DNA and Protein Requirements for Substrate Conformational Changes Necessary for Human Flap Endonuclease-1-catalyzed Reaction

Flap Endonuclease 1

(2013) Lata Balakrishnan et al.   Annual Review of Biochemistry

Proline Scanning Mutagenesis Reveals a Role for the Flap Endonuclease-1 Helical Cap in Substrate Unpairing

(2013) Nikesh Patel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Single-molecule characterization of Fen1 and Fen1/PCNA complexes acting on flap substrates

(2013) Timothy D. Craggs et al.   NUCLEIC ACIDS RESEARCH

Observation of unpaired substrate DNA in the flap endonuclease-1 active site

(2013) L. David Finger et al.   NUCLEIC ACIDS RESEARCH

Sequential and Multistep Substrate Interrogation Provides the Scaffold for Specificity in Human Flap Endonuclease 1

(2013) Mohamed A. Sobhy et al.   Cell Reports

Interstrand disulfide crosslinking of DNA bases supports a double nucleotide unpairing mechanism for flap endonucleases

(2012) Amanda Beddows et al.   CHEMICAL COMMUNICATIONS

A toolkit and benchmark study for FRET-restrained high-precision structural modeling

(2012) Stanislav Kalinin et al.   NATURE METHODS

Flap endonucleases pass 5′-flaps through a flexible arch using a disorder-thread-order mechanism to confer specificity for free 5′-ends

(2012) Nikesh Patel et al.   NUCLEIC ACIDS RESEARCH

Human Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 Superfamily

(2011) Susan E. Tsutakawa et al.   CELL

Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease Family

(2011) Jillian Orans et al.   CELL

Neutralizing Mutations of Carboxylates That Bind Metal 2 in T5 Flap Endonuclease Result in an Enzyme That Still Requires Two Metal Ions

(2011) Christopher G. Tomlinson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unpairing and gating: sequence-independent substrate recognition by FEN superfamily nucleases

(2011) Jane A. Grasby et al.   TRENDS IN BIOCHEMICAL SCIENCES

Substrate recognition and catalysis by flap endonucleases and related enzymes

(2010) Christopher G. Tomlinson et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Brønsted Analysis and Rate-Limiting Steps for the T5 Flap Endonuclease Catalyzed Hydrolysis of Exonucleolytic Substrates

(2010) Blanka Sengerová et al.   BIOCHEMISTRY

Flap Endonuclease 1 Mechanism Analysis Indicates Flap Base Binding Prior to Threading

(2010) Jason W. Gloor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional regulation of FEN1 nuclease and its link to cancer

(2010) L. Zheng et al.   NUCLEIC ACIDS RESEARCH

The 3′-Flap Pocket of Human Flap Endonuclease 1 Is Critical for Substrate Binding and Catalysis

(2009) L. David Finger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Spectroscopic studies of position-specific DNA "breathing" fluctuations at replication forks and primer-template junctions

(2009) D. Jose et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Three Metal Ions Participate in the Reaction Catalyzed by T5 Flap Endonuclease

(2008) Karl Syson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY