Injury-Induced Inhibition of Bystander Neurons Requires dSarm and Signaling from Glia

Structural and Mechanistic Regulation of the Pro-degenerative NAD Hydrolase SARM1

(2020) Matthew Bratkowski et al.   Cell Reports

Gene therapy targeting SARM1 blocks pathological axon degeneration in mice

(2019) Stefanie Geisler et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Functional and structural damage of neurons by innate immune mechanisms during neurodegeneration

(2018) Christina Ising et al.   Cell Death & Disease

Sarm1/Myd88-5 Regulates Neuronal Intrinsic Immune Response to Traumatic Axonal Injuries

(2018) Qi Wang et al.   Cell Reports

Pharmacological bypass of NAD+ salvage pathway protects neurons from chemotherapy-induced degeneration

(2018) Hui-wen Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An expanded toolkit for gene tagging based on MiMIC and scarless CRISPR tagging in Drosophila

(2018) David Li-Kroeger et al.   eLife

Deletion of Sarm1 gene is neuroprotective in two models of peripheral neuropathy

(2017) Elliot Turkiew et al.   JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Intracellular calcium release through IP 3 R or RyR contributes to secondary axonal degeneration

(2017) Ben C. Orem et al.   NEUROBIOLOGY OF DISEASE

Axon Death Pathways Converge on Axundead to Promote Functional and Structural Axon Disassembly

(2017) Lukas J. Neukomm et al.   NEURON

The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD + Cleavage Activity that Promotes Pathological Axonal Degeneration

(2017) Kow Essuman et al.   NEURON

Axon degeneration induces glial responses through Draper-TRAF4-JNK signalling

(2017) Tsai-Yi Lu et al.   Nature Communications

A novel Drosophila injury model reveals severed axons are cleared through a Draper/MMP-1 signaling cascade

(2017) Maria D Purice et al.   eLife

MAPK signaling promotes axonal degeneration by speeding the turnover of the axonal maintenance factor NMNAT2

(2017) Lauren J Walker et al.   eLife

Axonal Degeneration in Tauopathies: Disease Relevance and Underlying Mechanisms

(2017) Andrew Kneynsberg et al.   Frontiers in Neuroscience

Attenuated traumatic axonal injury and improved functional outcome after traumatic brain injury in mice lackingSarm1

(2016) Nils Henninger et al.   BRAIN

Nmnat 1: a Security Guard of Retinal Ganglion Cells (RGCs) in Response to High Glucose Stress

(2016) Rong-Mei Zhou et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Progressive Decrease of Mitochondrial Motility during Maturation of Cortical Axons In Vitro and In Vivo

(2016) Tommy L. Lewis et al.   CURRENT BIOLOGY

A Defensive Kicking Behavior in Response to Mechanical Stimuli Mediated by Drosophila Wing Margin Bristles

(2016) J. Li et al.   JOURNAL OF NEUROSCIENCE

Axon Self-Destruction: New Links among SARM1, MAPKs, and NAD+ Metabolism

(2016) Josiah Gerdts et al.   NEURON

Traumatic Axonal Injury: Mechanisms and Translational Opportunities

(2016) Ciaran S. Hill et al.   TRENDS IN NEUROSCIENCES

Functional Gustatory Role of Chemoreceptors in Drosophila Wings

(2016) Hussein Raad et al.   Cell Reports

Neuroprotection mediated by inhibition of calpain during acute viral encephalitis

(2016) Charles L. Howe et al.   Scientific Reports

Pathological Axonal Death through a MAPK Cascade that Triggers a Local Energy Deficit

(2015) Jing Yang et al.   CELL

SARM1 activation triggers axon degeneration locally via NAD+ destruction

(2015) J. Gerdts et al.   SCIENCE

Absence of SARM1 Rescues Development and Survival of NMNAT2-Deficient Axons

(2015) Jonathan Gilley et al.   Cell Reports

Wallerian Degeneration Is Executed by an NMN-SARM1-Dependent Late Ca 2+ Influx but Only Modestly Influenced by Mitochondria

(2015) Andrea Loreto et al.   Cell Reports

A Voltage-Gated Calcium Channel Regulates Lysosomal Fusion with Endosomes and Autophagosomes and Is Required for Neuronal Homeostasis

(2015) Xuejun Tian et al.   PLOS BIOLOGY

A rise in NAD precursor nicotinamide mononucleotide (NMN) after injury promotes axon degeneration

(2014) M Di Stefano et al.   CELL DEATH AND DIFFERENTIATION

Rapid in vivo forward genetic approach for identifying axon death genes inDrosophila

(2014) Lukas J. Neukomm et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PI3K Signaling and Stat92E Converge to Modulate Glial Responsiveness to Axonal Injury

(2014) Johnna Doherty et al.   PLOS BIOLOGY

Sarm1-Mediated Axon Degeneration Requires Both SAM and TIR Interactions

(2013) J. Gerdts et al.   JOURNAL OF NEUROSCIENCE

Deletions within its subcellular targeting domain enhance the axon protective capacity of Nmnat2 in vivo

(2013) Stefan Milde et al.   Scientific Reports

The Phr1 Ubiquitin Ligase Promotes Injury-Induced Axon Self-Destruction

(2013) Elisabetta Babetto et al.   Cell Reports

A Novel Drosophila Model of Nerve Injury Reveals an Essential Role of Nmnat in Maintaining Axonal Integrity

(2012) Yanshan Fang et al.   CURRENT BIOLOGY

Axon degeneration in Parkinson's disease

(2012) Robert E. Burke et al.   EXPERIMENTAL NEUROLOGY

Electrophysiological Abnormalities in Both Axotomized and Nonaxotomized Pyramidal Neurons following Mild Traumatic Brain Injury

(2012) J. E. Greer et al.   JOURNAL OF NEUROSCIENCE

MEGF10 and MEGF11 mediate homotypic interactions required for mosaic spacing of retinal neurons

(2012) Jeremy N. Kay et al.   NATURE

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

(2012) Robert D. Bell et al.   NATURE

Negative regulation of glial engulfment activity by Draper terminates glial responses to axon injury

(2012) Mary A Logan et al.   NATURE NEUROSCIENCE

dSarm/Sarm1 Is Required for Activation of an Injury-Induced Axon Death Pathway

(2012) J. M. Osterloh et al.   SCIENCE

The Highwire Ubiquitin Ligase Promotes Axonal Degeneration by Tuning Levels of Nmnat Protein

(2012) Xin Xiong et al.   PLOS BIOLOGY

Matrix Metalloproteinases Are Associated With Increased Blood–Brain Barrier Opening in Vascular Cognitive Impairment

(2011) Eduardo Candelario-Jalil et al.   STROKE

Activation of autophagy during cell death requires the engulfment receptor Draper

(2010) Christina K. McPhee et al.   NATURE

Altered functional connectivity in the motor network after traumatic brain injury

(2010) M. Kasahara et al.   NEUROLOGY

Endogenous Nmnat2 Is an Essential Survival Factor for Maintenance of Healthy Axons

(2010) Jonathan Gilley et al.   PLOS BIOLOGY

Ensheathing Glia Function as Phagocytes in the Adult Drosophila Brain

(2009) J. Doherty et al.   JOURNAL OF NEUROSCIENCE

Glial precursors clear sensory neuron corpses during development via Jedi-1, an engulfment receptor

(2009) Hsiao-Huei Wu et al.   NATURE NEUROSCIENCE

c-Jun is a negative regulator of myelination

(2008) David B. Parkinson et al.   JOURNAL OF CELL BIOLOGY