Article
Oncology
Jianzhang Qin, Yishuai Li, Zhe Li, Xuebo Qin, Xuetao Zhou, Hao Zhang, Shujun Li
Summary: LINC00114 promotes the development of esophageal cancer by recruiting EZH2 to enhance the H3K27me3 of DLC1.
CLINICAL EPIGENETICS
(2022)
Review
Oncology
Wuhan Yu, Ning Liu, Xiaogang Song, Lang Chen, Mancai Wang, Guohui Xiao, Tengfei Li, Zheyuan Wang, Youcheng Zhang
Summary: This article focuses on the value of EZH2 research in gastric cancer by examining its crucial involvement in gastric cancer progression. The article first introduces the two main functions of EZH2: histone methylation modification and DNA methylation. It then provides a detailed description of the mechanisms of EZH2 in gastric cancer-related events, and concludes with a summary of the progress in the development of EZH2 inhibitors. This review article provides researchers studying the epigenetics of gastric cancer with new research ideas to find new targets for studying the pathogenesis of gastric cancer.
Article
Chemistry, Medicinal
Bin Zhou, Beilei Wang, Fengming Zou, Husheng Mei, Qingwang Liu, Shuang Qi, Wenliang Wang, Rui Jin, Aoli Wang, Yongfei Chen, Feiyang Liu, Wenchao Wang, Jing Liu, Qingsong Liu
Summary: A novel covalent EZH2 degrader was discovered, which can reduce the expression of EZH2 in multiple types of cancer and exhibit antiproliferation activity. This study provides an opportunity for the development of new drug candidates.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Lin Xu, Jiandong Gao, Di Huang, Pinglan Lin, Dongsheng Yao, Feng Yang, Yaheng Zhang, Xuejun Yang, Ming Wu, Chaoyang Ye
Summary: Emodin delays the progression of chronic renal failure and inhibits renal tubulointerstitial fibrosis by reducing extracellular collagen deposition and inhibiting pro-fibrotic signaling pathways, through down-regulation of EZH2.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Medicine, Research & Experimental
Xiaomin Gao, Yonghan Peng, Ziyu Fang, Ling Li, Shaoxiong Ming, Hao Dong, Rui Li, Yasheng Zhu, Wei Zhang, Baoyi Zhu, Junhao Liao, Zeyu Wang, Min Liu, Weijian Li, Jianwen Zeng, Xiaofeng Gao
Summary: Inhibition of EZH2 attenuates hyperoxaluria-induced TECs injury and reduces CaOx crystal deposition by modulating the JNK/FoxO3a pathway. EZH2 may be a promising therapeutic target in TECs injury.
Article
Oncology
Cong Xu, Hong-Li Yang, Yi-Kun Yang, Li Pan, Hai-Ying Chen
Summary: ZNF750 has the potential to inhibit the renewal ability of CSC-like cells and decrease their invasion and migration abilities. This study provides further insights into the mechanisms of oral squamous cell carcinoma.
Article
Cell Biology
Sumukh Thakar, Yash T. Katakia, Shyam Kumar Ramakrishnan, Niyati Pandya Thakkar, Syamantak Majumder
Summary: The research reveals that intermittent high glucose exposure induces endothelial inflammation, possibly through increased H3K27me3 levels, EZH2 nuclear retention, and inhibition of KLF2 and KLF4 gene expression.
Article
Medicine, Research & Experimental
Nisha Gautam, Satbir Kaur, Surender Kashyap
Summary: In this study, three SNPs (rs.2302427C>G, rs.3757441C>T, and rs.6950683T>C) of the EZH2 gene were analyzed for genetic polymorphism. The results showed that two of these SNPs have a protective role in breast cancer development, and two haplotypes were associated with a lower risk of breast cancer. Specifically, the SNP rs.2302427C>G was identified as an important prognostic biomarker for breast cancer patient survival.
ARCHIVES OF MEDICAL RESEARCH
(2023)
Article
Oncology
Xiaxia Shao, Tao Zhao, Lei Xi, Yuhong Zhang, Jia He, Jie Zeng, Lichun Deng
Summary: The study demonstrated that the upregulation of LINC00565 and EZH2 in CRC tissues, especially in advanced stages and large tumor sizes, highlights their diagnostic value in CRC. LINC00565, predominantly located in the cytoplasm, binds with EZH2 and together they co-regulate the functions of CRC cells.
Article
Medicine, Research & Experimental
Dongyou Yue, Zhiying Wang, Yongan Yang, Zhenjun Hu, Ganping Luo, Fu Wang
Summary: The study showed that the EZH2 inhibitor GSK343 could protect the intestine from sepsis-induced injury in mice by reducing inflammation, suppressing cell apoptosis, and promoting tight junction protein expression.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Cell Biology
Lihong Shi, Qiangsheng Zhang, Shirui Zhu, Qing Tang, Xin Chen, Rui Lan, Ningyu Wang, Yongxia Zhu
Summary: The expression of EZH2 is associated with the migration and invasion of OC cells. Inhibition of EZH2 using SKLB-03220 reduces the migration and invasion ability of OC cells by upregulating TIMP2 and downregulating MMP9.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Shanshan Sun, Feng Yu, Danying Xu, Haiyan Zheng, Min Li
Summary: This review summarizes the dynamic functions of the histone methyltransferase EZH2 in the tumor microenvironment, including its regulation of tumor cells, immune cells, and other components of the TME. The potential of combination therapy to enable immune checkpoint blockade in cancer treatment is also discussed.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Article
Cell Biology
Xiaoyang Yang, Mengjie Wan, Feng Yu, Xiuji Wu
Summary: This study elucidates that upregulation of CCNA1 in AML cells promotes chemoresistance, while downregulation of FOXA2 and the action of EZH2 increase sensitivity of AML cells to drugs.
CELLULAR SIGNALLING
(2021)
Article
Cell Biology
Li Wen, Qian Ren, Fan Guo, Xiaoyan Du, Hongliu Yang, Ping Fu, Liang Ma
Summary: Despite progress in understanding the mechanism of acute kidney injury (AKI), there are no effective drugs for treatment or prevention. This study found that the ligand-activated transcription factor aryl hydrocarbon receptor (AhR) was abnormally increased in cisplatin-induced AKI. Inhibition of AhR alleviated kidney dysfunction and tubular injury, and improved cellular senescence. Mechanistically, AhR expression was correlated with the increase of methyltransferase EZH2, and AhR inhibition suppressed EZH2 expression. The study suggests that AhR and EZH2 have mutual regulation and AhR could be a promising target for AKI treatment.
CELL DEATH & DISEASE
(2023)
Article
Biotechnology & Applied Microbiology
Xuezhu Huang, Qin Yang, Lingling Xie, Sihong Lei
Summary: This experiment investigated the role of EZH2 in depression and found that EZH2 overexpression was involved in neuroinflammation. Silencing EZH2 reversed depression-like behaviors and inflammation. Furthermore, EZH2 regulated microglia polarization by targeting miR-29b-3p and MMP2 expression.
Article
Endocrinology & Metabolism
Christopher R. Paradise, M. Lizeth Galvan, Oksana Pichurin, Sofia Jerez, Eva Kubrova, S. Sharare Dehghani, Margarita E. Carrasco, Roman Thaler, A. Noelle Larson, Andre J. van Wijnen, Amel Dudakovic
Summary: The research demonstrates that Brd4 is a key epigenetic regulator required for normal chondrogenesis and endochondral ossification, with loss of Brd4 leading to abnormal cartilage development in mice and delayed long bone formation.
Article
Biochemistry & Molecular Biology
Mahshid Mohammadi, Leila Bagheri, Amr Badreldin, Pedram Fatehi, Leila Pakzad, Zacharias Suntres, Andre J. van Wijnen
Summary: This review focuses on the lichen-derived metabolite gyrophoric acid and other select secondary metabolites that modulate cellular pathways relevant to several biomedical diseases. The chemical structures, biochemical activities, and therapeutic potential of these compounds are discussed, particularly their effects on cancer cells and their potential applications in other cellular processes controlled by cell growth and differentiation.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Orthopedics
Smitha E. Mathew, Yong Xie, Leila Bagheri, Liam E. Claton, Lin Chu, Amr Badreldin, Matthew P. Abdel, Andre J. van Wijnen, Geoffrey F. Haft, Todd A. Milbrandt, A. Noelle Larson
Summary: This study found that serum titanium, cobalt, and chromium levels are elevated in children with spinal implants compared to those with extremity implants, particularly in patients with growing spine devices. Histological analysis revealed the presence of metal debris and increased macrophage activity in tissue biopsies adjacent to growing spine implants. However, the clinical significance of these findings remains to be determined.
JOURNAL OF PEDIATRIC ORTHOPAEDICS
(2022)
Article
Surgery
Sydney L. Proffer, Christopher R. Paradise, Emily DeGrazia, Yael Halaas, K. Kay Durairaj, Michael Somenek, Angela Sivly, Andrea J. Boon, Atta Behfar, Saranya P. Wyles
Summary: This study evaluated the safety and effectiveness of a platelet-derived exosome product called HPE for skin rejuvenation. The results showed that HPE significantly improved overall skin health, reducing redness, wrinkles, and melanin production, while improving skin luminosity and color evenness. The product was found to be safe, well-tolerated, and well-liked by participants.
AESTHETIC SURGERY JOURNAL
(2022)
Article
Genetics & Heredity
Parisa Dashti, Jeroen van de Peppel, Roman Thaler, Christopher R. Paradise, Gary S. Stein, Martin A. Montecino, Johannes P. T. M. van Leeuwen, Bram J. van der Eerden, Amel Dudakovic, Andre J. van Wijnen
Summary: This study found that Smyd2 inhibits proliferation and mineral deposition by osteoblasts, and operates parallel to the suppressive effects of Ezh2 and H3K27 trimethylation on osteoblast differentiation.
Editorial Material
Orthopedics
Andre J. van Wijnen, Eric A. Lewallen
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2023)
Review
Biochemistry & Molecular Biology
Praneet Dara, Zeba Farooqui, Fackson Mwale, Chungyoul Choe, Andre J. van Wijnen, Hee-Jeong Im
Summary: Chronic pain conditions caused by arthritis have devastating effects on both individuals and society. The main objective of pharmacological treatments is to reduce pain, and several types of drugs have been considered. Naltrexone, an oral-activated opioid antagonist, has been shown to have beneficial effects on chronic pain conditions such as fibromyalgia and multiple sclerosis.
Article
Orthopedics
Hayman Lui, Cedryck Vaquette, Janet M. Denbeigh, Randy Bindra, Andre J. van Wijnen, Sanjeev Kakar
Summary: This study aims to assess the use of growth factors (BMP2 and GDF5) for bone and ligament regeneration in a multiphasic scaffold in a rabbit knee model. The addition of BMP2 and GDF5 in the BLB scaffold resulted in heterotopic bone formation and ligament failure.
JOURNAL OF WRIST SURGERY
(2023)
Article
Endocrinology & Metabolism
Stephane Blouin, Farzaneh Khani, Phaedra Messmer, Paul Roschger, Markus A. Hartmann, Andre J. van Wijnen, Roman Thaler, Barbara M. Misof
Summary: Vitamin C is crucial for bone health and low levels of serum Vitamin C increase the risk of skeletal fractures. This study examined the effects of Vitamin C on femoral structure, bone formation, and bone mineralization density distribution in mice. The results showed that Vitamin C depletion significantly reduced cortical thickness and bone volume, as well as diminished the amount of newly formed bone tissue. Additionally, Vitamin C supplementation led to higher calcium concentrations and suggested a longer bone tissue age. Female mice were found to be more sensitive to Vitamin C deficiency. These findings highlight the key role of Vitamin C in bone formation rate and its potential in preventing bone-degenerative diseases, especially in females.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Dermatology
Steven Dayan, Nimit Gandhi, John Wilson, Eljona Kola, Laura Eaton Jankov, Karen Copeland, Chris Paradise, Atta Behfar
Summary: This study compares the effects of human platelet extract (HPE) and standard care on post-laser recovery and finds that HPE can reduce crusting, shorten recovery time, and result in brighter and more youthful skin.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Felipe Arratia, Cristopher Fierro, Alejandro Blanco, Sebastian Fuentes, Daniela Nahuelquen, Martin Montecino, Adriana Rojas, Rodrigo Aguilar
Summary: In cancer cells, the lncRNA MALAT1 collaborates with the epigenetic modifier PRC2. Through genomic binding analysis, 1293 genomic sites were identified where PRC2 and MALAT1 concur, with the majority being within gene promoter regions. These findings indicate that MALAT1 and PRC2 can bind together to actively-transcribed genes in cancer cells, controlling a subset of genes related to cancer malignancy and epigenetic regulation.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Biology
Sanae Kobayashi, Jonathan Maldonado, Alexis Gaete, Ingrid Araya, Constanza Aguado-Norese, Nicolas Cumplido, Sebastian Diaz, Alonso Espinoza, Edelmira Fernandez, Felipe Gajardo, Felipe Gonzalez-Ordenes, Khantati Hauyon, Piedad Maldonado, Rodrigo Maldonado, Isabel Pochet, Anibal Riveros, Paula Sandoval, Ailynne Sepulveda-Gonzalez, Camila Stuardo, Patricio Tapia-Reyes, Carolina Thornton, Soledad Undurraga, Macarena A. Varas, Camilo Valdivieso, Rodrigo A. Gutierrez, Ariel Orellana, Martin L. Montecino, Alejandro Maass, Mauricio Gonzalez, Miguel Allende, Christian Hodar, Paula Irles
Summary: Despite being the largest fraction of animal life, there are only a few hundred insect species whose genomes have been sequenced. The earwigs, as one of the basally derived insect groups and with its importance in agroecosystems, have lacked genomic information. However, a project was successfully carried out by engaging high school students from twelve schools in Chile to collect earwig specimens, extract genomic DNA, and perform genome sequencing using nanopore sequencers.
BIOLOGICAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Gisella Bermudez, Camila Bernal, Andrea Otalora, Paula Sanchez, Gino Nardocci, Alejandra Canas, Liliana Lopez-Kleine, Martin Montecino, Adriana Rojas
Summary: In this study, we identified TALAM1 as a genetic target of the RUNX2 transcription factor in lung cancer and confirmed the negative regulatory effect of RUNX2 on TALAM1 expression.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)