Class I Histone Deacetylase HDAC1 and WRN RECQ Helicase Contribute Additively to Protect Replication Forks upon Hydroxyurea-induced Arrest

A rapid and efficient method to purify proteins at replication forks under native conditions

(2016) Kai Him Thomas Leung et al.   BIOTECHNIQUES

Class I histone deacetylase inhibitors inhibit the retention of BRCA1 and 53BP1 at the site of DNA damage

(2015) Takayo Fukuda et al.   CANCER SCIENCE

DNA2 drives processing and restart of reversed replication forks in human cells

(2015) Saravanabhavan Thangavel et al.   JOURNAL OF CELL BIOLOGY

Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells

(2015) Ralph Zellweger et al.   JOURNAL OF CELL BIOLOGY

The Replication Checkpoint Prevents Two Types of Fork Collapse without Regulating Replisome Stability

(2015) Huzefa Dungrawala et al.   MOLECULAR CELL

Replication fork reversal in eukaryotes: from dead end to dynamic response

(2015) Kai J. Neelsen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The WRN exonuclease domain protects nascent strands from pathological MRE11/EXO1-dependent degradation

(2015) Chiara Iannascoli et al.   NUCLEIC ACIDS RESEARCH

A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging

(2015) W. Zhang et al.   SCIENCE

Human RecQ Helicases in DNA Repair, Recombination, and Replication

(2014) Deborah L. Croteau et al.   Annual Review of Biochemistry

DNA Replication and Oncogene-Induced Replicative Stress

(2014) Stephanie A. Hills et al.   CURRENT BIOLOGY

Identification of a large protein network involved in epigenetic transmission in replicating DNA of embryonic stem cells

(2014) Sergi Aranda et al.   NUCLEIC ACIDS RESEARCH

The causes of replication stress and their consequences on genome stability and cell fate

(2014) Indiana Magdalou et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

BRCA1 haploinsufficiency for replication stress suppression in primary cells

(2014) Shailja Pathania et al.   Nature Communications

Nonenzymatic Role for WRN in Preserving Nascent DNA Strands after Replication Stress

(2014) Fengtao Su et al.   Cell Reports

The physiological roles of histone deacetylase (HDAC) 1 and 2: complex co-stars with multiple leading parts

(2013) Richard D.W. Kelly et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Transcription and beyond: the role of mammalian class I lysine deacetylases

(2013) Mirjam Andrea Moser et al.   CHROMOSOMA

Identification of Proteins at Active, Stalled, and Collapsed Replication Forks Using Isolation of Proteins on Nascent DNA (iPOND) Coupled with Mass Spectrometry

(2013) Bianca M. Sirbu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Causes and consequences of replication stress

(2013) Michelle K. Zeman et al.   NATURE CELL BIOLOGY

Spectrum and Risk of Neoplasia in Werner Syndrome: A Systematic Review

(2013) Julia M. Lauper et al.   PLoS One

Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells

(2013) Ophir Shalem et al.   SCIENCE

Histone deacetylases 1 and 2 maintain S-phase chromatin and DNA replication fork progression

(2013) Srividya Bhaskara et al.   Epigenetics & Chromatin

The Replication Fork: Understanding the Eukaryotic Replication Machinery and the Challenges to Genome Duplication

(2013) Adam Leman et al.   Genes

A Distinct Replication Fork Protection Pathway Connects Fanconi Anemia Tumor Suppressors to RAD51-BRCA1/2

(2012) Katharina Schlacher et al.   CANCER CELL

Distinct functions of human RECQ helicases WRN and BLM in replication fork recovery and progression after hydroxyurea-induced stalling

(2012) Julia M. Sidorova et al.   DNA REPAIR

Monitoring the spatiotemporal dynamics of proteins at replication forks and in assembled chromatin using isolation of proteins on nascent DNA

(2012) Bianca M Sirbu et al.   Nature Protocols

ATR signalling: more than meeting at the fork

(2011) Edward A. Nam et al.   BIOCHEMICAL JOURNAL

Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11

(2011) Katharina Schlacher et al.   CELL

Analysis of protein dynamics at active, stalled, and collapsed replication forks

(2011) B. M. Sirbu et al.   GENES & DEVELOPMENT

Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes

(2011) Marcus Bantscheff et al.   NATURE BIOTECHNOLOGY

The Human WRN and BLM RecQ Helicases Differentially Regulate Cell Proliferation and Survival after Chemotherapeutic DNA Damage

(2010) F. J. Mao et al.   CANCER RESEARCH

The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrest

(2010) Julia M. Sidorova et al.   CELL CYCLE

Roles of Werner syndrome protein in protection of genome integrity

(2010) Marie L. Rossi et al.   DNA REPAIR

ATR and ATM differently regulate WRN to prevent DSBs at stalled replication forks and promote replication fork recovery

(2010) Francesca Ammazzalorso et al.   EMBO JOURNAL

Hydroxyurea-Stalled Replication Forks Become Progressively Inactivated and Require Two Different RAD51-Mediated Pathways for Restart and Repair

(2010) Eva Petermann et al.   MOLECULAR CELL

Pathways of mammalian replication fork restart

(2010) Eva Petermann et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Human HDAC1 and HDAC2 function in the DNA-damage response to promote DNA nonhomologous end-joining

(2010) Kyle M Miller et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Human RECQ helicases: Roles in DNA metabolism, mutagenesis and cancer biology

(2010) Raymond J. Monnat   SEMINARS IN CANCER BIOLOGY

Ageing-related chromatin defects through loss of the NURD complex

(2009) Gianluca Pegoraro et al.   NATURE CELL BIOLOGY

Microfluidic-assisted analysis of replicating DNA molecules

(2009) Julia M Sidorova et al.   Nature Protocols

Roles of the Werner syndrome RecQ helicase in DNA replication

(2008) Julia M. Sidorova   DNA REPAIR

Replication fork stalling in WRN-deficient cells is overcome by prompt activation of a MUS81-dependent pathway

(2008) Annapaola Franchitto et al.   JOURNAL OF CELL BIOLOGY