Inflammatory response in hematopoietic stem and progenitor cells triggered by activating SHP2 mutations evokes blood defects

Heterogeneous disease-propagating stem cells in juvenile myelomonocytic leukemia

(2021) Eleni Louka et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Modeling Inflammation in Zebrafish for the Development of Anti-inflammatory Drugs

(2021) Yufei Xie et al.   Frontiers in Cell and Developmental Biology

Exploring the genetic and epigenetic origins of juvenile myelomonocytic leukemia using newborn screening samples

(2021) Astrid Behnert et al.   LEUKEMIA

Germline-Activating RRAS2 Mutations Cause Noonan Syndrome

(2019) Tetsuya Niihori et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Zebrafish: Housing and husbandry recommendations

(2019) Peter Aleström et al.   LABORATORY ANIMALS

More Than Suppression: Glucocorticoid Action on Monocytes and Macrophages

(2019) Jan M. Ehrchen et al.   Frontiers in Immunology

Despite mutation acquisition in hematopoietic stem cells, JMML-propagating cells are not always restricted to this compartment

(2019) Aurélie Caye et al.   LEUKEMIA

The Rasopathy family: Consequences of germline activation of the RAS/MAPK pathway

(2018) Mylène Tajan et al.   ENDOCRINE REVIEWS

FateID infers cell fate bias in multipotent progenitors from single-cell RNA-seq data

(2018) Josip S Herman et al.   NATURE METHODS

Hematopoietic-restricted Ptpn11E76K reveals indolent MPN progression in mice

(2018) Stefan P. Tarnawsky et al.   Oncotarget

The zebrafish: A fintastic model for hematopoietic development and disease

(2018) Aniket V. Gore et al.   Wiley Interdisciplinary Reviews-Developmental Biology

The Critical Role of Inflammation in the Pathogenesis and Progression of Myeloid Malignancies

(2018) Brianna Craver et al.   Cancers

Effective CRISPR/Cas9-based nucleotide editing in zebrafish to model human genetic cardiovascular disorders

(2018) Federico Tessadori et al.   Disease Models & Mechanisms

Hif-1α–Induced Expression of Il-1β Protects against Mycobacterial Infection in Zebrafish

(2018) Nikolay V. Ogryzko et al.   JOURNAL OF IMMUNOLOGY

Shp2–Mitogen-Activated Protein Kinase Signaling Drives Proliferation during Zebrafish Embryo Caudal Fin Fold Regeneration

(2017) Alexander James Hale et al.   MOLECULAR AND CELLULAR BIOLOGY

Single-cell sequencing reveals dissociation-induced gene expression in tissue subpopulations

(2017) Susanne C van den Brink et al.   NATURE METHODS

Single-cell imaging of normal and malignant cell engraftment into optically clear prkdc -null SCID zebrafish

(2016) John C. Moore et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Leukaemogenic effects of Ptpn11 activating mutations in the stem cell microenvironment

(2016) Lei Dong et al.   NATURE

Ex vivo tools for the clonal analysis of zebrafish hematopoiesis

(2016) Ondrej Svoboda et al.   Nature Protocols

A Single-Cell Transcriptome Atlas of the Human Pancreas

(2016) Mauro J. Muraro et al.   Cell Systems

SHP2 sails from physiology to pathology

(2015) Mylène Tajan et al.   European Journal of Medical Genetics

Juvenile myelomonocytic leukemia displays mutations in components of the RAS pathway and the PRC2 network

(2015) Aurélie Caye et al.   NATURE GENETICS

Myeloid Dysregulation in a Human Induced Pluripotent Stem Cell Model of PTPN11 -Associated Juvenile Myelomonocytic Leukemia

(2015) Sonia Mulero-Navarro et al.   Cell Reports

Zebrafish eaf1 suppresses foxo3b expression to modulate transcriptional activity of gata1 and spi1 in primitive hematopoiesis

(2014) Bo Hu et al.   DEVELOPMENTAL BIOLOGY

Juvenile myelomonocytic leukaemia and Noonan syndrome

(2014) Marion Strullu et al.   JOURNAL OF MEDICAL GENETICS

PZR Coordinates Shp2 Noonan and LEOPARD Syndrome Signaling in Zebrafish and Mice

(2014) J. Paardekooper Overman et al.   MOLECULAR AND CELLULAR BIOLOGY

Validation of noise models for single-cell transcriptomics

(2014) Dominic Grün et al.   NATURE METHODS

Optimized cell transplantation using adult rag2 mutant zebrafish

(2014) Qin Tang et al.   NATURE METHODS

Distinct and Overlapping Functions of ptpn11 Genes in Zebrafish Development

(2014) Monica Bonetti et al.   PLoS One

Efficient Mutagenesis by Cas9 Protein-Mediated Oligonucleotide Insertion and Large-Scale Assessment of Single-Guide RNAs

(2014) James A. Gagnon et al.   PLoS One

The RASopathies

(2013) Katherine A. Rauen   Annual Review of Genomics and Human Genetics

Pivotal role of Pten in the balance between proliferation and differentiation of hematopoietic stem cells in zebrafish

(2013) S. Choorapoikayil et al.   BLOOD

The zebrafish granulocyte colony-stimulating factors (Gcsfs): 2 paralogous cytokines and their roles in hematopoietic development and maintenance

(2013) D. L. Stachura et al.   BLOOD

Identification and Functional Characterization of Cardiac Pacemaker Cells in Zebrafish

(2012) Federico Tessadori et al.   PLoS One

Haploinsufficiency of the genes encoding the tumor suppressor Pten predisposes zebrafish to hemangiosarcoma

(2011) S. Choorapoikayil et al.   Disease Models & Mechanisms

Noonan syndrome gain-of-function mutations in NRAS cause zebrafish gastrulation defects

(2011) V. Runtuwene et al.   Disease Models & Mechanisms

Non–lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatasePtpn11(Shp2) on malignant transformation of hematopoietic cells

(2011) Dan Xu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

mpeg1 promoter transgenes direct macrophage-lineage expression in zebrafish

(2010) F. Ellett et al.   BLOOD

Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis

(2009) G. Chan et al.   BLOOD

ccbe1 is required for embryonic lymphangiogenesis and venous sprouting

(2009) Benjamin M Hogan et al.   NATURE GENETICS

Noonan syndrome cardiac defects are caused by PTPN11 acting in endocardium to enhance endocardial-mesenchymal transformation

(2009) T. Araki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA