Aesculin suppresses the NLRP3 inflammasome-mediated pyroptosis via the Akt/GSK3β/NF-κB pathway to mitigate myocardial ischemia/reperfusion injury

Formononetin ameliorates myocardial ischemia/reperfusion injury in rats by suppressing the ROS-TXNIP-NLRP3 pathway

(2020) Dan-Shu Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inflammasome‐associated cell death: Pyroptosis, apoptosis, and physiological implications

(2020) Kohsuke Tsuchiya   MICROBIOLOGY AND IMMUNOLOGY

Scutellarin protects against myocardial ischemia-reperfusion injury by suppressing NLRP3 inflammasome activation

(2020) Li-jiao Xu et al.   PHYTOMEDICINE

Periostin aggravates NLRP3 inflammasome-mediated pyroptosis in myocardial ischemia-reperfusion injury

(2020) Lei Yao et al.   MOLECULAR AND CELLULAR PROBES

Esculin reduces P2X7 and reverses mitochondrial dysfunction in the renal cortex of diabetic rats

(2020) R.S. Serralha et al.   LIFE SCIENCES

Multitarget Strategies to Reduce Myocardial Ischemia/Reperfusion Injury

(2019) Sean M. Davidson et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Coumarins ameliorate diabetogenic action of dexamethasone via Akt activation and AMPK signaling in skeletal muscle

(2019) Zejun Mo et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Aesculin protects against DSS-Induced colitis though activating PPARγ and inhibiting NF-кB pathway

(2019) Xinlei Tian et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Emerging insights into molecular mechanisms underlying pyroptosis and functions of inflammasomes in diseases

(2019) Fangfang Lu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Hype or hope: Vagus nerve stimulation against acute myocardial ischemia-reperfusion injury

(2019) Mingxian Chen et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Pyroptosis and its relationship to atherosclerosis

(2018) Yuan-Jun Xu et al.   CLINICA CHIMICA ACTA

Inflammasome, pyroptosis, and cytokines in myocardial ischemia-reperfusion injury

(2018) Stefano Toldo et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Antithrombotic potential of esculin 7, 3′, 4′, 5′, 6′-O-pentasulfate (EPS) for its role in thrombus reduction using rat thrombosis model

(2018) Irshad Ahmad et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Esculin prevents Lipopolysaccharide/D-Galactosamine-induced acute liver injury in mice

(2018) Aiyun Liu et al.   MICROBIAL PATHOGENESIS

The mechanisms of NLRP3 inflammasome/pyroptosis activation and their role in Parkinson's disease

(2018) Shuo Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Gastroprotective effect of esculin on ethanol-induced gastric lesion in mice

(2017) Weifeng Li et al.   FUNDAMENTAL & CLINICAL PHARMACOLOGY

Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases

(2017) Si Ming Man et al.   IMMUNOLOGICAL REVIEWS

Simultaneous determination of anemoside B4, phellodendrine, berberine, palmatine, obakunone, esculin, esculetin in rat plasma by UPLC–ESI–MS/MS and its application to a comparative pharmacokinetic study in normal and ulcerative colitis rats

(2017) Lianrong Yang et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Ischemia/Reperfusion Injury following Acute Myocardial Infarction: A Critical Issue for Clinicians and Forensic Pathologists

(2017) Margherita Neri et al.   MEDIATORS OF INFLAMMATION

NLRP3 Inflammasome Activation-Mediated Pyroptosis Aggravates Myocardial Ischemia/Reperfusion Injury in Diabetic Rats

(2017) Zhen Qiu et al.   Oxidative Medicine and Cellular Longevity

Cardiovascular Diseases and Risk‐Factor Burden in Urban and Rural Communities in High‐, Middle‐, and Low‐Income Regions of China: A Large Community‐Based Epidemiological Study

(2017) Ruohua Yan et al.   Journal of the American Heart Association

Pretreatment with low-dose gadolinium chloride attenuates myocardial ischemia/reperfusion injury in rats

(2016) Min Chen et al.   ACTA PHARMACOLOGICA SINICA

Ginkgolide K protects the heart against endoplasmic reticulum stress injury by activating the inositol-requiring enzyme 1α/X box-binding protein-1 pathway

(2016) Shoubao Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Esculin attenuates endotoxin shock induced by lipopolysaccharide in mouse and NO production in vitro through inhibition of NF-κB activation

(2016) Weifeng Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Esculin improves dyslipidemia, inflammation and renal damage in streptozotocin-induced diabetic rats

(2015) Yue-Hua Wang et al.   BMC Complementary and Alternative Medicine

Esculin Inhibits the Inflammation of LPS-Induced Acute Lung Injury in Mice Via Regulation of TLR/NF-κB Pathways

(2015) Zhang Tianzhu et al.   INFLAMMATION

Esculin exhibited anti-inflammatory activities in vivo and regulated TNF-α and IL-6 production in LPS-stimulated mouse peritoneal macrophages in vitro through MAPK pathway

(2015) Xiaofeng Niu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Esculin and its oligomer fractions inhibit adhesion and migration of U87 glioblastoma cells and in vitro angiogenesis

(2015) Imen Mokdad-Bzeouich et al.   TUMOR BIOLOGY

Protective Effect of Esculin on Streptozotocin-Induced Diabetic Renal Damage in Mice

(2014) Ki Sung Kang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Increasing Glutamate Promotes Ischemia-Reperfusion-Induced Ventricular Arrhythmias in Rats in vivo

(2014) Xianlin Sun et al.   PHARMACOLOGY

Targeted Deletion of the Extracellular Signal-Regulated Protein Kinase 5 Attenuates Hypertrophic Response and Promotes Pressure Overload–Induced Apoptosis in the Heart

(2010) Tomomi E. Kimura et al.   CIRCULATION RESEARCH

Egr-1, the Potential Target of Calcium Channel Blockers in Cardioprotection with Ischemia/Reperfusion Injury in Rats

(2009) Zhanqin Huang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY