The m6A RNA Demethylase ALKBH5 Promotes Radioresistance and Invasion Capability of Glioma Stem Cells

m6A demethylase ALKBH5 inhibits pancreatic cancer tumorigenesis by decreasing WIF-1 RNA methylation and mediating Wnt signaling

(2020) Bo Tang et al.   Molecular Cancer

m6A demethylase ALKBH5 inhibits tumor growth and metastasis by reducing YTHDFs-mediated YAP expression and inhibiting miR-107/LATS2–mediated YAP activity in NSCLC

(2020) Dan Jin et al.   Molecular Cancer

Role of Rad51 and DNA repair in cancer: A molecular perspective

(2020) Erik Laurini et al.   PHARMACOLOGY & THERAPEUTICS

FTO Facilitates Lung Adenocarcinoma Cell Progression by Activating Cell Migration Through mRNA Demethylation

(2020) Yudi Ding et al.   OncoTargets and Therapy

N6-Isopentenyladenosine Enhances the Radiosensitivity of Glioblastoma Cells by Inhibiting the Homologous Recombination Repair Protein RAD51 Expression

(2020) Giovanna Navarra et al.   Frontiers in Oncology

Insights into the Regulatory Role of m6A Epitranscriptome in Glioblastoma

(2020) Silvia Galardi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The potential role of RNA N6-methyladenosine in Cancer progression

(2020) Tianyi Wang et al.   Molecular Cancer

LncRNA SOX2OT promotes temozolomide resistance by elevating SOX2 expression via ALKBH5-mediated epigenetic regulation in glioblastoma

(2020) Boyang Liu et al.   Cell Death & Disease

ALKBH5 suppresses malignancy of hepatocellular carcinoma via m6A-guided epigenetic inhibition of LYPD1

(2020) Yunhao Chen et al.   Molecular Cancer

ALKBH5 regulates anti–PD-1 therapy response by modulating lactate and suppressive immune cell accumulation in tumor microenvironment

(2020) Na Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

m6A modification in RNA: biogenesis, functions and roles in gliomas

(2020) Yuhao Zhang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Determination of the migration effect and molecular docking of verteporfin in different subtypes of breast cancer cells

(2020) Changran Wei et al.   Molecular Medicine Reports

The FTO/miR‐181b‐3p/ARL5B signaling pathway regulates cell migration and invasion in breast cancer

(2020) Yuanyuan Xu et al.   Cancer Communications

Reality CHEK: Understanding the biology and clinical potential of CHK1

(2020) Fiifi Neizer-Ashun et al.   CANCER LETTERS

Surmounting cancer drug resistance: New insights from the perspective of N6-methyladenosine RNA modification

(2020) Bowen Li et al.   DRUG RESISTANCE UPDATES

Alpha6-Integrin Regulates FGFR1 Expression through the ZEB1/YAP1 Transcription Complex in Glioblastoma Stem Cells Resulting in Enhanced Proliferation and Stemness

(2019) Aline KOWALSKI-CHAUVEL et al.   Cancers

Targeted and Synergic Glioblastoma Treatment: Multifunctional Nanoparticles Delivering Verteporfin as Adjuvant Therapy for Temozolomide Chemotherapy

(2019) Diogo S. Pellosi et al.   MOLECULAR PHARMACEUTICS

RNA N6-methyladenosine demethylase FTO promotes breast tumor progression through inhibiting BNIP3

(2019) Yi Niu et al.   Molecular Cancer

Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia

(2019) Yue Huang et al.   CANCER CELL

ALKBH5 inhibited autophagy of epithelial ovarian cancer through miR-7 and BCL-2

(2019) Hongtao Zhu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

The role of m6A RNA methylation in human cancer

(2019) Xiao-Yu Chen et al.   Molecular Cancer

ALKBH5 promotes invasion and metastasis of gastric cancer by decreasing methylation of the lncRNA NEAT1

(2019) Jun Zhang et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

ALKBH5 Holds Prognostic Values and Inhibits the Metastasis of Colon Cancer

(2019) Peipei Yang et al.   PATHOLOGY & ONCOLOGY RESEARCH

Glioblastoma Multiforme: An Overview of Emerging Therapeutic Targets

(2019) Olivia G. Taylor et al.   Frontiers in Oncology

The Chk1 inhibitor SAR-020106 sensitizes human glioblastoma cells to irradiation, to temozolomide, and to decitabine treatment

(2019) Ina Patties et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

ALKBH5-m6A-FOXM1 signaling axis promotes proliferation and invasion of lung adenocarcinoma cells under intermittent hypoxia

(2019) Yinghui Chao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

3D proteome-wide scale screening and activity evaluation of a new ALKBH5 inhibitor in U87 glioblastoma cell line

(2019) Alessio Malacrida et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Verteporfin inhibits oxidative phosphorylation and induces cell death specifically in glioma stem cells

(2019) Kenta Kuramoto et al.   FEBS Journal

m 6 A demethylase FTO facilitates tumor progression in lung squamous cell carcinoma by regulating MZF1 expression

(2018) Jiqin Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m 6 A/MYC/CEBPA Signaling

(2018) Rui Su et al.   CELL

Role of N 6 -methyladenosine modification in cancer

(2018) Xiaolan Deng et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

FTO regulates the chemo-radiotherapy resistance of cervical squamous cell carcinoma (CSCC) by targeting β-catenin through mRNA demethylation

(2018) Shun Zhou et al.   MOLECULAR CARCINOGENESIS

YAP and MRTF-A, transcriptional co-activators of RhoA-mediated gene expression, are critical for glioblastoma tumorigenicity

(2018) Olivia M. Yu et al.   ONCOGENE

Inhibiting Integrin β8 to Differentiate and Radiosensitize Glioblastoma-initiating Cells

(2018) Laure Malric et al.   MOLECULAR CANCER RESEARCH

Alpha-6 integrin promotes radioresistance of glioblastoma by modulating DNA damage response and the transcription factor Zeb1

(2018) Aline Kowalski-Chauvel et al.   Cell Death & Disease

FGFR1/FOXM1 pathway: a key regulator of glioblastoma stem cells radioresistance and a prognosis biomarker

(2018) Valérie Gouazé-Andersson et al.   Oncotarget

The Gene Ontology Resource: 20 years and still GOing strong

(2018)   NUCLEIC ACIDS RESEARCH

Rindopepimut with temozolomide for patients with newly diagnosed, EGFRvIII-expressing glioblastoma (ACT IV): a randomised, double-blind, international phase 3 trial

(2017) Michael Weller et al.   LANCET ONCOLOGY

Essential role of METTL3-mediated m6A modification in glioma stem-like cells maintenance and radioresistance

(2017) A Visvanathan et al.   ONCOGENE

Expression signatures of DNA repair genes correlate with survival prognosis of astrocytoma patients

(2017) Juliana Ferreira de Sousa et al.   TUMOR BIOLOGY

m 6 A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells

(2017) Qi Cui et al.   Cell Reports

RAD51 Is a Selective DNA Repair Target to Radiosensitize Glioma Stem Cells

(2017) Harry O. King et al.   Stem Cell Reports

Verteporfin inhibits growth of human glioma in vitro without light activation

(2017) Ahmad Al-Moujahed et al.   Scientific Reports

Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma

(2016) Michele Ceccarelli et al.   CELL

Verteporfin, a suppressor of YAP–TEAD complex, presents promising antitumor properties on ovarian cancer

(2016) Zhengyu Li et al.   OncoTargets and Therapy

Selective Inhibition of Parallel DNA Damage Response Pathways Optimizes Radiosensitization of Glioblastoma Stem-like Cells

(2015) S. U. Ahmed et al.   CANCER RESEARCH

Cancer stem cells in glioblastoma

(2015) Justin D. Lathia et al.   GENES & DEVELOPMENT

Anti-inflammatory drugs and uterine cervical cancer cells: Antineoplastic effect of meclofenamic acid

(2015) ALEJANDRO D. SORIANO-HERNANDEZ et al.   Oncology Letters

Three-Dimensional (3D) Tumor Spheroid Invasion Assay

(2015) Maria Vinci et al.   Jove-Journal of Visualized Experiments

Increased sensitivity to ionizing radiation by targeting the homologous recombination pathway in glioma initiating cells

(2014) Yi Chieh Lim et al.   Molecular Oncology

Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5

(2014) Yue Huang et al.   NUCLEIC ACIDS RESEARCH

Curbing false discovery rates in interpretation of genome-wide expression profiles

(2013) Bernard Ycart et al.   JOURNAL OF BIOMEDICAL INFORMATICS

A Role for Homologous Recombination and Abnormal Cell-Cycle Progression in Radioresistance of Glioma-Initiating Cells

(2012) Y. C. Lim et al.   MOLECULAR CANCER THERAPEUTICS

Human Glioblastoma Stem-Like Cells are More Sensitive to Allogeneic NK and T Cell-Mediated Killing Compared with Serum-Cultured Glioblastoma Cells

(2011) Tony Avril et al.   BRAIN PATHOLOGY

L1CAM regulates DNA damage checkpoint response of glioblastoma stem cells through NBS1

(2011) Lin Cheng et al.   EMBO JOURNAL

Antitumor effect of meclofenamic acid on human androgen-independent prostate cancer: a preclinical evaluation

(2011) Alejandro D. Soriano-Hernández et al.   INTERNATIONAL UROLOGY AND NEPHROLOGY

Rad51 inhibition is an effective means of targeting DNA repair in glioma models and CD133+ tumor-derived cells

(2011) S. C. Short et al.   NEURO-ONCOLOGY

γH2AX: a sensitive molecular marker of DNA damage and repair

(2010) L-J Mah et al.   LEUKEMIA