Transient Antibiotic Tolerance Triggered by Nutrient Shifts From Gluconeogenic Carbon Sources to Fatty Acid

The Canonical Long-Chain Fatty Acid Sensing Machinery Processes Arachidonic Acid To Inhibit Virulence in Enterohemorrhagic Escherichia coli

(2021) Melissa Ellermann et al.   mBio

Clinically relevant mutations in core metabolic genes confer antibiotic resistance

(2021) Allison J. Lopatkin et al.   SCIENCE

Bacterial persisters are a stochastically formed subpopulation of low-energy cells

(2021) Sylvie Manuse et al.   PLOS BIOLOGY

Designing an irreversible metabolic switch for scalable induction of microbial chemical production

(2021) Ahmad A. Mannan et al.   Nature Communications

PvrA is a novel regulator that contributes to Pseudomonas aeruginosa pathogenesis by controlling bacterial utilization of long chain fatty acids

(2020) Xiaolei Pan et al.   NUCLEIC ACIDS RESEARCH

Metabolite Sequestration Enables Rapid Recovery from Fatty Acid Depletion in Escherichia coli

(2020) Christopher J. Hartline et al.   mBio

Bacterial metabolic heterogeneity: origins and applications in engineering and infectious disease

(2020) Trent D Evans et al.   CURRENT OPINION IN BIOTECHNOLOGY

A universal trade-off between growth and lag in fluctuating environments

(2020) Markus Basan et al.   NATURE

Implications of initial physiological conditions for bacterial adaptation to changing environments

(2020) Matthias Heinemann et al.   Molecular Systems Biology

Bacterial persistence promotes the evolution of antibiotic resistance by increasing survival and mutation rates

(2019) Etthel Martha Windels et al.   ISME Journal

Definitions and guidelines for research on antibiotic persistence

(2019) Nathalie Q. Balaban et al.   NATURE REVIEWS MICROBIOLOGY

Bacterial Metabolism and Antibiotic Efficacy

(2019) Jonathan M. Stokes et al.   Cell Metabolism

Covalently-assembled single-chain protein nanostructures with ultra-high stability

(2019) Wenqin Bai et al.   Nature Communications

Birth and Resuscitation of (p)ppGpp Induced Antibiotic Tolerant Persister Cells

(2019) Mikkel Skjoldan Svenningsen et al.   Scientific Reports

Bacterial metabolic state more accurately predicts antibiotic lethality than growth rate

(2019) Allison J. Lopatkin et al.   Nature Microbiology

Global gene expression analysis of Escherichia coli K-12 DH5α after exposure to 2.4 GHz wireless fidelity radiation

(2019) Ilham H. Said-Salman et al.   Scientific Reports

Targeting Antibiotic Tolerance, Pathogen by Pathogen

(2018) Sylvain Meylan et al.   CELL

Metabolic Feedback Circuits Provide Rapid Control of Metabolite Dynamics

(2018) Di Liu et al.   ACS Synthetic Biology

The Glyoxylate Shunt, 60 Years On

(2018) Stephen K. Dolan et al.   Annual Review of Microbiology

Redox, amino acid, and fatty acid metabolism intersect with bacterial virulence in the gut

(2018) Reed Pifer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibiotic resistance: a rundown of a global crisis

(2018) Bilal Aslam et al.   Infection and Drug Resistance

Taking chances and making mistakes: non-genetic phenotypic heterogeneity and its consequences for surviving in dynamic environments

(2017) Coco van Boxtel et al.   Journal of the Royal Society Interface

Metabolic constraints on the evolution of antibiotic resistance

(2017) Mattia Zampieri et al.   Molecular Systems Biology

Antibiotic tolerance facilitates the evolution of resistance

(2017) Irit Levin-Reisman et al.   SCIENCE

ATP-Dependent Persister Formation in Escherichia coli

(2017) Yue Shan et al.   mBio

Engineering Microbial Metabolite Dynamics and Heterogeneity

(2017) Alexander C. Schmitz et al.   Biotechnology Journal

Bacterial persistence is an active σSstress response to metabolic flux limitation

(2016) Jakub Leszek Radzikowski et al.   Molecular Systems Biology

Exploiting nongenetic cell-to-cell variation for enhanced biosynthesis

(2016) Yi Xiao et al.   Nature Chemical Biology

Multigene Editing in the Escherichia coli Genome via the CRISPR-Cas9 System

(2015) Yu Jiang et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Persister Heterogeneity Arising from a Single Metabolic Stress

(2015) Stephanie M. Amato et al.   CURRENT BIOLOGY

Recent functional insights into the role of (p)ppGpp in bacterial physiology

(2015) Vasili Hauryliuk et al.   NATURE REVIEWS MICROBIOLOGY

Deciphering death: a commentary on Gompertz (1825) 'On the nature of the function expressive of the law of human mortality, and on a new mode of determining the value of life contingencies'

(2015) T. B. L. Kirkwood   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Stochastic induction of persister cells by HipA through (p)ppGpp-mediated activation of mRNA endonucleases

(2015) Elsa Germain et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of stationary phase respiration impairs persister formation in E. coli

(2015) Mehmet A. Orman et al.   Nature Communications

Phenotypic bistability in Escherichia coli's central carbon metabolism

(2014) O. Kotte et al.   Molecular Systems Biology

Optimization of lag time underlies antibiotic tolerance in evolved bacterial populations

(2014) Ofer Fridman et al.   NATURE

Nutrient Transitions Are a Source of Persisters in Escherichia coli Biofilms

(2014) Stephanie M. Amato et al.   PLoS One

The role of metabolism in bacterial persistence

(2014) Stephanie M. Amato et al.   Frontiers in Microbiology

Metabolic Control of Persister Formation in Escherichia coli

(2013) Stephanie M. Amato et al.   MOLECULAR CELL

Starvation, Together with the SOS Response, Mediates High Biofilm-Specific Tolerance to the Fluoroquinolone Ofloxacin

(2013) Steve P. Bernier et al.   PLoS Genetics

Design of a dynamic sensor-regulator system for production of chemicals and fuels derived from fatty acids

(2012) Fuzhong Zhang et al.   NATURE BIOTECHNOLOGY

Role of persister cells in chronic infections: clinical relevance and perspectives on anti-persister therapies

(2011) M. Fauvart et al.   JOURNAL OF MEDICAL MICROBIOLOGY

Metabolite-enabled eradication of bacterial persisters by aminoglycosides

(2011) Kyle R. Allison et al.   NATURE

BglBrick vectors and datasheets: A synthetic biology platform for gene expression

(2011) Taek Lee et al.   Journal of Biological Engineering

Emergence of Pseudomonas aeruginosa Strains Producing High Levels of Persister Cells in Patients with Cystic Fibrosis

(2010) L. R. Mulcahy et al.   JOURNAL OF BACTERIOLOGY

The Frequency of Persisters in Escherichia coli Reflects the Kinetics of Awakening from Dormancy

(2010) A. Joers et al.   JOURNAL OF BACTERIOLOGY

Functional roles for noise in genetic circuits

(2010) Avigdor Eldar et al.   NATURE

A synthetic three-color scaffold for monitoring genetic regulation and noise

(2010) Robert Cox et al.   Journal of Biological Engineering

Novel persistence genes inPseudomonas aeruginosaidentified by high-throughput screening

(2009) Valerie N. De Groote et al.   FEMS MICROBIOLOGY LETTERS

Timing and Dynamics of Single Cell Gene Expression in the Arabinose Utilization System

(2008) Judith A. Megerle et al.   BIOPHYSICAL JOURNAL

Growth ofMycobacterium tuberculosisbiofilms containing free mycolic acids and harbouring drug-tolerant bacteria

(2008) Anil K. Ojha et al.   MOLECULAR MICROBIOLOGY

Single-cell protein induction dynamics reveals a period of vulnerability to antibiotics in persister bacteria

(2008) O. Gefen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA