Group VIA Phospholipase A2Mitigates Palmitate-induced β-Cell Mitochondrial Injury and Apoptosis

Mitochondrial dysfunction and activation of iNOS are responsible for the palmitate-induced decrease in adiponectin synthesis in 3T3L1 adipocytes

(2012) Min Jae Jeon et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

The Patatin-Containing Phospholipase A pPLAIIα Modulates Oxylipin Formation and Water Loss in Arabidopsis thaliana

(2012) Wen-Yu Yang et al.   Molecular Plant

Mass spectrometry analysis of oxidized phosphatidylcholine and phosphatidylethanolamine

(2011) Valerie B. O'Donnell   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Development of diabetes in lean Ncb5or-null mice is associated with manifestations of endoplasmic reticulum and oxidative stress in beta cells

(2011) WenFang Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Beta-cell injury in Ncb5or-null mice is exacerbated by consumption of a high-fat diet

(2011) Ying Guo et al.   EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY

Mitochondrial Dysfunction andβ-Cell Failure in Type 2 Diabetes Mellitus

(2011) Zhongmin Alex Ma et al.   Experimental Diabetes Research

Ncb5or Deficiency Increases Fatty Acid Catabolism and Oxidative Stress

(2011) Ming Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Group VIA PLA2(iPLA2β) Is Activated Upstream of p38 Mitogen-activated Protein Kinase (MAPK) in Pancreatic Islet β-Cell Signaling

(2011) Haowei Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Different effects of oleate vs. palmitate on mitochondrial function, apoptosis, and insulin signaling in L6 skeletal muscle cells: role of oxidative stress

(2010) Larysa Yuzefovych et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Cholesterol and peroxidized cardiolipin in mitochondrial membrane properties, permeabilization and cell death

(2010) Joan Montero et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Evidence for proteolytic processing and stimulated organelle redistribution of iPLA2β

(2010) Haowei Song et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Effects of pharmacological inhibition of NADPH oxidase or iNOS on pro-inflammatory cytokine, palmitic acid or H2O2-induced mouse islet or clonal pancreatic β-cell dysfunction

(2010) Marta Michalska et al.   BIOSCIENCE REPORTS

Arachidonic acid actions on functional integrity and attenuation of the negative effects of palmitic acid in a clonal pancreatic β-cell line

(2010) Deirdre C. Keane et al.   CLINICAL SCIENCE

Protection of Pancreatic β-Cells by Group VIA Phospholipase A2-Mediated Repair of Mitochondrial Membrane Peroxidation

(2010) Zhengshan Zhao et al.   ENDOCRINOLOGY

Formation of 4-hydroxynonenal from cardiolipin oxidation: Intramolecular peroxyl radical addition and decomposition

(2010) Wei Liu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effects of Endoplasmic Reticulum Stress on Group VIA Phospholipase A2in Beta Cells Include Tyrosine Phosphorylation and Increased Association with Calnexin

(2010) Haowei Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HL-1 mouse cardiomyocyte injury and death after simulated ischemia and reperfusion: roles of pH, Ca2+-independent phospholipase A2, and Na+/H+ exchange

(2009) Ann-Dorit Andersen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Linking Fatty Acid Stress to  -Cell Mitochondrial Dynamics

(2009) A. Wiederkehr et al.   DIABETES

Mitochondrial Networking Protects  -Cells From Nutrient-Induced Apoptosis

(2009) A. J.A. Molina et al.   DIABETES

Cardiolipin Remodeling in the Heart

(2009) Genevieve C Sparagna et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

The role of calcium-independent phospholipase A2in cardiolipin remodeling in the spontaneously hypertensive heart failure rat heart

(2009) Derek K. Zachman et al.   JOURNAL OF LIPID RESEARCH

Role of calcium-independent phospholipase A2 in the pathogenesis of Barth syndrome

(2009) A. Malhotra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic β-cells

(2008) Elida Lai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Rosiglitazone counteracts palmitate-induced β-cell dysfunction by suppression of MAP kinase, inducible nitric oxide synthase and caspase 3 activities

(2008) S. Meidute Abaraviciene et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Calcium-independent Phospholipase A2(iPLA2β)-mediated Ceramide Generation Plays a Key Role in the Cross-talk between the Endoplasmic Reticulum (ER) and Mitochondria during ER Stress-induced Insulin-secreting Cell Apoptosis

(2008) Xiaoyong Lei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Decreased iPLA2γ expression induces lipid peroxidation and cell death and sensitizes cells to oxidant-induced apoptosis

(2008) Gilbert R. Kinsey et al.   JOURNAL OF LIPID RESEARCH

Phospholipase A2structure/function, mechanism, and signaling

(2008) John E. Burke et al.   JOURNAL OF LIPID RESEARCH

RPLC-Ion-Trap-FTMS Method for Lipid Profiling of Plasma: Method Validation and Application to p53 Mutant Mouse Model

(2008) Chunxiu Hu et al.   JOURNAL OF PROTEOME RESEARCH

Palmitate-Induced β-Cell Dysfunction Is Associated with Excessive NO Production and Is Reversed by Thiazolidinedione-Mediated Inhibition of GPR40 Transduction Mechanisms

(2008) Sandra Meidute Abaraviciene et al.   PLoS One

Glucose homeostasis, insulin secretion, and islet phospholipids in mice that overexpress iPLA2β in pancreatic β-cells and in iPLA2β-null mice

(2007) Shunzhong Bao et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM