Fatty Acid Signaling: The New Function of Intracellular Lipases

Bile acid signaling and liver regeneration

(2015) Mingjie Fan et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Free fatty acids as modulators of the NLRP3 inflammasome in obesity/type 2 diabetes

(2014) Sylvie Legrand-Poels et al.   BIOCHEMICAL PHARMACOLOGY

Role of Nrf2 in chronic liver disease

(2014) Wei Tang   WORLD JOURNAL OF GASTROENTEROLOGY

Fatty Acid–Regulated Transcription Factors in the Liver

(2013) Donald B. Jump et al.   Annual Review of Nutrition

Vascular smooth muscle cells isolated from adipose triglyceride lipase-deficient mice exhibit distinct phenotype and phenotypic plasticity

(2013) Yanhui Lin et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Bile acid receptors in non-alcoholic fatty liver disease

(2013) Yuanyuan Li et al.   BIOCHEMICAL PHARMACOLOGY

Role of adipose triglyceride lipase (PNPLA2) in protection from hepatic inflammation in mouse models of steatohepatitis and endotoxemia

(2013) Pooja Jha et al.   HEPATOLOGY

The effects of dietary fatty acids on the postprandial triglyceride-rich lipoprotein/apoB48 receptor axis in human monocyte/macrophage cells

(2013) Lourdes M. Varela et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Regulation of energy metabolism by long-chain fatty acids

(2013) Manabu T. Nakamura et al.   PROGRESS IN LIPID RESEARCH

Thioesterase superfamily member 2/acyl-CoA thioesterase 13 (Them2/Acot13) regulates hepatic lipid and glucose metabolism

(2012) Hye Won Kang et al.   FASEB JOURNAL

Liver specific inactivation of carboxylesterase 3/triacylglycerol hydrolase decreases blood lipids without causing severe steatosis in mice

(2012) Jihong Lian et al.   HEPATOLOGY

Lipolytic Products Activate Peroxisome Proliferator-activated Receptor (PPAR) α and δ in Brown Adipocytes to Match Fatty Acid Oxidation with Supply

(2012) Emilio P. Mottillo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myocardial triacylglycerol metabolism

(2012) Petra C. Kienesberger et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Acyl Coenzyme A Thioesterase Them5/Acot15 Is Involved in Cardiolipin Remodeling and Fatty Liver Development

(2012) E. Zhuravleva et al.   MOLECULAR AND CELLULAR BIOLOGY

Targeted deletion of thioesterase superfamily member 1 promotes energy expenditure and protects against obesity and insulin resistance

(2012) Y. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of Gene Regulation by Fatty Acids

(2012) Anastasia Georgiadi et al.   Advances in Nutrition

New players on the metabolic stage

(2012) David E. Cohen   Adipocyte

The phospholipid monolayer associated with perilipin-enriched lipid droplets is a highly organized rigid membrane structure

(2011) Stephen M. Storey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Intracellular fatty acids suppress β-adrenergic induction of PKA-targeted gene expression in white adipocytes

(2011) Emilio P. Mottillo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Aldehyde stress and up-regulation of Nrf2-mediated antioxidant systems accompany functional adaptations in cardiac mitochondria from mice fedn−3 polyunsaturated fatty acids

(2011) Ethan J. Anderson et al.   BIOCHEMICAL JOURNAL

Rat liver mitochondrial membrane characteristics and mitochondrial functions are more profoundly altered by dietary lipid quantity than by dietary lipid quality: effect of different nutritional lipid patterns

(2011) Manar Aoun et al.   BRITISH JOURNAL OF NUTRITION

Autophagy in Hypothalamic AgRP Neurons Regulates Food Intake and Energy Balance

(2011) Susmita Kaushik et al.   Cell Metabolism

Desnutrin/ATGL Is Regulated by AMPK and Is Required for a Brown Adipose Phenotype

(2011) Maryam Ahmadian et al.   Cell Metabolism

Synergistic induction of lipid catabolism and anti-inflammatory lipids in white fat of dietary obese mice in response to calorie restriction and n-3 fatty acids

(2011) P. Flachs et al.   DIABETOLOGIA

The resurgence of Hormone-Sensitive Lipase (HSL) in mammalian lipolysis

(2011) Antonis D. Lampidonis et al.   GENE

Reduced Expression of Adipose Triglyceride Lipase Enhances Tumor Necrosis Factor α-induced Intercellular Adhesion Molecule-1 Expression in Human Aortic Endothelial Cells via Protein Kinase C-dependent Activation of Nuclear Factor-κB

(2011) Tomoaki Inoue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Triacylglycerol Accumulation Activates the Mitochondrial Apoptosis Pathway in Macrophages

(2011) Elma Aflaki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuroprotective and Ameliorative Actions of Polyunsaturated Fatty Acids Against Neuronal Diseases: Implication of Fatty Acid–Binding Proteins (FABP) and G Protein–Coupled Receptor 40 (GPR40) in Adult Neurogenesis

(2011) Nadezhda B. Boneva et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-α and PGC-1

(2011) Guenter Haemmerle et al.   NATURE MEDICINE

Autophagy in health and disease. 1. Regulation and significance of autophagy: an overview

(2010) Maryam Mehrpour et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Macrophage Adipose Triglyceride Lipase Deficiency Attenuates Atherosclerotic Lesion Development in Low-Density Lipoprotein Receptor Knockout Mice

(2010) Bart Lammers et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Differential control of ATGL-mediated lipid droplet degradation by CGI-58 and G0S2

(2010) Xin Lu et al.   CELL CYCLE

Loss of TGH/Ces3 in Mice Decreases Blood Lipids, Improves Glucose Tolerance, and Increases Energy Expenditure

(2010) Enhui Wei et al.   Cell Metabolism

The G0/G1 Switch Gene 2 Regulates Adipose Lipolysis through Association with Adipose Triglyceride Lipase

(2010) Xingyuan Yang et al.   Cell Metabolism

Adipose triglyceride lipase is a major hepatic lipase that regulates triacylglycerol turnover and fatty acid signaling and partitioning

(2010) Kuok Teong Ong et al.   HEPATOLOGY

Efficient Phagocytosis Requires Triacylglycerol Hydrolysis by Adipose Triglyceride Lipase

(2010) Prakash G. Chandak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechanisms underlying the cardioprotective effects of omega-3 polyunsaturated fatty acids

(2010) Yuriko Adkins et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Altered Lipid Droplet Dynamics in Hepatocytes Lacking Triacylglycerol Hydrolase Expression

(2010) Huajin Wang et al.   MOLECULAR BIOLOGY OF THE CELL

Autophagy in mammalian development and differentiation

(2010) Noboru Mizushima et al.   NATURE CELL BIOLOGY

Functional and structural properties of mammalian acyl-coenzyme A thioesterases

(2010) Brenda Kirkby et al.   PROGRESS IN LIPID RESEARCH

The Akt C-Terminal Modulator Protein Is an Acyl-CoA Thioesterase of the Hotdog-Fold Family

(2009) Hong Zhao et al.   BIOCHEMISTRY

Carboxy-Terminal Modulator Protein (CTMP) is a mitochondrial protein that sensitizes cells to apoptosis

(2009) Arnaud Parcellier et al.   CELLULAR SIGNALLING

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Cardiac overexpression of hormone-sensitive lipase inhibits myocardial steatosis and fibrosis in streptozotocin diabetic mice

(2008) Masami Ueno et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Differential transcriptional modulation of biological processes in adipocyte triglyceride lipase and hormone-sensitive lipase-deficient mice

(2008) Montserrat Pinent et al.   GENOMICS

Adipose triglyceride lipase and the lipolytic catabolism of cellular fat stores

(2008) Rudolf Zechner et al.   JOURNAL OF LIPID RESEARCH

Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets

(2008) Masato Furuhashi et al.   NATURE REVIEWS DRUG DISCOVERY

Molecular Mechanisms of Lipotoxicity in Nonalcoholic Fatty Liver Disease

(2008) Harmeet Malhi et al.   SEMINARS IN LIVER DISEASE

The opposing effects of n−3 and n−6 fatty acids

(2007) Gerd Schmitz et al.   PROGRESS IN LIPID RESEARCH