Bioactive peptide inhibits acute myeloid leukemia cell proliferation by downregulating ALKBH5-mediated m6A demethylation of EIF4EBP1 and MLST8 mRNA

m6A demethylase ALKBH5 inhibits tumor growth and metastasis by reducing YTHDFs-mediated YAP expression and inhibiting miR-107/LATS2–mediated YAP activity in NSCLC

(2020) Dan Jin et al.   Molecular Cancer

RNA demethylase ALKBH5 prevents pancreatic cancer progression by posttranscriptional activation of PER1 in an m6A-YTHDF2-dependent manner

(2020) Xingya Guo et al.   Molecular Cancer

ALKBH5 promotes the proliferation of renal cell carcinoma by regulating AURKB expression in an m6A-dependent manner

(2020) Xiaolei Zhang et al.   Annals of Translational Medicine

ALKBH5 suppresses malignancy of hepatocellular carcinoma via m6A-guided epigenetic inhibition of LYPD1

(2020) Yunhao Chen et al.   Molecular Cancer

ALKBH5 regulates anti–PD-1 therapy response by modulating lactate and suppressive immune cell accumulation in tumor microenvironment

(2020) Na Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The m6A RNA Demethylase ALKBH5 Promotes Radioresistance and Invasion Capability of Glioma Stem Cells

(2020) Aline Kowalski-Chauvel et al.   Cancers

mTOR Signaling in Cancer and mTOR Inhibitors in Solid Tumor Targeting Therapy

(2019) Tian Tian et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

ALKBH5 inhibited autophagy of epithelial ovarian cancer through miR-7 and BCL-2

(2019) Hongtao Zhu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

ALKBH5-m6A-FOXM1 signaling axis promotes proliferation and invasion of lung adenocarcinoma cells under intermittent hypoxia

(2019) Yinghui Chao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Acute myeloid leukemia: 2019 update on risk-stratification and management

(2018) Elihu H. Estey   AMERICAN JOURNAL OF HEMATOLOGY

mTOR kinase leads to PTEN-loss-induced cellular senescence by phosphorylating p53

(2018) Seung Hee Jung et al.   ONCOGENE

Targeting the anion exchanger 2 with specific peptides as a new therapeutic approach in B lymphoid neoplasms

(2017) Jon Celay et al.   HAEMATOLOGICA

Assessment of multifunctional activity of bioactive peptides derived from fermented milk by specific Lactobacillus plantarum strains

(2017) J.E. Aguilar-Toalá et al.   JOURNAL OF DAIRY SCIENCE

Targeting the anion exchanger 2 with specific peptides as a new therapeutic approach in B lymphoid neoplasms

(2017) Jon Celay et al.   HAEMATOLOGICA

Antimicrobial Peptides As Biologic and Immunotherapeutic Agents against Cancer: A Comprehensive Overview

(2017) Raheleh Roudi et al.   Frontiers in Immunology

mTORC2 mediates CXCL12-induced angiogenesis

(2016) Mary E. Ziegler et al.   ANGIOGENESIS

Targeting the mTOR Pathway in Leukemia

(2016) Shira Dinner et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Purification and identification of anti-inflammatory peptides derived from simulated gastrointestinal digests of velvet antler protein ( Cervus elaphus Linnaeus)

(2016) Lei Zhao et al.   JOURNAL OF FOOD AND DRUG ANALYSIS

Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA

(2016) Chuanzhao Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

‘Acute myeloid leukemia: a comprehensive review and 2016 update’

(2016) I De Kouchkovsky et al.   Blood Cancer Journal

Anticancer bioactive peptide-3 inhibits human gastric cancer growth by targeting miR-338-5p

(2016) Zhiwei Xing et al.   Cell and Bioscience

Anticancer bioactive peptides suppress human colorectal tumor cell growth and induce apoptosis via modulating the PARP-p53-Mcl-1 signaling pathway

(2015) Li-ya Su et al.   ACTA PHARMACOLOGICA SINICA

Introduction to the review series on advances in acute myeloid leukemia (AML)

(2015) B. Lowenberg et al.   BLOOD

Targeting novel signaling pathways for resistant acute myeloid leukemia

(2015) Kathleen M. Sakamoto et al.   MOLECULAR GENETICS AND METABOLISM

Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5

(2014) Yue Huang et al.   NUCLEIC ACIDS RESEARCH

The mTORC1 effectors S6K1 and 4E-BP play different roles in CNS axon regeneration

(2014) Liu Yang et al.   Nature Communications

Do the Lactotripeptides Isoleucine-Proline-Proline and Valine-Proline-Proline Reduce Systolic Blood Pressure in European Subjects? A Meta-Analysis of Randomized Controlled Trials

(2013) A. F. G. Cicero et al.   AMERICAN JOURNAL OF HYPERTENSION

Transcriptome-wide mapping of N6-methyladenosine by m6A-seq based on immunocapturing and massively parallel sequencing

(2013) Dan Dominissini et al.   Nature Protocols

Anticancer β-Hairpin Peptides: Membrane-Induced Folding Triggers Activity

(2012) Chomdao Sinthuvanich et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Bioactive Peptides and Depsipeptides with Anticancer Potential: Sources from Marine Animals

(2012) Guadalupe-Miroslava Suarez-Jimenez et al.   Marine Drugs

ALKBH5 Is a Mammalian RNA Demethylase that Impacts RNA Metabolism and Mouse Fertility

(2012) Guanqun Zheng et al.   MOLECULAR CELL

N6-methyl-adenosine (m6A) in RNA: An Old Modification with A Novel Epigenetic Function

(2012) Yamei Niu et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

MicroRNA-30e* promotes human glioma cell invasiveness in an orthotopic xenotransplantation model by disrupting the NF-κB/IκBα negative feedback loop

(2011) Lili Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Caspase 3–mediated stimulation of tumor cell repopulation during cancer radiotherapy

(2011) Qian Huang et al.   NATURE MEDICINE

The anti-cancer peptide, PNC-27, induces tumor cell lysis as the intact peptide

(2010) Kelley A. Sookraj et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Development of Peptides as Potential Drugs for Cancer Therapy

(2010) Zhi Li et al.   CURRENT PHARMACEUTICAL DESIGN

mTOR signaling is activated by FLT3 kinase and promotes survival of FLT3-mutated acute myeloid leukemia cells

(2010) Weina Chen et al.   Molecular Cancer

mTOR: from growth signal integration to cancer, diabetes and ageing

(2010) Roberto Zoncu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Development and biological activities of marine-derived bioactive peptides: A review

(2010) Se-Kwon Kim et al.   Journal of Functional Foods