Na/K-ATPase as a target for anticancer drugs: studies with perillyl alcohol

Perillyl alcohol improves functional and histological outcomes against ischemia–reperfusion injury by attenuation of oxidative stress and repression of COX-2, NOS-2 and NF-κB in middle cerebral artery occlusion rats

(2015) Rizwana Tabassum et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The Sodium Pump α1 Subunit as a Potential Target to Combat Apoptosis-Resistant Glioblastomas

(2015) Florence Lefranc et al.   NEOPLASIA

From Na+/K+-ATPase and Cardiac Glycosides to Cytotoxicity and Cancer Treatment

(2013) Petr Babula et al.   Anti-Cancer Agents in Medicinal Chemistry

Piperlongumine selectively kills glioblastoma multiforme cells via reactive oxygen species accumulation dependent JNK and p38 activation

(2013) Ju Mei Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

4-Bromo-2-(piperidin-1-yl)thiazol-5-yl-phenyl methanone (12b) inhibits Na+/K+-ATPase and Ras oncogene activity in cancer cells

(2013) Florence Lefranc et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Na+,K+-ATPase as a docking station: protein–protein complexes of the Na+,K+-ATPase

(2012) Linda Reinhard et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Chemical Synthesis of the Cardiotonic Steroid Glycosides and Related Natural Products

(2012) Brian Heasley   CHEMISTRY-A EUROPEAN JOURNAL

Influence of the Active Compounds of Perilla frutescens Leaves on Lipid Membranes

(2012) Lars Duelund et al.   JOURNAL OF NATURAL PRODUCTS

p38 MAPK inhibitors attenuate pro-inflammatory cytokine production and the invasiveness of human U251 glioblastoma cells

(2012) Yiu To Yeung et al.   JOURNAL OF NEURO-ONCOLOGY

Inhibition of EGFR/MAPK signaling reduces microglial inflammatory response and the associated secondary damage in rats after spinal cord injury

(2012) Wen-sheng Qu et al.   Journal of Neuroinflammation

Assembling the puzzle of anti-cancer mechanisms triggered by cardiac glycosides

(2012) Claudia Cerella et al.   MITOCHONDRION

Perillyl Alcohol for the Treatment of Temozolomide-Resistant Gliomas

(2012) H.-Y. Cho et al.   MOLECULAR CANCER THERAPEUTICS

Ouabain-induced apoptosis and Rho kinase: a novel caspase-2 cleavage site and fragment of Rock-2

(2010) Mustafa Ark et al.   APOPTOSIS

Targeting SRC in glioblastoma tumors and brain metastases: Rationale and preclinical studies

(2010) Manmeet S. Ahluwalia et al.   CANCER LETTERS

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

Efficacy of monoterpene perillyl alcohol upon survival rate of patients with recurrent glioblastoma

(2010) Clovis O. da Fonseca et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

HB-EGF synthesis and release induced by cholesterol depletion of human epidermal keratinocytes is controlled by extracellular atp and involves both p38 and ERK1/2 signaling pathways

(2010) Séverine Giltaire et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The anticancer drug perillyl alcohol is a Na/K-ATPase inhibitor

(2010) Diogo G. Garcia et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

A Direct Comparison of the Anticancer Activities of Digitoxin MeON-Neoglycosides and O-Glycosides

(2010) Anand Krishnan V. Iyer et al.   ACS Medicinal Chemistry Letters

The Na+/K+-ATPase is the Achilles Heel of multi-drug-resistant cancer cells

(2009) Tatjana Mijatovic et al.   CANCER LETTERS

Perillyl alcohol attenuates Ras-ERK signaling to inhibit murine skin inflammation and tumorigenesis

(2009) Sandeep Chand Chaudhary et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Cytotoxic Effects of Cardiac Glycosides in Colon Cancer Cells, Alone and in Combination with Standard Chemotherapeutic Drugs

(2009) Jenny Felth et al.   JOURNAL OF NATURAL PRODUCTS

TARGETING THE α 1 SUBUNIT OF THE SODIUM PUMP TO COMBAT GLIOBLASTOMA CELLS

(2009) Florence Lefranc et al.   NEUROSURGERY

Cisplatin sensitivity of oral squamous carcinoma cells is regulated by Na+,K+-ATPase activity rather than copper-transporting P-type ATPases, ATP7A and ATP7B

(2008) Zunaid Ahmed et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Na+/K+-ATPase α subunits as new targets in anticancer therapy

(2008) Tatjana Mijatovic et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Examination of the Cellular Mechanisms by Which Marinobufagenin Inhibits Cytotrophoblast Function

(2008) Mohammad N. Uddin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Pilot Study of Perillyl Alcohol in Pancreatic Cancer

(2008) Jesus M. Matos et al.   JOURNAL OF SURGICAL RESEARCH

Novel therapeutic applications of cardiac glycosides

(2008) Ioannis Prassas et al.   NATURE REVIEWS DRUG DISCOVERY

The Na/K-ATPase/Src complex and cardiotonic steroid-activated protein kinase cascades

(2008) Zhichuan Li et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Preliminary results from a phase I/II study of perillyl alcohol intranasal administration in adults with recurrent malignant gliomas

(2008) Clovis Orlando da Fonseca et al.   SURGICAL NEUROLOGY