Neutrophil Elastase Activates Protease-activated Receptor-2 (PAR2) and Transient Receptor Potential Vanilloid 4 (TRPV4) to Cause Inflammation and Pain

Cathepsin S Causes Inflammatory PainviaBiased Agonism of PAR2and TRPV4

(2014) Peishen Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sensitisation of TRPV4 by PAR2 is independent of intracellular calcium signalling and can be mediated by the biased agonist neutrophil elastase

(2014) Silvia Sostegni et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Cathepsin S Signals via PAR2 and Generates a Novel Tethered Ligand Receptor Agonist

(2014) Sarina B. Elmariah et al.   PLoS One

The potential of neutrophil elastase inhibitors as anti-inflammatory therapies

(2013) Peter A. Henriksen   CURRENT OPINION IN HEMATOLOGY

The Bile Acid Receptor TGR5 Does Not Interact with β-Arrestins or Traffic to Endosomes but Transmits Sustained Signals from Plasma Membrane Rafts

(2013) Dane D. Jensen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protease-activated Receptor 2 (PAR2) Protein and Transient Receptor Potential Vanilloid 4 (TRPV4) Protein Coupling Is Required for Sustained Inflammatory Signaling

(2013) Daniel P. Poole et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neutrophil Elastase and Proteinase-3 Trigger G Protein-biased Signaling through Proteinase-activated Receptor-1 (PAR1)

(2013) Koichiro Mihara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of G-protein-coupled receptor kinase 6 (GRK6) after acute spinal cord injury in adult rat

(2013) Binbin Sun et al.   JOURNAL OF MOLECULAR HISTOLOGY

Decreased Expression and Role of GRK6 in Spinal Cord of Rats After Chronic Constriction Injury

(2013) Yuan Zhou et al.   NEUROCHEMICAL RESEARCH

Organization of cAMP signalling microdomains for optimal regulation by Ca2+entry

(2012) Debbie Willoughby   BIOCHEMICAL SOCIETY TRANSACTIONS

Proteolytic activation of the epithelial sodium channel (ENaC) by the cysteine protease cathepsin-S

(2012) Silke Haerteis et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

TRPV4-Mediated Calcium Influx into Human Bronchial Epithelia upon Exposure to Diesel Exhaust Particles

(2011) Jinju Li et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

Neutrophil Elastase Acts as a Biased Agonist for Proteinase-activated Receptor-2 (PAR2)

(2011) Rithwik Ramachandran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

G protein-coupled receptor kinases: More than just kinases and not only for GPCRs

(2011) Eugenia V. Gurevich et al.   PHARMACOLOGY & THERAPEUTICS

A role for transient receptor potential vanilloid 4 in tonicity-induced neurogenic inflammation

(2010) N Vergnolle et al.   BRITISH JOURNAL OF PHARMACOLOGY

A mutation of the epithelial sodium channel associated with atypical cystic fibrosis increases channel open probability and reduces Na+self inhibition

(2010) Robert Rauh et al.   JOURNAL OF PHYSIOLOGY-LONDON

Activation of the TRPV4 Ion Channel Is Enhanced by Phosphorylation

(2009) Hueng-Chuen Fan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein kinase D isoforms are expressed in rat and mouse primary sensory neurons and are activated by agonists of protease-activated receptor 2

(2009) Silvia Amadesi et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Protease-activated receptors as drug targets in inflammation and pain

(2009) Nathalie Vergnolle   PHARMACOLOGY & THERAPEUTICS

Transient receptor potential vanilloid 4 mediates protease activated receptor 2-induced sensitization of colonic afferent nerves and visceral hyperalgesia

(2008) Walter E. B. Sipe et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Prostatic trypsin-like kallikrein-related peptidases (KLKs) and other prostate-expressed tryptic proteinases as regulators of signalling via proteinase-activated receptors (PARs)

(2008) Andrew J. Ramsay et al.   BIOLOGICAL CHEMISTRY

G protein-coupled receptor kinase 6 controls post-inflammatory visceral hyperalgesia

(2008) Niels Eijkelkamp et al.   BRAIN BEHAVIOR AND IMMUNITY

Kallikrein-related Peptidase 4 (KLK4) Initiates Intracellular Signaling via Protease-activated Receptors (PARs)

(2008) Andrew J. Ramsay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cleavage in the γ-subunit of the epithelial sodium channel (ENaC) plays an important role in the proteolytic activation of near-silent channels

(2008) Alexei Diakov et al.   JOURNAL OF PHYSIOLOGY-LONDON

Role of Tissue Kallikrein in Prevention and Recovery of Gentamicin-Induced Renal Injury

(2008) Grant Bledsoe et al.   TOXICOLOGICAL SCIENCES