Activation of the CaMKII-Sarm1-ASK1-p38 MAP kinase pathway protects against axon degeneration caused by loss of mitochondria

Metaxins are core components of mitochondrial transport adaptor complexes

(2021) Yinsuo Zhao et al.   Nature Communications

Preservation of vision after CaMKII-mediated protection of retinal ganglion cells

(2021) Xinzheng Guo et al.   CELL

Calsyntenin-3 interacts with both α- and β-neurexins in the regulation of excitatory synaptic innervation in specific Schaffer collateral pathways

(2020) Hyeonho Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloidogenic processing of amyloid β protein precursor (APP) is enhanced in the brains of Alcadein α-deficient mice

(2020) Naoya Gotoh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TRPV4 disrupts mitochondrial transport and causes axonal degeneration via a CaMKII-dependent elevation of intracellular Ca2+

(2020) Brian M. Woolums et al.   Nature Communications

Melting dsDNA Donor Molecules Greatly Improves Precision Genome Editing in Caenorhabditis elegans

(2020) Krishna S. Ghanta et al.   GENETICS

Injury-Induced Inhibition of Bystander Neurons Requires dSarm and Signaling from Glia

(2020) Jiun-Min Hsu et al.   NEURON

NATF (Native And Tissue-Specific Fluorescence): A Strategy for Bright, Tissue-Specific GFP Labeling of Native Proteins in Caenorhabditis elegans

(2019) Siwei He et al.   GENETICS

Innervation of thermogenic adipose tissue via a calsyntenin 3β–S100b axis

(2019) Xing Zeng et al.   NATURE

Structural Evidence for an Octameric Ring Arrangement of SARM1

(2019) Michael Sporny et al.   JOURNAL OF MOLECULAR BIOLOGY

NAD+ cleavage activity by animal and plant TIR domains in cell death pathways

(2019) Shane Horsefield et al.   SCIENCE

DLK Activation Synergizes with Mitochondrial Dysfunction to Downregulate Axon Survival Factors and Promote SARM1-Dependent Axon Degeneration

(2019) Daniel W. Summers et al.   MOLECULAR NEUROBIOLOGY

Axonal transport: Driving synaptic function

(2019) Pedro Guedes-Dias et al.   SCIENCE

Mitochondrial impairment activates the Wallerian pathway through depletion of NMNAT2 leading to SARM1-dependent axon degeneration

(2019) Andrea Loreto et al.   NEUROBIOLOGY OF DISEASE

Converging cellular themes for the hereditary spastic paraplegias

(2018) Craig Blackstone   CURRENT OPINION IN NEUROBIOLOGY

Loss of Sarm1 does not suppress motor neuron degeneration in the SOD1G93A mouse model of amyotrophic lateral sclerosis

(2018) Owen M Peters et al.   HUMAN MOLECULAR GENETICS

UNC-16/JIP3 and UNC-76/FEZ1 limit the density of mitochondria in C. elegans neurons by maintaining the balance of anterograde and retrograde mitochondrial transport

(2018) Guruprasada Reddy Sure et al.   Scientific Reports

The C-terminal of CASY-1/Calsyntenin regulates GABAergic synaptic transmission at the Caenorhabditis elegans neuromuscular junction

(2018) Shruti Thapliyal et al.   PLoS Genetics

New insights into the complex role of mitochondria in Parkinson’s disease

(2018) Anne Grünewald et al.   PROGRESS IN NEUROBIOLOGY

Aberrant information transfer interferes with functional axon regeneration

(2018) Chen Ding et al.   eLife

CaMKII Isoforms in Learning and Memory: Localization and Function

(2018) Gisela Zalcman et al.   Frontiers in Molecular Neuroscience

Deletion of Sarm1 gene is neuroprotective in two models of peripheral neuropathy

(2017) Elliot Turkiew et al.   JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM

Axon Death Pathways Converge on Axundead to Promote Functional and Structural Axon Disassembly

(2017) Lukas J. Neukomm et al.   NEURON

The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD + Cleavage Activity that Promotes Pathological Axonal Degeneration

(2017) Kow Essuman et al.   NEURON

The Kinesin Adaptor Calsyntenin-1 Organizes Microtubule Polarity and Regulates Dynamics during Sensory Axon Arbor Development

(2017) Tristan J. Lee et al.   Frontiers in Cellular Neuroscience

MAPK signaling promotes axonal degeneration by speeding the turnover of the axonal maintenance factor NMNAT2

(2017) Lauren J Walker et al.   eLife

Attenuated traumatic axonal injury and improved functional outcome after traumatic brain injury in mice lackingSarm1

(2016) Nils Henninger et al.   BRAIN

Calsyntenin 1-mediated trafficking of axon guidance receptors regulates the switch in axonal responsiveness at a choice point

(2016) Tobias A. Alther et al.   DEVELOPMENT

The role of calsyntenin-3 in dystrophic neurite formation in Alzheimer's disease brain

(2016) Yoko Uchida et al.   Geriatrics & Gerontology International

The Galaxy platform for accessible, reproducible and collaborative biomedical analyses: 2016 update

(2016) Enis Afgan et al.   NUCLEIC ACIDS RESEARCH

Stochastic left–right neuronal asymmetry inCaenorhabditis elegans

(2016) Amel Alqadah et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

SARM1-specific motifs in the TIR domain enable NAD+loss and regulate injury-induced SARM1 activation

(2016) Daniel W. Summers et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Apoptotic Engulfment Machinery Regulates Axonal Degeneration in C. elegans Neurons

(2016) Annika L.A. Nichols et al.   Cell Reports

SLO BK Potassium Channels Couple Gap Junctions to Inhibition of Calcium Signaling in Olfactory Neuron Diversification

(2016) Amel Alqadah et al.   PLoS Genetics

Pathological Axonal Death through a MAPK Cascade that Triggers a Local Energy Deficit

(2015) Jing Yang et al.   CELL

The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

(2015) Alicia M. Pickrell et al.   NEURON

Cognitive Deficits in Calsyntenin-2-deficient Mice Associated with Reduced GABAergic Transmission

(2015) Tatiana V Lipina et al.   NEUROPSYCHOPHARMACOLOGY

SARM1 activation triggers axon degeneration locally via NAD+ destruction

(2015) J. Gerdts et al.   SCIENCE

Neurodegeneration in C. elegans models of ALS requires TIR-1/Sarm1 immune pathway activation in neurons

(2015) Julie Vérièpe et al.   Nature Communications

Tissue Expression Pattern of PMK-2 p38 MAPK Is Established by the miR-58 Family in C. elegans

(2015) Daniel J. Pagano et al.   PLoS Genetics

Axons Degenerate in the Absence of Mitochondria in C. elegans

(2014) Randi L. Rawson et al.   CURRENT BIOLOGY

Cytoplasmic Fragment of Alcadein α Generated by Regulated Intramembrane Proteolysis Enhances Amyloid β-Protein Precursor (APP) Transport into the Late Secretory Pathway and Facilitates APP Cleavage

(2014) Norio Takei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calsyntenin-1 Regulates Targeting of Dendritic NMDA Receptors and Dendritic Spine Maturation in CA1 Hippocampal Pyramidal Cells during Postnatal Development

(2014) J. Ster et al.   JOURNAL OF NEUROSCIENCE

Calsyntenin-1 Regulates Axon Branching and Endosomal Trafficking during Sensory Neuron Development In Vivo

(2014) O. Y. Ponomareva et al.   JOURNAL OF NEUROSCIENCE

Mitochondrial Dysfunction Induces Sarm1-Dependent Cell Death in Sensory Neurons

(2014) D. W. Summers et al.   JOURNAL OF NEUROSCIENCE

CaMKII: Claiming Center Stage in Postsynaptic Function and Organization

(2014) Johannes W. Hell   NEURON

Role of synaptic phosphatidylinositol 3-kinase in a behavioral learning response in C. elegans

(2014) H. Ohno et al.   SCIENCE

Sarm1-Mediated Axon Degeneration Requires Both SAM and TIR Interactions

(2013) J. Gerdts et al.   JOURNAL OF NEUROSCIENCE

Dominant optic atrophy, OPA1, and mitochondrial quality control: understanding mitochondrial network dynamics

(2013) Marcel V Alavi et al.   Molecular Neurodegeneration

The Caenorhabditis elegans voltage-gated calcium channel subunits UNC-2 and UNC-36 and the calcium-dependent kinase UNC-43/CaMKII regulate neuromuscular junction morphology

(2013) Raymond C Caylor et al.   Neural Development

The Specific α-Neurexin Interactor Calsyntenin-3 Promotes Excitatory and Inhibitory Synapse Development

(2013) Katherine L. Pettem et al.   NEURON

Mitochondrial Trafficking in Neurons

(2013) T. L. Schwarz   Cold Spring Harbor Perspectives in Biology

Anoxia-Reoxygenation Regulates Mitochondrial Dynamics through the Hypoxia Response Pathway, SKN-1/Nrf, and Stomatin-Like Protein STL-1/SLP-2

(2013) Piya Ghose et al.   PLoS Genetics

CaMKII binding to GluN2B is critical during memory consolidation

(2012) Amy R Halt et al.   EMBO JOURNAL

Calsyntenin-1 mediates axonal transport of the amyloid precursor protein and regulates A  production

(2012) A. Vagnoni et al.   HUMAN MOLECULAR GENETICS

Role of Rhodopsin and Arrestin Phosphorylation in Retinal Degeneration of Drosophila

(2012) I. Kristaponyte et al.   JOURNAL OF NEUROSCIENCE

Fast gapped-read alignment with Bowtie 2

(2012) Ben Langmead et al.   NATURE METHODS

dSarm/Sarm1 Is Required for Activation of an Injury-Induced Axon Death Pathway

(2012) J. M. Osterloh et al.   SCIENCE

Calsyntenin-1 shelters APP from proteolytic processing during anterograde axonal transport

(2012) M. Steuble et al.   Biology Open

Targeting of pro-apoptotic TLR adaptor SARM to mitochondria: definition of the critical region and residues in the signal sequence

(2011) Porkodi Panneerselvam et al.   BIOCHEMICAL JOURNAL

Voltage-Gated Calcium Channels

(2011) W. A. Catterall   Cold Spring Harbor Perspectives in Biology

In vivo Laser Axotomy in C. elegans

(2011) Alexandra B. Byrne et al.   Jove-Journal of Visualized Experiments

Calcium Dysregulation and Homeostasis of Neural Calcium in the Molecular Mechanisms of Neurodegenerative Diseases Provide Multiple Targets for Neuroprotection

(2010) Gregor Zündorf et al.   ANTIOXIDANTS & REDOX SIGNALING

Mitochondrial calcium channels

(2010) Uta C. Hoppe   FEBS LETTERS

Jalview Version 2--a multiple sequence alignment editor and analysis workbench

(2009) A. M. Waterhouse et al.   BIOINFORMATICS

The DLK-1 Kinase Promotes mRNA Stability and Local Translation in C. elegans Synapses and Axon Regeneration

(2009) Dong Yan et al.   CELL

Alcadein Cleavages by Amyloid β-Precursor Protein (APP) α- and γ-Secretases Generate Small Peptides, p3-Alcs, Indicating Alzheimer Disease-related γ-Secretase Dysfunction

(2009) Saori Hata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

What is the mitochondrial permeability transition pore?

(2009) Andrew P. Halestrap   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

CaMKII phosphorylates collapsin response mediator protein 2 and modulates axonal damage during glutamate excitotoxicity

(2009) Sheng T. Hou et al.   JOURNAL OF NEUROCHEMISTRY

CaMKII associates with CaV1.2 L-type calcium channels via selected β subunits to enhance regulatory phosphorylation

(2009) Sunday A. Abiria et al.   JOURNAL OF NEUROCHEMISTRY

Calcium signaling in neurodegeneration

(2009) Philippe Marambaud et al.   Molecular Neurodegeneration

Enzymatic assembly of DNA molecules up to several hundred kilobases

(2009) Daniel G Gibson et al.   NATURE METHODS

Heterosynaptic Molecular Dynamics: Locally Induced Propagating Synaptic Accumulation of CaM Kinase II

(2009) Jacqueline Rose et al.   NEURON

KIBRA and CLSTN2 polymorphisms exert interactive effects on human episodic memory

(2009) Claudia Preuschhof et al.   NEUROPSYCHOLOGIA

Calsyntenins Mediate TGN Exit of APP in a Kinesin-1-Dependent Manner

(2009) Alexander Ludwig et al.   TRAFFIC

Calcium signaling and neurodegenerative diseases

(2009) Ilya Bezprozvanny   TRENDS IN MOLECULAR MEDICINE