Distinguishing genetic correlation from causation across 52 diseases and complex traits

Mixed-model association for biobank-scale datasets

(2018) Po-Ru Loh et al.   NATURE GENETICS

Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases

(2018) Marie Verbanck et al.   NATURE GENETICS

The MR-Base platform supports systematic causal inference across the human phenome

(2018) Gibran Hemani et al.   eLife

Interpreting findings from Mendelian randomization using the MR-Egger method

(2017) Stephen Burgess et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Robust inference in summary data Mendelian randomization via the zero modal pleiotropy assumption

(2017) Fernando Pires Hartwig et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Genetic effects on gene expression across human tissues

(2017) François Aguet et al.   NATURE

Mendelian randomization in cardiometabolic disease: challenges in evaluating causality

(2017) Michael V. Holmes et al.   Nature Reviews Cardiology

Evidence of directional and stabilizing selection in contemporary humans

(2017) Jaleal S. Sanjak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reproductive fitness and genetic risk of psychiatric disorders in the general population

(2017) Niamh Mullins et al.   Nature Communications

Association of Body Mass Index With Cardiometabolic Disease in the UK Biobank

(2017) Donald M. Lyall et al.   JAMA Cardiology

Thyroid function and risk of type 2 diabetes: a population-based prospective cohort study

(2016) Layal Chaker et al.   BMC Medicine

Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator

(2016) Jack Bowden et al.   GENETIC EPIDEMIOLOGY

Instrumental Variables Estimation With Some Invalid Instruments and its Application to Mendelian Randomization

(2016) Hyunseung Kang et al.   JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION

Effects of Statins on Bone Mineral Density and Fracture Risk

(2016) Zongze Wang et al.   MEDICINE

Genome-wide association study of cognitive functions and educational attainment in UK Biobank (N=112 151)

(2016) G Davies et al.   MOLECULAR PSYCHIATRY

Detection and interpretation of shared genetic influences on 42 human traits

(2016) Joseph K Pickrell et al.   NATURE GENETICS

Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets

(2016) Zhihong Zhu et al.   NATURE GENETICS

Integrative approaches for large-scale transcriptome-wide association studies

(2016) Alexander Gusev et al.   NATURE GENETICS

Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression

(2015) J. Bowden et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Adiposity as a cause of cardiovascular disease: a Mendelian randomization study

(2015) S. Hagg et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Identification and Inference With Many Invalid Instruments

(2015) Michal Kolesár et al.   JOURNAL OF BUSINESS & ECONOMIC STATISTICS

Common polygenic risk for autism spectrum disorder (ASD) is associated with cognitive ability in the general population

(2015) T-K Clarke et al.   MOLECULAR PSYCHIATRY

The UK10K project identifies rare variants in health and disease

(2015)   NATURE

Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index

(2015) Jian Yang et al.   NATURE GENETICS

An atlas of genetic correlations across human diseases and traits

(2015) Brendan Bulik-Sullivan et al.   NATURE GENETICS

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

A gene-based association method for mapping traits using reference transcriptome data

(2015) Eric R Gamazon et al.   NATURE GENETICS

UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age

(2015) Cathie Sudlow et al.   PLOS MEDICINE

Vitamin D and Risk of Multiple Sclerosis: A Mendelian Randomization Study

(2015) Lauren E. Mokry et al.   PLOS MEDICINE

Causal Effects of Body Mass Index on Cardiometabolic Traits and Events: A Mendelian Randomization Analysis

(2014) Michael V. Holmes et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Thyroid and the Heart

(2014) Ira Martin Grais et al.   AMERICAN JOURNAL OF MEDICINE

Methodological Challenges in Mendelian Randomization

(2014) Tyler J. VanderWeele et al.   EPIDEMIOLOGY

Mendelian randomization: genetic anchors for causal inference in epidemiological studies

(2014) G. Davey Smith et al.   HUMAN MOLECULAR GENETICS

Network Mendelian randomization: using genetic variants as instrumental variables to investigate mediation in causal pathways

(2014) S. Burgess et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Mendelian Randomization Analysis With Multiple Genetic Variants Using Summarized Data

(2013) Stephen Burgess et al.   GENETIC EPIDEMIOLOGY

Decreased Bone Mineral Density in Subjects Carrying Familial Defective Apolipoprotein B-100

(2013) Laura M. Yerges-Armstrong et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Common variants associated with plasma triglycerides and risk for coronary artery disease

(2013) Ron Do et al.   NATURE GENETICS

Causal Relationship between Obesity and Vitamin D Status: Bi-Directional Mendelian Randomization Analysis of Multiple Cohorts

(2013) Karani S. Vimaleswaran et al.   PLOS MEDICINE

Plasma HDL cholesterol and risk of myocardial infarction: a mendelian randomisation study

(2012) Benjamin F Voight et al.   LANCET

Mining methylome databases

(2012) Colm J. O’Rourke et al.   TRENDS IN GENETICS

The Effect of Elevated Body Mass Index on Ischemic Heart Disease Risk: Causal Estimates from a Mendelian Randomisation Approach

(2012) Børge G. Nordestgaard et al.   PLOS MEDICINE

Unraveling the Directional Link between Adiposity and Inflammation: A Bidirectional Mendelian Randomization Approach

(2009) Paul Welsh et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Acute Thyroid Hormone Withdrawal in Athyreotic Patients Results in a State of Insulin Resistance

(2009) Gabriela Brenta et al.   THYROID

Decrease of brachial-ankle pulse wave velocity in female subclinical hypothyroid patients during normalization of thyroid function: a double-blind, placebo-controlled study

(2008) Toshiki Nagasaki et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY