Article
Biochemistry & Molecular Biology
Ze Zhang, Ruoyan Liu, Yafei Wang, Yun Wang, Yanjie Shuai, Chuangwu Ke, Rui Jin, Xudong Wang, Jingtao Luo
Summary: The study reveals that phosphorylation of MICAL2 at Tyr445 and Tyr463 by ARG mediates F-actin disassembly and promotes HNSCC progression.
Article
Multidisciplinary Sciences
Mitchell E. Fane, Yash Chhabra, Gretchen M. Alicea, Devon A. Maranto, Stephen M. Douglass, Marie R. Webster, Vito W. Rebecca, Gloria E. Marino, Filipe Almeida, Brett L. Ecker, Daniel J. Zabransky, Laura Huser, Thomas Beer, Hsin-Yao Tang, Andrew Kossenkov, Meenhard Herlyn, David W. Speicher, Wei Xu, Xiaowei Xu, Elizabeth M. Jaffee, Julio A. Aguirre-Ghiso, Ashani T. Weeraratna
Summary: The aged lung microenvironment provides a permissive niche for the growth and dissemination of melanoma cells, while age-related changes in the skin suppress melanoma growth but drive dissemination. Reprogramming of lung fibroblasts and activation of WNT5A promote the metastasis and dissemination of melanoma cells by inhibiting WNT5A in melanoma cells.
Article
Biochemistry & Molecular Biology
Seungmin Shin, Seungyeon Yang, Minjoong Kim, Eun Kyung Lee, Soojung Claire Hur, Seung Min Jeong
Summary: Metastasis is a malignant characteristic of cancer cells. Melanoma cells undergo metabolic reprogramming during metastasis, specifically upregulation of fatty acid oxidation (FAO). Inhibition of FAO impairs migration of melanoma cells by regulating autophagosome formation. FAO inhibition increases autophagosome formation and suppresses migration and invasion properties of melanoma cells. Modulating cellular acetyl-CoA levels may be a potential therapeutic strategy for inhibiting cancer metastasis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Paula Colon-Bolea, Rocio Garcia-Gomez, Berta Casar
Summary: Metastasis is a complicated process in which cancer cells escape from the primary tumor and spread to distant organs. RAC1, a member of the RHO family, plays a crucial role in cancer migration, invasion, angiogenesis, and metastasis. Targeting RAC1 is seen as a promising strategy for treating metastatic cutaneous melanoma.
Article
Biochemistry & Molecular Biology
Vladimir Cermak, Aneta Skarkova, Ladislav Merta, Veronika Kolomaznikova, Veronika Palusova, Stjepan Uldrijan, Daniel Rosel, Jan Brabek
Summary: This study shows that phenotype plasticity in melanoma can be induced by treatment with p38 MAPK inhibitors, leading to a switch from a more dedifferentiated invasive phenotype to a more differentiated state. This phenotypic change is accompanied by alterations in gene expression and morphological transition, contributing to invasion and metastasis in melanoma.
Review
Oncology
Mickael Ohanna, Pierric Biber, Marcel Deckert
Summary: ——Metastatic melanoma is a aggressive skin tumor with poor prognosis, and current treatments have limited efficacy. This review discusses the role of ubiquitination in melanoma development and resistance to therapy and highlights the potential of deubiquitination enzymes as novel therapeutic targets.
Article
Dermatology
Alessandra Marconi, Marika Quadri, Francesca Farnetani, Silvana Ciardo, Elisabetta Palazzo, Roberta Lotti, Anna Maria Cesinaro, Luca Fabbiani, Cristina Vaschieri, Mario Puviani, Cristina Magnoni, Shaniko Kaleci, Carlo Pincelli, Giovanni Pellacani
Summary: In this study, four distinct melanoma subtypes were identified using reflectance confocal microscopy, each with a specific biomolecular profile and biological behavior associated with tumor aggressiveness.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Cell Biology
Fangzhou Ye, Yiran Liang, Yajie Wang, Robert Le Yang, Dan Luo, Yaming Li, Yuhan Jin, Dianwen Han, Bing Chen, Wenjing Zhao, Lijuan Wang, Xi Chen, Tingting Ma, Xiaoli Kong, Qifeng Yang
Summary: Breast cancer is a common malignancy and exosome-mediated communication between cancer-associated fibroblasts (CAFs) and breast cancer cells plays a role in tumor progression. This study identified circTBPL1 as an upregulated circRNA in exosomes derived from CAFs. Transfer of exosomal circTBPL1 from CAFs to breast cancer cells promoted cell proliferation, migration, and invasion. Further investigation revealed that circTBPL1 acts as a sponge for miR-653-5p, leading to increased expression of TPBG and enhanced breast cancer progression. These findings suggest that exosomal circTBPL1 could serve as a biomarker and therapeutic target for breast cancer.
CELL DEATH & DISEASE
(2023)
Article
Multidisciplinary Sciences
Song Wu, Tao Tang, Hongchi Zhou, Jing Huang, Xiaoliang Kang, Junli Zhang
Summary: This study reveals that LINC01343 acts as a crucial oncogene in hepatocellular carcinoma (HCC). LINC01343 negatively regulates the expression of miR-526b-5p, which in turn modulates ROBO1 expression, affecting HCC cell proliferation and migration.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Shun Li, David Mark Pritchard, Lu-Gang Yu
Summary: Galectin-3, commonly overexpressed in many epithelial cancers, is shown to promote cancer development, progression, and metastasis. This study reveals that galectin-3 secretion by human colon cancer cells induces the secretion of proteases, leading to disruption of epithelial monolayer integrity and increased permeability, ultimately promoting tumor cell invasion. This effect is mediated through cellular PYK2-GSK3 alpha/beta signaling and can be prevented by galectin-3 binding inhibitors. These findings highlight the importance of galectin-3 as a potential therapeutic target for cancer treatment.
CELL DEATH & DISEASE
(2023)
Article
Oncology
Gang Heng, Benqi Huang, Yanbing Shen, Dan Wang, Zhen Lan, Yuxuan Yao, Jianxin Zhang, Jiankun Jia, Chengcheng Zhang
Summary: The study found that serum CA242 levels were associated with clinical prognosis in HCCA patients, and vascular invasion and lymph node metastasis played significant roles in mediating the impact of CA242 on prognosis.
FRONTIERS IN ONCOLOGY
(2022)
Article
Veterinary Sciences
Yan Yan Song, Qi Qi Lu, Lu Lu Han, Shu Wei Yan, Xin Zhuo Zhang, Ruo Dan Liu, Shao Rong Long, Jing Cui, Zhong Quan Wang
Summary: This study found that serine proteases and cysteine proteases in the ESPs of T. spiralis IIL play main roles in hydrolysing occludin, claudin-1 and E-cad, and upregulating claudin-2 expression. The challenge infection results showed that treatment with specific inhibitors or inhibitor mixtures significantly reduced expulsion of IIL from the gut, and led to reductions in intestinal adult worms compared to the control group. These findings suggest that serine proteases and cysteine proteases may be key target molecules for vaccines against larval invasion and development.
VETERINARY RESEARCH
(2022)
Article
Endocrinology & Metabolism
Linchun Wen, Lu Xu, Beibei Cai, Zihao Liu, Lixue Wang
Summary: This study found that NLRC5 promotes the invasion and metastasis of LUAD cells by activating the PI3K/AKT pathway.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Cell Biology
Stefania Cane, Roza Maria Barouni, Marina Fabbi, John Cuozzo, Giulio Fracasso, Annalisa Adamo, Stefano Ugel, Rosalinda Trovato, Francesco De Sanctis, Mauro Giacca, Rita Lawlor, Aldo Scarpa, Borislav Rusev, Gabriella Lionetto, Salvatore Paiella, Roberto Salvia, Claudio Bassi, Susanna Mandruzzato, Silvano Ferrini, Vincenzo Bronte
Summary: Preclinical studies have shown that myeloid cells can suppress antitumor immunity by degrading L-arginine, but differences in ARG1 expression and function in rodents and humans have hindered clinical translation. This study discovered that neutrophil extracellular traps (NETs) released by activated neutrophils in patients with PDAC create a microdomain where cathepsin S (CTSS) cleaves human ARG1 (hARG1) into different forms with enhanced enzymatic activity. These NET-associated hARG1 molecules suppress T lymphocytes, but their proliferation can be restored by blocking CTSS cleavage or using hARG1-specific monoclonal antibodies, suggesting potential therapeutic strategies for PDAC.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Plant Sciences
Yu Kou, Qidi Sun, Rentao Zhu, Zhijie Lin, Zhuoqun Li, Hairong Xu, Xuan Feng, Yanqing Liu
Summary: The study aimed to find a natural drug monomer that can effectively reverse the polarity of tumor-associated macrophages, inhibit melanoma metastasis, and improve survival time. Dioscin was found to repolarize macrophages from M2 to M1 phenotype and suppress melanoma migration, invasion, and metastasis through activation of Cx43-GJs/IFN-gamma/STAT1 pathway and inhibition of Cx43-GJs/IL-4/JAK2/STAT3 pathway.
Article
Biochemistry & Molecular Biology
A. Jain, R. Tripathi, C. P. Turpin, C. Wang, R. Plattner
Article
Biochemistry & Molecular Biology
Rakshamani Tripathi, Leann S. Fiore, Dana L. Richards, Yuchen Yang, Jinpeng Liu, Chi Wang, Rina Plattner
Article
Pharmacology & Pharmacy
Kaushik Bhattacharya, Suman K. Samanta, Rakshamani Tripathi, Asish Mallick, Sarmila Chandra, Bikas C. Pal, Chandrima Shaha, Chitra Mandal
BIOCHEMICAL PHARMACOLOGY
(2010)
Article
Cell Biology
Rakshamani Tripathi, Dipankar Ash, Chandrima Shaha
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2014)
Article
Immunology
Rakshamani Tripathi, Durga Prasad Mishra, Chandrima Shaha
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2009)
Article
Oncology
Rakshamani Tripathi, Tanmoy Samadder, Sarika Gupta, Avadhesha Surolia, Chandrima Shaha
MOLECULAR CANCER THERAPEUTICS
(2011)
Review
Biology
Chandrima Shaha, Rakshamani Tripathi, Durga Prasad Mishra
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2010)
Article
Oncology
Anastasia Lyon, Rakshamani Tripathi, Christina Meeks, Daheng He, Yuanyuan Wu, Jinpeng Liu, Chi Wang, Jing Chen, Haining Zhu, Sujata Mukherjee, Saptadwipa Ganguly, Rina Plattner
Summary: Melanomas with NRAS mutations are aggressive and difficult to treat. In cases where immune checkpoint blockade is not effective, there are no good treatment options. However, targeting the RAF/MEK/ERK pathway can potentially improve survival. ABL1/2 and DDR1 have been identified as critical factors in MEK inhibitor resistance in NRAS-mutant melanomas.
Article
Multidisciplinary Sciences
Rakshamani Tripathi, Zulong Liu, Aditi Jain, Anastasia Lyon, Christina Meeks, Dana Richards, Jinpeng Liu, Daheng He, Chi Wang, Marika Nespi, Andrey Rymar, Peng Wang, Melissa Wilson, Rina Plattner
NATURE COMMUNICATIONS
(2020)
Article
Oncology
Rakshamani Tripathi, Rina Plattner
MOLECULAR & CELLULAR ONCOLOGY
(2018)
Article
Oncology
Kaushik Bhattacharya, Arup K. Bag, Rakshamani Tripathi, Suman K. Samanta, Bikas C. Pal, Chandrima Shaha, Chitra Mandal
AMERICAN JOURNAL OF CANCER RESEARCH
(2014)
Article
Biology
Rakshamani Tripathi, J. P. Kamat
INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY
(2007)
Article
Chemistry, Applied
Rakshamani Tripathi, H. Mohan, J. P. Kamat