A Functional Screening Identifies a New Organic Selenium Compound Targeting Cancer Stem Cells: Role of c‐Myc Transcription Activity Inhibition in Liver Cancer

A new protocol for long‐term culture of a specific subpopulation of liver cancer stem cells enriched by cell surface markers

(2020) Biao Zhang et al.   FEBS Open Bio

c-Myc inactivation of p53 through the pan-cancer lncRNA MILIP drives cancer pathogenesis

(2020) Yu Chen Feng et al.   Nature Communications

The mTORC 2‐Akt cascade is crucial for c‐Myc to promote hepatocarcinogenesis in mice and men

(2019) Zhong Xu et al.   HEPATOLOGY

Arsenic trioxide inhibits liver cancer stem cells and metastasis by targeting SRF/MCM7 complex

(2019) Hai-Yang Wang et al.   Cell Death & Disease

Non-genomic mechanisms of protein phosphatase 2A (PP2A) regulation in cancer

(2018) Otto Kauko et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Comprehensive Characterization of Cancer Driver Genes and Mutations

(2018) Matthew H. Bailey et al.   CELL

Emerging roles of Myc in stem cell biology and novel tumor therapies

(2018) Go J. Yoshida   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Phase I clinical trial of quarfloxin administered weekly×3 of a four week cycle

(2017) T. R. Fitch et al.   JOURNAL OF CLINICAL ONCOLOGY

Dual targeting of p53 and c-MYC selectively eliminates leukaemic stem cells

(2016) Sheela A. Abraham et al.   NATURE

Ergosterol peroxide activates Foxo3-mediated cell death signaling by inhibiting AKT and c-Myc in human hepatocellular carcinoma cells

(2016) Xiangmin Li et al.   Oncotarget

Hepatocellular carcinoma

(2016) Josep M. Llovet et al.   Nature Reviews Disease Primers

Small Molecule Microarrays Enable the Identification of a Selective, Quadruplex-Binding Inhibitor of MYC Expression

(2015) Kenneth M. Felsenstein et al.   ACS Chemical Biology

Selenium compounds as therapeutic agents in cancer

(2015) Aristi P. Fernandes et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Keratin 19, a Cancer Stem Cell Marker in Human Hepatocellular Carcinoma

(2015) T. Kawai et al.   CLINICAL CANCER RESEARCH

MicroRNA-125b attenuates epithelial-mesenchymal transitions and targets stem-like liver cancer cells through small mothers against decapentaplegic 2 and 4

(2015) Jun-Nian Zhou et al.   HEPATOLOGY

Synthesis and biological applications of selenoureas

(2014) Raja Azadar Hussain et al.   APPLIED ORGANOMETALLIC CHEMISTRY

Cancer stem cells as a target population for drug discovery

(2014) Claire Bouvard et al.   Future Medicinal Chemistry

Multiplexed immunohistochemistry, imaging, and quantitation: A review, with an assessment of Tyramide signal amplification, multispectral imaging and multiplex analysis

(2014) Edward C. Stack et al.   METHODS

Modeling Pathogenesis of Primary Liver Cancer in Lineage-Specific Mouse Cell Types

(2013) Ágnes Holczbauer et al.   GASTROENTEROLOGY

Hepatocellular carcinoma-associated mesenchymal stem cells promote hepatocarcinoma progression: Role of the S100A4-miR155-SOCS1-MMP9 axis

(2013) Xin-Long Yan et al.   HEPATOLOGY

BMP4 Administration Induces Differentiation of CD133+Hepatic Cancer Stem Cells, Blocking Their Contributions to Hepatocellular Carcinoma

(2012) Lixing Zhang et al.   CANCER RESEARCH

MYC on the Path to Cancer

(2012) Chi V. Dang   CELL

TGF-β signaling and epithelial–mesenchymal transition in cancer progression

(2012) Yoko Katsuno et al.   CURRENT OPINION IN ONCOLOGY

Oncogene-specific formation of chemoresistant murine hepatic cancer stem cells

(2012) Edward Kai-Hua Chow et al.   HEPATOLOGY

The evolving concept of cancer and metastasis stem cells

(2012) Irène Baccelli et al.   JOURNAL OF CELL BIOLOGY

Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy

(2012) Geeta Mehta et al.   JOURNAL OF CONTROLLED RELEASE

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

(2011) Jake E. Delmore et al.   CELL

Epimorphin promotes human hepatocellular carcinoma invasion and metastasis through activation of focal adhesion kinase/extracellular signal-regulated kinase/matrix metalloproteinase-9 axis

(2011) Ya-Li Jia et al.   HEPATOLOGY

Antagonistic effects of selenium and lipid peroxides on growth control in early hepatocellular carcinoma

(2011) Nataliya Rohr-Udilova et al.   HEPATOLOGY

Sonic Hedgehog Pathway Is Essential for Maintenance of Cancer Stem-Like Cells in Human Gastric Cancer

(2011) Zhou Song et al.   PLoS One

In Vitro Cytotoxicity and In Vivo Efficacy, Pharmacokinetics, and Metabolism of 10074-G5, a Novel Small-Molecule Inhibitor of c-Myc/Max Dimerization

(2010) D. M. Clausen et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Targeting cancer stem cells by inhibiting Wnt, Notch and Hedgehog pathways

(2010) Naoko Takebe et al.   Nature Reviews Clinical Oncology

Central Role of c-Myc during Malignant Conversion in Human Hepatocarcinogenesis

(2009) P. Kaposi-Novak et al.   CANCER RESEARCH

Myc's other life: stem cells and beyond

(2009) Elisa Laurenti et al.   CURRENT OPINION IN CELL BIOLOGY

ELDA: Extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays

(2009) Yifang Hu et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Pro-proliferative FoxM1 is a target of p53-mediated repression

(2009) A M Barsotti et al.   ONCOGENE

Extracellular thiol-assisted selenium uptake dependent on the xc- cystine transporter explains the cancer-specific cytotoxicity of selenite

(2009) E. Olm et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficacy, pharmacokinetics, tisssue distribution, and metabolism of the Myc–Max disruptor, 10058-F4 [Z,E]-5-[4-ethylbenzylidine]-2-thioxothiazolidin-4-one, in mice

(2008) Jianxia Guo et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

NUPR1 Interacts with p53, Transcriptionally Regulates p21 and Rescues Breast Epithelial Cells from Doxorubicin-Induced Genotoxic Stress

(2008) David Clark et al.   CURRENT CANCER DRUG TARGETS