Neutralizing Mutations of Carboxylates That Bind Metal 2 in T5 Flap Endonuclease Result in an Enzyme That Still Requires Two Metal Ions

Human Flap Endonuclease Structures, DNA Double-Base Flipping, and a Unified Understanding of the FEN1 Superfamily

(2011) Susan E. Tsutakawa et al.   CELL

Structures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease Family

(2011) Jillian Orans et al.   CELL

Coupled 5′ Nucleotide Recognition and Processivity in Xrn1-Mediated mRNA Decay

(2011) Martin Jinek et al.   MOLECULAR CELL

Structural and biochemical studies of the 5′→3′ exoribonuclease Xrn1

(2011) Jeong Ho Chang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Substrate recognition and catalysis by flap endonucleases and related enzymes

(2010) Christopher G. Tomlinson et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Brønsted Analysis and Rate-Limiting Steps for the T5 Flap Endonuclease Catalyzed Hydrolysis of Exonucleolytic Substrates

(2010) Blanka Sengerová et al.   BIOCHEMISTRY

Mechanism of Holliday junction resolution by the human GEN1 protein

(2010) U. Rass et al.   GENES & DEVELOPMENT

One is enough: insights into the two-metal ion nuclease mechanism from global analysis and computational studies

(2010) Cynthia M. Dupureur   Metallomics

Nucleases: diversity of structure, function and mechanism

(2010) Wei Yang   QUARTERLY REVIEWS OF BIOPHYSICS

The 3′-Flap Pocket of Human Flap Endonuclease 1 Is Critical for Substrate Binding and Catalysis

(2009) L. David Finger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure and function of the 5′→3′ exoribonuclease Rat1 and its activating partner Rai1

(2009) Song Xiang et al.   NATURE

Active site substitutions delineate distinct classes of eubacterial flap endonuclease

(2008) Lee M. Allen et al.   BIOCHEMICAL JOURNAL

Three Metal Ions Participate in the Reaction Catalyzed by T5 Flap Endonuclease

(2008) Karl Syson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY