A Narrative Review of the Antitumor Activity of Monoterpenes from Essential Oils: An Update

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2021) Hyuna Sung et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Apoptotic effect of β-pinene on oral squamous cell carcinoma as one of the major compounds from essential oil of medicinal plant Piper rivinoides Kunth

(2021) Thaíssa Queiróz Machado et al.   NATURAL PRODUCT RESEARCH

Chemopreventive Potential of Myrtenal against Nitrosamine-Initiated, Radiation-Promoted Rat Bladder Carcinogenesis

(2021) Mostafa A. Farrag et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Antioxidant Properties of Camphene-Based Thiosemicarbazones: Experimental and Theoretical Evaluation

(2020) Lijuan Yang et al.   MOLECULES

R-(-)-carvone Attenuated Doxorubicin Induced Cardiotoxicity In Vivo and Potentiated Its Anticancer Toxicity In Vitro

(2020) Manal Mohammad Abbas et al.   Balkan Medical Journal

Proapoptotic Activity of Achillea membranacea Essential Oil and Its Major Constituent 1,8-Cineole against A2780 Ovarian Cancer Cells

(2020) Ashraf N. Abdalla et al.   MOLECULES

Comparison of ultrastructural changes and the anticarcinogenic effects of thymol and carvacrol on ovarian cancer cells: which is more effective?

(2020) Hulya Elbe et al.   ULTRASTRUCTURAL PATHOLOGY

Citral Induced Apoptosis through Modulation of Key Genes Involved in Fatty Acid Biosynthesis in Human Prostate Cancer Cells: In Silico and In Vitro Study

(2020) Sri Renukadevi Balusamy et al.   Biomed Research International

Citronellol, an Acyclic Monoterpene Induces Mitochondrial-Mediated Apoptosis through Activation of Proapoptotic Factors in MCF-7 and MDA-MB-231 Human Mammary Tumor Cells

(2020) Jayaganesh Rajendran et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

p-Cymene and Rosmarinic Acid Ameliorate TNBS-Induced Intestinal Inflammation Upkeeping ZO-1 and MUC-2: Role of Antioxidant System and Immunomodulation

(2020) Rodrigo de Oliveira Formiga et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Evaluation of Apoptosis Pathway of Geraniol on Ishikawa Cells

(2020) Betül Kuzu et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Thymol induces mitochondrial pathway-mediated apoptosis via ROS generation, macromolecular damage and SOD diminution in A549 cells

(2020) Devasahayam Jaya Balan et al.   Pharmacological Reports

Natural Products Targeting the Mitochondria in Cancers

(2020) Yue Yang et al.   MOLECULES

Antifungal activity and antidiarrheal activity via antimotility mechanisms of (-)-fenchone in experimental models

(2020) Michelle Liz de Souza Pessoa et al.   WORLD JOURNAL OF GASTROENTEROLOGY

p-Cymene attenuates cancer pain via inhibitory pathways and modulation of calcium currents

(2019) Wagner B.R. Santos et al.   PHYTOMEDICINE

Natural Product Triterpenoids and Their Semi-Synthetic Derivatives with Potential Anticancer Activity

(2019) Yulin Ren et al.   PLANTA MEDICA

Therapeutic potential of monoterpene α-thujone, the main compound of Thuja occidentalis L. essential oil, against malignant glioblastoma multiforme cells in vitro

(2019) Maciej Pudełek et al.   FITOTERAPIA

p ‐Cymene, a natural antioxidant, in Canadian total diet foods: occurrence and dietary exposures

(2019) Xu‐Liang Cao et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Essential Oils as Antimicrobial Agents—Myth or Real Alternative?

(2019) Katarzyna Wińska et al.   MOLECULES

In Vivo Anti-Tumor Effects of Citral on 4T1 Breast Cancer Cells via Induction of Apoptosis and Downregulation of Aldehyde Dehydrogenase Activity

(2019) Nigjeh et al.   MOLECULES

Essential Oil Composition of Alluaudia procera and in Vitro Biological Activity on Two Drug-Resistant Models

(2019) Poma et al.   MOLECULES

α-Pinene Induces Apoptotic Cell Death via Caspase Activation in Human Ovarian Cancer Cells

(2019) Jing Hou et al.   MEDICAL SCIENCE MONITOR

Enhanced anticancer efficiency of doxorubicin against human glioma by natural borneol through triggering ROS-mediated signal

(2019) Wen-qiang Cao et al.   BIOMEDICINE & PHARMACOTHERAPY

Therapeutic potential of natural products in glioblastoma treatment: targeting key glioblastoma signaling pathways and epigenetic alterations

(2019) M. N. Abbas et al.   Clinical & Translational Oncology

Natural Products and Synthetic Analogs as a Source of Antitumor Drugs

(2019) Javad Sharifi-Rad et al.   Biomolecules

Carvacrol Induced Program Cell Death and Cell Cycle Arrest in Androgen-Independent Human Prostate Cancer Cells via Inhibition of Notch Signaling

(2019) Fahad Khan et al.   Anti-Cancer Agents in Medicinal Chemistry

A multiple endpoint approach reveals potential in vitro anticancer properties of thymoquinone in human renal carcinoma cells

(2019) J.G. Costa et al.   FOOD AND CHEMICAL TOXICOLOGY

Natural borneol sensitizes human glioma cells to cisplatin-induced apoptosis by triggering ROS-mediated oxidative damage and regulation of MAPKs and PI3K/AKT pathway

(2019) Wen-qiang Cao et al.   PHARMACEUTICAL BIOLOGY

Thymol Elicits HCT-116 Colorectal Carcinoma Cell Death Through Induction of Oxidative Stress

(2018) Anil Kumar Chauhan et al.   Anti-Cancer Agents in Medicinal Chemistry

Carvacrol Targets AXL to Inhibit Cell Proliferation and Migration in Non-small Cell Lung Cancer Cells

(2018)   ANTICANCER RESEARCH

Anticancer Properties of Essential Oils: an overview

(2018) Milene Aparecida Andrade et al.   CURRENT CANCER DRUG TARGETS

The application of natural products in cancer therapy by targeting apoptosis pathways

(2018) Yan Wang et al.   CURRENT DRUG METABOLISM

Investigation of molecular mechanism of recognition between citral and MARK4: A newer therapeutic approach to attenuate cancer cell progression

(2018) Farha Naz et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Borneol and Luteolin from Chrysanthemum morifolium Regulates Ubiquitin-Signal Degradation

(2018) Tsui-Ling Chang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Thymol inhibits oral squamous cell carcinoma growth via mitochondria-mediated apoptosis

(2018) Jorge J. De La Chapa et al.   JOURNAL OF ORAL PATHOLOGY & MEDICINE

Linalool induces cell cycle arrest and apoptosis in HepG2 cells through oxidative stress generation and modulation of Ras/MAPK and Akt/mTOR pathways

(2018) Boris Rodenak-Kladniew et al.   LIFE SCIENCES

Effects of carvacrol on human fibroblast (WS-1) and gastric adenocarcinoma (AGS) cells in vitro and on Wistar rats in vivo

(2018) Ayse Günes-Bayir et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

A Comparative Evaluation of the Cytotoxic and Antioxidant Activity of Mentha crispa Essential Oil, Its Major Constituent Rotundifolone, and Analogues on Human Glioblastoma

(2018) Hasan Turkez et al.   Oxidative Medicine and Cellular Longevity

Bioactive compound 1,8-Cineole selectively induces G2/M arrest in A431 cells through the upregulation of the p53 signaling pathway and molecular docking studies

(2018) Sowndarya Sampath et al.   PHYTOMEDICINE

Carvacrol induces cytotoxicity in human cervical cancer cells but causes cisplatin resistance: Involvement of MEK-ERK activation

(2018) Iva Potočnjak et al.   PHYTOTHERAPY RESEARCH

D-limonene exhibits antitumor activity by inducing autophagy and apoptosis in lung cancer

(2018) Xiao Yu et al.   OncoTargets and Therapy

In vitro and in vivo antitumor potential of carvacrol nanoemulsion against human lung adenocarcinoma A549 cells via mitochondrial mediated apoptosis

(2018) Imran Khan et al.   Scientific Reports

Comparative Analysis of Chemical Composition, Anti-Inflammatory Activity and Antitumor Activity in Essential Oils from Siegesbeckia orientalis, S. glabrescens and S. pubescens with an ITS Sequence Analysis

(2018) Xiaoxu Gao et al.   MOLECULES

In-vitro evaluation of apoptotic effect of OEO and thymol in 2D and 3D cell cultures and the study of their interaction mode with DNA

(2018) Tahereh Jamali et al.   Scientific Reports

Myrtenal-induced V-ATPase inhibition - A toxicity mechanism behind tumor cell death and suppressed migration and invasion in melanoma

(2018) Brunna Xavier Martins et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

α-pinene regulates miR-221 and induces G2/M phase cell cycle arrest in human hepatocellular carcinoma cells

(2018) Qiuxiang Xu et al.   BIOSCIENCE REPORTS

Thymoquinone-induced antitumor and apoptosis in human lung adenocarcinoma cells

(2018) Saeed Samarghandian et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Alpha pinene modulates UVA-induced oxidative stress, DNA damage and apoptosis in human skin epidermal keratinocytes

(2018) Ramasamy Karthikeyan et al.   LIFE SCIENCES

Preventive effect of D-carvone during DMBA induced mouse skin tumorigenesis by modulating xenobiotic metabolism and induction of apoptotic events

(2018) Thamizharasi Gopalakrishnan et al.   BIOMEDICINE & PHARMACOTHERAPY

Genotoxicity assessment of piperitenone oxide: An in vitro and in silico evaluation

(2017) Antonella Di Sotto et al.   FOOD AND CHEMICAL TOXICOLOGY

Geraniol attenuates 4NQO-induced tongue carcinogenesis through downregulating the activation of NF-κB in rats

(2017) Arumugam Madankumar et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Carvacrol Induces Reactive Oxygen Species (ROS)-mediated Apoptosis Along with Cell Cycle Arrest at G0/G1 in Human Prostate Cancer Cells

(2017) Fahad Khan et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Novel Antitumor Invasive Actions of p-Cymene by Decreasing MMP-9/TIMP-1 Expression Ratio in Human Fibrosarcoma HT-1080 Cells

(2016) JingZhe Li et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

Discovery of a Novel Anti-Cancer Agent Targeting Both Topoisomerase I & II as Well as Telomerase Activities in Human Lung Adenocarcinoma A549 Cells In Vitro and In Vivo: Cinnamomum verum Component Cuminaldehyde

(2016) Ta-Wei Chen et al.   CURRENT CANCER DRUG TARGETS

Carvacrol induces mitochondria-mediated apoptosis in HL-60 promyelocytic and Jurkat T lymphoma cells

(2016) Elango Bhakkiyalakshmi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The structural modification of natural products for novel drug discovery

(2016) Hong Yao et al.   Expert Opinion on Drug Discovery

Perillyl alcohol efficiently scavenges activity of cellular ROS and inhibits the translational expression of hypoxia-inducible factor-1α via mTOR/4E-BP1 signaling pathways

(2016) Juan Ma et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Enhancement of CD3AK cell proliferation and killing ability by α-Thujone

(2016) Yu Zhou et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Anticancer Effect of Thymol on AGS Human Gastric Carcinoma Cells

(2016) Seo-Hee Kang et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Citral reduces breast tumor growth by inhibiting the cancer stem cell marker ALDH1A3

(2016) Margaret Lois Thomas et al.   Molecular Oncology

Evaluation of Antiparasitc Activity of Mentha crispa Essential Oil, Its Major Constituent Rotundifolone and Analogues against Trypanosoma brucei

(2016) Damião de Sousa et al.   PLANTA MEDICA

Anticancer effect of linalool via cancer-specific hydroxyl radical generation in human colon cancer

(2016) Kenichi Iwasaki et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Cuminaldehyde from Cinnamomum verum Induces Cell Death through Targeting Topoisomerase 1 and 2 in Human Colorectal Adenocarcinoma COLO 205 Cells

(2016) Kuen-daw Tsai et al.   Nutrients

Geraniol suppresses prostate cancer growth through down-regulation of E2F8

(2016) Sanghoon Lee et al.   Cancer Medicine

Terpinen-4-ol: A Novel and Promising Therapeutic Agent for Human Gastrointestinal Cancers

(2016) Shiran Shapira et al.   PLoS One

Carvacrol inhibits proliferation and induces apoptosis in human colon cancer cells

(2015) Kai Fan et al.   ANTI-CANCER DRUGS

Camphene isolated from essential oil of Piper cernuum (Piperaceae) induces intrinsic apoptosis in melanoma cells and displays antitumor activity in vivo

(2015) Natalia Girola et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Linalool Induces Cell Cycle Arrest and Apoptosis in Leukemia Cells and Cervical Cancer Cells through CDKIs

(2015) Mei-Yin Chang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Anti-tumor effect of α-pinene on human hepatoma cell lines through inducing G2/M cell cycle arrest

(2015) Weiqiang Chen et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Na/K-ATPase as a target for anticancer drugs: studies with perillyl alcohol

(2015) Diogo Gomes Garcia et al.   Molecular Cancer

Evaluation of the Cytotoxicity of Structurally Correlated p-Menthane Derivatives

(2015) Luciana Andrade et al.   MOLECULES

Antitumor Properties of the Leaf Essential Oil of Zornia brasiliensis

(2015) Emmanoel Costa et al.   PLANTA MEDICA

Natural borneol enhances bisdemethoxycurcumin-induced cell cycle arrest in the G2/M phase through up-regulation of intracellular ROS in HepG2 cells

(2015) Jianping Chen et al.   Food & Function

Chemoprevention Gene Therapy (CGT) of Pancreatic Cancer Using Perillyl Alcohol and a Novel Chimeric Serotype Cancer Terminator Virus

(2014) S. Sarkar et al.   CURRENT MOLECULAR MEDICINE

Thymol, a monoterpene phenolic derivative of cymene, abrogates mercury-induced oxidative stress resultant cytotoxicity and genotoxicity in hepatocarcinoma cells

(2014) Nishan B. Shettigar et al.   ENVIRONMENTAL TOXICOLOGY

Carvacrol modulates instability of xenobiotic metabolizing enzymes and downregulates the expressions of PCNA, MMP-2, and MMP-9 during diethylnitrosamine-induced hepatocarcinogenesis in rats

(2014) Jayakumar Subramaniyan et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Linalool Exhibits Cytotoxic Effects by Activating Antitumor Immunity

(2014) Mei-Yin Chang et al.   MOLECULES

L-Carvone Induces p53, Caspase 3 Mediated Apoptosis and Inhibits the Migration of Breast Cancer Cell Lines

(2014) Pinaki B. Patel et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Suppression by Geraniol of the Growth of A549 Human Lung Adenocarcinoma Cells and Inhibition of the Mevalonate Pathway in Culture and In Vivo: Potential Use in Cancer Chemotherapy

(2014) Marianela Galle et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Induction of Necrosis in Human Liver Tumor Cells by α-Phellandrene

(2014) Shu-Ling Hsieh et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Antitumorigenic Potential of Linalool Is Accompanied by Modulation of Oxidative Stress: An In Vivo Study in Sarcoma-180 Solid Tumor Model

(2014) Samarjit Jana et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Effect of citral on the cytotoxicity of doxorubicin in human B-lymphoma cells

(2014) Darinee Dangkong et al.   PHARMACEUTICAL BIOLOGY

Antitumor Activity of Monoterpenes Found in Essential Oils

(2014) Marianna Vieira Sobral et al.   TheScientificWorldJOURNAL

In vitrocytotoxicity, genotoxicity and antioxidant potentials of thymol on human blood cells

(2013) Elanur Aydın et al.   JOURNAL OF ESSENTIAL OIL RESEARCH

Dietary camphene attenuates hepatic steatosis and insulin resistance in mice

(2013) Sohee Kim et al.   Obesity

Investigation of cytotoxic, genotoxic and oxidative properties of carvacrol in human blood cells

(2013) Hasan Türkez et al.   TOXICOLOGY AND INDUSTRIAL HEALTH

Potential anticancer activity of carvone in N2a neuroblastoma cell line

(2013) Elanur Aydın et al.   TOXICOLOGY AND INDUSTRIAL HEALTH

In VitroandIn VivoAntitumor Effects of the Essential Oil from the Leaves ofGuatteria friesiana

(2012) Anny Britto et al.   PLANTA MEDICA

Antitumor Activity of the Essential Oil from the Leaves ofCroton regelianusand Its Component Ascaridole

(2009) Daniel P. Bezerra et al.   CHEMISTRY & BIODIVERSITY