Group VIB Phospholipase A2Promotes Proliferation of INS-1 Insulinoma Cells and Attenuates Lipid Peroxidation and Apoptosis Induced by Inflammatory Cytokines and Oxidant Agents

Production of H2O2 in the Endoplasmic Reticulum Promotes In Vivo Disulfide Bond Formation

(2012) Éva Margittai et al.   ANTIOXIDANTS & REDOX SIGNALING

Glucose-induced beta cell dysfunction in vivo in rats: link between oxidative stress and endoplasmic reticulum stress

(2012) C. Tang et al.   DIABETOLOGIA

Mass spectrometry analysis of oxidized phosphatidylcholine and phosphatidylethanolamine

(2011) Valerie B. O'Donnell   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Development of diabetes in lean Ncb5or-null mice is associated with manifestations of endoplasmic reticulum and oxidative stress in beta cells

(2011) WenFang Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Phospholipase A2Enzymes: Physical Structure, Biological Function, Disease Implication, Chemical Inhibition, and Therapeutic Intervention

(2011) Edward A. Dennis et al.   CHEMICAL REVIEWS

Characterization of oxidation products from 1-palmitoyl-2-linoleoyl-sn-glycerophosphatidylcholine in aqueous solutions and their reactions with cysteine, histidine and lysine residues

(2011) Ivana Milic et al.   CHEMISTRY AND PHYSICS OF LIPIDS

H2O2-induced secretion of tumor necrosis factor-α evokes apoptosis of cardiac myocytes through reactive oxygen species-dependent activation of p38 MAPK

(2011) Zhilong Chen et al.   CYTOTECHNOLOGY

Mitochondrial Dysfunction andβ-Cell Failure in Type 2 Diabetes Mellitus

(2011) Zhongmin Alex Ma et al.   Experimental Diabetes Research

Group VIA PLA2(iPLA2β) Is Activated Upstream of p38 Mitogen-activated Protein Kinase (MAPK) in Pancreatic Islet β-Cell Signaling

(2011) Haowei Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Low-Level Laser Therapy Activates NF-kB via Generation of Reactive Oxygen Species in Mouse Embryonic Fibroblasts

(2011) Aaron C-H. Chen et al.   PLoS One

Endoplasmic reticulum stress and pancreatic β-cell death

(2011) Sonya G. Fonseca et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Activation of group VI phospholipase A2 isoforms in cardiac endothelial cells

(2010) Janhavi Sharma et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Mice deficient in Group VIB phospholipase A2 (iPLA2γ) exhibit relative resistance to obesity and metabolic abnormalities induced by a Western diet

(2010) Haowei Song et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Cholesterol and peroxidized cardiolipin in mitochondrial membrane properties, permeabilization and cell death

(2010) Joan Montero et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Evidence for proteolytic processing and stimulated organelle redistribution of iPLA2β

(2010) Haowei Song et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Group VIA Ca2+-independent phospholipase A2 (iPLA2β) and its role in β-cell programmed cell death

(2010) Xiaoyong Lei et al.   BIOCHIMIE

The unfolded protein response is required to maintain the integrity of the endoplasmic reticulum, prevent oxidative stress and preserve differentiation in β-cells

(2010) R. J. Kaufman et al.   DIABETES OBESITY & METABOLISM

Protection of Pancreatic β-Cells by Group VIA Phospholipase A2-Mediated Repair of Mitochondrial Membrane Peroxidation

(2010) Zhengshan Zhao et al.   ENDOCRINOLOGY

Effects of Endoplasmic Reticulum Stress on Group VIA Phospholipase A2in Beta Cells Include Tyrosine Phosphorylation and Increased Association with Calnexin

(2010) Haowei Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic Ablation of Calcium-independent Phospholipase A2γ Prevents Obesity and Insulin Resistance during High Fat Feeding by Mitochondrial Uncoupling and Increased Adipocyte Fatty Acid Oxidation

(2010) David J. Mancuso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Quantitative assays for esterified oxylipins generated by immune cells

(2010) Alwena H Morgan et al.   Nature Protocols

Nitric oxides mediates a shift from early necrosis to late apoptosis in cytokine-treated β-cells that is associated with irreversible DNA damage

(2009) Katherine J. Hughes et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Oxidative stress is induced by islet amyloid formation and time-dependently mediates amyloid-induced beta cell apoptosis

(2009) S. Zraika et al.   DIABETOLOGIA

Spontaneous Development of Endoplasmic Reticulum Stress That Can Lead to Diabetes Mellitus Is Associated with Higher Calcium-independent Phospholipase A2Expression

(2009) Xiaoyong Lei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic Ablation of Calcium-independent Phospholipase A2γ Leads to Alterations in Hippocampal Cardiolipin Content and Molecular Species Distribution, Mitochondrial Degeneration, Autophagy, and Cognitive Dysfunction

(2009) David J. Mancuso et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphatidylethanolamine-esterified Eicosanoids in the Mouse

(2009) Alwena H. Morgan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cardiolipin Remodeling in the Heart

(2009) Genevieve C Sparagna et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

The role of calcium-independent phospholipase A2in cardiolipin remodeling in the spontaneously hypertensive heart failure rat heart

(2009) Derek K. Zachman et al.   JOURNAL OF LIPID RESEARCH

Rotenone induces apoptosis in MCF-7 human breast cancer cell-mediated ROS through JNK and p38 signaling

(2009) Yea-Tzy Deng et al.   MOLECULAR CARCINOGENESIS

Role of calcium-independent phospholipase A2 in the pathogenesis of Barth syndrome

(2009) A. Malhotra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial Reactive Oxygen Species Are Obligatory Signals for Glucose-Induced Insulin Secretion

(2008) C. Leloup et al.   DIABETES

The Unfolded Protein Response: A Pathway That Links Insulin Demand with β-Cell Failure and Diabetes

(2008) Donalyn Scheuner et al.   ENDOCRINE REVIEWS

Calcium-independent Phospholipase A2(iPLA2β)-mediated Ceramide Generation Plays a Key Role in the Cross-talk between the Endoplasmic Reticulum (ER) and Mitochondria during ER Stress-induced Insulin-secreting Cell Apoptosis

(2008) Xiaoyong Lei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Decreased iPLA2γ expression induces lipid peroxidation and cell death and sensitizes cells to oxidant-induced apoptosis

(2008) Gilbert R. Kinsey et al.   JOURNAL OF LIPID RESEARCH

Mammalian patatin domain containing proteins: a family with diverse lipolytic activities involved in multiple biological functions

(2008) Petra C. Kienesberger et al.   JOURNAL OF LIPID RESEARCH

RPLC-Ion-Trap-FTMS Method for Lipid Profiling of Plasma: Method Validation and Application to p53 Mutant Mouse Model

(2008) Chunxiu Hu et al.   JOURNAL OF PROTEOME RESEARCH