The roles of hnRNP A2 / B1 in RNA biology and disease

Heterogeneous nuclear ribonucleoprotein A2/B1 is a negative regulator of human breast cancer metastasis by maintaining the balance of multiple genes and pathways

(2020) Yu Liu et al.   EBioMedicine

SP1‐mediated overexpression of lncRNA LINC01234 as a ceRNA facilitates non‐small‐cell lung cancer progression via regulating OTUB1

(2019) Jing‐jing Xie et al.   JOURNAL OF CELLULAR PHYSIOLOGY

m6A-induced lncRNA RP11 triggers the dissemination of colorectal cancer cells via upregulation of Zeb1

(2019) Yingmin Wu et al.   Molecular Cancer

LncRNA SOX2‐OT regulates proliferation and metastasis of nasopharyngeal carcinoma cells through miR‐146b‐5p/HNRNPA2B1 pathway

(2019) Enqin Zhang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Nuclear hnRNPA2B1 initiates and amplifies the innate immune response to DNA viruses

(2019) Lei Wang et al.   SCIENCE

Long noncoding RNA LINC00657 induced by SP1 contributes to the non‐small cell lung cancer progression through targeting miR‐26b‐5p/COMMD8 axis

(2019) Rui Zhang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Stress granule mediated protein aggregation and underlying gene defects in the FTD-ALS spectrum

(2019) Yalda Baradaran-Heravi et al.   NEUROBIOLOGY OF DISEASE

RGG/RG Motif Regions in RNA Binding and Phase Separation

(2018) P. Andrew Chong et al.   JOURNAL OF MOLECULAR BIOLOGY

Global Profiling of hnRNP A2/B1-RNA Binding on Chromatin Highlights LncRNA Interactions

(2018) Eric D. Nguyen et al.   RNA Biology

Molecular basis for the specific and multivariant recognitions of RNA substrates by human hnRNP A2/B1

(2018) Baixing Wu et al.   Nature Communications

Long noncoding RNA miR503HG, a prognostic indicator, inhibits tumor metastasis by regulating the HNRNPA2B1/NF-κB pathway in hepatocellular carcinoma

(2018) Hui Wang et al.   Theranostics

Linking hnRNP Function to ALS and FTD Pathology

(2018) Maria D. Purice et al.   Frontiers in Neuroscience

Genetic and Pathological Assessment of hnRNPA1, hnRNPA2/B1, and hnRNPA3 in Familial and Sporadic Amyotrophic Lateral Sclerosis

(2017) Jennifer A. Fifita et al.   Neurodegenerative Diseases

TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics

(2017) Ian R. Mackenzie et al.   NEURON

Splicing factor hnRNPA2B1 contributes to tumorigenic potential of breast cancer cells through STAT3 and ERK1/2 signaling pathway

(2017) Ying Hu et al.   TUMOR BIOLOGY

The cellular protein hnRNP A2/B1 enhances HIV-1 transcription by unfolding LTR promoter G-quadruplexes

(2017) Matteo Scalabrin et al.   Scientific Reports

LncRNA-uc002mbe.2 Interacting with hnRNPA2B1 Mediates AKT Deactivation and p21 Up-Regulation Induced by Trichostatin in Liver Cancer Cells

(2017) Ting Chen et al.   Frontiers in Pharmacology

Identification of autoantibodies to ECH1 and HNRNPA2B1 as potential biomarkers in the early detection of lung cancer

(2017) Liping Dai et al.   OncoImmunology

Clinical and neuropathological features of ALS/FTD with TIA1 mutations

(2017) Veronica Hirsch-Reinshagen et al.   Acta Neuropathologica Communications

Nm23-H1-stabilized hnRNPA2/B1 promotes internal ribosomal entry site (IRES)-mediated translation of Sp1 in the lung cancer progression

(2017) Chia-Yang Hung et al.   Scientific Reports

Global identification of hnRNP A1 binding sites for SSO-based splicing modulation

(2016) Gitte H. Bruun et al.   BMC BIOLOGY

C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles

(2016) Kyung-Ha Lee et al.   CELL

A widespread sequence-specific mRNA decay pathway mediated by hnRNPs A1 and A2/B1

(2016) Rene Geissler et al.   GENES & DEVELOPMENT

The hnRNP family: insights into their role in health and disease

(2016) Thomas Geuens et al.   HUMAN GENETICS

Cholinergic Regulation of hnRNPA2/B1 Translation by M1 Muscarinic Receptors

(2016) B. Kolisnyk et al.   JOURNAL OF NEUROSCIENCE

hnRNPA2/B1 Function in Neurodegeneration: It’s a Gain, Not a Loss

(2016) Saskia Hutten et al.   NEURON

Protein-RNA Networks Regulated by Normal and ALS-Associated Mutant HNRNPA2B1 in the Nervous System

(2016) Fernando J. Martinez et al.   NEURON

A position-specific 3′UTR sequence that accelerates mRNA decay

(2016) Rene Geissler et al.   RNA Biology

An RNA matchmaker protein regulates the activity of the long noncoding RNA HOTAIR

(2016) Emily K. Meredith et al.   RNA

Regulation of alternative splicing of Bcl-x by BC200 contributes to breast cancer pathogenesis

(2016) R Singh et al.   Cell Death & Disease

Antiangiogenic VEGF-Ax: A New Participant in Tumor Angiogenesis

(2015) S. M. Eswarappa et al.   CANCER RESEARCH

A Liquid-to-Solid Phase Transition of the ALS Protein FUS Accelerated by Disease Mutation

(2015) Avinash Patel et al.   CELL

HNRNPA2B1 Is a Mediator of m6A-Dependent Nuclear RNA Processing Events

(2015) Claudio R. Alarcón et al.   CELL

Abnormal levels of heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1) in tumour tissue and blood samples from patients diagnosed with lung cancer

(2015) Paul Dowling et al.   Molecular BioSystems

Effects of hnRNP A2/B1 Knockdown on Inhibition of Glioblastoma Cell Invasion, Growth and Survival

(2015) Jinmu Deng et al.   MOLECULAR NEUROBIOLOGY

hnRNPA2/B1 activates cyclooxygenase-2 and promotes tumor growth in human lung cancers

(2015) Yang Xuan et al.   Molecular Oncology

Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia

(2015) Axel Freischmidt et al.   NATURE NEUROSCIENCE

Inhibition of Inflammation and Bone Erosion by RNA Interference-Mediated Silencing of Heterogeneous Nuclear RNP A2/B1 in Two Experimental Models of Rheumatoid Arthritis

(2015) Sonja Herman et al.   Arthritis & Rheumatology

A Function for the hnRNP A1/A2 Proteins in Transcription Elongation

(2015) Bruno Lemieux et al.   PLoS One

Sp1-mediated microRNA-182 expression regulates lung cancer progression

(2015) Wen-Bin Yang et al.   Oncotarget

Programmed Translational Readthrough Generates Antiangiogenic VEGF-Ax

(2014) Sandeepa M. Eswarappa et al.   CELL

Ribonucleoprotein HNRNPA2B1 Interacts With and Regulates Oncogenic KRAS in Pancreatic Ductal Adenocarcinoma Cells

(2014) Carles Barceló et al.   GASTROENTEROLOGY

Shutdown of Achaete-scute Homolog-1 Expression by Heterogeneous Nuclear Ribonucleoprotein (hnRNP)-A2/B1 in Hypoxia

(2014) Mumtaz Kasim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interactions of noncanonical motifs with hnRNP A2 promote activity-dependent RNA transport in neurons

(2014) Ilham A. Muslimov et al.   JOURNAL OF CELL BIOLOGY

No mutations in hnRNPA1 and hnRNPA2B1 in Dutch patients with amyotrophic lateral sclerosis, frontotemporal dementia, and inclusion body myopathy

(2014) Meinie Seelen et al.   NEUROBIOLOGY OF AGING

Cerebrospinal Fluid Extracellular Vesicles Undergo Age Dependent Declines and Contain Known and Novel Non-coding RNAs

(2014) Ashlee Tietje et al.   PLoS One

Sorting it out: Regulation of exosome loading

(2014) Carolina Villarroya-Beltri et al.   SEMINARS IN CANCER BIOLOGY

TheETFDHc.158A>G Variation Disrupts the Balanced Interplay of ESE- and ESS-Binding Proteins thereby Causing Missplicing and Multiple Acyl-CoA Dehydrogenation Deficiency

(2013) Rikke K. J. Olsen et al.   HUMAN MUTATION

Forebrain Deletion of the Vesicular Acetylcholine Transporter Results in Deficits in Executive Function, Metabolic, and RNA Splicing Abnormalities in the Prefrontal Cortex

(2013) B. Kolisnyk et al.   JOURNAL OF NEUROSCIENCE

A compendium of RNA-binding motifs for decoding gene regulation

(2013) Debashish Ray et al.   NATURE

Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS

(2013) Hong Joo Kim et al.   NATURE

N6-methyladenosine-dependent regulation of messenger RNA stability

(2013) Xiao Wang et al.   NATURE

hnRNPA2B1 and hnRNPA1 mutations are rare in patients with “multisystem proteinopathy” and frontotemporal lobar degeneration phenotypes

(2013) Isabelle Le Ber et al.   NEUROBIOLOGY OF AGING

SPRi-Based Strategy to Identify Specific Biomarkers in Systemic Lupus Erythematosus, Rheumatoid Arthritis and Autoimmune Hepatitis

(2013) Elvire Beleoken et al.   PLoS One

Molecular basis for the action of a dietary flavonoid revealed by the comprehensive identification of apigenin human targets

(2013) D. Arango et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Long Noncoding RNA Mediates Both Activation and Repression of Immune Response Genes

(2013) S. Carpenter et al.   SCIENCE

Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs

(2013) Carolina Villarroya-Beltri et al.   Nature Communications

Promoter-associated small double-stranded RNA interacts with heterogeneous nuclear ribonucleoprotein A2/B1 to induce transcriptional activation

(2012) Jia Hu et al.   BIOCHEMICAL JOURNAL

Comprehensive Analysis of mRNA Methylation Reveals Enrichment in 3′ UTRs and near Stop Codons

(2012) Kate D. Meyer et al.   CELL

Cholinergic-associated loss of hnRNP-A/B in Alzheimer's disease impairs cortical splicing and cognitive function in mice

(2012) Amit Berson et al.   EMBO Molecular Medicine

Development and validation of a novel reporter assay for human papillomavirus type 16 late gene expression

(2012) Beatrice Orrù et al.   JOURNAL OF VIROLOGICAL METHODS

Heterogeneous nuclear ribonucleoprotein A2/B1 in association with hTERT is a potential biomarker for hepatocellular carcinoma

(2012) Hideki Mizuno et al.   LIVER INTERNATIONAL

Systematic discovery of structural elements governing stability of mammalian messenger RNAs

(2012) Hani Goodarzi et al.   NATURE

Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq

(2012) Dan Dominissini et al.   NATURE

Mutually exclusive splicing regulates the Nav 1.6 sodium channel function through a combinatorial mechanism that involves three distinct splicing regulatory elements and their ligands

(2012) Lorena Zubović et al.   NUCLEIC ACIDS RESEARCH

Integrative Genome-wide Analysis Reveals Cooperative Regulation of Alternative Splicing by hnRNP Proteins

(2012) Stephanie C. Huelga et al.   Cell Reports

MicroRNA-277 Modulates the Neurodegeneration Caused by Fragile X Premutation rCGG Repeats

(2012) Huiping Tan et al.   PLoS Genetics

Splicing Factor hnRNP A2/B1 Regulates Tumor Suppressor Gene Splicing and Is an Oncogenic Driver in Glioblastoma

(2011) R. Golan-Gerstl et al.   CANCER RESEARCH

Retrotransposon activation contributes to fragile X premutation rCGG-mediated neurodegeneration

(2011) H. Tan et al.   HUMAN MOLECULAR GENETICS

Nucleic acid-stimulated antigen-presenting cells trigger T cells to induce disease in a rat transfer model of inflammatory arthritis

(2011) Markus H. Hoffmann et al.   JOURNAL OF AUTOIMMUNITY

Spatial code recognition in neuronal RNA targeting: Role of RNA–hnRNP A2 interactions

(2011) Ilham A. Muslimov et al.   JOURNAL OF CELL BIOLOGY

The Discoidin domain receptor 1 gene has a functional A2RE sequence

(2011) Barbara Roig et al.   JOURNAL OF NEUROCHEMISTRY

Heterogeneous Nuclear Ribonucleoprotein A2 Participates in the Replication of Japanese Encephalitis Virus through an Interaction with Viral Proteins and RNA

(2011) H. Katoh et al.   JOURNAL OF VIROLOGY

Molecular Mechanisms of Long Noncoding RNAs

(2011) Kevin C. Wang et al.   MOLECULAR CELL

A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD

(2011) Alan E. Renton et al.   NEURON

Alternative splicing in spinal muscular atrophy underscores the role of an intron definition model

(2011) Natalia N. Singh et al.   RNA Biology

Proteomic analysis of pancreatic intraepithelial neoplasia and pancreatic carcinoma in rat models

(2011) Lei Wang   WORLD JOURNAL OF GASTROENTEROLOGY

Up-regulation and subcellular localization of hnRNP A2/B1 in the development of hepatocellular carcinoma

(2010) Huaqing Cui et al.   BMC CANCER

Expression proteomics of UPF1 knockdown in HeLa cells reveals autoregulation of hnRNP A2/B1 mediated by alternative splicing resulting in nonsense-mediated mRNA decay

(2010) Nicholas J McGlincy et al.   BMC GENOMICS

hnRNP A2/B1 Modulates Epithelial-Mesenchymal Transition in Lung Cancer Cell Lines

(2010) J. Tauler et al.   CANCER RESEARCH

Aberrant expression and localization of hnRNP-A2/B1 is a common event in human gastric adenocarcinoma

(2010) Guang-Jun Jing et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Proteomic Identification of Paclitaxel-Resistance Associated hnRNP A2 and GDI 2 Proteins in Human Ovarian Cancer Cells

(2010) Dong Hyeon Lee et al.   JOURNAL OF PROTEOME RESEARCH

TIA1 Prevents Skipping of a Critical Exon Associated with Spinal Muscular Atrophy

(2010) N. N. Singh et al.   MOLECULAR AND CELLULAR BIOLOGY

Activation of Akt Is Essential for the Propagation of Mitochondrial Respiratory Stress Signaling and Activation of the Transcriptional Coactivator Heterogeneous Ribonucleoprotein A2

(2010) Manti Guha et al.   MOLECULAR BIOLOGY OF THE CELL

RNAa Is Conserved in Mammalian Cells

(2010) Vera Huang et al.   PLoS One

The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism

(2010) C. V. Clower et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential Subcellular Distributions and Trafficking Functions of hnRNP A2/B1 Spliceoforms

(2010) Siew Ping Han et al.   TRAFFIC

RNA metabolism and the pathogenesis of motor neuron diseases

(2010) Robin Lemmens et al.   TRENDS IN NEUROSCIENCES

Vascular Endothelial Growth Factor

(2009) Napoleone Ferrara   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

hnRNP A2 Regulates Alternative mRNA Splicing of TP53INP2 to Control Invasive Cell Migration

(2009) K. Moran-Jones et al.   CANCER RESEARCH

A Systematic Survey Identifies Prions and Illuminates Sequence Features of Prionogenic Proteins

(2009) Simon Alberti et al.   CELL

Heterogeneous Nuclear Ribonucleoprotein A2 Is a Common Transcriptional Coactivator in the Nuclear Transcription Response to Mitochondrial Respiratory Stress

(2009) Manti Guha et al.   MOLECULAR BIOLOGY OF THE CELL

HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer

(2009) Charles J. David et al.   NATURE

Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis

(2009) T. J. Kwiatkowski et al.   SCIENCE

Antisense Masking of an hnRNP A1/A2 Intronic Splicing Silencer Corrects SMN2 Splicing in Transgenic Mice

(2008) Yimin Hua et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Hypoxia-inducible factor 1 and cancer pathogenesis

(2008) Gregg L. Semenza   IUBMB LIFE

Activation of oligodendroglial Fyn kinase enhances translation of mRNAs transported in hnRNP A2–dependent RNA granules

(2008) Robin White et al.   JOURNAL OF CELL BIOLOGY

Multiplexed Dendritic Targeting of α Calcium Calmodulin-dependent Protein Kinase II, Neurogranin, and Activity-regulated Cytoskeleton-associated Protein RNAs by the A2 Pathway

(2008) Yuanzheng Gao et al.   MOLECULAR BIOLOGY OF THE CELL

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

(2008) Heather R. Christofk et al.   NATURE

Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?

(2008) Witold Filipowicz et al.   NATURE REVIEWS GENETICS

TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis

(2008) J. Sreedharan et al.   SCIENCE