Why we scratch an itch: the molecules, cells and circuits of itch

The Epithelial Cell-Derived Atopic Dermatitis Cytokine TSLP Activates Neurons to Induce Itch

(2013) Sarah R. Wilson et al.   CELL

Understanding the pathophysiology of itch

(2013) Lilit Garibyan et al.   Dermatologic Therapy

TRPA1 controls inflammation and pruritogen responses in allergic contact dermatitis

(2013) Boyi Liu et al.   FASEB JOURNAL

Potentiation of the Transient Receptor Potential Vanilloid 1 Channel Contributes to Pruritogenesis in a Rat Model of Liver Disease

(2013) Majedeline Belghiti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chronic itch development in sensory neurons requires BRAF signaling pathways

(2013) Zhong-Qiu Zhao et al.   JOURNAL OF CLINICAL INVESTIGATION

TRPA1-Dependent Pruritus in IL-13-Induced Chronic Atopic Dermatitis

(2013) M.-H. Oh et al.   JOURNAL OF IMMUNOLOGY

Exacerbation of Allergen-Induced Eczema in TLR4- and TRIF-Deficient Mice

(2013) E. B. Brandt et al.   JOURNAL OF IMMUNOLOGY

Barrier Abnormality Due to Ceramide Deficiency Leads to Psoriasiform Inflammation in a Mouse Model

(2013) Kimiko Nakajima et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The Absence of a Microbiota Enhances TSLP Expression in Mice with Defective Skin Barrier but Does Not Affect the Severity of their Allergic Inflammation

(2013) Laura J. Yockey et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The Ion Channel TRPA1 Is Required for Chronic Itch

(2013) S. R. Wilson et al.   JOURNAL OF NEUROSCIENCE

Ontogeny of Excitatory Spinal Neurons Processing Distinct Somatic Sensory Modalities

(2013) Y. Xu et al.   JOURNAL OF NEUROSCIENCE

Itch and Analgesia Resulting from Intrathecal Application of Morphine: Contrasting Effects on Different Populations of Trigeminothalamic Tract Neurons

(2013) H. R. Moser et al.   JOURNAL OF NEUROSCIENCE

Bacteria activate sensory neurons that modulate pain and inflammation

(2013) Isaac M. Chiu et al.   NATURE

Activity-dependent silencing reveals functionally distinct itch-generating sensory neurons

(2013) David P Roberson et al.   NATURE NEUROSCIENCE

Excitatory Superficial Dorsal Horn Interneurons Are Functionally Heterogeneous and Required for the Full Behavioral Expression of Pain and Itch

(2013) Xidao Wang et al.   NEURON

Peptidergic CGRPα Primary Sensory Neurons Encode Heat and Itch and Tonically Suppress Sensitivity to Cold

(2013) Eric S. McCoy et al.   NEURON

Neural processing of itch

(2013) Tasuku Akiyama et al.   NEUROSCIENCE

Omalizumab for the Treatment of Chronic Idiopathic or Spontaneous Urticaria

(2013) Marcus Maurer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Topical Application of a Vitamin D Analogue Exacerbates Atopic Dermatitis and Induces the Atopic Dermatitis-like Phenotype in Stat6VT Mice

(2013) Matthew J. Turner et al.   PEDIATRIC DERMATOLOGY

Physiological Function of Gastrin-Releasing Peptide and Neuromedin B Receptors in Regulating Itch Scratching Behavior in the Spinal Cord of Mice

(2013) Devki D. Sukhtankar et al.   PLoS One

The Cells and Circuitry for Itch Responses in Mice

(2013) S. K. Mishra et al.   SCIENCE

TRPA1: A Gatekeeper for Inflammation

(2012) Diana M. Bautista et al.   Annual Review of Physiology

TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice

(2012) Tong Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

Pruriceptive spinothalamic tract neurons: physiological properties and projection targets in the primate

(2012) Steve Davidson et al.   JOURNAL OF NEUROPHYSIOLOGY

A Nociceptive Signaling Role for Neuromedin B

(2012) S. K. Mishra et al.   JOURNAL OF NEUROSCIENCE

Mechanisms of Itch Evoked by  -Alanine

(2012) Q. Liu et al.   JOURNAL OF NEUROSCIENCE

Endothelin-1 induces itch and pain in the mouse cheek model

(2012) Lenyta Oliveira Gomes et al.   LIFE SCIENCES

The Majority of Dorsal Spinal Cord Gastrin Releasing Peptide is Synthesized Locally Whereas Neuromedin B is Highly Expressed in Pain- and Itch-Sensing Somatosensory Neurons

(2012) Michael S Fleming et al.   Molecular Pain

A subpopulation of nociceptors specifically linked to itch

(2012) Liang Han et al.   NATURE NEUROSCIENCE

Peripheral mechanisms of itch

(2012) Benjamin McNeil et al.   Neuroscience Bulletin

Emerging role of Toll-like receptors in the control of pain and itch

(2012) Tong Liu et al.   Neuroscience Bulletin

Unidirectional Cross-Activation of GRPR by MOR1D Uncouples Itch and Analgesia Induced by Opioids

(2011) Xian-Yu Liu et al.   CELL

Pain and itch: insights into the neural circuits of aversive somatosensation in health and disease

(2011) Sarah E Ross   CURRENT OPINION IN NEUROBIOLOGY

Overexpression of Cathepsin S Induces Chronic Atopic Dermatitis in Mice

(2011) Nari Kim et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

TRPA1 is required for histamine-independent, Mas-related G protein–coupled receptor–mediated itch

(2011) Sarah R Wilson et al.   NATURE NEUROSCIENCE

A tale of two itches. Common features and notable differences in brain activation evoked by cowhage and histamine induced itch

(2011) Alexandru D.P. Papoiu et al.   NEUROIMAGE

Role of transient receptor potential ankyrin subfamily member 1 in pruritus induced by endothelin-1

(2011) Jiexian Liang et al.   NEUROSCIENCE LETTERS

Transmitters and Pathways Mediating Inhibition of Spinal Itch-Signaling Neurons by Scratching and Other Counterstimuli

(2011) Tasuku Akiyama et al.   PLoS One

Analysis of cellular and behavioral responses to imiquimod reveals a unique itch pathway in transient receptor potential vanilloid 1 (TRPV1)-expressing neurons

(2011) S.-J. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Distinct Roles of Two GPCRs, MrgprC11 and PAR2, in Itch and Hyperalgesia

(2011) Q. Liu et al.   Science Signaling

Topical Therapies for Pruritus

(2011) Sarina B. Elmariah et al.   SEMINARS IN CUTANEOUS MEDICINE AND SURGERY

TRPV1-lineage neurons are required for thermal sensation

(2010) Santosh K Mishra et al.   EMBO JOURNAL

Therapeutic efficacy of AM156, a novel prostanoid DP2 receptor antagonist, in murine models of allergic rhinitis and house dust mite-induced pulmonary inflammation

(2010) Karin J. Stebbins et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Therapy of pruritus

(2010) Tejesh Patel et al.   EXPERT OPINION ON PHARMACOTHERAPY

Par2 Inactivation Inhibits Early Production of TSLP, but Not Cutaneous Inflammation, in Netherton Syndrome Adult Mouse Model

(2010) Anaïs Briot et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Cathepsin S Elicits Itch and Signals via Protease-Activated Receptors

(2010) Vemuri B. Reddy et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Inhibition of Inflammatory Pain by Activating B-Type Natriuretic Peptide Signal Pathway in Nociceptive Sensory Neurons

(2010) F.-X. Zhang et al.   JOURNAL OF NEUROSCIENCE

The PXR is a drug target for chronic inflammatory liver disease

(2010) Karen Wallace et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Toll-like receptor 7 mediates pruritus

(2010) Tong Liu et al.   NATURE NEUROSCIENCE

VGLUT2-Dependent Glutamate Release from Nociceptors Is Required to Sense Pain and Suppress Itch

(2010) Yang Liu et al.   NEURON

VGLUT2-Dependent Sensory Neurons in the TRPV1 Population Regulate Pain and Itch

(2010) Malin C. Lagerström et al.   NEURON

Spontaneous itch in the absence of hyperalgesia in a mouse hindpaw dry skin model

(2010) Tasuku Akiyama et al.   NEUROSCIENCE LETTERS

Pain behavior in the formalin test persists after ablation of the great majority of C-fiber nociceptors

(2010) Shannon D. Shields et al.   PAIN

Enhanced scratching evoked by PAR-2 agonist and 5-HT but not histamine in a mouse model of chronic dry skin itch

(2010) T. Akiyama et al.   PAIN

The multiple pathways for itch and their interactions with pain

(2010) Steve Davidson et al.   TRENDS IN NEUROSCIENCES

Effect of epinastine hydrochloride on murine self-scratching behavior after skin-scratching stimulation

(2009) Halifu Yilinuer et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Participation of Proteinase-Activated Receptor-2 in Passive Cutaneous Anaphylaxis-Induced Scratching Behavior and the Inhibitory Effect of Tacrolimus

(2009) Yu Zhu et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Sensory Neuron-Specific GPCR Mrgprs Are Itch Receptors Mediating Chloroquine-Induced Pruritus

(2009) Qin Liu et al.   CELL

Cellular and Molecular Mechanisms of Pain

(2009) Allan I. Basbaum et al.   CELL

Mrgprd Enhances Excitability in Specific Populations of Cutaneous Murine Polymodal Nociceptors

(2009) K. K. Rau et al.   JOURNAL OF NEUROSCIENCE

Relief of itch by scratching: state-dependent inhibition of primate spinothalamic tract neurons

(2009) Steve Davidson et al.   NATURE NEUROSCIENCE

TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms

(2009) N. Imamachi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli

(2009) D. J. Cavanaugh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular Basis of Itch Sensation

(2009) Y.-G. Sun et al.   SCIENCE

Anti-interleukin-31-antibodies ameliorate scratching behaviour in NC/Nga mice: a model of atopic dermatitis

(2008) Øystein Grimstad et al.   EXPERIMENTAL DERMATOLOGY

The Toll-like receptor 2 R753Q mutation modifies cytokine production and Toll-like receptor expression in atopic dermatitis

(2008) Salima Mrabet-Dahbi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Transgenic Expression of Interleukin-13 in the Skin Induces a Pruritic Dermatitis and Skin Remodeling

(2008) Tao Zheng et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Animal Models of Atopic Dermatitis

(2008) Haoli Jin et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Separate Peripheral Pathways for Pruritus in Man

(2008) Barbara Namer et al.   JOURNAL OF NEUROPHYSIOLOGY

A Role for Polymodal C-Fiber Afferents in Nonhistaminergic Itch

(2008) L. M. Johanek et al.   JOURNAL OF NEUROSCIENCE

Activation of Proteinase-Activated Receptors Induces Itch-Associated Response Through Histamine-Dependent and -Independent Pathways in Mice

(2008) Kenichiro Tsujii et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Involvement of serotonin receptors 5-HT1 and 5-HT2 in 12(S)-HPETE-induced scratching in mice

(2007) Dae-Kwon Kim et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Activation of Proteinase-Activated Receptor-2 by Human Kallikrein-Related Peptidases

(2007) Kristina Stefansson et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY