The negative cell cycle regulators, p27Kip1, p18Ink4c, and GSK-3, play critical role in maintaining quiescence of adult human pancreaticβ-cells and restrict their ability to proliferate

RETRACTED: Betatrophin: A Hormone that Controls Pancreatic β Cell Proliferation

(2013) Peng Yi et al.   CELL

Free Fatty Acids Block Glucose-Induced  -Cell Proliferation in Mice by Inducing Cell Cycle Inhibitors p16 and p18

(2012) J. Pascoe et al.   DIABETES

 -Cell Mass and Turnover in Humans: Effects of obesity and aging

(2012) Y. Saisho et al.   DIABETES CARE

Pancreatic Beta Cells in Very Old Mice Retain Capacity for Compensatory Proliferation

(2012) Miri Stolovich-Rain et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Formation of a Human β-Cell Population within Pancreatic Islets Is Set Early in Life

(2012) Brigid E. Gregg et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

In Vitro Proliferation of Adult Human Beta-Cells

(2012) Sabine Rutti et al.   PLoS One

Control of pancreatic β-cell fate by insulin signaling: The sweet spot hypothesis

(2011) James D Johnson et al.   CELL CYCLE

Regulated and Reversible Induction of Adult Human  -Cell Replication

(2011) K. K. Takane et al.   DIABETES

Epidermal growth factor (EGF)-receptor signalling is needed for murine beta cell mass expansion in response to high-fat diet and pregnancy but not after pancreatic duct ligation

(2011) E. Hakonen et al.   DIABETOLOGIA

Skp2 Is Required for Incretin Hormone-Mediated β-Cell Proliferation

(2011) Shuen-Ing Tschen et al.   MOLECULAR ENDOCRINOLOGY

PDGF signalling controls age-dependent proliferation in pancreatic β-cells

(2011) Hainan Chen et al.   NATURE

GSK-3 inactivation or depletion promotes β-cell replication via down regulation of the CDK inhibitor, p27 (Kip1)

(2011) Jeffrey Stein et al.   Islets

Cell cycle control of β-cell replication in the prenatal and postnatal human pancreas

(2010) Christina U. Köhler et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Gastrointestinal hormones and the regulation of β-cell mass

(2010) Jeremy A. Lavine et al.   Annals of the New York Academy of Sciences

Induction of Human β-Cell Proliferation and Engraftment Using a Single G1/S Regulatory Molecule, cdk6

(2010) Nathalie M. Fiaschi-Taesch et al.   DIABETES

Residual Insulin Production and Pancreatic  -Cell Turnover After 50 Years of Diabetes: Joslin Medalist Study

(2010) H. A. Keenan et al.   DIABETES

Conditional ablation of Gsk-3β in islet beta cells results in expanded mass and resistance to fat feeding-induced diabetes in mice

(2010) Y. Liu et al.   DIABETOLOGIA

Significant Human β-Cell Turnover Is Limited to the First Three Decades of Life as Determined byin VivoThymidine Analog Incorporation and Radiocarbon Dating

(2010) S. Perl et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Serotonin regulates pancreatic beta cell mass during pregnancy

(2010) Hail Kim et al.   NATURE MEDICINE

Survey of the Human Pancreatic  -Cell G1/S Proteome Reveals a Potential Therapeutic Role for Cdk-6 and Cyclin D1 in Enhancing Human  -Cell Replication and Function In Vivo

(2009) N. Fiaschi-Taesch et al.   DIABETES

The long lifespan and low turnover of human islet beta cells estimated by mathematical modelling of lipofuscin accumulation

(2009) M. Cnop et al.   DIABETOLOGIA

Glycogen Synthase Kinase-3 and Mammalian Target of Rapamycin Pathways Contribute to DNA Synthesis, Cell Cycle Progression, and Proliferation in Human Islets

(2008) H. Liu et al.   DIABETES

Exendin-4 Stimulation of Cyclin A2 in  -Cell Proliferation

(2008) W.-J. Song et al.   DIABETES

 -Cell Replication Is the Primary Mechanism Subserving the Postnatal Expansion of  -Cell Mass in Humans

(2008) J. J. Meier et al.   DIABETES

Expression of the GLP-1 Receptor in Mouse, Rat, and Human Pancreas

(2008) Ditte Tornehave et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

9-Cyano-1-azapaullone (Cazpaullone), a Glycogen Synthase Kinase-3 (GSK-3) Inhibitor Activating Pancreatic β Cell Protection and Replication

(2008) Hendrik Stukenbrock et al.   JOURNAL OF MEDICINAL CHEMISTRY

Growth factor control of pancreatic islet regeneration and function

(2008) Anke Assmann et al.   PEDIATRIC DIABETES