Progerin phosphorylation in interphase is lower and less mechanosensitive than lamin-A,C in iPS-derived mesenchymal stem cells

Mechanosensing by the nucleus: From pathways to scaling relationships

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Lamins in the nuclear interior − life outside the lamina

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Progerin-Induced Replication Stress Facilitates Premature Senescence in Hutchinson-Gilford Progeria Syndrome

(2017) Keith Wheaton et al.   MOLECULAR AND CELLULAR BIOLOGY

Cross-linked matrix rigidity and soluble retinoids synergize in nuclear lamina regulation of stem cell differentiation

(2017) Irena L. Ivanovska et al.   MOLECULAR BIOLOGY OF THE CELL

The molecular architecture of lamins in somatic cells

(2017) Yagmur Turgay et al.   NATURE

Permanent farnesylation of lamin A mutants linked to progeria impairs its phosphorylation at serine 22 during interphase

(2016) Olga Moiseeva et al.   Aging-US

A-type Lamins Form Distinct Filamentous Networks with Differential Nuclear Pore Complex Associations

(2016) Wei Xie et al.   CURRENT BIOLOGY

Molecular insights into the premature aging disease progeria

(2016) Sandra Vidak et al.   HISTOCHEMISTRY AND CELL BIOLOGY

MicroRNA-21 preserves the fibrotic mechanical memory of mesenchymal stem cells

(2016) Chen Xi Li et al.   NATURE MATERIALS

A High Throughput Phenotypic Screening reveals compounds that counteract premature osteogenic differentiation of HGPS iPS-derived mesenchymal stem cells

(2016) Alessandra Lo Cicero et al.   Scientific Reports

Lamins: Nuclear Intermediate Filament Proteins with Fundamental Functions in Nuclear Mechanics and Genome Regulation

(2015) Yosef Gruenbaum et al.   Annual Review of Biochemistry

AKT1-mediated Lamin A/C degradation is required for nuclear degradation and normal epidermal terminal differentiation

(2015) A S Naeem et al.   CELL DEATH AND DIFFERENTIATION

Perivascular Gli1+ Progenitors Are Key Contributors to Injury-Induced Organ Fibrosis

(2015) Rafael Kramann et al.   Cell Stem Cell

Proliferation of progeria cells is enhanced by lamina-associated polypeptide 2α (LAP2α) through expression of extracellular matrix proteins

(2015) Sandra Vidak et al.   GENES & DEVELOPMENT

Structural organization of nuclear lamins A, C, B1, and B2 revealed by superresolution microscopy

(2015) Takeshi Shimi et al.   MOLECULAR BIOLOGY OF THE CELL

Autophagy mediates degradation of nuclear lamina

(2015) Zhixun Dou et al.   NATURE

Fractal heterogeneity in minimal matrix models of scars modulates stiff-niche stem-cell responses via nuclear exit of a mechanorepressor

(2015) P. C. Dave P. Dingal et al.   NATURE MATERIALS

Nuclear stiffening and chromatin softening with progerin expression leads to an attenuated nuclear response to force

(2015) Elizabeth A. Booth et al.   Soft Matter

All-trans retinoic acid and rapamycin normalize Hutchinson Gilford progeria fibroblast phenotype

(2015) Camilla Pellegrini et al.   Oncotarget

Phosphorylation of lamins determine their structural properties and signaling functions

(2015) Elin Torvaldson et al.   Nucleus

Phosphorylation of lamins determine their structural properties and signaling functions

(2015) Elin Torvaldson et al.   Nucleus

Systems Mechanobiology: Tension-Inhibited Protein Turnover Is Sufficient to Physically Control Gene Circuits

(2014) P.C. Dave P. Dingal et al.   BIOPHYSICAL JOURNAL

Matrix Elasticity Regulates Lamin-A,C Phosphorylation and Turnover with Feedback to Actomyosin

(2014) Amnon Buxboim et al.   CURRENT BIOLOGY

Nuclear lamin stiffness is a barrier to 3D migration, but softness can limit survival

(2014) Takamasa Harada et al.   JOURNAL OF CELL BIOLOGY

Interphase phosphorylation of lamin A

(2014) V. Kochin et al.   JOURNAL OF CELL SCIENCE

Assessing Kinetics from Fixed Cells Reveals Activation of the Mitotic Entry Network at the S/G2 Transition

(2014) Karen Akopyan et al.   MOLECULAR CELL

Identification of differential protein interactors of lamin A and progerin

(2014) Nard Kubben et al.   Nucleus

The protein kinase Akt/PKB regulates both prelamin A degradation and Lmna gene expression

(2013) Jessika Bertacchini et al.   FASEB JOURNAL

Hutchinson–Gilford progeria syndrome alters nuclear shape and reduces cell motility in three dimensional model substrates

(2013) Elizabeth A. Booth-Gauthier et al.   Integrative Biology

Nuclear Lamin-A Scales with Tissue Stiffness and Enhances Matrix-Directed Differentiation

(2013) J. Swift et al.   SCIENCE

Prelamin A causes progeria through cell-extrinsic mechanisms and prevents cancer invasion

(2013) Jorge de la Rosa et al.   Nature Communications

A simple method for deriving functional MSCs and applied for osteogenesis in 3D scaffolds

(2013) Lijin Zou et al.   Scientific Reports

Clinical trial of a farnesyltransferase inhibitor in children with Hutchinson-Gilford progeria syndrome

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A proteomic study of Hutchinson–Gilford progeria syndrome: Application of 2D-chromotography in a premature aging disease

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Autophagic degradation of farnesylated prelamin A as a therapeutic approach to lamin-linked progeria

(2011) V. Cenni et al.   EUROPEAN JOURNAL OF HISTOCHEMISTRY

Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts

(2011) Kan Cao et al.   JOURNAL OF CLINICAL INVESTIGATION

Nuclear lamins and laminopathies

(2011) Howard J. Worman   JOURNAL OF PATHOLOGY

Recapitulation of premature ageing with iPSCs from Hutchinson–Gilford progeria syndrome

(2011) Guang-Hui Liu et al.   NATURE

A Human iPSC Model of Hutchinson Gilford Progeria Reveals Vascular Smooth Muscle and Mesenchymal Stem Cell Defects

(2010) Jinqiu Zhang et al.   Cell Stem Cell

Functional Coupling between the Extracellular Matrix and Nuclear Lamina by Wnt Signaling in Progeria

(2010) Lidia Hernandez et al.   DEVELOPMENTAL CELL

Role of progerin-induced telomere dysfunction in HGPS premature cellular senescence

(2010) E. K. Benson et al.   JOURNAL OF CELL SCIENCE

Progeria syndromes and ageing: what is the connection?

(2010) Christopher R. Burtner et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Lamin-binding Proteins

(2010) K. L. Wilson et al.   Cold Spring Harbor Perspectives in Biology

The Posttranslational Processing of Prelamin A and Disease

(2009) Brandon S.J. Davies et al.   Annual Review of Genomics and Human Genetics

Cell–Matrix De-Adhesion Dynamics Reflect Contractile Mechanics

(2009) Shamik Sen et al.   Cellular and Molecular Bioengineering

Increased expression of the Hutchinson–Gilford progeria syndrome truncated lamin A transcript during cell aging

(2009) Sofia Rodriguez et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Mammalian SUN Protein Interaction Networks at the Inner Nuclear Membrane and Their Role in Laminopathy Disease Processes

(2009) Farhana Haque et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A progeria mutation reveals functions for lamin A in nuclear assembly, architecture, and chromosome organization

(2009) P. Taimen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nuclear Shape, Mechanics, and Mechanotransduction

(2008) Kris Noel Dahl et al.   CIRCULATION RESEARCH

Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing

(2008) Paola Scaffidi et al.   NATURE CELL BIOLOGY