Bacterial metabolic state more accurately predicts antibiotic lethality than growth rate

A White-Box Machine Learning Approach for Revealing Antibiotic Mechanisms of Action

(2019) Jason H. Yang et al.   CELL

Robust, linear correlations between growth rates and β-lactam–mediated lysis rates

(2018) Anna J. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comparative activity of ceftriaxone, ciprofloxacin and gentamicin as a function of bacterial growth rate probed by Escherichia coli chromosome replication in the mouse peritonitis model

(2018) Maria Schei Haugan et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A global resource allocation strategy governs growth transition kinetics of Escherichia coli

(2017) David W. Erickson et al.   NATURE

ATP-Dependent Persister Formation in Escherichia coli

(2017) Yue Shan et al.   mBio

Persistence and reversal of plasmid-mediated antibiotic resistance

(2017) Allison J. Lopatkin et al.   Nature Communications

Nontargeted Metabolomics Reveals the Multilevel Response to Antibiotic Perturbations

(2017) Mattia Zampieri et al.   Cell Reports

Drivers of Bacterial Maintenance and Minimal Energy Requirements

(2017) Christopher P. Kempes et al.   Frontiers in Microbiology

Metabolic network architecture and carbon source determine metabolite production costs

(2016) Silvio Waschina et al.   FEBS Journal

Endless resistance. Endless antibiotics?

(2016) Jed F. Fisher et al.   MedChemComm

Growth-dependent bacterial susceptibility to ribosome-targeting antibiotics

(2015) P. Greulich et al.   Molecular Systems Biology

Overflow metabolism in Escherichia coli results from efficient proteome allocation

(2015) Markus Basan et al.   NATURE

Antibiotic efficacy is linked to bacterial cellular respiration

(2015) Michael A. Lobritz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antibiotics induce redox-related physiological alterations as part of their lethality

(2014) D. J. Dwyer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Environmental and stoichiometric controls on microbial carbon-use efficiency in soils

(2012) Stefano Manzoni et al.   NEW PHYTOLOGIST

Multiple Applications of Alamar Blue as an Indicator of Metabolic Function and Cellular Health in Cell Viability Bioassays

(2012) Sephra N. Rampersad   SENSORS

Multi-omics approach to study the growth efficiency and amino acid metabolism in Lactococcus lactis at various specific growth rates

(2011) Petri-Jaan Lahtvee et al.   Microbial Cell Factories

A comprehensive genome-scale reconstruction of Escherichia coli metabolism--2011

(2011) J. D. Orth et al.   Molecular Systems Biology

Quantitative prediction of cellular metabolism with constraint-based models: the COBRA Toolbox v2.0

(2011) Jan Schellenberger et al.   Nature Protocols

Shifts in growth strategies reflect tradeoffs in cellular economics

(2009) Douwe Molenaar et al.   Molecular Systems Biology

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

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