Trp channels and itch

Increased Expression of Three Types of Transient Receptor Potential Channels (TRPA1, TRPV4 and TRPV3) in Burn Scars with Post-burn Pruritus

(2015) Y Yang et al.   ACTA DERMATO-VENEREOLOGICA

HTR7 Mediates Serotonergic Acute and Chronic Itch

(2015) Takeshi Morita et al.   NEURON

Redefining the concept of protease-activated receptors: cathepsin S evokes itch via activation of Mrgprs

(2015) Vemuri B. Reddy et al.   Nature Communications

Potentials of the Circulating Pruritogenic Mediator Lysophosphatidic Acid in Development of Allergic Skin Inflammation in Mice

(2014) Yoshibumi Shimizu et al.   AMERICAN JOURNAL OF PATHOLOGY

The Bile Acid Receptor TGR5 Activates the TRPA1 Channel to Induce Itch in Mice

(2014) TinaMarie Lieu et al.   GASTROENTEROLOGY

Neural peptidase endothelin-converting enzyme 1 regulates endothelin 1–induced pruritus

(2014) Makiko Kido-Nakahara et al.   JOURNAL OF CLINICAL INVESTIGATION

Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing

(2014) Dmitry Usoskin et al.   NATURE NEUROSCIENCE

Dynorphin Acts as a Neuromodulator to Inhibit Itch in the Dorsal Horn of the Spinal Cord

(2014) Adam P. Kardon et al.   NEURON

Extracellular MicroRNAs Activate Nociceptor Neurons to Elicit Pain via TLR7 and TRPA1

(2014) Chul-Kyu Park et al.   NEURON

TLR4 enhances histamine-mediated pruritus by potentiating TRPV1 activity

(2014) Hyunjung Min et al.   Molecular Brain

Topical TRPM8 Agonist (Icilin) Relieved Vulva Pruritus Originating From Lichen Sclerosus et Atrophicus

(2013) J Han et al.   ACTA DERMATO-VENEREOLOGICA

TRP Channels and Pain

(2013) David Julius   Annual Review of Cell and Developmental Biology

Inhibition of capsaicin-driven nasal hyper-reactivity by SB-705498, a TRPV1 antagonist

(2013) Carlijn Holland et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

The Epithelial Cell-Derived Atopic Dermatitis Cytokine TSLP Activates Neurons to Induce Itch

(2013) Sarah R. Wilson et al.   CELL

Impact of TRPV3 on the development of allergic dermatitis as a dendritic cell modulator

(2013) Erika Yamamoto-Kasai et al.   EXPERIMENTAL DERMATOLOGY

TRPA1 controls inflammation and pruritogen responses in allergic contact dermatitis

(2013) Boyi Liu et al.   FASEB JOURNAL

The effects of a TRPV1 antagonist, SB-705498, in the treatment of seasonal allergic rhinitis

(2013) Philippe Bareille et al.   INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS

A sensory neuron–expressed IL-31 receptor mediates T helper cell–dependent itch: Involvement of TRPV1 and TRPA1

(2013) Ferda Cevikbas et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

The TGR5 receptor mediates bile acid–induced itch and analgesia

(2013) Farzad Alemi et al.   JOURNAL OF CLINICAL INVESTIGATION

TRPA1-Dependent Pruritus in IL-13-Induced Chronic Atopic Dermatitis

(2013) M.-H. Oh et al.   JOURNAL OF IMMUNOLOGY

IL-31 Is Produced by the Malignant T-Cell Population in Cutaneous T-Cell Lymphoma and Correlates with CTCL Pruritus

(2013) Elisha M. Singer et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The Ion Channel TRPA1 Is Required for Chronic Itch

(2013) S. R. Wilson et al.   JOURNAL OF NEUROSCIENCE

Activity-dependent silencing reveals functionally distinct itch-generating sensory neurons

(2013) David P Roberson et al.   NATURE NEUROSCIENCE

Neural processing of itch

(2013) Tasuku Akiyama et al.   NEUROSCIENCE

The Cells and Circuitry for Itch Responses in Mice

(2013) S. K. Mishra et al.   SCIENCE

Exome Sequencing Reveals Mutations in TRPV3 as a Cause of Olmsted Syndrome

(2012) Zhimiao Lin et al.   AMERICAN JOURNAL OF HUMAN GENETICS

TRPA1: A Gatekeeper for Inflammation

(2012) Diana M. Bautista et al.   Annual Review of Physiology

Development of PAC-14028, a novel transient receptor potential vanilloid type 1 (TRPV1) channel antagonist as a new drug for refractory skin diseases

(2012) Kyung-Min Lim et al.   ARCHIVES OF PHARMACAL RESEARCH

Recurrent heterozygous missense mutation, p.Gly573Ser, in the TRPV3 gene in an Indian boy with sporadic Olmsted syndrome

(2012) J.E. Lai-Cheong et al.   BRITISH JOURNAL OF DERMATOLOGY

Pruritus in Chronic Cholestatic Liver Disease

(2012) Chalermrat Bunchorntavakul et al.   Clinics in Liver Disease

Cathepsin E induces itch-related response through the production of endothelin-1 in mice

(2012) Tsugunobu Andoh et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Superoxide generation and leukocyte accumulation: key elements in the mediation of leukotriene B4-induced itch by transient receptor potential ankyrin 1 and transient receptor potential vanilloid 1

(2012) Elizabeth S. Fernandes et al.   FASEB JOURNAL

TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice

(2012) Tong Liu et al.   JOURNAL OF CLINICAL INVESTIGATION

TRPV3 as a Therapeutic Target for Itch

(2012) Erika Yamamoto-Kasai et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Pruriceptive spinothalamic tract neurons: physiological properties and projection targets in the primate

(2012) Steve Davidson et al.   JOURNAL OF NEUROPHYSIOLOGY

Mechanisms of Itch Evoked by  -Alanine

(2012) Q. Liu et al.   JOURNAL OF NEUROSCIENCE

Endothelin-1 induces itch and pain in the mouse cheek model

(2012) Lenyta Oliveira Gomes et al.   LIFE SCIENCES

Imiquimod Enhances Excitability of Dorsal Root Ganglion Neurons by Inhibiting Background (K2P) and Voltage-Gated (Kv1.1 and Kv1.2) Potassium Channels

(2012) Jaekwang Lee et al.   Molecular Pain

A subpopulation of nociceptors specifically linked to itch

(2012) Liang Han et al.   NATURE NEUROSCIENCE

Therapy of Human Papillomavirus-Related Disease

(2012) Peter L. Stern et al.   VACCINE

Oxidative stress induces itch via activation of transient receptor potential subtype ankyrin 1 in mice

(2012) Tong Liu et al.   Neuroscience Bulletin

Functional effects of interleukin 31 in human primary keratinocytes

(2011) S. Kasraie et al.   ALLERGY

Functional endothelin receptors are selectively expressed in isolectin B4-negative sensory neurons and are upregulated in isolectin B4-positive neurons by neurturin and glia-derived neurotropic factor

(2011) Vittorio Vellani et al.   BRAIN RESEARCH

Molecular signaling of pruritus induced by endothelin-1 in mice

(2011) Jiexian Liang et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Atopic dermatitis: a disease of altered skin barrier and immune dysregulation

(2011) Mark Boguniewicz et al.   IMMUNOLOGICAL REVIEWS

LPS Sensitizes TRPV1 via Activation of TLR4 in Trigeminal Sensory Neurons

(2011) A. Diogenes et al.   JOURNAL OF DENTAL RESEARCH

Antipruritic Effects of TRPV1 Antagonist in Murine Atopic Dermatitis and Itching Models

(2011) Jun-Won Yun et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Overexpression of Cathepsin S Induces Chronic Atopic Dermatitis in Mice

(2011) Nari Kim et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Distribution and Expression of Non-Neuronal Transient Receptor Potential (TRPV) Ion Channels in Rosacea

(2011) Mathias Sulk et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

BAM8-22 Peptide Produces Itch and Nociceptive Sensations in Humans Independent of Histamine Release

(2011) P. Sikand et al.   JOURNAL OF NEUROSCIENCE

Lysophosphatidic acid directly activates TRPV1 through a C-terminal binding site

(2011) Andrés Nieto-Posadas et al.   Nature Chemical Biology

TRPA1 is required for histamine-independent, Mas-related G protein–coupled receptor–mediated itch

(2011) Sarah R Wilson et al.   NATURE NEUROSCIENCE

Transient receptor potential channels as therapeutic targets

(2011) Magdalene M. Moran et al.   NATURE REVIEWS DRUG DISCOVERY

Itch Signaling in the Nervous System

(2011) Joseph Jeffry et al.   PHYSIOLOGY

Reduced TRPC Channel Expression in Psoriatic Keratinocytes Is Associated with Impaired Differentiation and Enhanced Proliferation

(2011) Kristina Leuner et al.   PLoS One

Analysis of cellular and behavioral responses to imiquimod reveals a unique itch pathway in transient receptor potential vanilloid 1 (TRPV1)-expressing neurons

(2011) S.-J. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TRPV3 regulates nitric oxide synthase-independent nitric oxide synthesis in the skin

(2011) Takashi Miyamoto et al.   Nature Communications

Thymic stromal lymphopoietin

(2010) Rui He et al.   Annals of the New York Academy of Sciences

TRP Channel Regulates EGFR Signaling in Hair Morphogenesis and Skin Barrier Formation

(2010) Xiping Cheng et al.   CELL

Therapy of pruritus

(2010) Tejesh Patel et al.   EXPERT OPINION ON PHARMACOTHERAPY

Lysophosphatidic Acid Is a Potential Mediator of Cholestatic Pruritus

(2010) Andreas E. Kremer et al.   GASTROENTEROLOGY

Systematic review of topical capsaicin in the treatment of pruritus

(2010) Sylvia M. D. Gooding et al.   INTERNATIONAL JOURNAL OF DERMATOLOGY

The TRPV4 Channel Contributes to Intercellular Junction Formation in Keratinocytes

(2010) Takaaki Sokabe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lipopolysaccharide From Porphyromonas gingivalis Sensitizes Capsaicin-Sensitive Nociceptors

(2010) Caio Cezar Randi Ferraz et al.   JOURNAL OF ENDODONTICS

Topical Application of TRPA1 Agonists and Brief Cold Exposure Accelerate Skin Permeability Barrier Recovery

(2010) Mitsuhiro Denda et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Cathepsin S Elicits Itch and Signals via Protease-Activated Receptors

(2010) Vemuri B. Reddy et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The Employment of Leukotriene Antagonists in Cutaneous Diseases Belonging to Allergological Field

(2010) Eustachio Nettis et al.   MEDIATORS OF INFLAMMATION

Toll-like receptor 7 mediates pruritus

(2010) Tong Liu et al.   NATURE NEUROSCIENCE

VGLUT2-Dependent Glutamate Release from Nociceptors Is Required to Sense Pain and Suppress Itch

(2010) Yang Liu et al.   NEURON

VGLUT2-Dependent Sensory Neurons in the TRPV1 Population Regulate Pain and Itch

(2010) Malin C. Lagerström et al.   NEURON

An Itch To Be Scratched

(2010) Kush N. Patel et al.   NEURON

Loss of Inhibitory Interneurons in the Dorsal Spinal Cord and Elevated Itch in Bhlhb5 Mutant Mice

(2010) Sarah E. Ross et al.   NEURON

Spontaneous itch in the absence of hyperalgesia in a mouse hindpaw dry skin model

(2010) Tasuku Akiyama et al.   NEUROSCIENCE LETTERS

Enhanced scratching evoked by PAR-2 agonist and 5-HT but not histamine in a mouse model of chronic dry skin itch

(2010) T. Akiyama et al.   PAIN

Successful Treatment of Therapy-resistant Pruritus in Lichen Amyloidosis with Menthol

(2009) M Frölich et al.   ACTA DERMATO-VENEREOLOGICA

TRPV1-mediated itch in seasonal allergic rhinitis

(2009) L. Alenmyr et al.   ALLERGY

Sensory Neuron-Specific GPCR Mrgprs Are Itch Receptors Mediating Chloroquine-Induced Pruritus

(2009) Qin Liu et al.   CELL

Capsaicin (TRPV1 Agonist) Therapy for Pain Relief

(2009) Helena Knotkova et al.   CLINICAL JOURNAL OF PAIN

Toll-like Receptors 3, 4, and 7 Are Expressed in the Enteric Nervous System and Dorsal Root Ganglia

(2009) Isabella Barajon et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Leukotriene B4 Mediates Sphingosylphosphorylcholine-Induced Itch-Associated Responses in Mouse Skin

(2009) Tsugunobu Andoh et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The Histamine H4 Receptor Mediates Inflammation and Pruritus in Th2-Dependent Dermal Inflammation

(2009) Jeffery M. Cowden et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Involvement of Tryptase and Proteinase-Activated Receptor-2 in Spontaneous Itch-Associated Response in Mice With Atopy-like Dermatitis

(2009) Kenichiro Tsujii et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Relief of itch by scratching: state-dependent inhibition of primate spinothalamic tract neurons

(2009) Steve Davidson et al.   NATURE NEUROSCIENCE

TRPV3 in keratinocytes transmits temperature information to sensory neurons via ATP

(2009) Sravan Mandadi et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

TRPV1-expressing primary afferents generate behavioral responses to pruritogens via multiple mechanisms

(2009) N. Imamachi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cellular Basis of Itch Sensation

(2009) Y.-G. Sun et al.   SCIENCE

Phospholipase C and protein kinase A mediate bradykinin sensitization of TRPA1: a molecular mechanism of inflammatory pain

(2008) Shenglan Wang et al.   BRAIN

Involvement of the BLT2receptor in the itch-associated scratching induced by 12-(S)-lipoxygenase products in ICR mice

(2008) H J Kim et al.   BRITISH JOURNAL OF PHARMACOLOGY

Anti-interleukin-31-antibodies ameliorate scratching behaviour in NC/Nga mice: a model of atopic dermatitis

(2008) Øystein Grimstad et al.   EXPERIMENTAL DERMATOLOGY

Specific TRPC6 Channel Activation, a Novel Approach to Stimulate Keratinocyte Differentiation

(2008) Margarethe Müller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impact of the Gly573Ser Substitution in TRPV3 on the Development of Allergic and Pruritic Dermatitis in Mice

(2008) Takeshi Yoshioka et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Evolving Concepts of Pathogenesis in Atopic Dermatitis and Other Eczemas

(2008) Jon M. Hanifin   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Overexpressed Transient Receptor Potential Vanilloid 3 Ion Channels in Skin Keratinocytes Modulate Pain Sensitivity via Prostaglandin E2

(2008) S. M. Huang et al.   JOURNAL OF NEUROSCIENCE

Transient Receptor Potential A1 Is a Sensory Receptor for Multiple Products of Oxidative Stress

(2008) D. A. Andersson et al.   JOURNAL OF NEUROSCIENCE

Cowhage-Evoked Itch Is Mediated by a Novel Cysteine Protease: A Ligand of Protease-Activated Receptors

(2008) V. B. Reddy et al.   JOURNAL OF NEUROSCIENCE

Hydroxyethyl starch–induced pruritus relieved by a combination of menthol and camphor

(2008) Justin M. Haught et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines

(2008) Robin L. Thurmond et al.   NATURE REVIEWS DRUG DISCOVERY

TRPC channels determine human keratinocyte differentiation: New insight into basal cell carcinoma

(2007) Benjamin Beck et al.   CELL CALCIUM

Involvement of serotonin receptors 5-HT1 and 5-HT2 in 12(S)-HPETE-induced scratching in mice

(2007) Dae-Kwon Kim et al.   EUROPEAN JOURNAL OF PHARMACOLOGY