Single-molecule characterization of Fen1 and Fen1/PCNA complexes acting on flap substrates

Flap Endonuclease 1

(2013) Lata Balakrishnan et al.   Annual Review of Biochemistry

Observation of unpaired substrate DNA in the flap endonuclease-1 active site

(2013) L. David Finger et al.   NUCLEIC ACIDS RESEARCH

Sequential and Multistep Substrate Interrogation Provides the Scaffold for Specificity in Human Flap Endonuclease 1

(2013) Mohamed A. Sobhy et al.   Cell Reports

Single-Molecule Observation of the Induction of k-Turn RNA Structure on Binding L7Ae Protein

(2012) Jia Wang et al.   BIOPHYSICAL JOURNAL

Interstrand disulfide crosslinking of DNA bases supports a double nucleotide unpairing mechanism for flap endonucleases

(2012) Amanda Beddows et al.   CHEMICAL COMMUNICATIONS

Coordination of multiple enzyme activities by a single PCNA in archaeal Okazaki fragment maturation

(2012) Thomas R Beattie et al.   EMBO JOURNAL

A toolkit and benchmark study for FRET-restrained high-precision structural modeling

(2012) Stanislav Kalinin et al.   NATURE METHODS

Flap endonucleases pass 5′-flaps through a flexible arch using a disorder-thread-order mechanism to confer specificity for free 5′-ends

(2012) Nikesh Patel et al.   NUCLEIC ACIDS RESEARCH

Repair complexes of FEN1 endonuclease, DNA, and Rad9-Hus1-Rad1 are distinguished from their PCNA counterparts by functionally important stability

(2012) J. Querol-Audi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rings in the Extreme: PCNA Interactions and Adaptations in the Archaea

(2012) Jody A. Winter et al.   ARCHAEA-AN INTERNATIONAL MICROBIOLOGICAL JOURNAL

The role of the DNA sliding clamp in Okazaki fragment maturation in archaea and eukaryotes

(2011) Thomas R. Beattie et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Human Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 Superfamily

(2011) Susan E. Tsutakawa et al.   CELL

Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease Family

(2011) Jillian Orans et al.   CELL

Fen1 mutations that specifically disrupt its interaction with PCNA cause aneuploidy-associated cancer

(2011) Li Zheng et al.   CELL RESEARCH

Accurate Distance Determination of Nucleic Acids via Förster Resonance Energy Transfer: Implications of Dye Linker Length and Rigidity

(2011) Simon Sindbert et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Protein induced fluorescence enhancement as a single molecule assay with short distance sensitivity

(2011) H. Hwang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Unpairing and gating: sequence-independent substrate recognition by FEN superfamily nucleases

(2011) Jane A. Grasby et al.   TRENDS IN BIOCHEMICAL SCIENCES

Proliferating cell nuclear antigen (PCNA): a key factor in DNA replication and cell cycle regulation

(2010) Wojciech Strzalka et al.   ANNALS OF BOTANY

Substrate recognition and catalysis by flap endonucleases and related enzymes

(2010) Christopher G. Tomlinson et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Flap Endonuclease 1 Mechanism Analysis Indicates Flap Base Binding Prior to Threading

(2010) Jason W. Gloor et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Global Structure of Forked DNA in Solution Revealed by High-Resolution Single-Molecule FRET

(2010) Tara Sabir et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Functional regulation of FEN1 nuclease and its link to cancer

(2010) L. Zheng et al.   NUCLEIC ACIDS RESEARCH

The 3′-Flap Pocket of Human Flap Endonuclease 1 Is Critical for Substrate Binding and Catalysis

(2009) L. David Finger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conformational Analysis of DNA Repair Intermediates by Time-Resolved Fluorescence Spectroscopy

(2009) Su Lin et al.   JOURNAL OF PHYSICAL CHEMISTRY A

The role of dynamic conformational ensembles in biomolecular recognition

(2009) David D Boehr et al.   Nature Chemical Biology

PCNA and XPF cooperate to distort DNA substrates

(2009) Richard D. Hutton et al.   NUCLEIC ACIDS RESEARCH

3D-DART: a DNA structure modelling server

(2009) M. van Dijk et al.   NUCLEIC ACIDS RESEARCH

A nano-positioning system for macromolecular structural analysis

(2008) Adam Muschielok et al.   NATURE METHODS

A practical guide to single-molecule FRET

(2008) Rahul Roy et al.   NATURE METHODS

PCNA stimulates catalysis by structure-specific nucleases using two distinct mechanisms: substrate targeting and catalytic step

(2008) R. D. Hutton et al.   NUCLEIC ACIDS RESEARCH

Orientation dependence in fluorescent energy transfer between Cy3 and Cy5 terminally attached to double-stranded nucleic acids

(2008) A. Iqbal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA