Cryo-EM structure of the human TACAN in a closed state

Analysis of the mechanosensor channel functionality of TACAN

(2021) Yiming Niu et al.   eLife

TMEM120A is a coenzyme A-binding membrane protein with structural similarities to ELOVL fatty acid elongase

(2021) Jing Xue et al.   eLife

TMEM120A contains a specific coenzyme A-binding site and might not mediate poking- or stretch-induced channel activities in cells

(2021) Yao Rong et al.   eLife

Mechanosensitive Ion Channels: Structural Features Relevant to Mechanotransduction Mechanisms

(2020) Peng Jin et al.   Annual Review of Neuroscience

TACAN Is an Ion Channel Involved in Sensing Mechanical Pain

(2020) Lou Beaulieu-Laroche et al.   CELL

Touching Base with Mechanical Pain

(2020) Oscar M. Arenas et al.   CELL

Collecting large datasets of rotational electron diffraction with ParallEM and SerialEM

(2020) Kiyofumi Takaba et al.   JOURNAL OF STRUCTURAL BIOLOGY

Molecular Crux of Hair Cell Mechanotransduction Machinery

(2020) Umar Al-Sheikh et al.   NEURON

Heterogeneous parallelization and acceleration of molecular dynamics simulations in GROMACS

(2020) Szilárd Páll et al.   JOURNAL OF CHEMICAL PHYSICS

Discoveries in structure and physiology of mechanically activated ion channels

(2020) J. M. Kefauver et al.   NATURE

Structure and mechanogating of the mammalian tactile channel PIEZO2

(2019) Li Wang et al.   NATURE

Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix

(2019) Dorothee Liebschner et al.   Acta Crystallographica Section D-Structural Biology

Mammalian Mechanoelectrical Transduction: Structure and Function of Force-Gated Ion Channels

(2019) Dominique Douguet et al.   CELL

TMC1 and TMC2 Proteins Are Pore-Forming Subunits of Mechanosensitive Ion Channels

(2019) Yanyan Jia et al.   NEURON

Bacterial Mechanosensors

(2018) Charles D. Cox et al.   Annual Review of Physiology

Structure and mechanogating mechanism of the Piezo1 channel

(2018) Qiancheng Zhao et al.   NATURE

Structure of the mechanosensitive OSCA channels

(2018) Mingfeng Zhang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

Cryo-EM structure of the mechanically activated ion channel OSCA1.2

(2018) Sebastian Jojoa-Cruz et al.   eLife

Structure of the mechanically activated ion channel Piezo1

(2017) Kei Saotome et al.   NATURE

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

Piezos thrive under pressure: mechanically activated ion channels in health and disease

(2017) Swetha E. Murthy et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Computational Lipidomics with insane: A Versatile Tool for Generating Custom Membranes for Molecular Simulations

(2015) Tsjerk A. Wassenaar et al.   Journal of Chemical Theory and Computation

ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB

(2015) James A. Maier et al.   Journal of Chemical Theory and Computation

CTFFIND4: Fast and accurate defocus estimation from electron micrographs

(2015) Alexis Rohou et al.   JOURNAL OF STRUCTURAL BIOLOGY

TMEM120A and B: Nuclear Envelope Transmembrane Proteins Important for Adipocyte Differentiation

(2015) Dzmitry G. Batrakou et al.   PLoS One

Lipid14: The Amber Lipid Force Field

(2014) Callum J. Dickson et al.   Journal of Chemical Theory and Computation

Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel

(2014) Stephen G. Brohawn et al.   NATURE

OSCA1 mediates osmotic-stress-evoked Ca2+ increases vital for osmosensing in Arabidopsis

(2014) Fang Yuan et al.   NATURE

Going Backward: A Flexible Geometric Approach to Reverse Transformation from Coarse Grained to Atomistic Models

(2013) Tsjerk A. Wassenaar et al.   Journal of Chemical Theory and Computation

Quantifying the local resolution of cryo-EM density maps

(2013) Alp Kucukelbir et al.   NATURE METHODS

Bacterial Mechanosensitive Channels—MscS: Evolution's Solution to Creating Sensitivity in Function

(2012) James H. Naismith et al.   Annual Review of Biophysics

Improved Parameters for the Martini Coarse-Grained Protein Force Field

(2012) Djurre H. de Jong et al.   Journal of Chemical Theory and Computation

H++ 3.0: automating pK prediction and the preparation of biomolecular structures for atomistic molecular modeling and simulations

(2012) R. Anandakrishnan et al.   NUCLEIC ACIDS RESEARCH

Cell-specific and lamin-dependent targeting of novel transmembrane proteins in the nuclear envelope

(2010) Poonam Malik et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Combining an Elastic Network With a Coarse-Grained Molecular Force Field: Structure, Dynamics, and Intermolecular Recognition

(2009) Xavier Periole et al.   Journal of Chemical Theory and Computation