Cancer stem cells as a target population for drug discovery

Small-molecule inhibition of BRD4 as a new potent approach to eliminate leukemic stem- and progenitor cells in acute myeloid leukemia (AML)

(2015) Harald Herrmann et al.   Oncotarget

Functional Heterogeneity of Genetically Defined Subclones in Acute Myeloid Leukemia

(2014) Jeffery M. Klco et al.   CANCER CELL

Individualized Medicine from Prewomb to Tomb

(2014) Eric J. Topol   CELL

Evolution of the Cancer Stem Cell Model

(2014) Antonija Kreso et al.   Cell Stem Cell

Metastatic Stem Cells: Sources, Niches, and Vital Pathways

(2014) Thordur Oskarsson et al.   Cell Stem Cell

Proto-Oncogenic Role of Mutant IDH2 in Leukemia Initiation and Maintenance

(2014) Lev M. Kats et al.   Cell Stem Cell

Organoid cultures for the analysis of cancer phenotypes

(2014) Norman Sachs et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Enrichment of breast cancer stem-like cells by growth on electrospun polycaprolactone-chitosan nanofiber scaffolds

(2014) Jennifer Sims-Mourtada et al.   International Journal of Nanomedicine

Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia

(2014) Liran I. Shlush et al.   NATURE

Activation of a promyelocytic leukemia–tumor protein 53 axis underlies acute promyelocytic leukemia cure

(2014) Julien Ablain et al.   NATURE MEDICINE

Selective inhibition of BET bromodomain epigenetic signalling interferes with the bone-associated tumour vicious cycle

(2014) François Lamoureux et al.   Nature Communications

Target Identification for Small Bioactive Molecules: Finding the Needle in the Haystack

(2013) Slava Ziegler et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Small Molecule–Based Approaches to Adult Stem Cell Therapies

(2013) Luke L. Lairson et al.   Annual Review of Pharmacology and Toxicology

Mutant IDH1 promotes leukemogenesis in vivo and can be specifically targeted in human AML

(2013) A. Chaturvedi et al.   BLOOD

Cancer heterogeneity: implications for targeted therapeutics

(2013) R Fisher et al.   BRITISH JOURNAL OF CANCER

Disulfiram targets cancer stem-like cells and reverses resistance and cross-resistance in acquired paclitaxel-resistant triple-negative breast cancer cells

(2013) P Liu et al.   BRITISH JOURNAL OF CANCER

Dormant Cancer Cells Contribute to Residual Disease in a Model of Reversible Pancreatic Cancer

(2013) W.-c. Lin et al.   CANCER RESEARCH

Glioblastoma Stem Cells Generate Vascular Pericytes to Support Vessel Function and Tumor Growth

(2013) Lin Cheng et al.   CELL

The Somatic Genomic Landscape of Glioblastoma

(2013) Cameron W. Brennan et al.   CELL

Heterogeneous phenotype of human glioblastoma:In vitrostudy

(2013) Tetyana Denysenko et al.   CELL BIOCHEMISTRY AND FUNCTION

Wnt signaling in stem and cancer stem cells

(2013) Jane D Holland et al.   CURRENT OPINION IN CELL BIOLOGY

Stem cells living with a Notch

(2013) U. Koch et al.   DEVELOPMENT

Induction of sarcomas by mutant IDH2

(2013) C. Lu et al.   GENES & DEVELOPMENT

Inhibition of Myc family proteins eradicates KRas-driven lung cancer in mice

(2013) L. Soucek et al.   GENES & DEVELOPMENT

Ganetespib blocks HIF-1 activity and inhibits tumor growth, vascularization, stem cell maintenance, invasion, and metastasis in orthotopic mouse models of triple-negative breast cancer

(2013) Lisha Xiang et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Short-term single treatment of chemotherapy results in the enrichment of ovarian cancer stem cell-like cells leading to an increased tumor burden

(2013) Khalid Abubaker et al.   Molecular Cancer

Tumour heterogeneity and cancer cell plasticity

(2013) Corbin E. Meacham et al.   NATURE

The causes and consequences of genetic heterogeneity in cancer evolution

(2013) Rebecca A. Burrell et al.   NATURE

Target identification and mechanism of action in chemical biology and drug discovery

(2013) Monica Schenone et al.   Nature Chemical Biology

Differential regulation of myeloid leukemias by the bone marrow microenvironment

(2013) Daniela S Krause et al.   NATURE MEDICINE

Self-renewal as a therapeutic target in human colorectal cancer

(2013) Antonija Kreso et al.   NATURE MEDICINE

Cell type-dependent pathogenic functions of overexpressed human cathepsin B in murine breast cancer progression

(2013) F Bengsch et al.   ONCOGENE

A Melanoma Brain Metastasis with a Donor-Patient Hybrid Genome following Bone Marrow Transplantation: First Evidence for Fusion in Human Cancer

(2013) Rossitza Lazova et al.   PLoS One

A High-Content Small Molecule Screen Identifies Sensitivity of Glioblastoma Stem Cells to Inhibition of Polo-Like Kinase 1

(2013) Davide Danovi et al.   PLoS One

Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3

(2013) P. Mao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Growing Self-Organizing Mini-Guts from a Single Intestinal Stem Cell: Mechanism and Applications

(2013) T. Sato et al.   SCIENCE

A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo

(2013) Y. Saito et al.   Science Translational Medicine

Mammospheres from murine mammary stem cell-enriched basal cells: Clonal characteristics and repopulating potential

(2013) Qiaoxiang Dong et al.   Stem Cell Research

Brief Report: Mesenchymal Stromal Cell Atrophy in Coculture Increases Aggressiveness of Transformed Cells

(2013) Maria D. Castellone et al.   STEM CELLS

Tumor Initiation in Human Malignant Melanoma and Potential Cancer Therapies

(2012) Jie Ma et al.   Anti-Cancer Agents in Medicinal Chemistry

Control of stem cells and cancer stem cells by Hedgehog signaling: Pharmacologic clues from pathway dissection

(2012) Sonia Coni et al.   BIOCHEMICAL PHARMACOLOGY

Identification of a selective small molecule inhibitor of breast cancer stem cells

(2012) Andrew R. Germain et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

ALDH marks leukemia stem cell

(2012) A. G. Fleischman   BLOOD

Cancer stem cells, the epithelial to mesenchymal transition (EMT) and radioresistance: Potential role of hypoxia

(2012) Delphine Tamara Marie-Egyptienne et al.   CANCER LETTERS

High aldehyde dehydrogenase activity enhances stem cell features in breast cancer cells by activating hypoxia-inducible factor-2α

(2012) Ran-Ju Kim et al.   CANCER LETTERS

Induction of the Stem-like Cell Regulator CD44 by Rho Kinase Inhibition Contributes to the Maintenance of Colon Cancer-Initiating Cells

(2012) H. Ohata et al.   CANCER RESEARCH

Identification of Drugs Including a Dopamine Receptor Antagonist that Selectively Target Cancer Stem Cells

(2012) Eleftherios Sachlos et al.   CELL

Lineage Tracing

(2012) Kai Kretzschmar et al.   CELL

Understanding cancer stem cell heterogeneity and plasticity

(2012) Dean G Tang   CELL RESEARCH

Cancer Stem Cells: Current Status and Evolving Complexities

(2012) Jane E. Visvader et al.   Cell Stem Cell

IDH1 and IDH2 Mutations in Tumorigenesis: Mechanistic Insights and Clinical Perspectives

(2012) H. Yang et al.   CLINICAL CANCER RESEARCH

ABCB5 expression and cancer stem cell hypothesis in oral squamous cell carcinoma

(2012) Martin Grimm et al.   EUROPEAN JOURNAL OF CANCER

Cancer stem cells as ‘units of selection’

(2012) Mel Greaves   Evolutionary Applications

Cancer stem cells in solid tumors: an overview and new approaches for their isolation and characterization

(2012) Virginia Tirino et al.   FASEB JOURNAL

Regulation of self-renewal in normal and cancer stem cells

(2012) Maria V. Verga Falzacappa et al.   FEBS Journal

Exploring the cancer stem cell phenotype with high-throughput screening applications

(2012) Heiko Wurdak   Future Medicinal Chemistry

The evolving concept of cancer and metastasis stem cells

(2012) Irène Baccelli et al.   JOURNAL OF CELL BIOLOGY

CD133 as a biomarker for putative cancer stem cells in solid tumours: limitations, problems and challenges

(2012) Philipp Grosse-Gehling et al.   JOURNAL OF PATHOLOGY

The developing cancer stem-cell model: clinical challenges and opportunities

(2012) Louis Vermeulen et al.   LANCET ONCOLOGY

Epigenetic alterations involved in cancer stem cell reprogramming

(2012) Purificación Muñoz et al.   Molecular Oncology

IDH mutation impairs histone demethylation and results in a block to cell differentiation

(2012) Chao Lu et al.   NATURE

Clonal evolution in cancer

(2012) Mel Greaves et al.   NATURE

A restricted cell population propagates glioblastoma growth after chemotherapy

(2012) Jian Chen et al.   NATURE

On-target JAK2/STAT3 inhibition slows disease progression in orthotopic xenografts of human glioblastoma brain tumor stem cells

(2012) Owen D. Stechishin et al.   NEURO-ONCOLOGY

Cancer–stromal cell interactions mediated by hypoxia-inducible factors promote angiogenesis, lymphangiogenesis and metastasis

(2012) G L Semenza   ONCOGENE

Selective Small Molecule Stat3 Inhibitor Reduces Breast Cancer Tumor-Initiating Cells and Improves Recurrence Free Survival in a Human-Xenograft Model

(2012) Bhuvanesh Dave et al.   PLoS One

A Stem Cell-Based Approach to Cartilage Repair

(2012) K. Johnson et al.   SCIENCE

Cancer stem cells and epithelial–mesenchymal transition: Concepts and molecular links

(2012) Christina Scheel et al.   SEMINARS IN CANCER BIOLOGY

Cancer Stem Cells as a Predictive Factor in Radiotherapy

(2012) Thomas B. Brunner et al.   SEMINARS IN RADIATION ONCOLOGY

ALDH1A Isozymes are Markers of Human Melanoma Stem Cells and Potential Therapeutic Targets

(2012) Yuchun Luo et al.   STEM CELLS

HEDGEHOG-GLI Signaling Drives Self-Renewal and Tumorigenicity of Human Melanoma-Initiating Cells

(2012) Roberta Santini et al.   STEM CELLS

Mouse models of pancreatic cancer

(2012) Marta Herreros-Villanueva   WORLD JOURNAL OF GASTROENTEROLOGY

Integrin αv Expression Is Required for the Acquisition of a Metastatic Stem/Progenitor Cell Phenotype in Human Prostate Cancer

(2011) Christel van den Hoogen et al.   AMERICAN JOURNAL OF PATHOLOGY

Drugging the Cancer Stem Cell Compartment: Lessons Learned from the Hedgehog and Wnt Signal Transduction Pathways

(2011) Michael E. Dodge et al.   Annual Review of Pharmacology and Toxicology

A small molecule screening strategy with validation on human leukemia stem cells uncovers the therapeutic efficacy of kinetin riboside

(2011) S. P. McDermott et al.   BLOOD

Bmi1 reprograms CML B-lymphoid progenitors to become B-ALL-initiating cells

(2011) A. Sengupta et al.   BLOOD

Inhibition of aldehyde dehydrogenase (ALDH) activity reduces chemotherapy and radiation resistance of stem-like ALDHhiCD44+ human breast cancer cells

(2011) Alysha K. Croker et al.   BREAST CANCER RESEARCH AND TREATMENT

An Integrated In Vitro and In Vivo High-Throughput Screen Identifies Treatment Leads for Ependymoma

(2011) Jennifer M. Atkinson et al.   CANCER CELL

VCAM-1 Promotes Osteolytic Expansion of Indolent Bone Micrometastasis of Breast Cancer by Engaging α4β1-Positive Osteoclast Progenitors

(2011) Xin Lu et al.   CANCER CELL

Activation of the aryl hydrocarbon receptor represses mammosphere formation in MCF-7 cells

(2011) Shuai Zhao et al.   CANCER LETTERS

Small Molecule Kinase Inhibitor Screen Identifies Polo-Like Kinase 1 as a Target for Neuroblastoma Tumor-Initiating Cells

(2011) Natalie Grinshtein et al.   CANCER RESEARCH

Activation of the Aryl Hydrocarbon Receptor AhR Promotes Retinoic Acid-Induced Differentiation of Myeloblastic Leukemia Cells by Restricting Expression of the Stem Cell Transcription Factor Oct4

(2011) R. P. Bunaciu et al.   CANCER RESEARCH

The Intestinal Stem Cell Signature Identifies Colorectal Cancer Stem Cells and Predicts Disease Relapse

(2011) Anna Merlos-Suárez et al.   Cell Stem Cell

Targeting HIF1α Eliminates Cancer Stem Cells in Hematological Malignancies

(2011) Yin Wang et al.   Cell Stem Cell

Differentiated Human Colorectal Cancer Cells Protect Tumor-Initiating Cells From Irinotecan

(2011) Benjamin L. Emmink et al.   GASTROENTEROLOGY

Expression of aldehyde dehydrogenase and CD133 defines ovarian cancer stem cells

(2011) Ilona Kryczek et al.   INTERNATIONAL JOURNAL OF CANCER

A Molecular Screening Approach to Identify and Characterize Inhibitors of Glioblastoma Stem Cells

(2011) K. Visnyei et al.   MOLECULAR CANCER THERAPEUTICS

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

(2011) Johannes Zuber et al.   NATURE

The cancer stem cell: premises, promises and challenges

(2011) Hans Clevers   NATURE MEDICINE

Twisted tango: brain tumor neurovascular interactions

(2011) Anita B Hjelmeland et al.   NATURE NEUROSCIENCE

Tumor-initiating stem cells of squamous cell carcinomas and their control by TGF-  and integrin/focal adhesion kinase (FAK) signaling

(2011) M. Schober et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Concise Review: Cancer Stem Cells and Minimal Residual Disease

(2011) Gabriel Ghiaur et al.   STEM CELLS

On the Stem Cell Origin of Cancer

(2010) Stewart Sell   AMERICAN JOURNAL OF PATHOLOGY

Chemical Control of Stem Cell Fate and Developmental Potential

(2010) Costas A. Lyssiotis et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Understanding the cancer stem cell

(2010) S Bomken et al.   BRITISH JOURNAL OF CANCER

Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

(2010) Maria E. Figueroa et al.   CANCER CELL

Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1

(2010) Roel G.W. Verhaak et al.   CANCER CELL

An RNAi Screen Identifies TRRAP as a Regulator of Brain Tumor-Initiating Cell Differentiation

(2010) Heiko Wurdak et al.   Cell Stem Cell

The Difficulty of Targeting Cancer Stem Cell Niches

(2010) M. A. LaBarge   CLINICAL CANCER RESEARCH

Cancer Stem Cells and Self-renewal

(2010) C. A. O'Brien et al.   CLINICAL CANCER RESEARCH

New models for cancer research: human cancer stem cell xenografts

(2010) Marta Baiocchi et al.   CURRENT OPINION IN PHARMACOLOGY

Clonogenic assays measure leukemia stem cell killing not detectable by chromium release and flow cytometric cytotoxicity assays

(2010) Brent A. Williams et al.   CYTOTHERAPY

Directed embryonic stem cell differentiation with small molecules

(2010) Shoutian Zhu et al.   Future Medicinal Chemistry

The therapeutic promise of the cancer stem cell concept

(2010) Natasha Y. Frank et al.   JOURNAL OF CLINICAL INVESTIGATION

Insights into the stem cells of chronic myeloid leukemia

(2010) I Sloma et al.   LEUKEMIA

More than Markers: Biological Significance of Cancer Stem Cell-Defining Molecules

(2010) S. B. Keysar et al.   MOLECULAR CANCER THERAPEUTICS

Selective inhibition of BET bromodomains

(2010) Panagis Filippakopoulos et al.   NATURE

Targeting cancer stem cells by inhibiting Wnt, Notch and Hedgehog pathways

(2010) Naoko Takebe et al.   Nature Reviews Clinical Oncology

Breast Cancer Stem-Like Cells Are Inhibited by a Non-Toxic Aryl Hydrocarbon Receptor Agonist

(2010) Gérald J. Prud'homme et al.   PLoS One

A small molecule accelerates neuronal differentiation in the adult rat

(2010) H. Wurdak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models

(2010) H. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Tissue-Specific Stem Cell as a Target for Chemoprevention

(2010) Sophia L. Maund et al.   Stem Cell Reviews and Reports

The Role of Human Aldehyde Dehydrogenase in Normal and Cancer Stem Cells

(2010) Irene Ma et al.   Stem Cell Reviews and Reports

Oncogenic Braf Induces Melanocyte Senescence and Melanoma in Mice

(2009) Nathalie Dhomen et al.   CANCER CELL

Proteomic and Genetic Approaches Identify Syk as an AML Target

(2009) Cynthia K. Hahn et al.   CANCER CELL

Hypoxia-Inducible Factors Regulate Tumorigenic Capacity of Glioma Stem Cells

(2009) Zhizhong Li et al.   CANCER CELL

Identification of Selective Inhibitors of Cancer Stem Cells by High-Throughput Screening

(2009) Piyush B. Gupta et al.   CELL

A Small Molecule Primes Embryonic Stem Cells for Differentiation

(2009) Shoutian Zhu et al.   Cell Stem Cell

Glioma Stem Cell Lines Expanded in Adherent Culture Have Tumor-Specific Phenotypes and Are Suitable for Chemical and Genetic Screens

(2009) Steven M. Pollard et al.   Cell Stem Cell

Synthesis at the Interface of Chemistry and Biology

(2009) Xu Wu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Hypoxia promotes expansion of the CD133-positive glioma stem cells through activation of HIF-1α

(2009) A Soeda et al.   ONCOGENE

Phenotypic and Functional Characterization of Human Mammary Stem/Progenitor Cells in Long Term Culture

(2009) Devaveena Dey et al.   PLoS One

Recent advances and method development for drug target identification

(2009) Janet N.Y. Chan et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Identification of the cellular targets of bioactive small organic molecules using affinity reagents

(2008) Benjamin J. Leslie et al.   CHEMICAL SOCIETY REVIEWS

An efficient method for derivation and propagation of glioblastoma cell lines that conserves the molecular profile of their original tumours

(2008) Talal M. Fael Al-Mayhani et al.   JOURNAL OF NEUROSCIENCE METHODS

Identification of cells initiating human melanomas

(2008) Tobias Schatton et al.   NATURE

Expression-based screening identifies the combination of histone deacetylase inhibitors and retinoids for neuroblastoma differentiation

(2008) C. K. Hahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA