In vitro Activity of Antivirulence Drugs Targeting the las or pqs Quorum Sensing Against Cystic Fibrosis Pseudomonas aeruginosa Isolates

A new horizon for the old antibacterial drug clofoctol

(2021) Christian Bailly et al.   DRUG DISCOVERY TODAY

Pseudomonas aeruginosa isolates defective in function of the LasR quorum sensing regulator are frequent in diverse environmental niches

(2021) Marie‐Christine Groleau et al.   ENVIRONMENTAL MICROBIOLOGY

Design and Evaluation of New Quinazolin-4(3H)-one Derived PqsR Antagonists as Quorum Sensing Quenchers in Pseudomonas aeruginosa

(2021) Fadi Soukarieh et al.   ACS Infectious Diseases

Anti-Virulence Activity of the Cell-Free Supernatant of the Antarctic Bacterium Psychrobacter sp. TAE2020 against Pseudomonas aeruginosa Clinical Isolates from Cystic Fibrosis Patients

(2021) Rosanna Papa et al.   Antibiotics-Basel

2-Alkyl-4-quinolone quorum sensing molecules are biomarkers for culture-independent Pseudomonas aeruginosa burden in adults with cystic fibrosis

(2021) Nur Masirah M. Zain et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Effects of Signal Disruption Depends on the Substrate Preference of the Lactonase

(2020) Kathleen Mahan et al.   Frontiers in Microbiology

RhlR-Regulated Acyl-Homoserine Lactone Quorum Sensing in a Cystic Fibrosis Isolate of Pseudomonas aeruginosa

(2020) Renae L. Cruz et al.   mBio

Pseudomonas aeruginosa adaptation and evolution in patients with cystic fibrosis

(2020) Elio Rossi et al.   NATURE REVIEWS MICROBIOLOGY

Activity and Impact on Resistance Development of Two Antivirulence Fluoropyrimidine Drugs in Pseudomonas aeruginosa

(2019) Francesco Imperi et al.   Frontiers in Cellular and Infection Microbiology

Social cheating in a Pseudomonas aeruginosa quorum-sensing variant

(2019) Ruiyi Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cystic Fibrosis and Pseudomonas aeruginosa: the Host-Microbe Interface

(2019) Sankalp Malhotra et al.   CLINICAL MICROBIOLOGY REVIEWS

In silico Selection and Experimental Validation of FDA-Approved Drugs as Anti-quorum Sensing Agents

(2019) Marta Mellini et al.   Frontiers in Microbiology

The third quorum-sensing system of Pseudomonas aeruginosa: Pseudomonas quinolone signal and the enigmatic PqsE protein

(2019) Selene García-Reyes et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Pseudomonas aeruginosa Quorum Sensing Systems as Drug Discovery Targets: Current Position and Future Perspectives.

(2018) Fadi Soukarieh et al.   JOURNAL OF MEDICINAL CHEMISTRY

In Silico and in Vitro-Guided Identification of Inhibitors of Alkylquinolone-Dependent Quorum Sensing in Pseudomonas aeruginosa

(2018) Fadi Soukarieh et al.   MOLECULES

Identification of FDA-approved drugs as antivirulence agents targeting the pqs quorum sensing system of Pseudomonas aeruginosa

(2018) Francesca D'Angelo et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Effect of efflux pump inhibition on Pseudomonas aeruginosa transcriptome and virulence

(2017) Giordano Rampioni et al.   Scientific Reports

Application of Dual Inhibition Concept within Looped Autoregulatory Systems toward Antivirulence Agents against Pseudomonas aeruginosa Infections

(2016) Andreas Thomann et al.   ACS Chemical Biology

Structure-Activity Relationships of 2-Sufonylpyrimidines as Quorum-Sensing Inhibitors to Tackle Biofilm Formation and eDNA Release ofPseudomonas aeruginosa

(2016) Andreas Thomann et al.   ChemMedChem

Quorum sensing signal–response systems in Gram-negative bacteria

(2016) Kai Papenfort et al.   NATURE REVIEWS MICROBIOLOGY

Pseudomonas aeruginosa Evolutionary Adaptation and Diversification in Cystic Fibrosis Chronic Lung Infections

(2016) Craig Winstanley et al.   TRENDS IN MICROBIOLOGY

LasR Variant Cystic Fibrosis Isolates Reveal an Adaptable Quorum-Sensing Hierarchy in Pseudomonas aeruginosa

(2016) John B. Feltner et al.   mBio

Is Quorum Sensing Interference a Viable Alternative to Treat Pseudomonas aeruginosa Infections?

(2016) Rodolfo García-Contreras   Frontiers in Microbiology

Pseudomonas aeruginosaquorum sensing molecules correlate with clinical status in cystic fibrosis

(2015) Helen L. Barr et al.   EUROPEAN RESPIRATORY JOURNAL

Toward Repositioning Niclosamide for Antivirulence Therapy of Pseudomonas aeruginosa Lung Infections: Development of Inhalable Formulations through Nanosuspension Technology

(2015) Gabriella Costabile et al.   MOLECULAR PHARMACEUTICS

High variability in quorum quenching and growth inhibition by furanone C-30 inPseudomonas aeruginosaclinical isolates from cystic fibrosis patients

(2015) Rodolfo García-Contreras et al.   Pathogens and Disease

The art of antibacterial warfare: Deception through interference with quorum sensing–mediated communication

(2014) Giordano Rampioni et al.   BIOORGANIC CHEMISTRY

Convergent evolution and adaptation of Pseudomonas aeruginosa within patients with cystic fibrosis

(2014) Rasmus Lykke Marvig et al.   NATURE GENETICS

Loss of Social Behaviours in Populations of Pseudomonas aeruginosa Infecting Lungs of Patients with Cystic Fibrosis

(2014) Natalie Jiricny et al.   PLoS One

Identification of Anti-virulence Compounds That Disrupt Quorum-Sensing Regulated Acute and Persistent Pathogenicity

(2014) Melissa Starkey et al.   PLoS Pathogens

Resistance to Quorum-Quenching Compounds

(2013) Rodolfo García-Contreras et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Structural Basis for Native Agonist and Synthetic Inhibitor Recognition by the Pseudomonas aeruginosa Quorum Sensing Regulator PqsR (MvfR)

(2013) Aravindan Ilangovan et al.   PLoS Pathogens

New Life for an Old Drug: the Anthelmintic Drug Niclosamide Inhibits Pseudomonas aeruginosa Quorum Sensing

(2012) F. Imperi et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The Multiple Signaling Systems Regulating Virulence in Pseudomonas aeruginosa

(2012) P. Nadal Jimenez et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Adaptation of Pseudomonas aeruginosa to the cystic fibrosis airway: an evolutionary perspective

(2012) Anders Folkesson et al.   NATURE REVIEWS MICROBIOLOGY

A multitask biosensor for micro-volumetric detection of N-3-oxo-dodecanoyl-homoserine lactone quorum sensing signal

(2011) Francesco Massai et al.   BIOSENSORS & BIOELECTRONICS

Quorum quenching quandary: resistance to antivirulence compounds

(2011) Toshinari Maeda et al.   ISME Journal

Quorum Sensing and Virulence of Pseudomonas aeruginosa during Lung Infection of Cystic Fibrosis Patients

(2010) Thomas Bjarnsholt et al.   PLoS One

Quorum sensing and environmental adaptation in Pseudomonas aeruginosa: a tale of regulatory networks and multifunctional signal molecules

(2009) Paul Williams et al.   CURRENT OPINION IN MICROBIOLOGY

Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America

(2008) Helen W. Boucher et al.   CLINICAL INFECTIOUS DISEASES

Pseudomonas aeruginosa lasR mutants are associated with cystic fibrosis lung disease progression

(2008) Lucas R. Hoffman et al.   Journal of Cystic Fibrosis

Federal Funding for the Study of Antimicrobial Resistance in Nosocomial Pathogens: No ESKAPE

(2008) Louis B. Rice   JOURNAL OF INFECTIOUS DISEASES