Article
Environmental Sciences
Yonggang Ma, Di Ran, Xueni Shi, Hongyan Zhao, Zongping Liu
Summary: Cadmium is a widespread environmental contaminant that causes severe bone metabolism disease and dental issues. It affects bone cell and teeth development, leading to oxidative stress and DNA damage, ultimately resulting in cell apoptosis.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Dentistry, Oral Surgery & Medicine
M. Farahat, G. A. S. Kazi, E. S. Hara, T. Matsumoto
Summary: This study systematically investigated the changes in Meckel's cartilage during embryonic development, revealing the distinct effects of biomechanical cues on its fate. The surrounding biomechanical properties play a crucial role in guiding the mineralization and degradation of Meckel's cartilage, which could be valuable for tissue engineering applications.
JOURNAL OF DENTAL RESEARCH
(2021)
Article
Engineering, Biomedical
Yamei Xu, Yao Yang, Ziyi Hua, Shuang Li, Zhenyu Yang, Qianzi Liu, Gang Fu, Ping Ji, Qingqing Wu
Summary: The BMP2 antibody shows promise as a replacement for rhBMP2 in bone tissue engineering, promoting bone formation and suppressing osteoclastogenesis. Further research is needed to clarify the specific osteogenic mechanism and adverse reactions associated with the antibody.
Review
Endocrinology & Metabolism
Yuhan Zhou, Hector M. Arredondo, Ning Wang
Summary: This mini review summarizes the latest research developments on the roles of P2Y receptors in bone biology, particularly focusing on receptors with both anabolic and catabolic functions. Targeting these receptors pharmacologically in bone-wasting diseases presents a challenge, and further research is needed to find more precise targeting strategies.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Review
Endocrinology & Metabolism
Fumiyuki Sasaki, Mikihito Hayashi, Takehito Ono, Tomoki Nakashima
Summary: RANKL is a key mediator of osteoclast differentiation and bone resorption, regulated by various factors including mechanical forces. Mechanosensing proteins and mechanosignaling proteins on the cell membrane play essential roles in osteoblast differentiation and function through soluble factors.
JOURNAL OF BONE AND MINERAL METABOLISM
(2021)
Article
Endocrinology & Metabolism
Charles N. Pagel, Pamu K. Kularathna, Reza Sanaei, Neil D. Young, John D. Hooper, Eleanor J. Mackie
Summary: Prostate cancer cells influence bone cell behavior through both PAR(2)-dependent and -independent mechanisms, including the inhibition of osteoclast differentiation independently of PAR(2) and the stimulation of osteogenesis dependent on PAR(2).
Review
Biochemistry & Molecular Biology
Hideki Kitaura, Aseel Marahleh, Fumitoshi Ohori, Takahiro Noguchi, Yasuhiko Nara, Adya Pramusita, Ria Kinjo, Jinghan Ma, Kayoko Kanou, Itaru Mizoguchi
Summary: TNF-alpha is a cytokine expressed by immune cells and is involved in host defense and bone-related cell functions. This review summarizes current research on the interaction between TNF-alpha and its receptors in bone cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Sooyeon Lee, Benjamin Thilo Krueger, Anita Ignatius, Jan Tuckermann
Summary: Glucocorticoids (GCs) regulate bone homeostasis in a cell-type specific manner and disturbance of circadian rhythm by exogenous GCs treatment can hamper bone integrity. GC signaling is also important for fracture healing and rheumatoid arthritis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Chikahiro Imashiro, Tetsuya Azuma, Shun Itai, Taiki Kuribara, Kiichiro Totani, Hiroaki Onoe, Kenjiro Takemura
Summary: In this study, it was found that ultrasound can promote vasculogenesis in vitro. The use of regulated ultrasound on three-dimensional-monocultured HUVECs clarified the effect of ultrasound on vasculogenesis, showing enhanced protein expression related to vasculogenesis and response to mechanical stress. This finding may be an innovation in the tissue engineering field.
BIOTECHNOLOGY AND BIOENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
Farshad Amiri, Melika Babaei, Nima Jamshidi, Maria Agheb, Mohammad Rafienia, Mohammad Kazemi
Summary: The study investigated the structural and biological properties of 3D-printed polyurethane scaffolds coated with gellan gum, hyaluronic acid, and glucosamine. The surface coating improved cell behavior, increased expression levels of collagen II and aggrecan genes, and enhanced the scaffold's mechanical and degradation properties, making it a promising candidate for meniscus tissue engineering.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Risa Kawatsura, Yusuke Hara, Masako Akiyama, Noriko Tachikawa, Ken-Ichi Nakahama
Summary: Osteoblasts communicate through gap junctions and propagate cAMP to inhibit excess osteoclastogenesis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Endocrinology & Metabolism
Lieve Verlinden, Stefanie Doms, Iris Janssens, Mark B. B. Meyer, J. Wesley Pike, Geert Carmeliet, Annemieke Verstuyf
Summary: Neuropilin 2 (NRP2) plays a role in bone homeostasis by regulating osteoblasts and osteoclasts. The expression of NRP2 in osteoblasts is induced by 1,25-dihydroxyvitamin D-3. Deletion of NRP2 in osteoblasts results in reduced bone mass, while deletion in osteoclasts does not have a bone phenotype.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Cell Biology
Huadie Liu, Sonya E. L. Craig, Vladimir Molchanov, Joseph S. Floramo, Yaguang Zhao, Tao Yang
Summary: SUMOylation is a key post-translational modification process involved in various biological processes, including the development and homeostasis of the skeletal system. Recent studies have suggested that targeting SUMOylation pathways could be a promising therapeutic approach for skeletal diseases.
Article
Biochemistry & Molecular Biology
Valentina Granata, Dario Strina, Maria Lucia Schiavone, Barbara Bottazzi, Alberto Mantovani, Antonio Inforzato, Cristina Sobacchi
Summary: The role of PTX3 in bone biology, particularly in osteoblasts and osteoclasts, is unclear. This study reveals the importance of PTX3 in regulating the activities of osteoblasts and osteoclasts, with inflammation having a major impact on the bone-related properties of PTX3.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Megan N. Michalski, Bart O. Williams
Summary: This review discusses the development and application of genetically engineered mouse models in musculoskeletal biology research, with a particular focus on tissue-specific gene knockout and the impact of CRISPR/Cas technology.
Article
Engineering, Biomedical
Steven B. Orr, Abby Chainani, Kirk J. Hippensteel, Alysha Kishan, Christopher Gilchrist, N. William Garrigues, David S. Ruch, Farshid Guilak, Dianne Little
ACTA BIOMATERIALIA
(2015)
Article
Engineering, Biomedical
Christopher R. Rowland, Lina A. Colucci, Farshid Guilak
Review
Orthopedics
M. Cucchiarini, A. L. McNulty, R. L. Mauck, L. A. Setton, F. Guilak, H. Madry
OSTEOARTHRITIS AND CARTILAGE
(2016)
Article
Orthopedics
J. L. Huebner, L. R. Landerman, T. J. Somers, F. J. Keefe, F. Guilak, J. A. Blumenthal, D. S. Caldwell, V. B. Kraus
OSTEOARTHRITIS AND CARTILAGE
(2016)
Article
Multidisciplinary Sciences
Franklin T. Moutos, Katherine A. Glass, Sarah A. Compton, Alison K. Ross, Charles A. Gersbach, Farshid Guilak, Bradley T. Estes
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2016)
Article
Chemistry, Physical
Lourdes Recha-Sancho, Franklin T. Moutos, Jordi Abella, Farshid Guilak, Carlos E. Semino
Article
Multidisciplinary Sciences
Oswaldo A. Lozoya, Christopher L. Gilchrist, Farshid Guilak
SCIENTIFIC REPORTS
(2016)
Article
Rheumatology
Chia-Lung Wu, Deeptee Jain, Jenna N. McNeill, Dianne Little, John A. Anderson, Janet L. Huebner, Virginia B. Kraus, Ramona M. Rodriguiz, William C. Wetsel, Farshid Guilak
ANNALS OF THE RHEUMATIC DISEASES
(2015)
Article
Multidisciplinary Sciences
Patrick Kanju, Yong Chen, Whasil Lee, Michele Yeo, Suk Hee Lee, Joelle Romac, Rafiq Shahid, Ping Fan, David M. Gooden, Sidney A. Simon, Ivan Spasojevic, Robert A. Mook, Rodger A. Liddle, Farshid Guilak, Wolfgang B. Liedtke
SCIENTIFIC REPORTS
(2016)
Article
Multidisciplinary Sciences
Priscilla Y. Hwang, Liufang Jing, Jun Chen, Foon-Lian Lim, Ruhang Tang, Hyowon Choi, Kenneth M. Cheung, Makarand V. Risbud, Charles A. Gersbach, Farshid Guilak, Victor Y. Leung, Lori A. Setton
SCIENTIFIC REPORTS
(2016)
Article
Multidisciplinary Sciences
Christopher J. O'Conor, Sendhilnathan Ramalingam, Nicole A. Zelenski, Halei C. Benefield, Isaura Rigo, Dianne Little, Chia-Lung Wu, Di Chen, Wolfgang Liedtke, Amy L. McNulty, Farshid Guilak
SCIENTIFIC REPORTS
(2016)
Article
Multidisciplinary Sciences
Christopher L. Gilchrist, Holly A. Leddy, Laurel Kaye, Natasha D. Case, Katheryn E. Rothenberg, Dianne Little, Wolfgang Liedtke, Brenton D. Hoffman, Farshid Guilak
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Multidisciplinary Sciences
Amber T. Collins, Guoli Hu, Hunter Newman, Michael H. Reinsvold, Monique R. Goldsmith, John N. Twomey-Kozak, Holly A. Leddy, Deepika Sharma, Leyao Shen, Louis E. DeFrate, Courtney M. Karner
Summary: This study investigated the influence of obesity on the mechanical properties of murine knee cartilage, revealing a significant reduction in cartilage stiffness associated with obesity, which may serve as an early indicator of disease progression.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Whasil Lee, Robert J. Nims, Alireza Savadipour, Qiaojuan Zhang, Holly A. Leddy, Fang Liu, Amy L. McNulty, Yong Chen, Farshid Guilak, Wolfgang B. Liedtke
Summary: The study reveals that interleukin-1 affects the expression and function of Piezo1 gene in osteoarthritis, leading to a detrimental calcium-driven feed-forward mechanism that can be targeted for intervention.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cell & Tissue Engineering
Vincent P. Willard, Holly A. Leddy, Daniel Palmer, Chia-Lung Wu, Wolfgang Liedtke, Farshid Guilak
Summary: The expression and activation of TRPV4 in chondrogenesis play a crucial role in regulating cartilaginous matrix production through modulation of chondrogenic gene markers and Ca2+ signaling. Understanding the involvement of TRPV4 in cartilage development may lead to new therapeutic strategies for cartilage-related diseases and accelerate stem cell differentiation for tissue engineering purposes.