Phospholipase A2inhibitors as potential therapeutic agents for the treatment of inflammatory diseases

2-Oxoamide inhibitors of phospholipase A2 activity and cellular arachidonate release based on dipeptides and pseudodipeptides

(2009) Efrosini Barbayianni et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Benzhydrylquinazolinediones: Novel cytosolic phospholipase A2α inhibitors with improved physicochemical properties

(2009) Steven J. Kirincich et al.   BIOORGANIC & MEDICINAL CHEMISTRY

1-(5-Carboxyindol-1-yl)propan-2-ones as inhibitors of human cytosolic phospholipase A2α: Synthesis and properties of bioisosteric benzimidazole, benzotriazole and indazole analogues

(2009) Stefanie Bovens et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Differing roles for members of the phospholipase A2 superfamily in experimental autoimmune encephalomyelitis

(2009) Athena Kalyvas et al.   BRAIN

Future Role for Selective Phospholipase A2 Inhibitors in the Prevention of Atherosclerotic Cardiovascular Disease

(2009) Robert S. Rosenson   CARDIOVASCULAR DRUGS AND THERAPY

Phospholipase A2 inhibitors

(2009) Hector M Garcia-Garcia et al.   CURRENT OPINION IN LIPIDOLOGY

The role of lipoprotein-associated phospholipase A2 on cardiovascular disease risk assessment and plaque rupture: a clinical review

(2009) Kota J. Reddy et al.   Journal of Clinical Lipidology

Reactions of Functionalized Sulfonamides: Application to Lowering the Lipophilicity of Cytosolic Phospholipase A2α Inhibitors∥

(2009) Lihren Chen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Location of Inhibitors Bound to Group IVA Phospholipase A2Determined by Molecular Dynamics and Deuterium Exchange Mass Spectrometry

(2009) John E. Burke et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Lipoprotein-Associated Phospholipase A2: A Risk Marker or a Risk Factor?

(2008) Amir Lerman et al.   AMERICAN JOURNAL OF CARDIOLOGY

Age-Related Changes in Bone Morphology Are Accelerated in Group VIA Phospholipase A2 (iPLA2β)-Null Mice

(2008) Sasanka Ramanadham et al.   AMERICAN JOURNAL OF PATHOLOGY

Biochemistry and Physiology of Mammalian Secreted Phospholipases A2

(2008) Gérard Lambeau et al.   Annual Review of Biochemistry

Role of Ca2+-independent phospholipase A2 in cell growth and signaling

(2008) Shelley B. Hooks et al.   BIOCHEMICAL PHARMACOLOGY

Antibacterial actions of secreted phospholipases A2. Review

(2008) T NEVALAINEN   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Structure–activity relationships of natural and non-natural amino acid-based amide and 2-oxoamide inhibitors of human phospholipase A2 enzymes

(2008) Georgia Antonopoulou et al.   BIOORGANIC & MEDICINAL CHEMISTRY

1-(2-Carboxyindol-5-yloxy)propan-2-ones as inhibitors of human cytosolic phospholipase A2α: Synthesis, biological activity, metabolic stability, and solubility

(2008) Alexandra Fritsche et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Intracellular phospholipase A2 group IVA and group VIA play important roles in Wallerian degeneration and axon regeneration after peripheral nerve injury

(2008) Rubèn López-Vales et al.   BRAIN

Inhibition of cyclooxygenases 1 and 2 by the phospholipase-blocker, arachidonyl trifluoromethyl ketone

(2008) H J Leis et al.   BRITISH JOURNAL OF PHARMACOLOGY

Biology of Secretory Phospholipase A2

(2008) Boris B. Boyanovsky et al.   CARDIOVASCULAR DRUGS AND THERAPY

Lipoprotein-Associated and Secretory Phospholipase A2 in Cardiovascular Disease: The Epidemiological Evidence

(2008) Wolfgang Koenig et al.   CARDIOVASCULAR DRUGS AND THERAPY

Biology of Platelet-activating Factor Acetylhydrolase (PAF-AH, Lipoprotein Associated Phospholipase A2)

(2008) Diana M. Stafforini   CARDIOVASCULAR DRUGS AND THERAPY

Phospholipase A2 Biochemistry

(2008) John E. Burke et al.   CARDIOVASCULAR DRUGS AND THERAPY

Effects of the Direct Lipoprotein-Associated Phospholipase A 2 Inhibitor Darapladib on Human Coronary Atherosclerotic Plaque

(2008) Patrick W. Serruys et al.   CIRCULATION

Cytosolic Phospholipase A2- : A Potential Therapeutic Target for Prostate Cancer

(2008) M. I. Patel et al.   CLINICAL CANCER RESEARCH

Role of lipoprotein-associated phospholipase A2 in atherosclerosis

(2008) Shahar Lavi et al.   Current Atherosclerosis Reports

Group VI Phospholipases A2: Homeostatic Phospholipases with Significant Potential as Targets for Novel Therapeutics

(2008) W. Wilkins III et al.   CURRENT DRUG TARGETS

Lipolytic enzymes as therapeutic targets

(2008) George Kokotos   EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY

Macrophage Secretory Phospholipase A2Group X Enhances Anti-inflammatory Responses, Promotes Lipid Accumulation, and Contributes to Aberrant Lung Pathology

(2008) Daniëlle M. J. Curfs et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phospholipase A2structure/function, mechanism, and signaling

(2008) John E. Burke et al.   JOURNAL OF LIPID RESEARCH

Indole Cytosolic Phospholipase A2α Inhibitors: Discovery and in Vitro and in Vivo Characterization of 4-{3-[5-Chloro-2-(2-{[(3,4-dichlorobenzyl)sulfonyl]amino}ethyl)-1-(diphenylmethyl)-1H-indol-3-yl]propyl}benzoic Acid, Efipladib

(2008) John C. McKew et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis of Polyfluoro Ketones for Selective Inhibition of Human Phospholipase A2Enzymes

(2008) Constantinos Baskakis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Highly Specific and Broadly Potent Inhibitors of Mammalian Secreted Phospholipases A2

(2008) Rob C. Oslund et al.   JOURNAL OF MEDICINAL CHEMISTRY

Blockade of cytosolic phospholipase A2α prevents experimental autoimmune encephalomyelitis and diminishes development of Th1 and Th17 responses

(2008) S MARUSIC et al.   JOURNAL OF NEUROIMMUNOLOGY

Synthesis of Medicinally Interesting Polyfluoro Ketones via Perfluoroalkyl Lithium Reagents

(2008) Christoforos G. Kokotos et al.   JOURNAL OF ORGANIC CHEMISTRY

The Effect of Darapladib on Plasma Lipoprotein-Associated Phospholipase A2 Activity and Cardiovascular Biomarkers in Patients With Stable Coronary Heart Disease or Coronary Heart Disease Risk Equivalent

(2008) Emile R. Mohler et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Inhibition of lipoprotein-associated phospholipase A2 reduces complex coronary atherosclerotic plaque development

(2008) Robert L Wilensky et al.   NATURE MEDICINE

Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease

(2008) Rene O Sanchez-Mejia et al.   NATURE NEUROSCIENCE

Inhibitory Effect of a Potent and Selective Cytosolic Phospholipase A2α Inhibitor RSC-3388 on Skin Inflammation in Mice

(2008) Mina Yamamoto et al.   PHARMACOLOGY

Expression of secretory phospholipase A2s in human atherosclerosis development

(2007) Masayo Kimura-Matsumoto et al.   ATHEROSCLEROSIS

Benzenesulfonamide indole inhibitors of cytosolic phospholipase A2α: Optimization of in vitro potency and rat pharmacokinetics for oral efficacy

(2007) Katherine L. Lee et al.   BIOORGANIC & MEDICINAL CHEMISTRY