The WRN exonuclease domain protects nascent strands from pathological MRE11/EXO1-dependent degradation

DNA2 drives processing and restart of reversed replication forks in human cells

(2015) Saravanabhavan Thangavel et al.   JOURNAL OF CELL BIOLOGY

Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells

(2015) Ralph Zellweger et al.   JOURNAL OF CELL BIOLOGY

Replication fork reversal in eukaryotes: from dead end to dynamic response

(2015) Kai J. Neelsen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

FBH1 Catalyzes Regression of Stalled Replication Forks

(2015) Kasper Fugger et al.   Cell Reports

Replication fork recovery and regulation of common fragile sites stability

(2014) Annapaola Franchitto et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

DNA Replication and Oncogene-Induced Replicative Stress

(2014) Stephanie A. Hills et al.   CURRENT BIOLOGY

DNA2 Cooperates with the WRN and BLM RecQ Helicases to Mediate Long-range DNA End Resection in Human Cells

(2014) Andreas Sturzenegger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Checkpoint-dependent and independent roles of the Werner syndrome protein in preserving genome integrity in response to mild replication stress

(2014) Giorgia Basile et al.   NUCLEIC ACIDS RESEARCH

Phosphorylation of EXO1 by CDKs 1 and 2 regulates DNA end resection and repair pathway choice

(2014) Nozomi Tomimatsu et al.   Nature Communications

Nonenzymatic Role for WRN in Preserving Nascent DNA Strands after Replication Stress

(2014) Fengtao Su et al.   Cell Reports

ATR phosphorylates SMARCAL1 to prevent replication fork collapse

(2013) F. B. Couch et al.   GENES & DEVELOPMENT

Replication Stress-Induced Genome Instability: The Dark Side of Replication Maintenance by Homologous Recombination

(2013) Antony M. Carr et al.   JOURNAL OF MOLECULAR BIOLOGY

Human RECQ1 promotes restart of replication forks reversed by DNA topoisomerase I inhibition

(2013) Matteo Berti et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Identification and Characterization of SMARCAL1 Protein Complexes

(2013) Rémy Bétous et al.   PLoS One

A Distinct Replication Fork Protection Pathway Connects Fanconi Anemia Tumor Suppressors to RAD51-BRCA1/2

(2012) Katharina Schlacher et al.   CANCER CELL

The Intra-S Phase Checkpoint Targets Dna2 to Prevent Stalled Replication Forks from Reversing

(2012) Jiazhi Hu et al.   CELL

Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions

(2012) Nozomi Tomimatsu et al.   DNA REPAIR

Distinct functions of human RECQ helicases WRN and BLM in replication fork recovery and progression after hydroxyurea-induced stalling

(2012) Julia M. Sidorova et al.   DNA REPAIR

SMARCAL1 catalyzes fork regression and Holliday junction migration to maintain genome stability during DNA replication

(2012) R. Betous et al.   GENES & DEVELOPMENT

Topoisomerase I poisoning results in PARP-mediated replication fork reversal

(2012) Arnab Ray Chaudhuri et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The WRN and MUS81 proteins limit cell death and genome instability following oncogene activation

(2012) I Murfuni et al.   ONCOGENE

Complex Chromosomal Rearrangements Mediated by Break-Induced Replication Involve Structure-Selective Endonucleases

(2012) Benjamin Pardo et al.   PLoS Genetics

Identification of Specific Inhibitors of Human RAD51 Recombinase Using High-Throughput Screening

(2011) Fei Huang et al.   ACS Chemical Biology

The Werner and Bloom Syndrome Proteins Help Resolve Replication Blockage by Converting (Regressed) Holliday Junctions to Functional Replication Forks

(2011) Amrita Machwe et al.   BIOCHEMISTRY

Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11

(2011) Katharina Schlacher et al.   CELL

DNA end resection—Unraveling the tail

(2011) Eleni P. Mimitou et al.   DNA REPAIR

BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair

(2011) A. V. Nimonkar et al.   GENES & DEVELOPMENT

The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrest

(2010) Julia M. Sidorova et al.   CELL CYCLE

Roles of Werner syndrome protein in protection of genome integrity

(2010) Marie L. Rossi et al.   DNA REPAIR

ATR and ATM differently regulate WRN to prevent DSBs at stalled replication forks and promote replication fork recovery

(2010) Francesca Ammazzalorso et al.   EMBO JOURNAL

Pathways of mammalian replication fork restart

(2010) Eva Petermann et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cooperation of RAD51 and RAD54 in regression of a model replication fork

(2010) Dmitry V. Bugreev et al.   NUCLEIC ACIDS RESEARCH

PARP is activated at stalled forks to mediate Mre11-dependent replication restart and recombination

(2009) Helen E Bryant et al.   EMBO JOURNAL

Replication fork reversal and the maintenance of genome stability

(2009) J. Atkinson et al.   NUCLEIC ACIDS RESEARCH

Sgs1 Helicase and Two Nucleases Dna2 and Exo1 Resect DNA Double-Strand Break Ends

(2008) Zhu Zhu et al.   CELL

Roles of the Werner syndrome RecQ helicase in DNA replication

(2008) Julia M. Sidorova   DNA REPAIR

Characterizing proteins and their interactions in cells and tissues using the in situ proximity ligation assay

(2008) Ola Söderberg et al.   METHODS

A forward chemical genetic screen reveals an inhibitor of the Mre11–Rad50–Nbs1 complex

(2008) Aude Dupré et al.   Nature Chemical Biology