Kinase Inhibitors as Potential Therapeutic Agents in the Treatment of COVID-19

The management of metastatic GIST: current standard and investigational therapeutics

(2021) Ciara M. Kelly et al.   Journal of Hematology & Oncology

Lonafarnib: First Approval

(2021) Sohita Dhillon   DRUGS

Severe covid-19 pneumonia: pathogenesis and clinical management

(2021) Amy H Attaway et al.   BMJ-British Medical Journal

Therapeutic Strategies in the Management of COVID-19

(2021) Rajashri R. Naik et al.   Frontiers in Molecular Biosciences

Kinases as Potential Therapeutic Targets for Anti-coronaviral Therapy

(2021) Thanigaimalai Pillaiyar et al.   JOURNAL OF MEDICINAL CHEMISTRY

COVID-19: potential therapeutics for pediatric patients

(2021) Nour K. Younis et al.   Pharmacological Reports

Therapeutic Effectiveness and Safety of Repurposing Drugs for the Treatment of COVID-19: Position Standing in 2021

(2021) Safaet Alam et al.   Frontiers in Pharmacology

Determining similarities of COVID-19 – lung cancer drugs and affinity binding mode analysis by graph neural network-based GEFA method

(2021) Cafer Budak et al.   JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS

Bemcentinib and Gilteritinib Inhibit Cell Growth and Impair the Endo-Lysosomal and Autophagy Systems in an AXL-Independent Manner

(2021) Daria Zdżalik-Bielecka et al.   MOLECULAR CANCER RESEARCH

The broad spectrum antiviral ivermectin targets the host nuclear transport importin α/β1 heterodimer

(2020) Sundy N.Y. Yang et al.   ANTIVIRAL RESEARCH

Recent discovery and development of inhibitors targeting coronaviruses

(2020) Thanigaimalai Pillaiyar et al.   DRUG DISCOVERY TODAY

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges

(2020) Chih-Cheng Lai et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Baricitinib as potential treatment for 2019-nCoV acute respiratory disease

(2020) Peter Richardson et al.   LANCET

Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding

(2020) Roujian Lu et al.   LANCET

A Novel Coronavirus from Patients with Pneumonia in China, 2019

(2020) Na Zhu et al.   NEW ENGLAND JOURNAL OF MEDICINE

Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

(2020) Daniel Blanco-Melo et al.   CELL

SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues

(2020) Carly G.K. Ziegler et al.   CELL

Case Report of a SARS-CoV-2 Infection in a Patient With Ulcerative Colitis on Tofacitinib

(2020) Jeffrey Jacobs et al.   INFLAMMATORY BOWEL DISEASES

Correction to: Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China

(2020) Qiurong Ruan et al.   INTENSIVE CARE MEDICINE

JAK Inhibition as a New Treatment Strategy for Patients with COVID-19

(2020) Farhad Seif et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Ruxolitinib in treatment of severe coronavirus disease 2019 (COVID-19): A multicenter, single-blind, randomized controlled trial

(2020) Yang Cao et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

TH17 responses in cytokine storm of COVID-19: An emerging target of JAK2 inhibitor Fedratinib

(2020) Dandan Wu et al.   JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION

CIGB-300 anticancer peptide regulates the protein kinase CK2-dependent phosphoproteome

(2020) Yasser Perera et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

SARS-CoV-2 entry factors are highly expressed in nasal epithelial cells together with innate immune genes

(2020) Waradon Sungnak et al.   NATURE MEDICINE

Remdesivir for severe acute respiratory syndrome coronavirus 2 causing COVID-19: An evaluation of the evidence

(2020) Yu-chen Cao et al.   Travel Medicine and Infectious Disease

Immunomodulation in COVID-19

(2020) Nicholas E Ingraham et al.   Lancet Respiratory Medicine

Incidence of venous and arterial thromboembolic events reported in the tofacitinib rheumatoid arthritis, psoriasis and psoriatic arthritis development programmes and from real-world data

(2020) Philip Mease et al.   ANNALS OF THE RHEUMATIC DISEASES

The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro

(2020) Leon Caly et al.   ANTIVIRAL RESEARCH

The Global Phosphorylation Landscape of SARS-CoV-2 Infection

(2020) Mehdi Bouhaddou et al.   CELL

COVID-19 pathophysiology: A review

(2020) Koichi Yuki et al.   CLINICAL IMMUNOLOGY

The Janus kinase 1/2 inhibitor ruxolitinib in COVID-19 with severe systemic hyperinflammation

(2020) F. La Rosée et al.   LEUKEMIA

Growth factor receptor signaling inhibition prevents SARS-CoV-2 replication

(2020) Kevin Klann et al.   MOLECULAR CELL

Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections

(2020) Quan-Xin Long et al.   NATURE MEDICINE

Ruxolitinib in Alleviating the Cytokine Storm of Hemophagocytic Lymphohistiocytosis

(2020) Li Jianguo et al.   PEDIATRICS

Repurposing of Kinase Inhibitors for Treatment of COVID-19

(2020) Ellen Weisberg et al.   PHARMACEUTICAL RESEARCH

Candidate drugs against SARS-CoV-2 and COVID-19

(2020) Dwight L. McKee et al.   PHARMACOLOGICAL RESEARCH

Targeting JAK-STAT Signaling to Control Cytokine Release Syndrome in COVID-19

(2020) Wei Luo et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Quercetin and Vitamin C: An Experimental, Synergistic Therapy for the Prevention and Treatment of SARS-CoV-2 Related Disease (COVID-19)

(2020) Ruben Manuel Luciano Colunga Biancatelli et al.   Frontiers in Immunology

An aberrant STAT pathway is central to COVID-19

(2020) Toshifumi Matsuyama et al.   CELL DEATH AND DIFFERENTIATION

Imatinib is not a potent anti-SARS-CoV-2 drug

(2020) Helong Zhao et al.   LEUKEMIA

Targeting Casein kinase 2 with quercetin or enzymatically modified isoquercitrin as a strategy for boosting the type 1 interferon response to viruses and promoting cardiovascular health

(2020) James J. DiNicolantonio et al.   MEDICAL HYPOTHESES

The recent outbreaks of human coronaviruses: A medicinal chemistry perspective

(2020) Thanigaimalai Pillaiyar et al.   MEDICINAL RESEARCH REVIEWS

Baricitinib improves respiratory function in patients treated with corticosteroids for SARS-CoV-2 pneumonia: an observational cohort study

(2020) Jose Luis Rodriguez-Garcia et al.   RHEUMATOLOGY

Tyrosine Kinase Inhibitors Play an Antiviral Action in Patients Affected by Chronic Myeloid Leukemia: A Possible Model Supporting Their Use in the Fight Against SARS-CoV-2

(2020) Sara Galimberti et al.   Frontiers in Oncology

Baricitinib treatment resolves lower-airway macrophage inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques

(2020) Timothy N. Hoang et al.   CELL

CK2 inhibition with silmitasertib promotes methuosis-like cell death associated to catastrophic massive vacuolization of colorectal cancer cells

(2019) Eduardo Silva-Pavez et al.   Cell Death & Disease

Axl Promotes Zika Virus Entry and Modulates the Antiviral State of Human Sertoli Cells

(2019) Daniel P. Strange et al.   mBio

Overall Survival with Osimertinib in Untreated, EGFR-Mutated Advanced NSCLC

(2019) Suresh S. Ramalingam et al.   NEW ENGLAND JOURNAL OF MEDICINE

Profile of Tofacitinib in the Treatment of Ulcerative Colitis: An Evidence-Based Review of Recent Data

(2019) Fumi Varyani et al.   Drug Design Development and Therapy

Coronavirus S protein-induced fusion is blocked prior to hemifusion by Abl kinase inhibitors

(2018) Jeanne M. Sisk et al.   JOURNAL OF GENERAL VIROLOGY

The effect of P38 MAP kinase inhibition in a mouse model of influenza

(2018) E. J. Growcott et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Abl and Arg mediate cysteine cathepsin secretion to facilitate melanoma invasion and metastasis

(2018) Rakshamani Tripathi et al.   Science Signaling

Saracatinib Inhibits Middle East Respiratory Syndrome-Coronavirus Replication In Vitro

(2018) Jin Shin et al.   Viruses-Basel

Abemaciclib: a CDK4/6 inhibitor for the treatment of HR+/HER2– advanced breast cancer

(2018) Silvia Paola Corona et al.   Drug Design Development and Therapy

Abl and Arg mediate cysteine cathepsin secretion to facilitate melanoma invasion and metastasis

(2018) Rakshamani Tripathi et al.   Science Signaling

Tofacitinib for the treatment of psoriasis and psoriatic arthritis

(2018) Anna Berekmeri et al.   Expert Review of Clinical Immunology

The PRIDE database and related tools and resources in 2019: improving support for quantification data

(2018) Yasset Perez-Riverol et al.   NUCLEIC ACIDS RESEARCH

Vaccinia virus hijacks EGFR signalling to enhance virus spread through rapid and directed infected cell motility

(2018) Corina Beerli et al.   Nature Microbiology

Anticancer kinase inhibitors impair intracellular viral trafficking and exert broad-spectrum antiviral effects

(2017) Elena Bekerman et al.   JOURNAL OF CLINICAL INVESTIGATION

Ivermectin and its target molecules: shared and unique modulation mechanisms of ion channels and receptors by ivermectin

(2017) I-Shan Chen et al.   JOURNAL OF PHYSIOLOGY-LONDON

Modulation of mitogen-activated protein kinase attenuates sepsis-induced acute lung injury in acute respiratory distress syndrome rats

(2017) Wei Fang et al.   Molecular Medicine Reports

Viral infections: Targeting host kinases

(2017) Crunkhorn Sarah   NATURE REVIEWS DRUG DISCOVERY

MERS, SARS and other coronaviruses as causes of pneumonia

(2017) Yudong Yin et al.   RESPIROLOGY

Preclinical studies of gilteritinib, a next-generation FLT3 inhibitor

(2016) Lauren Y. Lee et al.   BLOOD

An Overview of Severe Acute Respiratory Syndrome–Coronavirus (SARS-CoV) 3CL Protease Inhibitors: Peptidomimetics and Small Molecule Chemotherapy

(2016) Thanigaimalai Pillaiyar et al.   JOURNAL OF MEDICINAL CHEMISTRY

Abelson Kinase Inhibitors Are Potent Inhibitors of Severe Acute Respiratory Syndrome Coronavirus and Middle East Respiratory Syndrome Coronavirus Fusion

(2016) Christopher M. Coleman et al.   JOURNAL OF VIROLOGY

Janus kinase (JAK) inhibitors in the treatment of inflammatory and neoplastic diseases

(2016) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Identification and characterization of the role of c-terminal Src kinase in dengue virus replication

(2016) Rinki Kumar et al.   Scientific Reports

Response to ruxolitinib in patients with intermediate-1-, intermediate-2-, and high-risk myelofibrosis: results of the UK ROBUST Trial

(2015) Adam J. Mead et al.   BRITISH JOURNAL OF HAEMATOLOGY

First-in-Human Phase I Study of GSK2126458, an Oral Pan-Class I Phosphatidylinositol-3-Kinase Inhibitor, in Patients with Advanced Solid Tumor Malignancies

(2015) P. Munster et al.   CLINICAL CANCER RESEARCH

AP-2-Associated Protein Kinase 1 and Cyclin G-Associated Kinase Regulate Hepatitis C Virus Entry and Are Potential Drug Targets

(2015) Gregory Neveu et al.   JOURNAL OF VIROLOGY

Safety and efficacy of imatinib in CML over a period of 10 years: data from the randomized CML-study IV

(2015) L Kalmanti et al.   LEUKEMIA

Systematic review and meta-analysis of serious infections with tofacitinib and biologic disease-modifying antirheumatic drug treatment in rheumatoid arthritis clinical trials

(2015) Vibeke Strand et al.   ARTHRITIS RESEARCH & THERAPY

Stability-Indicating HPLC Determination of Gemcitabine in Pharmaceutical Formulations

(2015) Rahul Singh et al.   International Journal of Analytical Chemistry

Repurposing of Clinically Developed Drugs for Treatment of Middle East Respiratory Syndrome Coronavirus Infection

(2014) Julie Dyall et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Ruxolitinib and Tofacitinib Are Potent and Selective Inhibitors of HIV-1 Replication and Virus ReactivationIn Vitro

(2014) Christina Gavegnano et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Modulation of inflammation and pathology during dengue virus infection by p38 MAPK inhibitor SB203580

(2014) Yilong Fu et al.   ANTIVIRAL RESEARCH

First-in-Human Phase I Study of Pictilisib (GDC-0941), a Potent Pan-Class I Phosphatidylinositol-3-Kinase (PI3K) Inhibitor, in Patients with Advanced Solid Tumors

(2014) D. Sarker et al.   CLINICAL CANCER RESEARCH

Measurement of sorafenib plasma concentration by high-performance liquid chromatography in patients with advanced hepatocellular carcinoma: is it useful the application in clinical practice? A pilot study

(2014) Carmen Fucile et al.   MEDICAL ONCOLOGY

The PDZ-Binding Motif of Severe Acute Respiratory Syndrome Coronavirus Envelope Protein Is a Determinant of Viral Pathogenesis

(2014) Jose M. Jimenez-Guardeño et al.   PLoS Pathogens

Identification of 53 compounds that block Ebola virus-like particle entry via a repurposing screen of approved drugs

(2014) Jennifer Kouznetsova et al.   Emerging Microbes & Infections

Middle East Respiratory Syndrome Coronavirus Infection Mediated by the Transmembrane Serine Protease TMPRSS2

(2013) Kazuya Shirato et al.   JOURNAL OF VIROLOGY

The Small Molecules AZD0530 and Dasatinib Inhibit Dengue Virus RNA Replication via Fyn Kinase

(2013) M. de Wispelaere et al.   JOURNAL OF VIROLOGY

First-in-Human, Phase I Dose-Escalation Study of the Safety, Pharmacokinetics, and Pharmacodynamics of RO5126766, a First-in-Class Dual MEK/RAF Inhibitor in Patients with Solid Tumors

(2012) M. Martinez-Garcia et al.   CLINICAL CANCER RESEARCH

Productive Replication of Ebola Virus Is Regulated by the c-Abl1 Tyrosine Kinase

(2012) M. Garcia et al.   Science Translational Medicine

Identification and Targeting of an Interaction between a Tyrosine Motif within Hepatitis C Virus Core Protein and AP2M1 Essential for Viral Assembly

(2012) Gregory Neveu et al.   PLoS Pathogens

Epstein-Barr Virus LMP1 Activates EGFR, STAT3, and ERK through Effects on PKC 

(2011) C.-P. Kung et al.   JOURNAL OF VIROLOGY

EGFR and EphA2 are host factors for hepatitis C virus entry and possible targets for antiviral therapy

(2011) Joachim Lupberger et al.   NATURE MEDICINE

Casein kinase 2 regulates vaccinia virus actin tail formation

(2011) Diego E. Alvarez et al.   VIROLOGY

ABL Tyrosine Kinases: Evolution of Function, Regulation, and Specificity

(2010) J. Colicelli   Science Signaling

The Epidermal Growth Factor Receptor (EGFR) Promotes Uptake of Influenza A Viruses (IAV) into Host Cells

(2010) Thorsten Eierhoff et al.   PLoS Pathogens

Regulation of cell migration and morphogenesis by Abl-family kinases: emerging mechanisms and physiological contexts

(2009) W. D. Bradley et al.   JOURNAL OF CELL SCIENCE

Nilotinib: A second-generation tyrosine kinase inhibitor for chronic myeloid leukemia

(2009) Massimo Breccia et al.   LEUKEMIA RESEARCH

Rhinovirus-Induced Major Airway Mucin Production Involves a Novel TLR3-EGFR–Dependent Pathway

(2008) Lingxiang Zhu et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Plaque assay for human coronavirus NL63 using human colon carcinoma cells

(2008) Petra Herzog et al.   Virology Journal