Inhibition of Myocardial Cell Apoptosis Is Important Mechanism for Ginsenoside in the Limitation of Myocardial Ischemia/Reperfusion Injury

Preventive Effect of Canstatin against Ventricular Arrhythmia Induced by Ischemia/Reperfusion Injury: A Pilot Study

(2021) Akira Sugiyama et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A SIRT1 Activator, Ginsenoside Rc, Promotes Energy Metabolism in Cardiomyocytes and Neurons

(2021) Qingxia Huang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The Protective Effects of Shengmai Formula Against Myocardial Injury Induced by Ultrafine Particulate Matter Exposure and Myocardial Ischemia are Mediated by the PI3K/AKT/p38 MAPK/Nrf2 Pathway

(2021) Lina Chen et al.   Frontiers in Pharmacology

Protective effect of recombinant Lactobacillus plantarum against H2O2-induced oxidative stress in HUVEC cells

(2021) Guan Wang et al.   Journal of Zhejiang University-SCIENCE B

Novel Insight into the Role of Endoplasmic Reticulum Stress in the Pathogenesis of Myocardial Ischemia-Reperfusion Injury

(2021) Hang Zhu et al.   Oxidative Medicine and Cellular Longevity

Downregulated MicroRNA-327 Attenuates Oxidative Stress–Mediated Myocardial Ischemia Reperfusion Injury Through Regulating the FGF10/Akt/Nrf2 Signaling Pathway

(2021) Tao Zheng et al.   Frontiers in Pharmacology

Velvet Antler Ameliorates Cardiac Function by Restoring Sarcoplasmic Reticulum Ca2+-ATPase Activity in Rats With Heart Failure After Myocardial Infarction

(2021) Haoyue Shi et al.   Frontiers in Pharmacology

Overexpression of SERCA2a Alleviates Cardiac Microvascular Ischemic Injury by Suppressing Mfn2-Mediated ER/Mitochondrial Calcium Tethering

(2021) Feng Tian et al.   Frontiers in Cell and Developmental Biology

The protective effect of allicin on myocardial ischemia-reperfusion by inhibition of Ca2+ overload-induced cardiomyocyte apoptosis via the PI3K/GRK2/PLC-γ/IP3R signaling pathway

(2021) Tong Gao et al.   Aging-US

NF-KappaB interacting LncRNA: Review of its roles in neoplastic and non-neoplastic conditions

(2021) Bashdar Mahmud Hussen et al.   BIOMEDICINE & PHARMACOTHERAPY

Ginsenoside Rb1 protects from Staphylococcus aureus-induced oxidative damage and apoptosis through endoplasmic reticulum-stress and death receptor-mediated pathways

(2021) Aftab Shaukat et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Role of epigenetic regulation in myocardial ischemia/reperfusion injury

(2021) Keyan Wang et al.   PHARMACOLOGICAL RESEARCH

Suppression of apoptosis in vascular endothelial cell, the promising way for natural medicines to treat atherosclerosis

(2021) Huxinyue Duan et al.   PHARMACOLOGICAL RESEARCH

Protective Effects of Caesalpinia sappan Linn. and Its Bioactive Compounds on Cardiovascular Organs

(2021) Mas Rizky AA Syamsunarno et al.   Frontiers in Pharmacology

Fundamental Mechanisms of the Cell Death Caused by Nitrosative Stress

(2021) Fulin Wang et al.   Frontiers in Cell and Developmental Biology

The Role of the Signaling Pathways Involved in the Protective Effect of Exogenous Hydrogen Sulfide on Myocardial Ischemia-Reperfusion Injury

(2021) Shuangyu Lv et al.   Frontiers in Cell and Developmental Biology

Pyroptosis: A New Regulating Mechanism in Cardiovascular Disease

(2021) Nan Ji et al.   Journal of Inflammation Research

High-Energy Phosphates and Ischemic Heart Disease: From Bench to Bedside

(2021) Hao Yi-Dan et al.   Frontiers in Cardiovascular Medicine

Cardioprotective Effect of Stem-Leaf Saponins From Panax notoginseng on Mice With Sleep Derivation by Inhibiting Abnormal Autophagy Through PI3K/Akt/mTOR Pathway

(2021) Yin Cao et al.   Frontiers in Cardiovascular Medicine

Protective Roles of Xijiao Dihuang Tang on Coronary Artery Injury in Kawasaki Disease

(2021) Jian Zhang et al.   CARDIOVASCULAR DRUGS AND THERAPY

Glycyrrhizic acid ameliorates myocardial ischemia-reperfusion injury in rats through inhibiting endoplasmic reticulum stress

(2021) Tengfang Lai et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cardioprotective activity of ethyl acetate extract of Cinnamomi Ramulus against myocardial ischemia/reperfusion injury in rats via inhibiting NLRP3 inflammasome activation and pyroptosis

(2021) Lixia Peng et al.   PHYTOMEDICINE

Aesculin suppresses the NLRP3 inflammasome-mediated pyroptosis via the Akt/GSK3β/NF-κB pathway to mitigate myocardial ischemia/reperfusion injury

(2021) Xiao-na Xu et al.   PHYTOMEDICINE

Angiotensin II receptor blocker irbesartan attenuates sleep apnea–induced cardiac apoptosis and enhances cardiac survival and Sirtuin 1 upregulation

(2021) Pei-Ying Pai et al.   Sleep and Breathing

Ischemic heart disease and cardioprotection: Focus on estrogenic hormonal setting and microvascular health

(2021) Giulia Querio et al.   VASCULAR PHARMACOLOGY

Ginsenosides emerging as both bifunctional drugs and nanocarriers for enhanced antitumor therapies

(2021) Hong Wang et al.   JOURNAL OF NANOBIOTECHNOLOGY

Emerging Significance of Ginsenosides as Potentially Reversal Agents of Chemoresistance in Cancer Therapy

(2021) Jin-Feng Xu et al.   Frontiers in Pharmacology

Ginsenoside Rb1 Produces Antidepressant-Like Effects in a Chronic Social Defeat Stress Model of Depression Through the BDNF–Trkb Signaling Pathway

(2021) Ning Jiang et al.   Frontiers in Pharmacology

Hepatic Remote Ischemic Preconditioning (RIPC) Protects Heart Damages Induced by Ischemia Reperfusion Injury in Mice

(2021) Yanlong Ren et al.   Frontiers in Physiology

Induction of Apoptosis by Isoalantolactone in Human Hepatocellular Carcinoma Hep3B Cells through Activation of the ROS-Dependent JNK Signaling Pathway

(2021) Min Yeong Kim et al.   Pharmaceutics

Histochrome Attenuates Myocardial Ischemia-Reperfusion Injury by Inhibiting Ferroptosis-Induced Cardiomyocyte Death

(2021) Ji-Won Hwang et al.   Antioxidants

Cell death inhibitors protect against brain damage caused by cardiac ischemia/reperfusion injury

(2021) Suchan Liao et al.   Cell Death Discovery

Extracorporeal Cardiac Shock Waves Therapy Improves the Function of Endothelial Progenitor Cells After Hypoxia Injury via Activating PI3K/Akt/eNOS Signal Pathway

(2021) Mingqiang Wang et al.   Frontiers in Cardiovascular Medicine

Heart Disease and Stroke Statistics—2020 Update: A Report From the American Heart Association

(2020) Salim S. Virani et al.   CIRCULATION

Deletion of Rap1 protects against myocardial ischemia/reperfusion injury through suppressing cell apoptosis via activation of STAT3 signaling

(2020) Yin Cai et al.   FASEB JOURNAL

Ginsenoside Rb1 attenuates cardiomyocyte apoptosis induced by myocardial ischemia reperfusion injury through mTOR signal pathway

(2020) Chang-Yan Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Heat Shock Protein 70 Protects the Heart from Ischemia/Reperfusion Injury through Inhibition of p38 MAPK Signaling

(2020) Nan Song et al.   Oxidative Medicine and Cellular Longevity

Synergistic effects of low-level stress and a Western diet on metabolic homeostasis, mood and myocardial ischemic tolerance.

(2020) Eugene F. Du Toit et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Mitochondrial ROS in myocardial ischemia reperfusion and remodeling

(2020) Heiko Bugger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The Advances on the protective effects of ginsenosides on myocardial ischemia and ischemia-reperfusion injury

(2020) Jiazhen Wang et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Role of endoplasmic reticulum oxidase 1α in H9C2 cardiomyocytes following hypoxia/reoxygenation injury

(2020) Lina Lai et al.   Molecular Medicine Reports

The Role of Arachidonic Acid Metabolism in Myocardial Ischemia–Reperfusion Injury

(2020) Changjiang Zhang et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

A review of myocardial ischaemia/reperfusion injury: Pathophysiology, experimental models, biomarkers, genetics and pharmacological treatment

(2020) Mehmet Gunata et al.   CELL BIOCHEMISTRY AND FUNCTION

Ginsenoside Rb2 alleviates myocardial ischemia/reperfusion injury in rats through SIRT1 activation

(2020) Yan Xue et al.   JOURNAL OF FOOD SCIENCE

Ginsenosides for the treatment of metabolic syndrome and cardiovascular diseases: Pharmacology and mechanisms

(2020) Wenxiang Fan et al.   BIOMEDICINE & PHARMACOTHERAPY

Mechanisms dissection of the combination GRS derived from ShengMai preparations for the treatment of myocardial ischemia/reperfusion injury

(2020) Weiwei Yang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Protective action of the ginsenoside Rh3 in a rat myocardial ischemia-reperfusion injury model by inhibition of apoptosis induced via p38 mitogen-activated protein kinase/caspase-3 signaling

(2020) Liexiang Cao et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Ginsenoside Rb1 attenuates intestinal ischemia/reperfusion‑induced inflammation and oxidative stress via activation of the PI3K/Akt/Nrf2 signaling pathway

(2019) Sufang Chen et al.   Molecular Medicine Reports

Adeno-associated virus 9-mediated small RNA interference of TLR4 alleviates myocardial ischemia and reperfusion injury by inhibition of the NF-κB and MAPK signaling pathways in rats

(2019) Ting Xu et al.   CURRENT MOLECULAR MEDICINE

N-n-Butyl Haloperidol Iodide Ameliorates Oxidative Stress in Mitochondria Induced by Hypoxia/Reoxygenation through the Mitochondrial c-Jun N-Terminal Kinase/Sab/Src/Reactive Oxygen Species Pathway in H9c2 Cells

(2019) Qianwen Chu et al.   Oxidative Medicine and Cellular Longevity

S100a8/a9 Signaling Causes Mitochondrial Dysfunction and Cardiomyocytes Death in Response Ischemic/Reperfusion Injury

(2019) Yulin Li et al.   CIRCULATION

Antiarrhythmic effects of ginsenoside Rg2 on calcium chloride–induced arrhythmias without oral toxicity

(2019) Dongxia Gou et al.   Journal of Ginseng Research

Combination of the ginsenosides Rb3 and Rb2 exerts protective effects against myocardial ischemia reperfusion injury in rats

(2019) Xiaomin Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Molecular machinery and interplay of apoptosis and autophagy in coronary heart disease

(2019) Yan Dong et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Anthocyanidin attenuates myocardial ischemia induced injury via inhibition of ROS‐JNK‐Bcl‐2 pathway: New mechanism of anthocyanidin action

(2019) Madiha Zahra Syeda et al.   PHYTOTHERAPY RESEARCH

Apoptosis Induction of Fibroblast-Like Synoviocytes Is an Important Molecular-Mechanism for Herbal Medicine along with its Active Components in Treating Rheumatoid Arthritis

(2019) Qing Zhang et al.   Biomolecules

Ginsenoside Rb3 regulates energy metabolism and apoptosis in cardiomyocytes via activating PPARα pathway

(2019) Xu Chen et al.   BIOMEDICINE & PHARMACOTHERAPY

The Effect of Ginsenoside RB1, Diazoxide, and 5-Hydroxydecanoate on Hypoxia-Reoxygenation Injury of H9C2 Cardiomyocytes

(2019) Heng Zhang et al.   Evidence-based Complementary and Alternative Medicine

Ginsenoside Rg3-loaded, reactive oxygen species-responsive polymeric nanoparticles for alleviating myocardial ischemia-reperfusion injury

(2019) Lan Li et al.   JOURNAL OF CONTROLLED RELEASE

The role of the Fas/FasL signaling pathway in environmental toxicant-induced testicular cell apoptosis: An update

(2018) Mei Wang et al.   Systems Biology in Reproductive Medicine

Honey protects against cisplatin-induced hepatic and renal toxicity through inhibition of NF-κB-mediated COX-2 expression and the oxidative stress dependent BAX/Bcl-2/caspase-3 apoptotic pathway

(2018) Thikryat Neamatallah et al.   Food & Function

20(S)-Ginsenoside Rg2 attenuates myocardial ischemia/reperfusion injury by reducing oxidative stress and inflammation: role of SIRT1

(2018) Wenwen Fu et al.   RSC Advances

Ginsenoside Rg1 Ameliorates Rat Myocardial Ischemia-Reperfusion Injury by Modulating Energy Metabolism Pathways

(2018) Lin Li et al.   Frontiers in Physiology

Baicalin attenuates myocardial ischemia-reperfusion injury through Akt/NF-κB pathway

(2018) Yun Luan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Ginsenoside Rb3 protects cardiomyocytes against hypoxia/reoxygenation injury via activating the antioxidation signaling pathway of PERK/Nrf2/HMOX1

(2018) Jing Sun et al.   BIOMEDICINE & PHARMACOTHERAPY

Panax ginseng and Panax quinquefolius : From pharmacology to toxicology

(2017) Cesare Mancuso et al.   FOOD AND CHEMICAL TOXICOLOGY

Melatonin ameliorates myocardial ischemia reperfusion injury through SIRT3-dependent regulation of oxidative stress and apoptosis

(2017) Mengen Zhai et al.   JOURNAL OF PINEAL RESEARCH

Ischemia/Reperfusion Injury following Acute Myocardial Infarction: A Critical Issue for Clinicians and Forensic Pathologists

(2017) Margherita Neri et al.   MEDIATORS OF INFLAMMATION

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

(2017) Yupeng Wang et al.   NATURE

N-n-butyl Haloperidol Iodide Protects against Hypoxia/Reoxygenation Injury in Cardiac Microvascular Endothelial Cells by Regulating the ROS/MAPK/Egr-1 Pathway

(2017) Shishi Lu et al.   Frontiers in Pharmacology

Osmotin Protects H9c2 Cells from Simulated Ischemia-Reperfusion Injury through AdipoR1/PI3K/AKT Signaling Pathway

(2017) Jianhua Liu et al.   Frontiers in Physiology

Ginsenoside Rb1 protects against ischemia/reperfusion-induced myocardial injury via energy metabolism regulation mediated by RhoA signaling pathway

(2017) Yuan-Chen Cui et al.   Scientific Reports

Methylophiopogonanone A suppresses ischemia/reperfusion-induced myocardial apoptosis in mice via activating PI3K/Akt/eNOS signaling pathway

(2016) Fei He et al.   ACTA PHARMACOLOGICA SINICA

Analyzing the anti-ischemia–reperfusion injury effects of ginsenoside Rb1 mediated through the inhibition of p38α MAPK

(2016) Gonghao Li et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Potential Roles of Humanin on Apoptosis in the Heart

(2016) Savitree T. Charununtakorn et al.   Cardiovascular Therapeutics

Impact of miR-208 and its Target Gene Nemo-Like Kinase on the Protective Effect of Ginsenoside Rb1 in Hypoxia/Ischemia Injuried Cardiomyocytes

(2016) Xu Yan et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Ginsenoside Rg3 Improves Cardiac Function after Myocardial Ischemia/Reperfusion via Attenuating Apoptosis and Inflammation

(2016) Li-ping Zhang et al.   Evidence-based Complementary and Alternative Medicine

Roles and mechanisms of ginsenoside in cardiovascular diseases: progress and perspectives

(2016) Yingying Sun et al.   Science China-Life Sciences

The Relationship between the Bcl-2/Bax Proteins and the Mitochondria-Mediated Apoptosis Pathway in the Differentiation of Adipose-Derived Stromal Cells into Neurons

(2016) Quanquan Wang et al.   PLoS One

Biosynthesis and biotechnological production of ginsenosides

(2015) Yu-Jin Kim et al.   BIOTECHNOLOGY ADVANCES

Cardiac Oxidative Stress and Inflammatory Cytokines Response after Myocardial Infarction

(2015) Margherita Neri et al.   Current Vascular Pharmacology

Ginsenoside-Rb1 Protects Hypoxic- and Ischemic-Damaged Cardiomyocytes by Regulating Expression of miRNAs

(2015) Xu Yan et al.   Evidence-based Complementary and Alternative Medicine

Ginsenoside Rg3 attenuates myocardial ischemia/reperfusion injury via Akt/endothelial nitric oxide synthase signaling and the B-cell lymphoma/B-cell lymphoma-associated X protein pathway

(2015) YIPING WANG et al.   Molecular Medicine Reports

NF45 inhibits cardiomyocyte apoptosis following myocardial ischemia-reperfusion injury

(2015) Xiaojuan Liu et al.   PATHOLOGY RESEARCH AND PRACTICE

Ginsenoside Rb1 prevents hypoxia-reoxygenation-induced apoptosis in H9c2 cardiomyocytes via an estrogen receptor-dependent crosstalk among the Akt, JNK, and ERK 1/2 pathways using a label-free quantitative proteomics analysis

(2015) Qidi Ai et al.   RSC Advances

A p38MAPK/MK2 signaling pathway leading to redox stress, cell death and ischemia/reperfusion injury

(2014) Muhammad Ashraf et al.   Cell Communication and Signaling

Ginsenoside Rb3 Protects Cardiomyocytes against Ischemia-Reperfusion Injury via the Inhibition of JNK-Mediated NF-κB Pathway: A Mouse Cardiomyocyte Model

(2014) Lijia Ma et al.   PLoS One

A Molecular Web: Endoplasmic Reticulum Stress, Inflammation, and Oxidative Stress

(2014) Namrata Chaudhari et al.   Frontiers in Cellular Neuroscience

Reduced IRE1α mediates apoptotic cell death by disrupting calcium homeostasis via the InsP3 receptor

(2014) S M Son et al.   Cell Death & Disease

Ginsenoside-Rb3 protects the myocardium from ischemia-reperfusion injury via the inhibition of apoptosis in rats

(2014) XIAOMIN LIU et al.   Experimental and Therapeutic Medicine

Yin and Yang of ginseng pharmacology: ginsenosides vs gintonin

(2013) Dong-soon Im et al.   ACTA PHARMACOLOGICA SINICA

Ginsenoside RK3 Prevents Hypoxia-Reoxygenation Induced Apoptosis in H9c2 Cardiomyocytes via AKT and MAPK Pathway

(2013) Jing Sun et al.   Evidence-based Complementary and Alternative Medicine

Ginsenoside Rd Attenuates Myocardial Ischemia/Reperfusion Injury via Akt/GSK-3β Signaling and Inhibition of the Mitochondria-Dependent Apoptotic Pathway

(2013) Yang Wang et al.   PLoS One

Platelet Rich Plasma Clot Releasate Preconditioning Induced PI3K/AKT/NFκB Signaling Enhances Survival and Regenerative Function of Rat Bone Marrow Mesenchymal Stem Cells in Hostile Microenvironments

(2013) Yan Peng et al.   STEM CELLS AND DEVELOPMENT

Cardiomyocyte-expressed farnesoid-X-receptor is a novel apoptosis mediator and contributes to myocardial ischaemia/reperfusion injury

(2012) Jun Pu et al.   EUROPEAN HEART JOURNAL

Chronic toxicity of ginsenoside Re on Sprague-Dawley rats

(2012) Dan Lu et al.   JOURNAL OF ETHNOPHARMACOLOGY

Ginsenoside Rg1 inhibits autophagy in H9c2 cardiomyocytes exposed to hypoxia/reoxygenation

(2012) Zi-Long Zhang et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Ubiquitination and degradation of the FADD adaptor protein regulate death receptor-mediated apoptosis and necroptosis

(2012) Eun-Woo Lee et al.   Nature Communications

The role of oxidized cytochromecin regulating mitochondrial reactive oxygen species production and its perturbation in ischaemia

(2011) Philippe Pasdois et al.   BIOCHEMICAL JOURNAL

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

(2011) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Upregulation of heme oxygenase-1 expression by hydroxysafflor yellow A conferring protection from anoxia/reoxygenation-induced apoptosis in H9c2 cardiomyocytes

(2011) Shan-Xin Liu et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Ischemia and reperfusion—from mechanism to translation

(2011) Holger K Eltzschig et al.   NATURE MEDICINE

Protective effect of ginsenoside Rb1 against myocardial ischemia/reperfusion injury in streptozotocin-induced diabetic rats

(2010) Yang Wu et al.   MOLECULAR BIOLOGY REPORTS

Cell Death

(2009) Richard S. Hotchkiss et al.   NEW ENGLAND JOURNAL OF MEDICINE

Botanical characteristics, pharmacological effects and medicinal components of KoreanPanax ginsengC A Meyer

(2008) Kwang-tae CHOI   ACTA PHARMACOLOGICA SINICA

Nuclear Factor E2-Related Factor 2-Dependent Myocardiac Cytoprotection Against Oxidative and Electrophilic Stress

(2008) Hong Zhu et al.   Cardiovascular Toxicology

Shared Principles in NF-κB Signaling

(2008) Matthew S. Hayden et al.   CELL

Targeting p38-MAPK in the ischaemic heart: kill or cure?

(2008) R BASSI et al.   CURRENT OPINION IN PHARMACOLOGY

Phosphatase-mediated crosstalk between MAPK signaling pathways in the regulation of cell survival

(2007) Melissa R. Junttila et al.   FASEB JOURNAL