The Molecular Brakes of Adipose Tissue Lipolysis

Enlarged adipocytes from subcutaneous vs. visceral adipose tissue differentially contribute to metabolic dysfunction and atherogenic risk of patients with obesity

(2021) Juan Antonio Suárez-Cuenca et al.   Scientific Reports

Hypoxia-inducible lipid droplet-associated induces DGAT1 and promotes lipid storage in hepatocytes

(2021) Montserrat A. de la Rosa Rodriguez et al.   Molecular Metabolism

The ménage à trois of autophagy, lipid droplets and liver disease

(2021) Yasmina Filali-Mouncef et al.   Autophagy

Adipocyte lipolysis: from molecular mechanisms of regulation to disease and therapeutics

(2020) Alexander Yang et al.   BIOCHEMICAL JOURNAL

Lipophagy Impairment Is Associated With Disease Progression in NAFLD

(2020) Simone Carotti et al.   Frontiers in Physiology

Regulation of lipid droplet homeostasis by hypoxia inducible lipid droplet associated HILPDA

(2020) Montserrat A. de la Rosa Rodriguez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

A Membrane-Bound Diacylglycerol Species Induces PKCϵ-Mediated Hepatic Insulin Resistance

(2020) Kun Lyu et al.   Cell Metabolism

Lysosomal lipoprotein processing in endothelial cells stimulates adipose tissue thermogenic adaptation

(2020) Alexander W. Fischer et al.   Cell Metabolism

The Dynamics of the Neuropeptide Y Receptor Type 1 Investigated by Solid-State NMR and Molecular Dynamics Simulation

(2020) Alexander Vogel et al.   MOLECULES

Adipogenesis and metabolic health

(2019) Alexandra L. Ghaben et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Identification of an intrinsic lysophosphatidic acid acyltransferase activity in the lipolytic inhibitor G0/G1 switch gene 2 (G0S2)

(2019) Xiaodong Zhang et al.   FASEB JOURNAL

ABHD15 regulates adipose tissue lipolysis and hepatic lipid accumulation

(2019) Jacqueline Stöckli et al.   Molecular Metabolism

Lipid droplet size directs lipolysis and lipophagy catabolism in hepatocytes

(2019) Micah B. Schott et al.   JOURNAL OF CELL BIOLOGY

Sustained activation of autophagy suppresses adipocyte maturation via a lipolysis-dependent mechanism

(2019) Xing Zhang et al.   Autophagy

Brown adipose tissue and lipid metabolism

(2018) Joerg Heeren et al.   CURRENT OPINION IN LIPIDOLOGY

Classical and alternative roles for autophagy in lipid metabolism

(2018) Xiangyu Zhang et al.   CURRENT OPINION IN LIPIDOLOGY

Exploring the Function of Dynamic Phosphorylation-Dephosphorylation Cycles

(2018) Lendert Gelens et al.   DEVELOPMENTAL CELL

Metabolic flexibility as an adaptation to energy resources and requirements in health and disease

(2018) Reuben L Smith et al.   ENDOCRINE REVIEWS

Non-adrenergic control of lipolysis and thermogenesis in adipose tissues

(2018) Katharina Braun et al.   JOURNAL OF EXPERIMENTAL BIOLOGY

Hypoxia-inducible lipid droplet-associated protein inhibits adipose triglyceride lipase

(2018) Krishna M. Padmanabha Das et al.   JOURNAL OF LIPID RESEARCH

β-Adrenergic regulation of cardiac type 2A protein phosphatase through phosphorylation of regulatory subunit B56δ at S573

(2018) Antonella Ranieri et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Loss of ABHD15 Impairs the Anti-lipolytic Action of Insulin by Altering PDE3B Stability and Contributes to Insulin Resistance

(2018) Wenmin Xia et al.   Cell Reports

Brown adipose tissue derived ANGPTL4 controls glucose and lipid metabolism and regulates thermogenesis

(2018) Abhishek K. Singh et al.   Molecular Metabolism

Vacuolar protein sorting 13C is a novel lipid droplet protein that inhibits lipolysis in brown adipocytes

(2018) Vanesa D. Ramseyer et al.   Molecular Metabolism

Increased fat accumulation in liver may link insulin resistance with subcutaneous abdominal adipocyte enlargement, visceral adiposity, and hypoadiponectinemia in obese individuals

(2018) Juraj Koska et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Circulating FABP4 is eliminated by the kidney via glomerular filtration followed by megalin-mediated reabsorption

(2018) Suman Shrestha et al.   Scientific Reports

Unconventional secretion of FABP4 by endosomes and secretory lysosomes

(2017) Julien Villeneuve et al.   JOURNAL OF CELL BIOLOGY

Dietary Fatty Acid Spillover in Plasma: A Marker of Good Health, Bad Health, or Irrelevant?

(2017) Christos S Katsanos   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance

(2017) Daniel Garcia et al.   MOLECULAR CELL

The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue

(2017) Matthew D Lynes et al.   NATURE MEDICINE

Cytosolic lipolysis and lipophagy: two sides of the same coin

(2017) Rudolf Zechner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A-FABP mediates adaptive thermogenesis by promoting intracellular activation of thyroid hormones in brown adipocytes

(2017) Lingling Shu et al.   Nature Communications

Thermogenic adipocytes promote HDL turnover and reverse cholesterol transport

(2017) Alexander Bartelt et al.   Nature Communications

Inhibition of intracellular lipolysis promotes human cancer cell adaptation to hypoxia

(2017) Xiaodong Zhang et al.   eLife

Autophagy in the CNS and Periphery Coordinate Lipophagy and Lipolysis in the Brown Adipose Tissue and Liver

(2016) Nuria Martinez-Lopez et al.   Cell Metabolism

Parathyroid hormone induces adipocyte lipolysis via PKA-mediated phosphorylation of hormone-sensitive lipase

(2016) Sara Larsson et al.   CELLULAR SIGNALLING

Insulin: pancreatic secretion and adipocyte regulation

(2016) L.H. Baumgard et al.   DOMESTIC ANIMAL ENDOCRINOLOGY

Induction of autophagy improves hepatic lipid metabolism in glucose-6-phosphatase deficiency

(2016) Benjamin L. Farah et al.   JOURNAL OF HEPATOLOGY

AMPK Phosphorylates Desnutrin/ATGL and Hormone-Sensitive Lipase To Regulate Lipolysis and Fatty Acid Oxidation within Adipose Tissue

(2016) Sun-Joong Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

Lipolytic and thermogenic depletion of adipose tissue in cancer cachexia

(2016) Maria Tsoli et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Identification of VPS13C as a Galectin-12-Binding Protein That Regulates Galectin-12 Protein Stability and Adipogenesis

(2016) Ri-Yao Yang et al.   PLoS One

Endogenous and Synthetic ABHD5 Ligands Regulate ABHD5-Perilipin Interactions and Lipolysis in Fat and Muscle

(2015) Matthew A. Sanders et al.   Cell Metabolism

Impact of Reduced ATGL-Mediated Adipocyte Lipolysis on Obesity-Associated Insulin Resistance and Inflammation in Male Mice

(2015) Gabriele Schoiswohl et al.   ENDOCRINOLOGY

Fatty Acid Signaling: The New Function of Intracellular Lipases

(2015) Zuzana Papackova et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dependence of Brown Adipose Tissue Function on CD36-Mediated Coenzyme Q Uptake

(2015) Courtney M. Anderson et al.   Cell Reports

Adipose triglyceride lipase activity is inhibited by long-chain acyl-coenzyme A

(2014) Harald M. Nagy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Taking control over intracellular fatty acid levels is essential for the analysis of thermogenic function in cultured primary brown and brite/beige adipocytes

(2014) Y. Li et al.   EMBO REPORTS

Fat-specific Protein 27 (FSP27) Interacts with Adipose Triglyceride Lipase (ATGL) to Regulate Lipolysis and Insulin Sensitivity in Human Adipocytes

(2014) Tan Hooi Min Grahn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adipocyte Size Threshold Matters: Link with Risk of Type 2 Diabetes and Improved Insulin Resistance After Gastric Bypass

(2014) Aurelie Cotillard et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Dissecting adipose tissue lipolysis: molecular regulation and implications for metabolic disease

(2014) Thomas Svava Nielsen et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

The different shades of fat

(2014) Vivian Peirce et al.   NATURE

Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors

(2014) Thorsten Gnad et al.   NATURE

Null Mutation in Hormone-Sensitive Lipase Gene and Risk of Type 2 Diabetes

(2014) Jessica S. Albert et al.   NEW ENGLAND JOURNAL OF MEDICINE

FABP4 is secreted from adipocytes by adenyl cyclase-PKA- and guanylyl cyclase-PKG-dependent lipolytic mechanisms

(2014) Tomohiro Mita et al.   Obesity

Phospholipase C-Related Catalytically Inactive Protein (PRIP) Regulates Lipolysis in Adipose Tissue by Modulating the Phosphorylation of Hormone-Sensitive Lipase

(2014) Toshiya Okumura et al.   PLoS One

Lipolysis in lipid turnover, cancer cachexia, and obesity-induced insulin resistance

(2014) Peter Arner et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

White, brite, and brown adipocytes: the evolution and function of a heater organ in mammals

(2013) Yongguo Li et al.   CANADIAN JOURNAL OF ZOOLOGY

Adiponectin Receptor as a Key Player in Healthy Longevity and Obesity-Related Diseases

(2013) Toshimasa Yamauchi et al.   Cell Metabolism

Targeted Disruption of G0/G1 Switch Gene 2 Enhances Adipose Lipolysis, Alters Hepatic Energy Balance, and Alleviates High-Fat Diet-Induced Liver Steatosis

(2013) X. Zhang et al.   DIABETES

Autophagosomes contribute to intracellular lipid distribution in enterocytes

(2013) Salem Ait Khaldoun et al.   MOLECULAR BIOLOGY OF THE CELL

Partial Inhibition of Adipose Tissue Lipolysis Improves Glucose Metabolism and Insulin Sensitivity Without Alteration of Fat Mass

(2013) Amandine Girousse et al.   PLOS BIOLOGY

Activation of Thermogenesis in Brown Adipose Tissue and Dysregulated Lipid Metabolism Associated with Cancer Cachexia in Mice

(2012) M. Tsoli et al.   CANCER RESEARCH

Lipolytic Products Activate Peroxisome Proliferator-activated Receptor (PPAR) α and δ in Brown Adipocytes to Match Fatty Acid Oxidation with Supply

(2012) Emilio P. Mottillo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

G0/G1 switch gene-2 regulates human adipocyte lipolysis by affecting activity and localization of adipose triglyceride lipase

(2012) Martina Schweiger et al.   JOURNAL OF LIPID RESEARCH

Acylated and unacylated ghrelin attenuate isoproterenol-induced lipolysis in isolated rat visceral adipocytes through activation of phosphoinositide 3-kinase γ and phosphodiesterase 3B

(2011) Alessandra Baragli et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Desnutrin/ATGL Is Regulated by AMPK and Is Required for a Brown Adipose Phenotype

(2011) Maryam Ahmadian et al.   Cell Metabolism

Autophagy Regulates Cholesterol Efflux from Macrophage Foam Cells via Lysosomal Acid Lipase

(2011) Mireille Ouimet et al.   Cell Metabolism

Adiponectin Inhibits Lipolysis in Mouse Adipocytes

(2011) L. Qiao et al.   DIABETES

Adipocyte lipases and lipid droplet-associated proteins: insight from transgenic mouse models

(2011) A Girousse et al.   INTERNATIONAL JOURNAL OF OBESITY

Monoglyceride Lipase Deficiency in Mice Impairs Lipolysis and Attenuates Diet-induced Insulin Resistance

(2011) Ulrike Taschler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1

(2011) Guenter Haemmerle et al.   NATURE MEDICINE

Perilipin Deficiency and Autosomal Dominant Partial Lipodystrophy

(2011) Sheetal Gandotra et al.   NEW ENGLAND JOURNAL OF MEDICINE

Free Fatty Acid-Induced PP2A Hyperactivity Selectively Impairs Hepatic Insulin Action on Glucose Metabolism

(2011) Thomas Galbo et al.   PLoS One

The Minimal Domain of Adipose Triglyceride Lipase (ATGL) Ranges until Leucine 254 and Can Be Activated and Inhibited by CGI-58 and G0S2, Respectively

(2011) Irina Cornaciu et al.   PLoS One

Ablation of a galectin preferentially expressed in adipocytes increases lipolysis, reduces adiposity, and improves insulin sensitivity in mice

(2011) R.-Y. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alterations in cyclic nucleotide phosphodiesterase activities in omental and subcutaneous adipose tissues in human obesity

(2011) B Omar et al.   Nutrition & Diabetes

Hormone-sensitive lipase modulates adipose metabolism through PPARγ

(2010) Wen-Jun Shen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

An Autocrine Lactate Loop Mediates Insulin-Dependent Inhibition of Lipolysis through GPR81

(2010) Kashan Ahmed et al.   Cell Metabolism

The G0/G1 Switch Gene 2 Regulates Adipose Lipolysis through Association with Adipose Triglyceride Lipase

(2010) Xingyuan Yang et al.   Cell Metabolism

Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance

(2010) Ling Yang et al.   Cell Metabolism

B56α/Protein Phosphatase 2A Inhibits Adipose Lipolysis in High-Fat Diet-Induced Obese Mice

(2010) Brice P. Kinney et al.   ENDOCRINOLOGY

Patatin-like phospholipase domain-containing 3/adiponutrin deficiency in mice is not associated with fatty liver disease

(2010) Weiqin Chen et al.   HEPATOLOGY

Acute Peripheral Metabolic Effects of Intraarterial Ghrelin Infusion in Healthy Young Men

(2010) Esben Thyssen Vestergaard et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Pnpla3/Adiponutrin deficiency in mice does not contribute to fatty liver disease or metabolic syndrome

(2010) Mahesh K. Basantani et al.   JOURNAL OF LIPID RESEARCH

Insulin Regulates Adipocyte Lipolysis via an Akt-Independent Signaling Pathway

(2010) S. M. Choi et al.   MOLECULAR AND CELLULAR BIOLOGY

Adipose tissue angiogenesis as a therapeutic target for obesity and metabolic diseases

(2010) Yihai Cao   NATURE REVIEWS DRUG DISCOVERY

Gluttony, sloth and the metabolic syndrome: a roadmap to lipotoxicity

(2010) Roger H. Unger et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Serine/Threonine Phosphatases: Mechanism through Structure

(2009) Yigong Shi   CELL

Adipose Overexpression of Desnutrin Promotes Fatty Acid Use and Attenuates Diet-Induced Obesity

(2009) M. Ahmadian et al.   DIABETES

Markers of de novo lipogenesis in adipose tissue: associations with small adipocytes and insulin sensitivity in humans

(2009) R. Roberts et al.   DIABETOLOGIA

Hormone-sensitive lipase (HSL) is also a retinyl ester hydrolase: evidence from mice lacking HSL

(2009) Kristoffer Ström et al.   FASEB JOURNAL

Contribution of Adipose Triglyceride Lipase and Hormone-sensitive Lipase to Lipolysis in hMADS Adipocytes

(2009) Véronic Bezaire et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FoxO1 Controls Insulin-dependent Adipose Triglyceride Lipase (ATGL) Expression and Lipolysis in Adipocytes

(2009) Partha Chakrabarti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Another way to get rid of fat

(2009) Rudolf Zechner et al.   NATURE

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency

(2009) Kathy Jaworski et al.   NATURE MEDICINE

Mechanisms of Cancer Cachexia

(2009) Michael J. Tisdale   PHYSIOLOGICAL REVIEWS

Anatomical Profiling of G Protein-Coupled Receptor Expression

(2008) Jean B. Regard et al.   CELL

Ghrelin Infusion in Humans Induces Acute Insulin Resistance and Lipolysis Independent of Growth Hormone Signaling

(2008) E. T. Vestergaard et al.   DIABETES

Basal lipolysis, not the degree of insulin resistance, differentiates large from small isolated adipocytes in high-fat fed mice

(2008) S. Wueest et al.   DIABETOLOGIA

Activation of G Protein-Coupled Receptor 43 in Adipocytes Leads to Inhibition of Lipolysis and Suppression of Plasma Free Fatty Acids

(2008) Hongfei Ge et al.   ENDOCRINOLOGY

Adenosine A1 receptors regulate lipolysis and lipogenesis in mouse adipose tissue — Interactions with insulin

(2008) Stina M. Johansson et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Metabolic syndrome risk for cardiovascular disease and diabetes in the ARIC study

(2008) C M Ballantyne et al.   INTERNATIONAL JOURNAL OF OBESITY

AMP-activated Protein Kinase Is Activated as a Consequence of Lipolysis in the Adipocyte

(2008) Marie-Soleil Gauthier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Thematic Review Series: Glycerolipids.DGAT enzymes and triacylglycerol biosynthesis

(2008) Chi-Liang Eric Yen et al.   JOURNAL OF LIPID RESEARCH

Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease

(2008) Stefano Romeo et al.   NATURE GENETICS

Adenosine receptors: therapeutic aspects for inflammatory and immune diseases

(2008) György Haskó et al.   NATURE REVIEWS DRUG DISCOVERY

Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes

(2008) Adilson Guilherme et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Structural basis for the activation of PPARγ by oxidized fatty acids

(2008) Toshimasa Itoh et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Adipose Tissue Expandability in the Maintenance of Metabolic Homeostasis

(2008) Sarah L. Gray et al.   NUTRITION REVIEWS

Muscular diacylglycerol metabolism and insulin resistance

(2008) Silvie Timmers et al.   PHYSIOLOGY & BEHAVIOR

Autophagy and aging: keeping that old broom working

(2008) Ana Maria Cuervo   TRENDS IN GENETICS