Triptolide inhibits oxidative stress and inflammation via the microRNA-155-5p/brain-derived neurotrophic factor to reduce podocyte injury in mice with diabetic nephropathy

Icariin protects podocytes from NLRP3 activation by Sesn2-induced mitophagy through the Keap1-Nrf2/HO-1 axis in diabetic nephropathy

(2022) Xuansheng Ding et al.   PHYTOMEDICINE

miRNA-93-5p in exosomes derived from M2 macrophages improves lipopolysaccharide-induced podocyte apoptosis by targeting Toll-like receptor 4

(2022) Zhu Wang et al.   Bioengineered

Triptolide improves neurobehavioral functions, inflammation, and oxidative stress in rats under deep hypothermic circulatory arrest

(2021) Qiang Chen et al.   Aging-US

Apoptotic mechanism activated by blue light and cisplatinum in cutaneous squamous cell carcinoma cells

(2021) Maria Tartaglione et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Mechanism of miR-365 in regulating BDNF-TrkB signal axis of HFD/STZ induced diabetic nephropathy fibrosis and renal function

(2021) Peng Zhao et al.   INTERNATIONAL UROLOGY AND NEPHROLOGY

MicroRNAs as crucial mediators in the pharmacological activities of triptolide (Review)

(2021) Kun Zhou et al.   Experimental and Therapeutic Medicine

Forsythoside A Alleviates High Glucose-Induced Oxidative Stress and Inflammation in Podocytes by Inactivating MAPK Signaling via MMP12 Inhibition

(2021) Xiaohong Quan et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Chronic Inflammation in Chronic Kidney Disease Progression: Role of Nrf2

(2021) Peter Stenvinkel et al.   Kidney International Reports

Profile of podocyte translatome during development of type 2 and type 1 diabetic nephropathy using podocyte-specific TRAP mRNA RNA-seq

(2021) Yinqiu Wang et al.   DIABETES

Effects of growth hormone-releasing hormone receptor antagonist MIA-602 in mice with emotional disorders: a potential treatment for PTSD

(2021) Lucia Recinella et al.   MOLECULAR PSYCHIATRY

Baicalin Alleviates Oxidative Stress and Inflammation in Diabetic Nephropathy via Nrf2 and MAPK Signaling Pathway

(2021) Leyi Ma et al.   Drug Design Development and Therapy

Diabetic Nephropathy: Challenges in Pathogenesis, Diagnosis, and Treatment

(2021) Nur Samsu   Biomed Research International

Baicalin Attenuates Oxygen–Glucose Deprivation/Reoxygenation–Induced Injury by Modulating the BDNF-TrkB/PI3K/Akt and MAPK/Erk1/2 Signaling Axes in Neuron–Astrocyte Cocultures

(2021) Changxiang Li et al.   Frontiers in Pharmacology

Complement C7 is Specifically Expressed in Mesangial Cells and is a Potential Diagnostic Biomarker for Diabetic Nephropathy and is Regulated by miR-494-3p and miR-574-5p

(2021) Hang Guo et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Sarsasapogenin restores podocyte autophagy in diabetic nephropathy by targeting GSK3β signaling pathway

(2021) Xi-zhi Li et al.   BIOCHEMICAL PHARMACOLOGY

miR-188-3p abolishes germacrone-mediated podocyte protection in a mouse model of diabetic nephropathy in type I diabetes through triggering mitochondrial injury

(2021) Yunguang Wang et al.   Bioengineered

Inhibition of miR-17~92 Cluster Ameliorates High Glucose-Induced Podocyte Damage

(2020) Xiaobao Fan et al.   MEDIATORS OF INFLAMMATION

miR‐15b‐5p ameliorated high glucose‐induced podocyte injury through repressing apoptosis, oxidative stress, and inflammatory responses by targeting Sema3A

(2019) Yanqin Fu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Triptolide Inhibits Preformed Fibril-Induced Microglial Activation by Targeting the MicroRNA155-5p/SHIP1 Pathway

(2019) Yang Feng et al.   Oxidative Medicine and Cellular Longevity

Podoplanin mediates the renoprotective effect of berberine on diabetic kidney disease in mice

(2019) Jing Yu et al.   ACTA PHARMACOLOGICA SINICA

Triptolide suppresses human synoviocyte MH7A cells mobility and maintains redox balance by inhibiting autophagy

(2019) Chuanmei Xie et al.   BIOMEDICINE & PHARMACOTHERAPY

Role of p53/miR-155-5p/sirt1 loop in renal tubular injury of diabetic kidney disease

(2018) Yue Wang et al.   Journal of Translational Medicine

miR-423-5p suppresses high-glucose-induced podocyte injury by targeting Nox4

(2018) Yuxiang Xu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Triptolide Attenuates Renal Tubular Epithelial-mesenchymal Transition Via the MiR-188-5p-mediated PI3K/AKT Pathway in Diabetic Kidney Disease

(2018) Mei Xue et al.   International Journal of Biological Sciences

BDNF : mRNA expression in urine cells of patients with chronic kidney disease and its role in kidney function

(2018) Nicole Endlich et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Triptolide attenuates proteinuria and podocyte apoptosis via inhibition of NF-κB/GADD45B

(2018) Ling Wang et al.   Scientific Reports

Differential toxicities of triptolide to immortalized podocytes and the podocytes in vivo

(2018) Mengjie Sun et al.   BIOMEDICINE & PHARMACOTHERAPY

Triptolide prevents extracellular matrix accumulation in experimental diabetic kidney disease by targeting microRNA-137/Notch1 pathway

(2017) Fei Han et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Triptolide Restores Autophagy to Alleviate Diabetic Renal Fibrosis through the miR-141-3p/PTEN/Akt/mTOR Pathway

(2017) Xiao-yu Li et al.   Molecular Therapy-Nucleic Acids

Triptolide Improves Diabetic Nephropathy by Regulating Th Cell Balance and Macrophage Infiltration in Rat Models of Diabetic Nephropathy

(2016) H. Guo et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Cross-talk between angiotensin-II and toll-like receptor 4 triggers a synergetic inflammatory response in rat mesangial cells under high glucose conditions

(2015) Jinlei Lv et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

BDNF repairs podocyte damage by microRNA-mediated increase of actin polymerization

(2015) Min Li et al.   JOURNAL OF PATHOLOGY

Molecular and Cellular Events Mediating Glomerular Podocyte Dysfunction and Depletion in Diabetes Mellitus

(2014) P. Anil Kumar et al.   Frontiers in Endocrinology

Triptolide markedly attenuates albuminuria and podocyte injury in an animal model of diabetic nephropathy

(2013) RUIXIA MA et al.   Experimental and Therapeutic Medicine

Renoprotective effects of berberine and its possible molecular mechanisms in combination of high-fat diet and low-dose streptozotocin-induced diabetic rats

(2012) Feng Ling Wang et al.   MOLECULAR BIOLOGY REPORTS

Treatment of db/db diabetic mice with triptolide: a novel therapy for diabetic nephropathy

(2010) Q. Gao et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION