Exploiting nongenetic cell-to-cell variation for enhanced biosynthesis

Reinvigorating natural product combinatorial biosynthesis with synthetic biology

(2015) Eunji Kim et al.   Nature Chemical Biology

Stochasticity of metabolism and growth at the single-cell level

(2014) Daniel J. Kiviet et al.   NATURE

Microfluidic high-throughput culturing of single cells for selection based on extracellular metabolite production or consumption

(2014) Benjamin L Wang et al.   NATURE BIOTECHNOLOGY

Engineering synergy in biotechnology

(2014) Jens Nielsen et al.   Nature Chemical Biology

Semi-synthetic artemisinin: a model for the use of synthetic biology in pharmaceutical development

(2014) Chris J. Paddon et al.   NATURE REVIEWS MICROBIOLOGY

Transcript level and sequence determinants of protein abundance and noise in Escherichia coli

(2014) Joao C. Guimaraes et al.   NUCLEIC ACIDS RESEARCH

Evolution-guided optimization of biosynthetic pathways

(2014) Srivatsan Raman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Lost in Transition: Start-Up of Glycolysis Yields Subpopulations of Nongrowing Cells

(2014) J. H. van Heerden et al.   SCIENCE

Metabolic variability in bioprocessing: implications of microbial phenotypic heterogeneity

(2014) Frank Delvigne et al.   TRENDS IN BIOTECHNOLOGY

Harnessing Yarrowia lipolytica lipogenesis to create a platform for lipid and biofuel production

(2014) John Blazeck et al.   Nature Communications

Noise Propagation in Synthetic Gene Circuits for Metabolic Control

(2014) Diego A. Oyarzún et al.   ACS Synthetic Biology

Next generation biofuel engineering in prokaryotes

(2013) Luisa S Gronenberg et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Engineering dynamic pathway regulation using stress-response promoters

(2013) Robert H Dahl et al.   NATURE BIOTECHNOLOGY

Metabolic engineering of Escherichia coli using synthetic small regulatory RNAs

(2013) Dokyun Na et al.   NATURE BIOTECHNOLOGY

Heterogeneity in protein expression induces metabolic variability in a modeledEscherichia colipopulation

(2013) Piyush Labhsetwar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Single-Cell Metabolomics: Analytical and Biological Perspectives

(2013) R. Zenobi   SCIENCE

Metabolic Engineering: Past and Future

(2013) Benjamin M. Woolston et al.   Annual Review of Chemical and Biomolecular Engineering

Modular optimization of multi-gene pathways for fatty acids production in E. coli

(2013) Peng Xu et al.   Nature Communications

Programming adaptive control to evolve increased metabolite production

(2013) Howard H. Chou et al.   Nature Communications

Negative Feedback Regulation of Fatty Acid Production Based on a Malonyl-CoA Sensor–Actuator

(2013) Di Liu et al.   ACS Synthetic Biology

The development and application of a single-cell biosensor for the detection of l-methionine and branched-chain amino acids

(2012) Nurije Mustafi et al.   METABOLIC ENGINEERING

Design of a dynamic sensor-regulator system for production of chemicals and fuels derived from fatty acids

(2012) Fuzhong Zhang et al.   NATURE BIOTECHNOLOGY

Fluorescence Imaging of Cellular Metabolites with RNA

(2012) Jeremy S. Paige et al.   SCIENCE

Transcription Factor-Based Screens and Synthetic Selections for Microbial Small-Molecule Biosynthesis

(2012) Jeffrey A. Dietrich et al.   ACS Synthetic Biology

Modular Engineering of l-Tyrosine Production in Escherichia coli

(2011) Darmawi Juminaga et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Experimental methods and modeling techniques for description of cell population heterogeneity

(2011) R. Lencastre Fernandes et al.   BIOTECHNOLOGY ADVANCES

Central dogma at the single-molecule level in living cells

(2011) Gene-Wei Li et al.   NATURE

Biosensors and their applications in microbial metabolic engineering

(2011) Fuzhong Zhang et al.   TRENDS IN MICROBIOLOGY

BglBrick vectors and datasheets: A synthetic biology platform for gene expression

(2011) Taek Lee et al.   Journal of Biological Engineering

All genomic mutations in the antimicrobial surfactant-resistant mutant, Escherichia coli OW66, are involved in cell resistance to surfactant

(2010) Kunihiro Nakata et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Origin and analysis of microbial population heterogeneity in bioprocesses

(2010) Susann Müller et al.   CURRENT OPINION IN BIOTECHNOLOGY

The role of physiological heterogeneity in microbial population behavior

(2010) Mary E Lidstrom et al.   Nature Chemical Biology

RNA polymerase mutants found through adaptive evolution reprogram Escherichia coli for optimal growth in minimal media

(2010) T. M. Conrad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Manufacturing Molecules Through Metabolic Engineering

(2010) J. D. Keasling   SCIENCE

Quantifying E. coli Proteome and Transcriptome with Single-Molecule Sensitivity in Single Cells

(2010) Y. Taniguchi et al.   SCIENCE

Microbial Biosynthesis of Alkanes

(2010) A. Schirmer et al.   SCIENCE

Transgenerational Epigenetic Inheritance: Prevalence, Mechanisms, and Implications for the Study of Heredity and Evolution

(2009) Eva Jablonka et al.   QUARTERLY REVIEW OF BIOLOGY

Bistability, Epigenetics, and Bet-Hedging in Bacteria

(2008) Jan-Willem Veening et al.   Annual Review of Microbiology

Overproduction of free fatty acids in E. coli: Implications for biodiesel production

(2008) Xuefeng Lu et al.   METABOLIC ENGINEERING

A One Pot, One Step, Precision Cloning Method with High Throughput Capability

(2008) Carola Engler et al.   PLoS One