Transient Receptor Potential Vanilloid 4 Ion Channel Functions as a Pruriceptor in Epidermal Keratinocytes to Evoke Histaminergic Itch

Involvement of TRPV4 in Serotonin-Evoked Scratching

(2016) Tasuku Akiyama et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Plasma endothelin-1 levels during exacerbation of atopic dermatitis

(2015) Namjil N. Tsybikov et al.   ALLERGY AND ASTHMA PROCEEDINGS

Salvinorin A analogues PR-37 and PR-38 attenuate compound 48/80-induced itch responses in mice

(2015) M Salaga et al.   BRITISH JOURNAL OF PHARMACOLOGY

Neutrophil Elastase Activates Protease-activated Receptor-2 (PAR2) and Transient Receptor Potential Vanilloid 4 (TRPV4) to Cause Inflammation and Pain

(2015) Peishen Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RNA-Seq and ChIP-Seq Reveal SQSTM1/p62 as a Key Mediator of JunB Suppression of NF-κB-Dependent Inflammation

(2015) Xiaoling Zhang et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Intradermal endothelin-1 excites bombesin-responsive superficial dorsal horn neurons in the mouse

(2015) T. Akiyama et al.   JOURNAL OF NEUROPHYSIOLOGY

Cutaneous adverse effects of targeted therapies

(2015) James B. Macdonald et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Trp channels and itch

(2015) Shuohao Sun et al.   Seminars in Immunopathology

Keratinocytes can modulate and directly initiate nociceptive responses

(2015) Kyle M Baumbauer et al.   eLife

Itch in Ethnic Populations

(2014) H Tey et al.   ACTA DERMATO-VENEREOLOGICA

A Monoclonal Antibody that Targets a NaV1.7 Channel Voltage Sensor for Pain and Itch Relief

(2014) Jun-Ho Lee et al.   CELL

Activation of TLR-4 to produce tumour necrosis factor-α in neuropathic pain caused by paclitaxel

(2014) Z. Wu et al.   EUROPEAN JOURNAL OF PAIN

Cathepsin S Causes Inflammatory PainviaBiased Agonism of PAR2and TRPV4

(2014) Peishen Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transient Receptor Potential Vanilloid 4 (TRPV4) Is Downregulated in Keratinocytes in Human Non-Melanoma Skin Cancer

(2014) Camilla Fusi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions

(2014) Benjamin D. McNeil et al.   NATURE

Why we scratch an itch: the molecules, cells and circuits of itch

(2014) Diana M Bautista et al.   NATURE NEUROSCIENCE

Targeting TRP ion channels for itch relief

(2014) Xuming Zhang   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

TRPV4 as a therapeutic target for joint diseases

(2014) Amy L. McNulty et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

TRPV4 is necessary for trigeminal irritant pain and functions as a cellular formalin receptor

(2014) Yong Chen et al.   PAIN

A new itch to scratch for TSLP

(2014) Matthew J. Turner et al.   TRENDS IN IMMUNOLOGY

The neurology of itch

(2013) Amar Dhand et al.   BRAIN

The Epithelial Cell-Derived Atopic Dermatitis Cytokine TSLP Activates Neurons to Induce Itch

(2013) Sarah R. Wilson et al.   CELL

The Missing Link between Itch and Inflammation in Atopic Dermatitis

(2013) Sarina B. Elmariah et al.   CELL

TRPV3: a ‘more than skinny’ channel

(2013) Bernd Nilius et al.   EXPERIMENTAL DERMATOLOGY

TRPA1 controls inflammation and pruritogen responses in allergic contact dermatitis

(2013) Boyi Liu et al.   FASEB JOURNAL

Temporomandibular joint pain: A critical role for Trpv4 in the trigeminal ganglion

(2013) Yong Chen et al.   PAIN

UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling

(2013) Carlene Moore et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Cells and Circuitry for Itch Responses in Mice

(2013) S. K. Mishra et al.   SCIENCE

Exome Sequencing Reveals Mutations in TRPV3 as a Cause of Olmsted Syndrome

(2012) Zhimiao Lin et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Increased susceptibility ofTrpv4-deficient mice to obesity and obesity-induced osteoarthritis with very high-fat diet

(2012) Christopher J O'Conor et al.   ANNALS OF THE RHEUMATIC DISEASES

Functional Protein Pathway Activation Mapping of the Progression of Normal Skin to Squamous Cell Carcinoma

(2012) J. G. Einspahr et al.   Cancer Prevention Research

TRPV4 Is a Regulator of Adipose Oxidative Metabolism, Inflammation, and Energy Homeostasis

(2012) Li Ye et al.   CELL

Cathepsin E induces itch-related response through the production of endothelin-1 in mice

(2012) Tsugunobu Andoh et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Neuronal IL-17 receptor upregulates TRPV4 but not TRPV1 receptors in DRG neurons and mediates mechanical but not thermal hyperalgesia

(2012) Gisela Segond von Banchet et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

TRPV4-Mediated Calcium Influx into Human Bronchial Epithelia upon Exposure to Diesel Exhaust Particles

(2011) Jinju Li et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

G protein coupled receptor specificity for C3a and compound 48/80-induced degranulation in human mast cells: Roles of Mas-related genes MrgX1 and MrgX2

(2011) Sakeen W. Kashem et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Molecular signaling of pruritus induced by endothelin-1 in mice

(2011) Jiexian Liang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

The role of TRPV1 channel in aged human skin

(2011) Young Mee Lee et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Role of transient receptor potential ankyrin subfamily member 1 in pruritus induced by endothelin-1

(2011) Jiexian Liang et al.   NEUROSCIENCE LETTERS

The Role of the Histamine H4 Receptor in Atopic Dermatitis

(2010) Susanne Mommert et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Molecular Mechanisms of TRPV4-Mediated Neural Signaling

(2009) Wolfgang Liedtke   Annals of the New York Academy of Sciences

Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes

(2009) Mimi N. Phan et al.   ARTHRITIS AND RHEUMATISM

Sensory Neuron-Specific GPCR Mrgprs Are Itch Receptors Mediating Chloroquine-Induced Pruritus

(2009) Qin Liu et al.   CELL

Expression of histamine H4 receptor in human epidermal tissues and attenuation of experimental pruritus using H4 receptor antagonist

(2009) Katsunori Yamaura et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Diesel Exhaust Particles Activate the Matrix-Metalloproteinase-1 Gene in Human Bronchial Epithelia in a β-Arrestin–Dependent Manner via Activation of RAS

(2008) Jinju Li et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Selective Role for TRPV4 Ion Channels in Visceral Sensory Pathways

(2008) Stuart M. Brierley et al.   GASTROENTEROLOGY

Histamine Upregulates Keratinocyte MMP-9 Production via the Histamine H1 Receptor

(2008) Maria Gschwandtner et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Impact of the Gly573Ser Substitution in TRPV3 on the Development of Allergic and Pruritic Dermatitis in Mice

(2008) Takeshi Yoshioka et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY