Robust inference of bi-directional causal relationships in presence of correlated pleiotropy with GWAS summary data

Effect of selection bias on two sample summary data based Mendelian randomization

(2021) Kai Wang et al.   Scientific Reports

Constrained maximum likelihood-based Mendelian randomization robust to both correlated and uncorrelated pleiotropic effects

(2021) Haoran Xue et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Simultaneous estimation of bi-directional causal effects and heritable confounding from GWAS summary statistics

(2021) Liza Darrous et al.   Nature Communications

A robust and efficient method for Mendelian randomization with hundreds of genetic variants

(2020) Stephen Burgess et al.   Nature Communications

Genetics Insights in the Relationship Between Type 2 Diabetes and Coronary Heart Disease

(2020) Mark O. Goodarzi et al.   CIRCULATION RESEARCH

Mendelian randomization accounting for correlated and uncorrelated pleiotropic effects using genome-wide summary statistics

(2020) Jean Morrison et al.   NATURE GENETICS

Statistical inference in two-sample summary-data Mendelian randomization using robust adjusted profile score

(2020) Qingyuan Zhao et al.   ANNALS OF STATISTICS

An Exposure-Wide and Mendelian Randomization Approach to Identifying Modifiable Factors for the Prevention of Depression

(2020) Karmel W. Choi et al.   AMERICAN JOURNAL OF PSYCHIATRY

Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

(2019) Mengzhen Liu et al.   NATURE GENETICS

Elucidation of causal direction between asthma and obesity: a bi-directional Mendelian randomization study

(2019) Shujing Xu et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Mendelian randomization analysis using mixture models for robust and efficient estimation of causal effects

(2019) Guanghao Qi et al.   Nature Communications

Powerful three-sample genome-wide design and robust statistical inference in summary-data Mendelian randomization

(2019) Qingyuan Zhao et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Commentary: Orienting causal relationships between two phenotypes using bidirectional Mendelian randomization

(2019) Rebecca C Richmond et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

The bidirectional causal relationships of insomnia with five major psychiatric disorders: A Mendelian randomization study

(2019) Xue Gao et al.   EUROPEAN PSYCHIATRY

A global overview of pleiotropy and genetic architecture in complex traits

(2019) Kyoko Watanabe et al.   NATURE GENETICS

An approach to estimate bidirectional mediation effects with application to body mass index and fasting glucose

(2018) Rajesh Talluri et al.   ANNALS OF HUMAN GENETICS

Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases

(2018) Marie Verbanck et al.   NATURE GENETICS

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

(2018) Rainer Malik et al.   NATURE GENETICS

Mendelian randomization with a binary exposure variable: interpretation and presentation of causal estimates

(2018) Stephen Burgess et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

(2018) Evangelos Evangelou et al.   NATURE GENETICS

Distinguishing genetic correlation from causation across 52 diseases and complex traits

(2018) Luke J. O’Connor et al.   NATURE GENETICS

Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption

(2017) Fernando Pires Hartwig et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Mendelian randomization: a novel approach for the prediction of adverse drug events and drug repurposing opportunities

(2017) Venexia M Walker et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks

(2017) Florence Demenais et al.   NATURE GENETICS

Orienting the causal relationship between imprecisely measured traits using GWAS summary data

(2017) Gibran Hemani et al.   PLoS Genetics

Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease

(2017) Pim van der Harst et al.   CIRCULATION RESEARCH

Genome-wide associations for birth weight and correlations with adult disease

(2016) Momoko Horikoshi et al.   NATURE

New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk

(2016) Yingchang Lu et al.   Nature Communications

Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression

(2015) J. Bowden et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Genetic studies of body mass index yield new insights for obesity biology

(2015) Adam E. Locke et al.   NATURE

Instrumental Variable Analysis with a Nonlinear Exposure–Outcome Relationship

(2014) Stephen Burgess et al.   EPIDEMIOLOGY

Mendelian randomization: genetic anchors for causal inference in epidemiological studies

(2014) G. Davey Smith et al.   HUMAN MOLECULAR GENETICS

Defining the role of common variation in the genomic and biological architecture of adult human height

(2014) Andrew R Wood et al.   NATURE GENETICS

Discovery and refinement of loci associated with lipid levels

(2013) Cristen J Willer et al.   NATURE GENETICS

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

(2012)   NATURE GENETICS

C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization

(2010) N J Timpson et al.   INTERNATIONAL JOURNAL OF OBESITY

New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk

(2010) Josée Dupuis et al.   NATURE GENETICS