Gaussian curvature dilutes the nuclear lamina, favoring nuclear rupture, especially at high strain rate

The LINC complex transmits integrin-dependent tension to the nuclear lamina and represses epidermal differentiation

(2021) Emma Carley et al.   eLife

Scaling concepts in ‘omics: Nuclear lamin-B scales with tumor growth and often predicts poor prognosis, unlike fibrosis

(2021) Manasvita Vashisth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nonlinear mechanics of lamin filaments and the meshwork topology build an emergent nuclear lamina

(2020) K. Tanuj Sapra et al.   Nature Communications

Mechanosensing by the Lamina Protects against Nuclear Rupture, DNA Damage, and Cell-Cycle Arrest

(2019) Sangkyun Cho et al.   DEVELOPMENTAL CELL

Scaling laws indicate distinct nucleation mechanisms of holes in the nuclear lamina

(2019) Dan Deviri et al.   Nature Physics

Rescue of DNA damage after constricted migration reveals a mechano-regulated threshold for cell cycle

(2019) Yuntao Xia et al.   JOURNAL OF CELL BIOLOGY

Chromatin histone modifications and rigidity affect nuclear morphology independent of lamins

(2018) Andrew D. Stephens et al.   MOLECULAR BIOLOGY OF THE CELL

Constricted migration increases DNA damage and independently represses cell cycle

(2018) Charlotte R. Pfeifer et al.   MOLECULAR BIOLOGY OF THE CELL

Progerin phosphorylation in interphase is lower and less mechanosensitive than lamin-A,C in iPS-derived mesenchymal stem cells

(2018) Sangkyun Cho et al.   Nucleus

Progerin phosphorylation in interphase is lower and less mechanosensitive than lamin-A,C in iPS-derived mesenchymal stem cells

(2018) Sangkyun Cho et al.   Nucleus

Nuclear rupture at sites of high curvature compromises retention of DNA repair factors

(2018) Yuntao Xia et al.   JOURNAL OF CELL BIOLOGY

Local, transient tensile stress on the nuclear membrane causes membrane rupture

(2018) Qiao Zhang et al.   MOLECULAR BIOLOGY OF THE CELL

Piezo’s membrane footprint and its contribution to mechanosensitivity

(2018) Christoph A Haselwandter et al.   eLife

The molecular architecture of lamins in somatic cells

(2017) Yagmur Turgay et al.   NATURE

Mitotic progression following DNA damage enables pattern recognition within micronuclei

(2017) Shane M. Harding et al.   NATURE

Nuclear constriction segregates mobile nuclear proteins away from chromatin

(2016) Jerome Irianto et al.   MOLECULAR BIOLOGY OF THE CELL

ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death

(2016) M. Raab et al.   SCIENCE

Nuclear envelope rupture and repair during cancer cell migration

(2016) C. M. Denais et al.   SCIENCE

Chromothripsis and Kataegis Induced by Telomere Crisis

(2015) John Maciejowski et al.   CELL

Differential basal-to-apical accessibility of lamin A/C epitopes in the nuclear lamina regulated by changes in cytoskeletal tension

(2015) Teemu O. Ihalainen et al.   NATURE MATERIALS

Nuclear lamin stiffness is a barrier to 3D migration, but softness can limit survival

(2014) Takamasa Harada et al.   JOURNAL OF CELL BIOLOGY

Catastrophic Nuclear Envelope Collapse in Cancer Cell Micronuclei

(2013) Emily M. Hatch et al.   CELL

Partners and post-translational modifications of nuclear lamins

(2013) Dan N. Simon et al.   CHROMOSOMA

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

(2013) J. Swift et al.   SCIENCE

A simple method for deriving functional MSCs and applied for osteogenesis in 3D scaffolds

(2013) Lijin Zou et al.   Scientific Reports

Soft substrates normalize nuclear morphology and prevent nuclear rupture in fibroblasts from a laminopathy patient with compound heterozygous LMNA mutations

(2013) Chiara Tamiello et al.   Nucleus

APLF promotes the assembly and activity of non-homologous end joining protein complexes

(2012) Gabrielle J Grundy et al.   EMBO JOURNAL

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Transient nuclear envelope rupturing during interphase in human cancer cells

(2012) Jesse D. Vargas et al.   Nucleus

The role of nuclear lamin B1 in cell proliferation and senescence

(2011) T. Shimi et al.   GENES & DEVELOPMENT

Repetitive disruptions of the nuclear envelope invoke temporary loss of cellular compartmentalization in laminopathies

(2011) Winnok H. De Vos et al.   HUMAN MOLECULAR GENETICS

Modeling cellular processes in 3D

(2011) Alex Mogilner et al.   TRENDS IN CELL BIOLOGY

Piezo1 and Piezo2 Are Essential Components of Distinct Mechanically Activated Cation Channels

(2010) B. Coste et al.   SCIENCE

Role of cortical tension in bleb growth

(2009) J.-Y. Tinevez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA