology

Regulatory T Cells as an Escape Mechanism to the Immune Response in Taenia crassiceps Infection

(2021) Laura Adalid-Peralta et al.   Frontiers in Cellular and Infection Microbiology

Genetic × environment variation in sheep lines bred for divergent resistance to strongyle infection

(2021) Guillaume Sallé et al.   Evolutionary Applications

Enteric Tuft Cells in Host-Parasite Interactions

(2021) Sruthi Rajeev et al.   Pathogens

Mice with diverse microbial exposure histories as a model for preclinical vaccine testing

(2021) Jessica K. Fiege et al.   Cell Host & Microbe

Genetic Background Affects the Mucosal Secretory IgA Levels, Parasite Burden, Lung Inflammation, and Mouse Susceptibility to Ascaris suum Infection

(2021) Luciana Maria Oliveira et al.   INFECTION AND IMMUNITY

Evidence of MHC class I and II influencing viral and helminth infection via the microbiome in a non-human primate

(2021) B. Karina Montero et al.   PLoS Pathogens

Helminth Coinfection Alters Monocyte Activation, Polarization, and Function in Latent Mycobacterium tuberculosis Infection

(2020) Anuradha Rajamanickam et al.   JOURNAL OF IMMUNOLOGY

The immune response of inbred laboratory mice to Litomosoides sigmodontis : a route to discovery in myeloid cell biology

(2020) Conor M Finlay et al.   PARASITE IMMUNOLOGY

Altered Immunity of Laboratory Mice in the Natural Environment Is Associated with Fungal Colonization

(2020) Frank Yeung et al.   Cell Host & Microbe

Rewilding Nod2 and Atg16l1 Mutant Mice Uncovers Genetic and Environmental Contributions to Microbial Responses and Immune Cell Composition

(2020) Jian-Da Lin et al.   Cell Host & Microbe

Genetic algorithms identify individuals with high risk of severe liver disease caused by schistosomes

(2020) Hélia Dessein et al.   HUMAN GENETICS

Gut Microbiota beyond Bacteria—Mycobiome, Virome, Archaeome, and Eukaryotic Parasites in IBD

(2020) Mario Matijašić et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

New Insights into the Immune System Using Dirty Mice

(2020) Sara E. Hamilton et al.   JOURNAL OF IMMUNOLOGY

The Intestinal Epithelium at the Forefront of Host–Helminth Interactions

(2020) Gillian Coakley et al.   TRENDS IN PARASITOLOGY

Helminth Sensing at the Intestinal Epithelial Barrier—A Taste of Things to Come

(2020) Aduragbemi A. Faniyi et al.   Frontiers in Immunology

Strong effects of lab-to-field environmental transitions on the bacterial intestinal microbiota of Mus musculus are modulated by Trichuris murisinfection

(2020) Julian Bär et al.   FEMS MICROBIOLOGY ECOLOGY

Host Immunity and Inflammation to Pulmonary Helminth Infections

(2020) Jill E. Weatherhead et al.   Frontiers in Immunology

Early Events Triggering the Initiation of a Type 2 Immune Response

(2020) Darine W. El-Naccache et al.   TRENDS IN IMMUNOLOGY

Baseline Gut Microbiota Composition Is Associated With Schistosoma mansoni Infection Burden in Rodent Models

(2020) Alba Cortés et al.   Frontiers in Immunology

Exclusive dependence of IL-10Rα signalling on intestinal microbiota homeostasis and control of whipworm infection

(2019) María A. Duque-Correa et al.   PLoS Pathogens

Laboratory mice born to wild mice have natural microbiota and model human immune responses

(2019) Stephan P. Rosshart et al.   SCIENCE

Polymorphic Immune Mechanisms Regulate Commensal Repertoire

(2019) Aly A. Khan et al.   Cell Reports

Immunity to gastrointestinal nematode infections

(2018) D Sorobetea et al.   Mucosal Immunology

Helminth–Bacterial Interactions: Cause and Consequence

(2018) Alexis Rapin et al.   TRENDS IN IMMUNOLOGY

Sentinels of the Type 2 Immune Response

(2018) Jakob von Moltke et al.   TRENDS IN IMMUNOLOGY

CD209a Synergizes with Dectin-2 and Mincle to Drive Severe Th17 Cell-Mediated Schistosome Egg-Induced Immunopathology

(2018) Parisa Kalantari et al.   Cell Reports

Rapid environmental effects on gut nematode susceptibility in rewilded mice

(2018) Jacqueline M. Leung et al.   PLOS BIOLOGY

Helminth Infections: Recognition and Modulation of the Immune Response by Innate Immune Cells

(2018) Claudia Cristina Motran et al.   Frontiers in Immunology

Manipulation of host and parasite microbiotas: Survival strategies during chronic nematode infection

(2018) Emily C. White et al.   Science Advances

Cytokines and beyond: Regulation of innate immune responses during helminth infection

(2018) Oyebola O. Oyesola et al.   CYTOKINE

First Responders: Innate Immunity to Helminths

(2018) Juan M. Inclan-Rico et al.   TRENDS IN PARASITOLOGY

Helminth Infections Induce Tissue Tolerance Mitigating Immunopathology but Enhancing Microbial Pathogen Susceptibility

(2018) George S. Yap et al.   Frontiers in Immunology

The Influence of Parasite Infections on Host Immunity to Co-infection With Other Pathogens

(2018) Neil A. Mabbott   Frontiers in Immunology

Recent Advances in Type-2-Cell-Mediated Immunity: Insights from Helminth Infection

(2017) Nicola L. Harris et al.   IMMUNITY

Helminth secretomes reflect different lifestyles and parasitized hosts

(2017) Yesid Cuesta-Astroz et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Enteric Helminths Promote Salmonella Coinfection by Altering the Intestinal Metabolome

(2017) Lisa A. Reynolds et al.   JOURNAL OF INFECTIOUS DISEASES

The role of rare innate immune cells in Type 2 immune activation against parasitic helminths

(2017) LAUREN M. WEBB et al.   PARASITOLOGY

Toxoplasma Co-infection Prevents Th2 Differentiation and Leads to a Helminth-Specific Th1 Response

(2017) Norus Ahmed et al.   Frontiers in Cellular and Infection Microbiology

Sequential Infection with Common Pathogens Promotes Human-like Immune Gene Expression and Altered Vaccine Response

(2016) Tiffany A. Reese et al.   Cell Host & Microbe

Macrobiota — helminths as active participants and partners of the microbiota in host intestinal homeostasis

(2016) William C Gause et al.   CURRENT OPINION IN MICROBIOLOGY

Leukotrienes provide an NFAT-dependent signal that synergizes with IL-33 to activate ILC2s

(2016) Jakob von Moltke et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Parasitological, Pathological, and Immunological Parameters Associated withSchistosoma mansoniInfection and Reinfection in BALB/c AND C57BL/6 Mice

(2016) Clarice Carvalho Alves et al.   JOURNAL OF PARASITOLOGY

Normalizing the environment recapitulates adult human immune traits in laboratory mice

(2016) Lalit K. Beura et al.   NATURE

Immunity to Helminths: Resistance, Regulation, and Susceptibility to Gastrointestinal Nematodes

(2015) Richard K. Grencis   Annual Review of Immunology

Variation in the Human Immune System Is Largely Driven by Non-Heritable Influences

(2015) Petter Brodin et al.   CELL

Minor genomic differences between related B6 and B10 mice affect severity of schistosome infection by governing the mode of dendritic cell activation

(2015) Patrick M. Smith et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Overcoming drug resistance for macro parasites

(2015) Mrigank Srivastava et al.   Future Microbiology

IL-22 and IL-22 binding protein (IL-22BP) regulate fibrosis and cirrhosis in hepatitis C virus and schistosome infections

(2015) Mathieu Sertorio et al.   HEPATOLOGY

Cohabitation in the Intestine: Interactions among Helminth Parasites, Bacterial Microbiota, and Host Immunity

(2015) Lisa A. Reynolds et al.   JOURNAL OF IMMUNOLOGY

Diversification of memory B cells drives the continuous adaptation of secretory antibodies to gut microbiota

(2015) Cornelia Lindner et al.   NATURE IMMUNOLOGY

Helminths and the microbiota: parts of the hygiene hypothesis

(2015) P. Loke et al.   PARASITE IMMUNOLOGY

Bacteria-induced egg hatching differs for Trichuris muris and Trichuris suis

(2015) Nermina Vejzagić et al.   Parasites & Vectors

Bacteria-induced hatching of Trichuris muris eggs occurs without direct contact between eggs and bacteria

(2015) Koichi Koyama   PARASITOLOGY RESEARCH

MHC variation sculpts individualized microbial communities that control susceptibility to enteric infection

(2015) Jason L. Kubinak et al.   Nature Communications

Innate and adaptive type 2 immune cell responses in genetically controlled resistance to intestinal helminth infection

(2014) Kara J Filbey et al.   IMMUNOLOGY AND CELL BIOLOGY

CD209a Expression on Dendritic Cells Is Critical for the Development of Pathogenic Th17 Cell Responses in Murine Schistosomiasis

(2014) H. E. Ponichtera et al.   JOURNAL OF IMMUNOLOGY

Major Histocompatibility Complex class IIb polymorphism influences gut microbiota composition and diversity

(2014) Daniel I. Bolnick et al.   MOLECULAR ECOLOGY

Neutrophils prime a long-lived effector macrophage phenotype that mediates accelerated helminth expulsion

(2014) Fei Chen et al.   NATURE IMMUNOLOGY

What helminth genomes have taught us about parasite evolution

(2014) MAGDALENA ZAROWIECKI et al.   PARASITOLOGY

EFFECT OF Bifidobacterium animalis ON MICE INFECTED WITH Strongyloides venezuelensis

(2014) Teresa Cristina Goulart Oliveira-Sequeira et al.   REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO

Helminth infection reactivates latent  -herpesvirus via cytokine competition at a viral promoter

(2014) T. A. Reese et al.   SCIENCE

Virus-helminth coinfection reveals a microbiota-independent mechanism of immunomodulation

(2014) L. C. Osborne et al.   SCIENCE

Lack of host gut microbiota alters immune responses and intestinal granuloma formation during schistosomiasis

(2013) M. Holzscheiter et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

The skin is an important bulwark of acquired immunity against intestinal helminths

(2013) Kazushige Obata-Ninomiya et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The genomes of four tapeworm species reveal adaptations to parasitism

(2013) Isheng J. Tsai et al.   NATURE

Effect of helminth-induced immunity on infections with microbial pathogens

(2013) Padmini Salgame et al.   NATURE IMMUNOLOGY

Into the wild: digging at immunology's evolutionary roots

(2013) Rick M Maizels et al.   NATURE IMMUNOLOGY

Trichuris muris research revisited: a journey through time

(2013) REBECCA J. M. HURST et al.   PARASITOLOGY

Genetic analysis of human predisposition to hepatosplenic disease caused by schistosomes reveals the crucial role of connective tissue growth factor in rapid progression to severe hepatic fibrosis

(2013) A. Dessein et al.   PATHOLOGIE BIOLOGIE

Antagonism between two intestinal parasites in humans: the importance of co-infection for infection risk and recovery dynamics

(2013) A. D. Blackwell et al.   PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Immune Regulation during Helminth Infections

(2013) Natasha M. Girgis et al.   PLoS Pathogens

Helminth Infections and Host Immune Regulation

(2012) H. J. McSorley et al.   CLINICAL MICROBIOLOGY REVIEWS

Coassociations between IL10 polymorphisms, IL-10 production, helminth infection, and asthma/wheeze in an urban tropical population in Brazil

(2012) Camila Alexandrina Figueiredo et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

T-Helper 17 Cells Are Associated With Pathology in Human Schistosomiasis

(2012) Moustapha Mbow et al.   JOURNAL OF INFECTIOUS DISEASES

Immunity to the model intestinal helminth parasite Heligmosomoides polygyrus

(2012) Lisa A. Reynolds et al.   Seminars in Immunopathology

Regulatory B-cell induction by helminths: Implications for allergic disease

(2011) Leonie Hussaarts et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The Pathogenic Th17 Cell Response to Major Schistosome Egg Antigen Is Sequentially Dependent on IL-23 and IL-1β

(2011) Mara G. Shainheit et al.   JOURNAL OF IMMUNOLOGY

Immunological Variation Between Inbred Laboratory Mouse Strains

(2011) R. S. Sellers et al.   VETERINARY PATHOLOGY

Hidden Consequences of Living in a Wormy World: Nematode‐Induced Immune Suppression Facilitates Tuberculosis Invasion in African Buffalo

(2010) Vanessa O. Ezenwa et al.   AMERICAN NATURALIST

The landscape of human genes involved in the immune response to parasitic worms

(2010) Matteo Fumagalli et al.   BMC EVOLUTIONARY BIOLOGY

The Lung Is an Important Site for Priming CD4 T-Cell-Mediated Protective Immunity against Gastrointestinal Helminth Parasites

(2010) M. Harvie et al.   INFECTION AND IMMUNITY

Cutting Edge: Novel Function of B Cell-Activating Factor in the Induction of IL-10-Producing Regulatory B Cells

(2010) M. Yang et al.   JOURNAL OF IMMUNOLOGY

Genetic and Household Determinants of Predisposition to Human Hookworm Infection in a Brazilian Community

(2010) Rupert J. Quinnell et al.   JOURNAL OF INFECTIOUS DISEASES

The population genetics of commensal Escherichia coli

(2010) Olivier Tenaillon et al.   NATURE REVIEWS MICROBIOLOGY

Acquired immune heterogeneity and its sources in human helminth infection

(2010) C. D. BOURKE et al.   PARASITOLOGY

Exploitation of the Intestinal Microflora by the Parasitic Nematode Trichuris muris

(2010) K. S. Hayes et al.   SCIENCE

Plasmodium chabaudi limits early Nippostrongylus brasiliensis-induced pulmonary immune activation and Th2 polarization in co-infected mice

(2009) Marieke A Hoeve et al.   BMC IMMUNOLOGY

Parasites represent a major selective force for interleukin genes and shape the genetic predisposition to autoimmune conditions

(2009) Matteo Fumagalli et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Variants of CTGF are associated with hepatic fibrosis in Chinese, Sudanese, and Brazilians infected with Schistosomes

(2009) Alain Dessein et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Helminth immunoregulation: The role of parasite secreted proteins in modulating host immunity

(2009) James P. Hewitson et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Genetic variation in resistance to mixed, predominantlyTeladorsagia circumcinctanematode infections of sheep: from heritabilities to gene identification

(2009) M. J. STEAR et al.   PARASITE IMMUNOLOGY

Teladorsagia circumcinctain the sheep abomasum: defining the role of dendritic cells in T cell regulation and protective immunity

(2009) T. N. MCNEILLY et al.   PARASITE IMMUNOLOGY

Genetic influence on the kinetics and associated pathology of the early stage (intestinal-hepatic) migration of Ascaris suum in mice

(2009) C. DOLD et al.   PARASITOLOGY

Predisposition to ascariasis: patterns, mechanisms and implications

(2009) C. V. HOLLAND   PARASITOLOGY

FVB/N mice are highly resistant to primary infection with Nippostrongylus brasiliensis

(2009) M. L. KNOTT et al.   PARASITOLOGY

Immunological Interactions between 2 Common Pathogens, Th1-Inducing Protozoan Toxoplasma gondii and the Th2-Inducing Helminth Fasciola hepatica

(2009) Catherine M. D. Miller et al.   PLoS One

Regulatory T Cell Expansion in HTLV-1 and Strongyloidiasis Co-infection Is Associated with Reduced IL-5 Responses to Strongyloides stercoralis Antigen

(2009) Martin Montes et al.   PLoS Neglected Tropical Diseases

On the hunt for helminths: innate immune cells in the recognition and response to helminth parasites

(2008) Jacqueline G. Perrigoue et al.   CELLULAR MICROBIOLOGY

Chronic Intestinal Nematode Infection Exacerbates Experimental Schistosoma mansoni Infection

(2008) Q. D. Bickle et al.   INFECTION AND IMMUNITY

Helminth infections: the great neglected tropical diseases

(2008) Peter J. Hotez et al.   JOURNAL OF CLINICAL INVESTIGATION

Two Quantitative Trait Loci Influence Whipworm(Trichuris trichiura)Infection in a Nepalese Population

(2008) Sarah Williams‐Blangero et al.   JOURNAL OF INFECTIOUS DISEASES

The dynamics of genetically marked Ascaris suum infections in pigs

(2008) P. NEJSUM et al.   PARASITOLOGY

Enhanced susceptibility to Trichuris muris infection of B10Br mice treated with the probiotic Lactobacillus casei

(2007) Ma Auxiliadora Dea-Ayuela et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Localization of Multiple Quantitative Trait Loci Influencing Susceptibility to Infection withAscaris lumbricoides

(2007) Sarah Williams‐Blangero et al.   JOURNAL OF INFECTIOUS DISEASES